Andrew Ghio

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. pmc Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Respir Res 9:10. 2008
  2. ncbi request reprint Mechanism of asthmatic exacerbation by ambient air pollution particles
    Andrew J Ghio
    Human Studies Division, NHEERL, USEPA, Research Triangle Park, NC 27711, USA
    Expert Rev Respir Med 2:109-18. 2008
  3. pmc Iron, human growth, and the global epidemic of obesity
    Rahul G Sangani
    Geisinger Medical Center, Danville, PA 17821, USA
    Nutrients 5:4231-49. 2013
  4. doi request reprint Sequestration of mitochondrial iron by silica particle initiates a biological effect
    Andrew J Ghio
    Human Studies Facility, 104 Mason Farm Road, Chapel Hill, NC
    Am J Physiol Lung Cell Mol Physiol 305:L712-24. 2013
  5. doi request reprint Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, US EPA, Chapel Hill, NC 27599 7315, USA
    J Cyst Fibros 12:390-8. 2013
  6. pmc Deficiency of α-1-antitrypsin influences systemic iron homeostasis
    Andrew J Ghio
    Human Studies Facility, US Environmental Protection Agency, 104 Mason Farm Rd, Chapel Hill, NC 27599, USA
    Int J Chron Obstruct Pulmon Dis 8:45-51. 2013
  7. doi request reprint Controlled human exposures to diesel exhaust
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina 27599 7315, USA
    Swiss Med Wkly 142:w13597. 2012
  8. pmc Case report: supraventricular arrhythmia after exposure to concentrated ambient air pollution particles
    Andrew J Ghio
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Chapel Hill, North Carolina, USA
    Environ Health Perspect 120:275-7. 2012
  9. doi request reprint Diesel exhaust particles and airway inflammation
    Andrew J Ghio
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina, USA
    Curr Opin Pulm Med 18:144-50. 2012
  10. doi request reprint Exposure to wood smoke particles produces inflammation in healthy volunteers
    Andrew J Ghio
    The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA
    Occup Environ Med 69:170-5. 2012

Detail Information

Publications91

  1. pmc Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Respir Res 9:10. 2008
    ..Because inhaled particles, such as silica, and certain infections can cause secondary pulmonary alveolar proteinosis (PAP), we tested the hypothesis that idiopathic PAP is associated with an altered iron homeostasis in the human lung...
  2. ncbi request reprint Mechanism of asthmatic exacerbation by ambient air pollution particles
    Andrew J Ghio
    Human Studies Division, NHEERL, USEPA, Research Triangle Park, NC 27711, USA
    Expert Rev Respir Med 2:109-18. 2008
    ..Other postulated mechanisms for asthmatic exacerbation following PM exposure include an impact on the incidence of infections and adjuvant effects...
  3. pmc Iron, human growth, and the global epidemic of obesity
    Rahul G Sangani
    Geisinger Medical Center, Danville, PA 17821, USA
    Nutrients 5:4231-49. 2013
    ..Testing potential associations between iron availability and both obesity and obesity-related diseases in populations will be difficult since fortification and supplementation is so extensively practiced. ..
  4. doi request reprint Sequestration of mitochondrial iron by silica particle initiates a biological effect
    Andrew J Ghio
    Human Studies Facility, 104 Mason Farm Road, Chapel Hill, NC
    Am J Physiol Lung Cell Mol Physiol 305:L712-24. 2013
    ..The resultant oxidative stress and biological response after particle exposure are either diminished or inhibited by increasing the cell iron concentration...
  5. doi request reprint Iron accumulates in the lavage and explanted lungs of cystic fibrosis patients
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, US EPA, Chapel Hill, NC 27599 7315, USA
    J Cyst Fibros 12:390-8. 2013
    ..We conclude that iron homeostasis is disrupted in CF patients with an accumulation of this metal and altered expression of iron-related proteins being evident in the lungs...
  6. pmc Deficiency of α-1-antitrypsin influences systemic iron homeostasis
    Andrew J Ghio
    Human Studies Facility, US Environmental Protection Agency, 104 Mason Farm Rd, Chapel Hill, NC 27599, USA
    Int J Chron Obstruct Pulmon Dis 8:45-51. 2013
    ..A1AT deficiency is associated with evidence of a disruption in iron homeostasis with plasma ferritin and nonheme iron concentrations being elevated among those with the ZZ genotype...
  7. doi request reprint Controlled human exposures to diesel exhaust
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina 27599 7315, USA
    Swiss Med Wkly 142:w13597. 2012
    ..Future research will focus on the relative importance of diesel exhaust components, potential interactions between components and other pollutants, effects in sensitive individuals, and effects of longer or repeated exposures...
  8. pmc Case report: supraventricular arrhythmia after exposure to concentrated ambient air pollution particles
    Andrew J Ghio
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Chapel Hill, North Carolina, USA
    Environ Health Perspect 120:275-7. 2012
    ..Exposure to air pollution can result in the onset of arrhythmias...
  9. doi request reprint Diesel exhaust particles and airway inflammation
    Andrew J Ghio
    Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina, USA
    Curr Opin Pulm Med 18:144-50. 2012
    ..We review the recent controlled human exposures to diesel exhaust and DEPs, and summarize the investigations into the associations between this emission source air pollution particle and airway inflammation...
  10. doi request reprint Exposure to wood smoke particles produces inflammation in healthy volunteers
    Andrew J Ghio
    The National Health and Environmental Effects Research Laboratory, US EPA, Research Triangle Park, North Carolina, USA
    Occup Environ Med 69:170-5. 2012
    ..This investigation tested the postulate that healthy volunteers exposed to WSP would demonstrate evidence of both pulmonary and systemic inflammation...
  11. doi request reprint Composition of air pollution particles and oxidative stress in cells, tissues, and living systems
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health B Crit Rev 15:1-21. 2012
    ..Consequently, oxidative stress in cells and tissues is a central mechanism by which PM exposure leads to injury, disease, and mortality...
  12. pmc Hepcidin expression in human airway epithelial cells is regulated by interferon-γ
    Marie D Frazier
    Department of Pediatrics, Marshall University, Huntington, WV 25701, USA
    Respir Res 12:100. 2011
    ..Therefore, we hypothesized that hepcidin is expressed in airway epithelial cells and is regulated by early phase cytokines...
  13. ncbi request reprint Divalent metal transporter-1 decreases metal-related injury in the lung
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Am J Physiol Lung Cell Mol Physiol 289:L460-7. 2005
    ..These results thus demonstrate for the first time a primary role for DMT1 in lung metal transport and detoxification...
  14. ncbi request reprint Colchicine decreases airway hyperreactivity after phosgene exposure
    Andrew Ghio
    National Health Effects and Environmental Research Laboratory U S Environmental Protection Agency, Office of Research and Development, Research Triangle Park, NC 27599, USA
    Inhal Toxicol 17:277-85. 2005
    ..Colchicine may affect injury and changes in expiratory resistance and dynamic compliance by diminishing the incursion of inflammatory cells, but other properties of this medication may also be responsible for the observed results...
  15. doi request reprint Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Am J Respir Cell Mol Biol 38:715-23. 2008
    ..This loss of cellular iron after CO is in line with certain biological effects of the gas that have been implicated in the protection of cell viability...
  16. ncbi request reprint The association between serum ferritin and uric acid in humans
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Free Radic Res 39:337-42. 2005
    ..We tested the hypothesis that there is an association between iron availability and urate production in healthy humans by correlating serum concentrations of ferritin with uric acid levels...
  17. ncbi request reprint Ferruginous bodies: implications in the mechanism of fiber and particle toxicity
    Andrew J Ghio
    United States Environmental Protection Agency, Research, Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 32:643-9. 2004
    ..It is recommended that an identification of ferruginous bodies in the lung be regarded as support for a metal-catalyzed oxidative stress in the mechanism of cell and tissue injury...
  18. ncbi request reprint Biological effects of Utah Valley ambient air particles in humans: a review
    Andrew J Ghio
    Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Aerosol Med 17:157-64. 2004
    ..In addition, correlates between findings of epidemiological studies and the biological effects of PM in cell and human investigation were demonstrated...
  19. ncbi request reprint Disruption of iron homeostasis as a mechanism of biologic effect by ambient air pollution particles
    Andrew J Ghio
    Clinical Research Branch, Human Studies Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27599, USA
    Inhal Toxicol 17:709-16. 2005
    ..An association between metal equilibrium in the lower respiratory tract and biological effect in the lung could explain the observed differential toxicity of ultrafine, fine, and coarse particles and disparities in host susceptibility...
  20. doi request reprint Gadolinium exposure disrupts iron homeostasis in cultured cells
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Biol Inorg Chem 16:567-75. 2011
    ..We conclude that gadolinium impacts cell iron homeostasis to change import and storage of the metal and biological effects of exposure...
  21. ncbi request reprint Iron homeostasis in the lung
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Biol Res 39:67-77. 2006
    ..This pathway is likely to be the major method for the control of oxidative stress presented to the respiratory tract...
  22. doi request reprint Disruption of iron homeostasis and lung disease
    Andrew J Ghio
    Human Studies Division, ORD, NHEERL, US EPA, Campus Box 7315, 104 Mason Farm Road, Chapel Hill, NC 27599 7315, USA
    Biochim Biophys Acta 1790:731-9. 2009
    ..Finally, iron homeostasis is disrupted in numerous chronic lung diseases including pulmonary alveolar proteinosis, transplantation, cigarette smoking, and cystic fibrosis...
  23. doi request reprint Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Am J Respir Crit Care Med 178:1130-8. 2008
    ..Lung injury after cigarette smoking is related to particle retention. Iron accumulates with the deposition of these particles...
  24. ncbi request reprint Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers
    Andrew J Ghio
    Clinical Research Branch, Human Studies Division, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 34:723-9. 2006
    ..Linear structures were irregularly interrupted by deposition of iron-abundant material. The capacity of these synthetic fibers to complex iron and generate an oxidative stress is confirmed in vitro...
  25. ncbi request reprint Exercise-induced pulmonary hemorrhage after running a marathon
    Andrew J Ghio
    Human Studies Division, US EPA, Campus Box 7315, Chapel Hill, NC 27599 7315, USA
    Lung 184:331-3. 2006
    ..EIPH in humans may occur without any evidence on clinical presentation; its incidence may be far greater than currently suspected...
  26. ncbi request reprint Iron accumulation and expression of iron-related proteins following murine exposure to crocidolite
    Andrew Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Environ Pathol Toxicol Oncol 28:153-62. 2009
    ..Elevations in available iron affect changes in the expression of Dcytb, DMT1, ferritin, and FPN1, which further modify metal homeostasis in the lung...
  27. ncbi request reprint Lung injury after ozone exposure is iron dependent
    Andrew J Ghio
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, 104 Mason Farm Rd, Chapel Hill, NC 27599 7315, USA
    Am J Physiol Lung Cell Mol Physiol 292:L134-43. 2007
    ..With exposure to O3, elevated DMT1 expression diminished oxidative stress (i.e., aldehyde generation) and IL-8 release. We conclude that iron participates critically in the oxidative stress and biological effects after O3 exposure...
  28. ncbi request reprint Exposure to concentrated ambient particles (CAPs): a review
    Andrew J Ghio
    Clinical Research Branch, Human Studies Division, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Inhal Toxicol 16:53-9. 2004
    ..In addition, it appears that specific components in CAPS may differentially affect these tissues...
  29. pmc Biologic effects of oil fly ash
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office for Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 110:89-94. 2002
    ..The extrapolation of this body of investigation on ROFA to the field of ambient air PM is difficult, as particles in numerous environments have such small amounts of vanadium...
  30. doi request reprint Disruption of iron homeostasis in mesothelial cells after talc pleurodesis
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Am J Respir Cell Mol Biol 46:80-6. 2012
    ..e., a fibro-inflammatory response). Talc pleurodesis can function as a model of the human response to mineral oxide particle exposure, albeit a massive one...
  31. ncbi request reprint Inflammatory lung injury after bronchial instillation of air pollution particles
    A J Ghio
    Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27599 7315, USA
    Am J Respir Crit Care Med 164:704-8. 2001
    ..Findings suggest that mass may not be the most appropriate metric to use in assessing health effects after PM exposure but rather specific components must be identified and assessed...
  32. ncbi request reprint Iron regulates xanthine oxidase activity in the lung
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Am J Physiol Lung Cell Mol Physiol 283:L563-72. 2002
    ....
  33. doi request reprint Complications of TNF-α antagonists and iron homeostasis
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, USEPA, Research Triangle Park, NC 27711, USA
    Med Hypotheses 78:33-5. 2012
    ..g. IFN-γ, IL-1, and IL-6) will similarly be associated with infections and neoplastic complications...
  34. ncbi request reprint DMT1 expression is increased in the lungs of hypotransferrinemic mice
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Am J Physiol Lung Cell Mol Physiol 284:L938-44. 2003
    ..Increased expression of -IRE DMT1 in the lungs of the Hp mice could be responsible for elevated concentrations of the metal in these tissues...
  35. ncbi request reprint Diminished injury in hypotransferrinemic mice after exposure to a metal-rich particle
    A J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Am J Physiol Lung Cell Mol Physiol 278:L1051-61. 2000
    ..Rather, these mice demonstrated a diminished injury that was associated with an increase in the metal storage and transport proteins...
  36. ncbi request reprint Exposure to concentrated ambient air particles alters hematologic indices in humans
    Andrew J Ghio
    National Health and Environmental Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Inhal Toxicol 15:1465-78. 2003
    ..We conclude that exposure of healthy volunteers to CAPs can be associated with decreases of both white blood cell (WBC) count and LDH and increased concentrations of fibrinogen in the blood...
  37. ncbi request reprint Effect of metal removal on the toxicity of airborne particulate matter from the Utah Valley
    Alejandro R Molinelli
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Inhal Toxicol 14:1069-86. 2002
    ..Taken together, our results suggest that removal of metal cations attenuates cellular responses to the aqueous extract and support a role for transition metal involvement in PM-associated increases in morbidity and mortality...
  38. doi request reprint Zinc transport by respiratory epithelial cells and interaction with iron homeostasis
    Zhongping Deng
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC 27599 7310, USA
    Biometals 22:803-15. 2009
    ..Comparable to other metal exposures, changes in iron homeostasis may contribute to the biological effects of zinc in specific cells and tissues...
  39. ncbi request reprint Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos
    Xinchao Wang
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, USA
    Am J Respir Cell Mol Biol 34:286-92. 2006
    ..We conclude that the response of respiratory epithelial cells to asbestos includes oxidant-mediated mechanisms to sequester catalytically active iron associated with the fiber...
  40. doi request reprint The role of cardiovascular disease-associated iron overload in Libby amphibole-induced acute pulmonary injury and inflammation
    Jonathan Shannahan
    University of North Carolina Chapel Hill, NC, USA
    Inhal Toxicol 23:129-41. 2011
    ..We conclude that underlying CVD-associated Fe-overload is likely linked to persistent lung injury, inflammation and antioxidant decompensation following LA exposure in rats...
  41. ncbi request reprint Overexpression of extracellular superoxide dismutase decreases lung injury after exposure to oil fly ash
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Am J Physiol Lung Cell Mol Physiol 283:L211-8. 2002
    ..This supports a participation of oxidative stress in the inflammatory injury after PM exposure rather than reflecting a response to metals alone...
  42. ncbi request reprint Exposure of BEAS-2B cells to secondary organic aerosol coated on magnetic nanoparticles
    Myoseon Jang
    Department of Environmental Sciences and Engineering, CB 7431, Rosenau Hall, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Chem Res Toxicol 19:1044-50. 2006
    ..These results support that MNP can effectively deliver SOAs to epithelial cells in vitro resulting in a significant biological effects...
  43. ncbi request reprint TNF, IFN-gamma, and endotoxin increase expression of DMT1 in bronchial epithelial cells
    Xinchao Wang
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, USA
    Am J Physiol Lung Cell Mol Physiol 289:L24-33. 2005
    ..Increased expression of this protein appears to be included in a coordinated response of the cell and tissue where the function might be to diminish availability of metal...
  44. ncbi request reprint Iron-binding and storage proteins in sputum
    Neil E Alexis
    Center for Environmental Medicine and Lung Biology, and Division of Pulmonary Medicine and Allergy, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Inhal Toxicol 14:387-400. 2002
    ..The finding of decreased transferrin with increased ferritin suggests a local cellular response via iron-response elements (IRE) associated with the mRNAs for these two iron-binding proteins...
  45. ncbi request reprint Zinc-induced PTEN protein degradation through the proteasome pathway in human airway epithelial cells
    Weidong Wu
    Center for Environmental Medicine, Asthma, and Lung Biology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 278:28258-63. 2003
    ..In summary, exposure to Zn2+ ions causes PTEN degradation and loss of function, which is mediated by an ubiquitin-associated proteolytic process in the airway epithelium...
  46. ncbi request reprint Asbestos-induced activation of cell signaling pathways in human bronchial epithelial cells
    Xinchao Wang
    National Health Effects and Environmental Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Exp Lung Res 32:229-43. 2006
    ..These results show that crocidolite can activate the phosphorylation of EGF receptor and its downstream cell signal pathway in BEAS-2B cells and this is associated with the oxidative stress presented by the fibers...
  47. ncbi request reprint Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
    Sukhdev S Brar
    Cannon Research Center, Carolinas Medical Center, Charlotte, North Carolina, USA
    Mol Cancer Ther 3:1049-60. 2004
    ..These findings present a novel strategy for treating metastatic melanoma by employing an old drug toward a new therapeutic use...
  48. doi request reprint Metals in air pollution particles decrease whole-blood coagulation time
    Rahul G Sangani
    Human Studies Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Chapel Hill, North Carolina, USA
    Inhal Toxicol 22:621-6. 2010
    ..These metals can potentially contribute to procoagulative effects observed following human exposures to air pollution particles...
  49. doi request reprint Acid and organic aerosol coatings on magnetic nanoparticles increase iron concentrations in human airway epithelial cells
    Andrew J Ghio
    Clinical Research Branch, Human Studies Division, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Inhal Toxicol 21:659-67. 2009
    ..We conclude that MNP can interact with a SOA and an inorganic acid to present metal in a catalytically reactive state to cultured respiratory cells. This produces an oxidative stress to affect a release of IL-8...
  50. ncbi request reprint A comparison of studies on the effects of controlled exposure to fine, coarse and ultrafine ambient particulate matter from a single location
    James M Samet
    Human Studies Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27514, USA
    Inhal Toxicol 19:29-32. 2007
    ..These findings have relevant implications for the design of future chamber studies and the role of particle size fraction in the adverse health effects of PM exposure in humans...
  51. doi request reprint Panel discussion review: session four--assessing biological plausibility of epidemiological findings in air pollution research
    James S Brown
    National Center for Environmental Assessment, U S Environmental Protection Agency, RTP, North Carolina 27711, USA
    J Expo Sci Environ Epidemiol 17:S97-105. 2007
    ..This paper does not approach, nor was it intended to approach, the more formal analytical approach such as that used in EPA's development of its Science Assessment Document for the criteria pollutants...
  52. ncbi request reprint Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash
    Yuh Chin T Huang
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Exp Lung Res 28:19-38. 2002
    ..These results indicate that tyrosine phosphorylation of EGF receptors in the lung, possibly as a result of inhibition of protein tyrosine phosphatases, mediates constriction of pulmonary vessels induced by ROFA...
  53. ncbi request reprint In vivo lipid-derived free radical formation by NADPH oxidase in acute lung injury induced by lipopolysaccharide: a model for ARDS
    Keizo Sato
    Free Radical Metabolite Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    FASEB J 16:1713-20. 2002
    ..Rats treated intratracheally with LPS generate lipid-derived free radicals via activation of NADPH oxidase...
  54. doi request reprint Pulmonary oxidative stress, inflammation, and dysregulated iron homeostasis in rat models of cardiovascular disease
    Jonathan H Shannahan
    Curriculum in Toxicology, University of North Carolina, Chapel Hill, North Carolina, USA
    J Toxicol Environ Health A 73:641-56. 2010
    ....
  55. ncbi request reprint Vascular effects of ambient pollutant particles and metals
    Yuh Chin T Huang
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Curr Vasc Pharmacol 4:199-203. 2006
    ..Understanding how metals induce vasoconstriction may lead to the development of novel vasodilator therapies for vascular diseases...
  56. ncbi request reprint Acute phase reaction in healthy volunteers after bronchoscopy with lavage
    Yuh Chin T Huang
    Human Studies Division, US EPA, 104 Mason Farm Rd, Chapel Hill, NC 27599 7315, USA
    Chest 129:1565-9. 2006
    ..The scope of the acute phase response induced by the procedure is not fully evaluated. The purpose of the study is to characterize the acute phase response induced by bronchoscopy with BAL...
  57. ncbi request reprint In vitro studies: what is their role in toxicology?
    Robert B Devlin
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Exp Toxicol Pathol 57:183-8. 2005
    ..This coherence between an in vivo and in vitro response provides relevance to additional in vitro studies that characterize the mechanisms by which these particles cause adverse health effects...
  58. ncbi request reprint The role of soluble components in ambient fine particles-induced changes in human lungs and blood
    Yuh Chin T Huang
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Inhal Toxicol 15:327-42. 2003
    ....
  59. ncbi request reprint Disruption of iron homeostasis in the lungs of transplant patients
    Christopher Pugh
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA
    J Heart Lung Transplant 24:1821-7. 2005
    ..Using samples acquired from surveillance bronchoalveolar lavage (BAL), we tested the postulate that there is a disruption of iron equilibrium in transplanted lung, which can worsen with time...
  60. ncbi request reprint Oxalate deposition on asbestos bodies
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, USA
    Hum Pathol 34:737-42. 2003
    ..We conclude that iron-catalyzed production of oxalate from ascorbate can account for the deposition of this crystal on ferruginous bodies...
  61. pmc Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice
    Joshua G McCaskill
    Department of Medicine, Division of Pulmonary Diseases and Cricital Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7219, USA
    Am J Respir Cell Mol Biol 35:347-56. 2006
    ....
  62. pmc Controlled human exposures to ambient pollutant particles in susceptible populations
    Yuh Chin T Huang
    Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Environ Health 8:33. 2009
    ....
  63. ncbi request reprint Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome
    Andrew J Ghio
    National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Crit Care Med 31:395-400. 2003
    ..Using bronchoalveolar lavage fluid, we quantified concentrations of iron and iron-related proteins in the lower respiratory tract in patients with acute respiratory distress syndrome and healthy volunteers...
  64. pmc Biodiesel exhaust: the need for health effects research
    Kimberly J Swanson
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Health Perspect 115:496-9. 2007
    ..Biodiesel exhaust emission has been extensively characterized under field and laboratory conditions, but there have been limited cytotoxicity and mutagenicity studies on the effects of biodiesel exhaust in biologic systems...
  65. ncbi request reprint Calcium stone lithoptysis in primary ciliary dyskinesia
    Marcus P Kennedy
    UNC Chapel Hill, Division of Pulmonary and Critical Care Medicine, Chapel Hill, NC 277599 7020, USA
    Respir Med 101:76-83. 2007
    ..An association between lithoptysis and primary ciliary dyskinesia (PCD) has not been previously reported. However, reports of lithoptysis from 2 older patients (>60 yr) prompted a study of this association...
  66. pmc Neutrophil elastase increases airway epithelial nonheme iron levels
    Bernard M Fischer
    Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
    Clin Transl Sci 2:333-9. 2009
    ..We demonstrated in vitro that NE increased intracellular non-heme iron levels and degraded ferritin. Our results suggest that NE digests ferritin increasing the extracellular iron pool available for cellular uptake...
  67. pmc Mass spectrometric analysis of biomarkers and dilution markers in exhaled breath condensate reveals elevated purines in asthma and cystic fibrosis
    Charles R Esther
    Division of Pediatric Pulmonology, Chapel Hill, North Carolina, USA
    Am J Physiol Lung Cell Mol Physiol 296:L987-93. 2009
    ..These results show that mass spectrometric analyses can be applied to measurement of purines in EBC and demonstrate that EBC adenosine-to-urea and AMP-to-urea ratios are potential noninvasive biomarkers of airways disease...
  68. pmc The critical role of intracellular zinc in adenosine A(2) receptor activation induced cardioprotection against reperfusion injury
    Rachel McIntosh
    Department of Anesthesiology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Mol Cell Cardiol 49:41-7. 2010
    ..NECA prevents reperfusion-induced zinc loss and relocates zinc to mitochondria. The inhibitory effects of zinc on both the mPTP opening and the mitochondrial metabolic activity may account for the cardioprotective effect of NECA...
  69. ncbi request reprint Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease
    Thaw Sint
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Inhal Toxicol 20:25-9. 2008
    ..To provide a greater awareness of PM levels, the U.S. Environmental Protection Agency now includes levels of air pollution particles in an air quality index...
  70. ncbi request reprint Iron increases expression of iron-export protein MTP1 in lung cells
    Funmei Yang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, Texas 78284, USA
    Am J Physiol Lung Cell Mol Physiol 283:L932-9. 2002
    ..These studies suggest the presence of iron mobilization and/or detoxification pathways in the lung that are crucial for iron homeostasis and lung defense...
  71. ncbi request reprint Iron homeostasis in the lung following asbestos exposure
    Andrew J Ghio
    Antioxid Redox Signal 10:371-7. 2008
    ..Based on these findings, we propose a model of oxidative stress and human lung injury after asbestos exposure...
  72. ncbi request reprint Siderophages in sputum
    Andrew J Ghio
    Acta Cytol 47:695-6. 2003
  73. ncbi request reprint Superoxide-dependent iron uptake: a new role for anion exchange protein 2
    Andrew J Ghio
    P O Box 3315, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Cell Mol Biol 29:653-60. 2003
    ..We thus disclose a novel ferri-reductase mechanism of NTBI uptake by human lung cells that employs superoxide exchange for HCO3- by AE2 protein in the plasma membrane...
  74. ncbi request reprint Blockade of tissue factor: treatment for organ injury in established sepsis
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 167:1200-9. 2003
    ..These results show that blockade of coagulation attenuates acute lung and renal injury in established Gram-negative sepsis accompanied by antiinflammatory effects of therapy...
  75. ncbi request reprint DMT1: a mammalian transporter for multiple metals
    Michael D Garrick
    Department of Biochemistry, SUNY at Buffalo, Buffalo, NY 14214, USA
    Biometals 16:41-54. 2003
    ..Thus the -IRE form could be part of a detoxification system in which +IRE DMT1 does not participate. How does iron status affect other metals' toxicity? In the case of Mn, iron deficiency may enhance cellular responses...
  76. ncbi request reprint Haptoglobin reduces lung injury associated with exposure to blood
    Funmei Yang
    Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Am J Physiol Lung Cell Mol Physiol 284:L402-9. 2003
    ..We propose that an Hp-mediated Hb catabolism process exists in alveolar macrophages. This process is likely coupled to an iron mobilization pathway and may be an efficient mechanism to reduce oxidative damage associated with hemolysis...
  77. ncbi request reprint Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Am J Physiol Lung Cell Mol Physiol 283:L791-8. 2002
    ..This study demonstrates that AE2 expression is regulated by oxidative stress in airway epithelial cells and that this regulation correlates with activation of AP-1...
  78. ncbi request reprint Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells
    Xinchao Wang
    Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill 27599, USA
    Am J Physiol Lung Cell Mol Physiol 282:L987-95. 2002
    ..We conclude that airway epithelial cells increase mRNA and expression of the Nramp2/DMT1/DCT1 without an IRE after exposure to iron. The increase results in an elevated transport of iron and its probable detoxification by these cells...
  79. ncbi request reprint Carbon monoxide promotes hypoxic pulmonary vascular remodeling
    Martha Sue Carraway
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 282:L693-702. 2002
    ..CO also increased lung HO activity and HO-1 mRNA and protein expression in small pulmonary arteries during hypoxia. These data indicate an overall propensity of CO in HH to promote vascular remodeling and increase PVR in vivo...
  80. ncbi request reprint The iron cycle and oxidative stress in the lung
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 36:850-7. 2004
    ..These pathways seem to be the primary mechanism for control of oxidative stress presented by iron in the respiratory tract...
  81. ncbi request reprint Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung
    Funmei Yang
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, 78229, USA
    Am J Physiol Lung Cell Mol Physiol 289:L14-23. 2005
    ..Although it is responsible for exporting nutrient iron from enterocytes to the circulation in the intestine, it could play a role in iron detoxification in airway epithelial cells in the lung...
  82. pmc Lung surfactant gelation induced by epithelial cells exposed to air pollution or oxidative stress
    Jay W Anseth
    Department of Chemical Engineering, Stanford University Medical Center, 300 Pasteur Drive, Stanford, CA 94305 5236, USA
    Am J Respir Cell Mol Biol 33:161-8. 2005
    ..A549 cells treated with H2O2 demonstrate a dose-dependent increase in lung surfactant gelation. The ISR is a unique and sensitive instrument to characterize surfactant gelation induced by oxidatively stressed AEC...
  83. pmc Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Clin Invest 117:2952-61. 2007
    ..These results provide a potential mechanism linking ambient particulate matter exposure and thrombotic events...
  84. pmc Metal particles are inappropriate for testing a postulate of extrapulmonary transport
    Andrew J Ghio
    Environ Health Perspect 115:A70; author reply A70-1. 2007
  85. ncbi request reprint Complement levels and activity in the normal and LPS-injured lung
    Molly S Bolger
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 292:L748-59. 2007
    ....
  86. ncbi request reprint Hepcidin expression and iron transport in alveolar macrophages
    Ngoc Bich Nguyen
    Department of Cellular and Structural Biology, The University of Texas Health Science Center, San Antonio, 78229, USA
    Am J Physiol Lung Cell Mol Physiol 291:L417-25. 2006
    ....
  87. ncbi request reprint Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells
    Jennifer L Turi
    Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Lung Cell Mol Physiol 291:L272-80. 2006
    ..production decreased when Dcytb function was blocked. The presence of Dcytb in airway epithelial cells and its regulation by iron therefore may contribute to pulmonary cytoprotection...
  88. pmc Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Respir Cell Mol Biol 34:670-6. 2006
    ..The intratracheal instillation of particulate matter results in alveolar epithelial injury and decreased alveolar fluid clearance, conceivably due to downregulation of the Na,K-ATPase...
  89. ncbi request reprint Transient hypoxia and downregulation of circulating prohepcidin concentrations in healthy young men
    Christian Benedict
    Haematologica 92:125-6. 2007
    ..Prohepcidin concentrations were significantly lower 150 min after the end of hypoxia than after normoxia (p=0.028)...
  90. ncbi request reprint [Study of IL-8 overexpression in A549 cells induced by crocidolite fibers]
    Xin Chao Wang
    School of Public Health, Zhengzhou University, Zhengzhou 450052, China
    Wei Sheng Yan Jiu 34:141-3. 2005
    ..This study was to investigate the effect of crocidolite fibers on IL-8 protein and mRNA levels in A549 cells cultured supernatant and the role of tyrosine kinase inhibitor PD98059 on IL-8 expression...
  91. ncbi request reprint Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure
    Hagir B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Free Radic Biol Med 32:246-56. 2002
    ..This mtDNA damage is associated with altered expression of mitochondrial cell death proteins, thereby suggesting a novel mechanism for systemic or environmental pro-oxidants to influence apoptosis...