M I Gilmour

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices
    Yong Ho Kim
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U, S, Environmental Protection Agency, Research Triangle Park, NC, USA
    Part Fibre Toxicol 11:29. 2014
  2. pmc Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway
    Seung Hyun Cho
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:1682-9. 2009
  3. doi request reprint Influence of air pollutants on allergic sensitization: the paradox of increased allergies and decreased resistance to infection
    M Ian Gilmour
    Environmental Public Health Division National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 40:312-4. 2012
  4. pmc Role of oxidative stress on diesel-enhanced influenza infection in mice
    Kymberly M Gowdy
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, 109 T, W, Alexander Dr, RTP, NC, 27711, USA
    Part Fibre Toxicol 7:34. 2010
  5. ncbi request reprint Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States
    M Ian Gilmour
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Durham, North Carolina 27711, USA
    Inhal Toxicol 19:7-16. 2007
  6. pmc How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma
    M Ian Gilmour
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:627-33. 2006
  7. ncbi request reprint Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion
    M Ian Gilmour
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Air Waste Manag Assoc 54:286-95. 2004
  8. pmc Air pollutant-enhanced respiratory disease in experimental animals
    M I Gilmour
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 109:619-22. 2001
  9. ncbi request reprint Animal models to assess the effects of air pollutants on allergic lung disease
    M K Selgrade
    National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Ann N Y Acad Sci 919:230-8. 2000
  10. ncbi request reprint Enhanced allergic responses to house dust mite by oral exposure to carbaryl in rats
    W Dong
    Immunotoxicology Branch, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 44:63-9. 1998

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Cardiopulmonary toxicity of peat wildfire particulate matter and the predictive utility of precision cut lung slices
    Yong Ho Kim
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U, S, Environmental Protection Agency, Research Triangle Park, NC, USA
    Part Fibre Toxicol 11:29. 2014
    ..Moreover, reliable alternatives to traditional animal toxicity testing are needed to reduce the number of animals required for hazard identification and risk assessments...
  2. pmc Comparative toxicity of size-fractionated airborne particulate matter collected at different distances from an urban highway
    Seung Hyun Cho
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:1682-9. 2009
    ..Epidemiologic studies have reported an association between proximity to highway traffic and increased cardiopulmonary illnesses...
  3. doi request reprint Influence of air pollutants on allergic sensitization: the paradox of increased allergies and decreased resistance to infection
    M Ian Gilmour
    Environmental Public Health Division National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 40:312-4. 2012
    ..A simplified model explains how the potentiation of the Th2 arm of immunity by diesel exhaust results in increased allergic sensitization, whereas cell-mediated (protective) immunity against viral infections is simultaneously reduced...
  4. pmc Role of oxidative stress on diesel-enhanced influenza infection in mice
    Kymberly M Gowdy
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, 109 T, W, Alexander Dr, RTP, NC, 27711, USA
    Part Fibre Toxicol 7:34. 2010
    ....
  5. ncbi request reprint Comparative toxicity of size-fractionated airborne particulate matter obtained from different cities in the United States
    M Ian Gilmour
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Durham, North Carolina 27711, USA
    Inhal Toxicol 19:7-16. 2007
    ..Further studies will assess how source profiles correlate with the observed effects for all locations and size fractions...
  6. pmc How exposure to environmental tobacco smoke, outdoor air pollutants, and increased pollen burdens influences the incidence of asthma
    M Ian Gilmour
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:627-33. 2006
    ....
  7. ncbi request reprint Differential pulmonary inflammation and in vitro cytotoxicity of size-fractionated fly ash particles from pulverized coal combustion
    M Ian Gilmour
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Air Waste Manag Assoc 54:286-95. 2004
    ..It is concluded that fly ash toxicity is inversely related with particle size and is associated with increased sulfur and trace element content...
  8. pmc Air pollutant-enhanced respiratory disease in experimental animals
    M I Gilmour
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 109:619-22. 2001
    ..This information can be used to predict the health risk of simple and complex exposures and to lend insight into the mechanisms of air pollution toxicity...
  9. ncbi request reprint Animal models to assess the effects of air pollutants on allergic lung disease
    M K Selgrade
    National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Ann N Y Acad Sci 919:230-8. 2000
    ..It is clear that environmental contaminants can exacerbate the expression of these features. Work is under way to explore underlying mechanisms and to develop methods for applying these data to human health risk assessment...
  10. ncbi request reprint Enhanced allergic responses to house dust mite by oral exposure to carbaryl in rats
    W Dong
    Immunotoxicology Branch, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 44:63-9. 1998
    ..The results suggest that carbaryl may cause systemic immune suppression, while enhancing pulmonary allergic responses to house dust mite antigen...
  11. ncbi request reprint Kinetic profile of influenza virus infection in three rat strains
    Mary J Daniels
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
    Comp Med 53:293-8. 2003
    ..The results indicate that F344 and SD rats respond in similar manner to viral infection, whereas viral replication was more limited in BN rats and was associated with a different profile of pulmonary cells...
  12. pmc Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice
    Pramila Singh
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 112:820-5. 2004
    ..Key words: automobile, diesel exhaust particles, forklift, mice, pulmonary toxicity, SRM 2975...
  13. ncbi request reprint Systemic administration of Bordetella pertussis enhances pulmonary sensitization to house dust mite in juvenile rats
    Wumin Dong
    Immunotoxicology Branch, MD 92, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Toxicol Sci 72:113-21. 2003
    ..These results suggest that simultaneous exposure to Th2-inducing vaccine components and allergenic proteins may be a risk factor for allergic sensitization and the development of asthma in susceptible individuals...
  14. doi request reprint Differential cardiopulmonary effects of size-fractionated ambient particulate matter in mice
    Haiyan Tong
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Cardiovasc Toxicol 10:259-67. 2010
    ..This study shows that exposure of mice to coarse PM results in significant pulmonary toxicity while ultrafine PM appears to enhance cardiac ischemia/reperfusion injury...
  15. doi request reprint Influence of acid functionalization on the cardiopulmonary toxicity of carbon nanotubes and carbon black particles in mice
    Haiyan Tong
    Human Studies Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 239:224-32. 2009
    ..Further experiments are needed to understand the physico-chemical processes involved in this phenomenon...
  16. ncbi request reprint Source apportionment of particulate matter in the U.S. and associations with lung inflammatory markers
    Rachelle M Duvall
    National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Inhal Toxicol 20:671-83. 2008
    ..Increases in inflammatory markers were not observed for coarse PM mass and source markers. These findings suggest that certain PM size fractions and sources are associated with markers of lung injury or inflammation...
  17. ncbi request reprint Assessing the health effects and risks associated with children's inhalation exposures--asthma and allergy
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, North California, USA
    J Toxicol Environ Health A 71:196-207. 2008
    ..Because asthma is a complex (multiple genes, phenotypes, organ systems) disease, this area is ripe for systems biology approaches...
  18. doi request reprint Effects of prenatal diesel exhaust inhalation on pulmonary inflammation and development of specific immune responses
    Tuya Sharkhuu
    Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, NHEERL, US Environmental Protection Agency EPA, Research Triangle Park, North Carolina 27711, United States
    Toxicol Lett 196:12-20. 2010
    ....
  19. pmc Induction of asthma and the environment: what we know and need to know
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:615-9. 2006
    ..Research to address these questions could have a significant public health and economic impact that would be well worth the investment...
  20. pmc Metal composition of ambient PM2.5 influences severity of allergic airways disease in mice
    Stephen H Gavett
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 111:1471-7. 2003
    ..These results are consistent with epidemiologic findings and show that metal composition of ambient PM(2.5) influences the severity of allergic respiratory disease...
  21. pmc Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particles
    David M DeMarini
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:814-9. 2004
    ....
  22. ncbi request reprint Mortality in dioxin-exposed mice infected with influenza: mitochondrial toxicity (reye's-like syndrome) versus enhanced inflammation as the mode of action
    Robert W Luebke
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, NC 27711, USA
    Toxicol Sci 69:109-16. 2002
    ..These results suggest that RS is an unlikely explanation for increased influenza mortality in TCDD-exposed mice. Rather, constituents in BALF implicate increased pulmonary inflammation as the mode of TCDD action...
  23. ncbi request reprint Exposure to ultraviolet radiation enhances mortality and pathology associated with influenza virus infection in mice
    L K Ryan
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Photochem Photobiol 72:497-507. 2000
    ..The mechanism of enhanced mortality is uncertain, but the data raises concerns that UVR may exacerbate early responses that contribute to the pathogenesis of a primary viral infection...
  24. ncbi request reprint Suppression of allergic immune responses to house dust mite (HDM) in rats exposed to 2,3,7,8-TCDD
    R W Luebke
    Experimental Toxicology Division, NHEERL, ORD, U S EPA, Research Triangle Park, North Carolina, USA
    Toxicol Sci 62:71-9. 2001
    ..We therefore conclude that TCDD exposure suppressed, rather than enhanced the development of allergic immune responses and the expression of immune-mediated lung disease...
  25. ncbi request reprint Diesel exhaust enhanced susceptibility to influenza infection is associated with decreased surfactant protein expression
    Jonathan Ciencewicki
    Curriculum of Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    Inhal Toxicol 19:1121-33. 2007
    ..Taken together, the results demonstrate that exposure to DE enhances the susceptibility to respiratory viral infections by reducing the expression and production of antimicrobial surfactant proteins...
  26. ncbi request reprint Genetic basis of murine antibacterial defense to streptococcal lung infection
    John W Hollingsworth
    Division of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, P O Box 3136, Durham, NC 27710, USA
    Immunogenetics 59:713-24. 2007
    ..These results demonstrate that innate differences in pulmonary host defense to S. zooepidemicus are dependent on host genetic factors...
  27. doi request reprint Isolation and quantitative estimation of diesel exhaust and carbon black particles ingested by lung epithelial cells and alveolar macrophages in vitro
    Rajiv K Saxena
    National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
    Biotechniques 44:799-805. 2008
    ..This technique can be applied to examine the interactions between cells and particles containing EC and to study the modulation of particle uptake in diseased tissue...
  28. doi request reprint Modulation of pulmonary inflammatory responses and antimicrobial defenses in mice exposed to diesel exhaust
    Kymberly Gowdy
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 229:310-9. 2008
    ....
  29. ncbi request reprint Murine pulmonary inflammatory responses following instillation of size-fractionated ambient particulate matter
    Colin A J Dick
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, USA
    J Toxicol Environ Health A 66:2193-2207. 2003
    ....
  30. doi request reprint Increased transcription of immune and metabolic pathways in naive and allergic mice exposed to diesel exhaust
    Tina Stevens
    Curriculum of Toxicology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 102:359-70. 2008
    ..This study shows for the first time early changes in gene expression induced by the combination of DE inhalation and mucosal immunization, which resulted in stronger development of allergic eosinophilia...
  31. ncbi request reprint Phenotypic comparison of allergic airway responses to house dust mite in three rat strains
    Pramila Singh
    North Carolina State University, College of Veterinary Medicine, Raleigh 27606, USA
    Am J Physiol Lung Cell Mol Physiol 284:L588-98. 2003
    ..Phenotypic differences in response to HDM were associated with differences in the Th1/Th2 cytokine balance and antioxidant capacity...