Suzanne E Fenton

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Suzanne E Fenton
    Division of Reproductive Toxicology, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 67:63-74. 2002
  2. ncbi request reprint Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring
    Sally S White
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 96:133-44. 2007
  3. pmc Mammary gland development as a sensitive end point after acute prenatal exposure to an atrazine metabolite mixture in female Long-Evans rats
    Rolondo R Enoch
    Department of Biology, North Carolina Central University, Durham, North Carolina, USA
    Environ Health Perspect 115:541-7. 2007
  4. pmc Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women
    Erin P Hines
    Reproductive Toxicology Division, Developmental Biology Branch, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 117:86-92. 2009
  5. pmc Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups
    Suzanne E Fenton
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U S EPA, MD 67, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:365-72. 2009
  6. ncbi request reprint Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences
    Suzanne E Fenton
    U S Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 67, Research Triangle Park, North Carolina 27711, USA
    Endocrinology 147:S18-24. 2006
  7. ncbi request reprint Collection and use of exposure data from human milk biomonitoring in the United States
    Suzanne E Fenton
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 68:1691-712. 2005
  8. pmc Analysis of PFOA in dosed CD1 mice. Part 1. Methods development for the analysis of tissues and fluids from pregnant and lactating mice and their pups
    Jessica L Reiner
    Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:360-4. 2009
  9. pmc Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures
    Sally S White
    U S EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
    Reprod Toxicol 27:289-98. 2009
  10. doi request reprint Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
    Erin P Hines
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Mol Cell Endocrinol 304:97-105. 2009

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Persistent abnormalities in the rat mammary gland following gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Suzanne E Fenton
    Division of Reproductive Toxicology, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 67:63-74. 2002
    ..Our data suggest that exposure to TCDD prior to migration of the mammary bud into the fat pad permanently alters mammary epithelial development in female rat offspring...
  2. ncbi request reprint Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring
    Sally S White
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 96:133-44. 2007
    ..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring...
  3. pmc Mammary gland development as a sensitive end point after acute prenatal exposure to an atrazine metabolite mixture in female Long-Evans rats
    Rolondo R Enoch
    Department of Biology, North Carolina Central University, Durham, North Carolina, USA
    Environ Health Perspect 115:541-7. 2007
    ..The extent to which these metabolites are responsible directly for the observed health effects is not understood...
  4. pmc Concentrations of phthalate metabolites in milk, urine, saliva, and Serum of lactating North Carolina women
    Erin P Hines
    Reproductive Toxicology Division, Developmental Biology Branch, Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 117:86-92. 2009
    ..Phthalates are ubiquitous in the environment, but concentrations in multiple media from breast-feeding U.S. women have not been evaluated...
  5. pmc Analysis of PFOA in dosed CD-1 mice. Part 2. Disposition of PFOA in tissues and fluids from pregnant and lactating mice and their pups
    Suzanne E Fenton
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, ORD, U S EPA, MD 67, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:365-72. 2009
    ..20. These data suggest that milk is a substantial PFOA exposure route in mice and should be considered in risk assessment modeling designs for this compound...
  6. ncbi request reprint Endocrine-disrupting compounds and mammary gland development: early exposure and later life consequences
    Suzanne E Fenton
    U S Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, MD 67, Research Triangle Park, North Carolina 27711, USA
    Endocrinology 147:S18-24. 2006
    ....
  7. ncbi request reprint Collection and use of exposure data from human milk biomonitoring in the United States
    Suzanne E Fenton
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 68:1691-712. 2005
    ..This article describes how the collection and use of exposure data from human milk biomonitoring in the United States can be designed to inform future research and policy...
  8. pmc Analysis of PFOA in dosed CD1 mice. Part 1. Methods development for the analysis of tissues and fluids from pregnant and lactating mice and their pups
    Jessica L Reiner
    Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:360-4. 2009
    ....
  9. pmc Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures
    Sally S White
    U S EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
    Reprod Toxicol 27:289-98. 2009
    ..These studies confirm a window of MG sensitivity in late fetal and early neonatal life, and demonstrate developmental PFOA exposure results in early and persistent MG effects, suggesting permanent consequences...
  10. doi request reprint Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
    Erin P Hines
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Mol Cell Endocrinol 304:97-105. 2009
    ..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...
  11. pmc Gestational and chronic low-dose PFOA exposures and mammary gland growth and differentiation in three generations of CD-1 mice
    Sally S White
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1070-6. 2011
    ....
  12. ncbi request reprint Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures
    Cynthia J Wolf
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:462-73. 2007
    ..Exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period...
  13. pmc Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats
    Jason P Stanko
    Reproductive Toxicology Division, US Environmental Protection Agency US EPA, ORD NHEERL, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 30:540-9. 2010
    ..These results indicate that a short, late prenatal exposure to mixture of chlorotriazine metabolites can cause chronic prostatitis in male LE rats. The mode of action for these effects is presently unclear...
  14. pmc Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay
    Darlene Dixon
    National Toxicology Program NTP Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Reprod Toxicol 33:506-12. 2012
    ..01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2)...
  15. ncbi request reprint Exposure parameters necessary for delayed puberty and mammary gland development in Long-Evans rats exposed in utero to atrazine
    Jennifer L Rayner
    Reproductive Toxicology Division, Office of Research and Development, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 195:23-34. 2004
    ..Our data suggest that milk-derived factors (growth factors or hormones), in addition to transplacental exposure during mammary bud outgrowth, may be involved in ATR mode of action on delayed mammary gland development...
  16. pmc Perinatal environmental exposures affect mammary development, function, and cancer risk in adulthood
    Suzanne E Fenton
    Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, U S Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
    Annu Rev Pharmacol Toxicol 52:455-79. 2012
    ..Such research is required to halt the increasing trend toward puberty at earlier ages...
  17. ncbi request reprint Assays for endogenous components of human milk: comparison of fresh and frozen samples and corresponding analytes in serum
    Erin P Hines
    Reproductive Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC, USA
    J Hum Lact 23:144-56. 2007
    ..The authors propose to use these assays in studies to examine relationships between the levels of milk components and children's health...
  18. pmc Endocrine disrupting properties of perfluorooctanoic acid
    Sally S White
    National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Steroid Biochem Mol Biol 127:16-26. 2011
    ..Further research in these areas is needed...
  19. doi request reprint Developmental exposure to a commercial PBDE mixture, DE-71: neurobehavioral, hormonal, and reproductive effects
    Prasada Rao S Kodavanti
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 116:297-312. 2010
    ..Some of these effects are similar to those seen with PCBs, and the persistence of these changes requires further investigation...
  20. pmc Cancer and developmental exposure to endocrine disruptors
    Linda S Birnbaum
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:389-94. 2003
    ..Implications of these new findings suggest that causes of endocrine-related cancers or susceptibility to cancer may be a result of developmental exposures rather than exposures existing at or near the time of tumor detection...
  21. pmc Exposure to diethylstilbestrol during sensitive life stages: a legacy of heritable health effects
    Casey E Reed
    Department of Health and Human Services, Division of the NTP, National Institute of Environmental Health Sciences, National Toxicology Program NTP Laboratories Branch, National Institutes of Health, Research Triangle Park, NC, USA
    Birth Defects Res C Embryo Today 99:134-46. 2013
    ..The mechanisms of cancer and endocrine disruption induced by DES are not fully understood. Future studies should focus on common target tissue pathways affected and the health of the DES grandchildren...
  22. ncbi request reprint Altered mammary gland development in male rats exposed to genistein and methoxychlor
    Xiao Juan Wang
    CIIT Centers for Health Research, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 91:93-103. 2006
    ..The distinctive responses associated with the GE+MXC combination were likely linked to enhanced actions of insulin-like growth factor 1 and related downstream pathways...
  23. ncbi request reprint A mixture of ammonium perchlorate and sodium chlorate enhances alterations of the pituitary-thyroid axis caused by the individual chemicals in adult male F344 rats
    Moazzam A Khan
    National Research Council, Environmental Carcinogenesis Divisions, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Toxicol Pathol 33:776-83. 2005
    ..1 + SC 1000, and AP 10 + SC 1000 mg/L). These data suggest that short-term exposure to the mixture of AP and SC enhances the effect of either chemical alone on the pituitary-thyroid axis in rats...
  24. ncbi request reprint A novel effect of dioxin: exposure during pregnancy severely impairs mammary gland differentiation
    Beth A Vorderstrasse
    Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164, USA
    Toxicol Sci 78:248-57. 2004
    ....
  25. ncbi request reprint Atrazine-induced reproductive tract alterations after transplacental and/or lactational exposure in male Long-Evans rats
    Jennifer L Rayner
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Toxicol Appl Pharmacol 218:238-48. 2007
    ..Inflammation present at PND120 does not increase in severity with time...
  26. ncbi request reprint Gestational exposure to nonylphenol causes precocious mammary gland development in female rat offspring
    Hyun Ju Moon
    Endocrine Toxicology Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea
    J Reprod Dev 53:333-44. 2007
    ..Exposure to them during the critical period of epithelial outgrowth altered the receptor levels of mammary progesterone and prolactin and might contribute to the differences in the mammary morphology at PND 41...
  27. ncbi request reprint Adverse effects of prenatal exposure to atrazine during a critical period of mammary gland growth
    Jennifer L Rayner
    Department of Environmental Sciences and Engineering, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 87:255-66. 2005
    ....
  28. ncbi request reprint Conclusions and recommendations of the expert panel: technical workshop on human milk surveillance and biomonitoring for environmental chemicals in the United States
    Cheston M Berlin
    Department of Pediatrics, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Toxicol Environ Health A 68:1825-31. 2005