Research Topics
| Mary E GilbertSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
| Collaborators
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Detail Information
Publications
Dose-dependent reductions in spatial learning and synaptic function in the dentate gyrus of adult rats following developmental thyroid hormone insufficiencyM E Gilbert
Neurotoxicology Division MD B105 05, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Brain Res 1069:10-22. 2006....
Developmental thyroid hormone insufficiency and brain development: A role for brain-derived neurotrophic factor (BDNF)?M E Gilbert
Toxicity Assessment Division, Neurotoxicology Branch, U S Environmental Protection Agency, Research Triangle Park, NC, USA Electronic address
Neuroscience 239:253-70. 2013..We further suggest that investigation of BDNF invoked by synaptic activation (i.e., plasticity, enrichment, trauma) may serve to elucidate a role of thyroid hormone in BDNF-regulated synaptic function...- An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcomeMary E Gilbert
U S Environmental Protection Agency, Research Triangle Park, NC, USA
Toxicol Sci 132:177-95. 2013..These findings have implications for regulation of TH-disrupting chemicals and suggest that standard behavioral assays do not readily detect neurotoxicity induced by modest developmental TH disruption... - Impact of low-level thyroid hormone disruption induced by propylthiouracil on brain development and functionMary E Gilbert
Neurotoxicology Branch, Toxicity Assessment Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 124:432-45. 2011..Biphasic dose-response profiles were evident in some measures (trace fear conditioning and LTP) but not others and serve to exemplify the complexity of the role of TH in brain development and its consequences for brain function... - Developmental thyroid hormone disruption: prevalence, environmental contaminants and neurodevelopmental consequencesMary E Gilbert
Toxicity Assessment Division MD B105 05, US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
Neurotoxicology 33:842-52. 2012..Additional work is required to understand the impact of low level perturbations of the thyroid axis to evaluate the risk associated with environmental contaminants with thyroid action... - Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampusM E Gilbert
Neurotoxicology Division MD B105 05, National Health and Environmental Effects Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Brain Res Dev Brain Res 145:19-29. 2003.... - Alterations in synaptic transmission and plasticity in area CA1 of adult hippocampus following developmental hypothyroidismM E Gilbert
Neurotoxicology Division MD B105 05, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Brain Res Dev Brain Res 148:11-8. 2004.... - Developmental lead (Pb) exposure reduces the ability of the NMDA antagonist MK-801 to suppress long-term potentiation (LTP) in the rat dentate gyrus, in vivoM E Gilbert
Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 29:385-93. 2007.... - Chronic developmental lead exposure reduces neurogenesis in adult rat hippocampus but does not impair spatial learningM E Gilbert
Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 86:365-74. 2005..Despite deficits in synaptic plasticity previously reported from our laboratory, and now structural plasticity, no significant impact on spatial learning was detected... - Thyroid hormone insufficiency during brain development reduces parvalbumin immunoreactivity and inhibitory function in the hippocampusM E Gilbert
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Endocrinology 148:92-102. 2007..These data demonstrate that moderate degrees of thyroid hormone insufficiency during the early postnatal period permanently alters interneuron expression of PV and compromises inhibitory function in the hippocampus... - Does the kindling model of epilepsy contribute to our understanding of multiple chemical sensitivity?M E Gilbert
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Ann N Y Acad Sci 933:68-91. 2001..Alternatively, kindling may be useful as a tool to selectively increase sensitivity in subcomponents of the neural fear circuit to address questions relating the role of anxiety in the development and expression of MCS... 
Developmental exposure to perchlorate alters synaptic transmission in hippocampus of the adult ratMary E Gilbert
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Health Perspect 116:752-60. 2008..Perchlorate is an environmental contaminant that blocks iodine uptake into the thyroid gland and reduces thyroid hormones. This action of perchlorate raises significant concern over its effects on brain development...- In vitro systems as simulations of in vivo conditions: the study of cognition and synaptic plasticity in neurotoxicologyM E Gilbert
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Ann N Y Acad Sci 919:119-32. 2000..The study of LTP serves as an excellent example of how in vivo phenomena can be taken to more simplified in vitro test systems to directly address cellular and biochemical mechanisms of information storage in brain... - Spatial learning and long-term potentiation in the dentate gyrus of the hippocampus in animals developmentally exposed to Aroclor 1254M E Gilbert
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 57:102-11. 2000.... - Moderate developmental undernutrition: Impact on growth and cognitive function in youth and old ageM E Gilbert
Toxicity Assessment Division, U S Environmental Protection Agency, Research Triangle Park, NC, USA
Neurotoxicol Teratol 32:362-72. 2010..These findings indicate that moderate fetal undernutrition followed by neonatal adequate nutrition does not appear to lead to obesity or neurological dysfunction in young adulthood or old age... - Marginal iodide deficiency and thyroid function: dose-response analysis for quantitative pharmacokinetic modelingM E Gilbert
Toxicity Assessment Division MD B105 05, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27711, USA
Toxicology 283:41-8. 2011..These results challenge existing models and provide essential information for development of quantitative BBDR models for ID during pregnancy and lactation... - Pre- and postnatal propylthiouracil-induced hypothyroidism impairs synaptic transmission and plasticity in area CA1 of the neonatal rat hippocampusLi Sui
National Research Council, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Endocrinology 144:4195-203. 2003.... - New and evolving concepts in the neurotoxicology of leadL D White
National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 225:1-27. 2007.... - A genomic analysis of subclinical hypothyroidism in hippocampus and neocortex of the developing rat brainJ E Royland
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
J Neuroendocrinol 20:1319-38. 2008.... - Reproductive effects of maternal and pre-weaning undernutrition in rat offspring: age at puberty, onset of female reproductive senescence and intergenerational pup growth and viabilityN Chernoff
U S Environmental Protection Agency, NHEERL, Research Triangle Park, NC 27711, USA
Reprod Toxicol 28:489-94. 2009..Females were bred to control males and no evidence of adverse reproductive effects was found in any F2 groups. The offspring of the F1 generation did not show an intergenerational effect as documented in humans... - Accumulation of methylmercury or polychlorinated biphenyls in in vitro models of rat neuronal tissueC A Meacham
Neurotoxicology Division, National Health and Environmental Effects Research Laboratory/ORD, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 205:177-87. 2005.... - Chronic developmental lead exposure increases the threshold for long-term potentiation in rat dentate gyrus in vivoM E Gilbert
National Research Council, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Brain Res 736:118-24. 1996..It is possible that the threshold changes in the induction of LTP reported here contribute to cognitive impairments associated with Pb exposure... - Chronic lead exposure accelerates decay of long-term potentiation in rat dentate gyrus in vivoM E Gilbert
National Research Council, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Brain Res 789:139-49. 1998..The reported effects of Pb on growth-related processes may thus contribute to a reduced persistence of LTP and the resulting cognitive deficits engendered by developmental Pb exposure... - Alterations in synaptic transmission and plasticity in hippocampus by a complex PCB mixture, Aroclor 1254M E Gilbert
National Research Council, Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicol Teratol 20:383-9. 1998..Acute effects of PCBs on calcium homeostasis, protein kinase C translocation, dopaminergic function, and hormonal action may contribute to the pattern of effects seen in synaptic transmission and plasticity in the hippocampus... - The influence of developmental period of lead exposure on long-term potentiation in the adult rat dentate gyrus in vivoM E Gilbert
National Research Council and Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicology 20:57-69. 1999..An attenuated ability to support neuroplastic change in synaptic function may contribute to cognitive deficits associated with Pb-induced toxicity... - Chronic developmental lead exposure and hippocampal long-term potentiation: biphasic dose-response relationshipM E Gilbert
National Research Council and Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicology 20:71-82. 1999.... - Field potential recordings in dentate gyrus of anesthetized rats: stability of baselineM E Gilbert
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Hippocampus 9:277-87. 1999..These data suggest that generalized surgical trauma contributes to the upward drift in response amplitude and indicate that long stabilization periods are required in acute surgical preparations for accurate field potential recordings... - Developmental exposure to a commercial PCB mixture (Aroclor 1254) produces a persistent impairment in long-term potentiation in the rat dentate gyrus in vivoM E Gilbert
Neurotoxicology Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Brain Res 850:87-95. 1999..Disruption of early brain ontogeny due to developmental PCB exposure may underlie perturbations in the neurological substrates that support synaptic plasticity and contribute to deficits in LTP and learning that persist into adulthood... - Perinatal exposure to polychlorinated biphenyls alters excitatory synaptic transmission and short-term plasticity in the hippocampus of the adult ratM E Gilbert
Neurotoxicology Division B105 05, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Neurotoxicology 24:851-60. 2003.... - Enhancement of paired-pulse depression in the dentate gyrus in vivo by the NMDA antagonist, MK-801, and electrical kindlingM E Gilbert
National Research Council, Research Triangle Park, NC 27711, USA
Brain Res 732:201-8. 1996..The latter findings indicate that the processes responsible for the reduction in late paired-pulse depression at high stimulus intensities are unaffected by either NMDA or kindling-induced modulation of late paired-pulse depression... - Behavioral effects of subchronic inhalation of toluene in adult ratsTracey E Beasley
Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Neurotoxicol Teratol 32:611-9. 2010..These results are consistent with a pattern of subtle and inconsistent long-term effects of daily exposure to toluene vapor, in contrast to robust and reliable effects of acute inhalation of the solvent... - Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure levelS M Lasley
Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, P O Box 1649, Peoria, Illinois 61656, USA
Toxicol Sci 66:139-47. 2002..E. Gilbert et al., 1999b, Neurotoxicology 20, 71-82) reinforce the conclusion that exposure-related changes in GLU release play a significant role in the Pb-induced effects seen in this model of synaptic plasticity... - Impairment in short-term but enhanced long-term synaptic potentiation and ERK activation in adult hippocampal area CA1 following developmental thyroid hormone insufficiencyL Sui
National Research Council, Washington, DC 20001, USA
Toxicol Sci 85:647-56. 2005..Such alterations in hippocampal synaptic function may contribute to persistent behavioral deficits associated with developmental hypothyroidism...