Research Topics
Species | Suzanne E FentonSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
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Publications
Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)Suzanne E Fenton
Division of Reproductive Toxicology, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 67:63-74. 2002..Our data suggest that exposure to TCDD prior to migration of the mammary bud into the fat pad permanently alters mammary epithelial development in female rat offspring...- Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspringSally S White
Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 96:133-44. 2007..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring... 
Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pupsSuzanne E Fenton
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U S EPA, MD 67, Research Triangle Park, NC 27711, USA
Reprod Toxicol 27:365-72. 2009..20. These data suggest that milk is a substantial PFOA exposure route in mice and should be considered in risk assessment modeling designs for this compound...- Collection and use of exposure data from human milk biomonitoring in the United StatesSuzanne E Fenton
National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
J Toxicol Environ Health A 68:1691-712. 2005..This article describes how the collection and use of exposure data from human milk biomonitoring in the United States can be designed to inform future research and policy... - Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequencesSuzanne E Fenton
U S Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 67, Research Triangle Park, North Carolina 27711, USA
Endocrinology 147:S18-24. 2006.... - Analysis of PFOA in dosed CD1 mice. Part 1. Methods development for the analysis of tissues and fluids from pregnant and lactating mice and their pupsJessica L Reiner
Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Reprod Toxicol 27:360-4. 2009.... - Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposuresSally S White
U S EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
Reprod Toxicol 27:289-98. 2009..These studies confirm a window of MG sensitivity in late fetal and early neonatal life, and demonstrate developmental PFOA exposure results in early and persistent MG effects, suggesting permanent consequences... - Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 miceSally S White
National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
Environ Health Perspect 119:1070-6. 2011.... 
Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-lifeErin P Hines
U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
Mol Cell Endocrinol 304:97-105. 2009..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...- Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assayDarlene Dixon
National Toxicology Program NTP Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
Reprod Toxicol 33:506-12. 2012..01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2)... - Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposuresCynthia J Wolf
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 95:462-73. 2007..Exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period... - Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthoodSuzanne E Fenton
Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U S Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Annu Rev Pharmacol Toxicol 52:455-79. 2012..Such research is required to halt the increasing trend toward puberty at earlier ages... - Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans ratsJason P Stanko
Reproductive Toxicology Division, US Environmental Protection Agency US EPA, ORD NHEERL, Research Triangle Park, NC 27711, USA
Reprod Toxicol 30:540-9. 2010..These results indicate that a short, late prenatal exposure to mixture of chlorotriazine metabolites can cause chronic prostatitis in male LE rats. The mode of action for these effects is presently unclear... - Assays for endogenous components of human milk: comparison of fresh and frozen samples and corresponding analytes in serumErin P Hines
Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC, USA
J Hum Lact 23:144-56. 2007..The authors propose to use these assays in studies to examine relationships between the levels of milk components and children's health... - Endocrine disrupting properties of perfluorooctanoic acidSally S White
National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
J Steroid Biochem Mol Biol 127:16-26. 2011..Further research in these areas is needed... - Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effectsPrasada Rao S Kodavanti
Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
Toxicol Sci 116:297-312. 2010..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation... - Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazineJennifer L Rayner
Reproductive Toxicology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Toxicol Appl Pharmacol 195:23-34. 2004..Our data suggest that milk-derived factors (growth factors or hormones), in addition to transplacental exposure during mammary bud outgrowth, may be involved in ATR mode of action on delayed mammary gland development... - Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina womenErin P Hines
Reproductive Toxicology Division, Developmental Biology Branch, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 117:86-92. 2009..Phthalates are ubiquitous in the environment, but concentrations in multiple media from breast-feeding U.S. women have not been evaluated... - Cancer and developmental exposure to endocrine disruptorsLinda S Birnbaum
Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 111:389-94. 2003..Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection... - Altered mammary gland development in male rats exposed to genistein and methoxychlorXiao-juan Wang
CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
Toxicol Sci 91:93-103. 2006..The distinctive responses associated with the GE+MXC combination were likely linked to enhanced actions of insulin-like growth factor 1 and related downstream pathways... - A mixture of ammonium perchlorate and sodium chlorate enhances alterations of the pituitary-thyroid axis caused by the individual chemicals in adult male F344 ratsMoazzam A Khan
National Research Council, Environmental Carcinogenesis Divisions, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Toxicol Pathol 33:776-83. 2005..1 + SC 1000, and AP 10 + SC 1000 mg/L). These data suggest that short-term exposure to the mixture of AP and SC enhances the effect of either chemical alone on the pituitary-thyroid axis in rats... - Adverse effects of prenatal exposure to atrazine during a critical period of mammary gland growthJennifer L Rayner
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Toxicol Sci 87:255-66. 2005.... - A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiationBeth A Vorderstrasse
Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164, USA
Toxicol Sci 78:248-57. 2004.... - Conclusions and recommendations of the expert panel: technical workshop on human milk surveillance and biomonitoring for environmental chemicals in the United StatesCheston M Berlin
Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Toxicol Environ Health A 68:1825-31. 2005 - Mammary gland development as a sensitive end point after acute prenatal exposure to an atrazine metabolite mixture in female Long-Evans ratsRolondo R Enoch
Department of Biology, North Carolina Central University, Durham, North Carolina, USA
Environ Health Perspect 115:541-7. 2007..The extent to which these metabolites are responsible directly for the observed health effects is not understood... - Gestational exposure to nonylphenol causes precocious mammary gland development in female rat offspringHyun Ju Moon
Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
J Reprod Dev 53:333-44. 2007..Exposure to them during the critical period of epithelial outgrowth altered the receptor levels of mammary progesterone and prolactin and might contribute to the differences in the mammary morphology at PND 41... - Atrazine-induced reproductive tract alterations after transplacental and/or lactational exposure in male Long-Evans ratsJennifer L Rayner
Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Toxicol Appl Pharmacol 218:238-48. 2007..Inflammation present at PND120 does not increase in severity with time...