Aimen K Farraj


Affiliation: U.S. Environmental Protection Agency
Country: USA


  1. Farraj A, Boykin E, Ledbetter A, Andrews D, Gavett S. Increased lung resistance after diesel particulate and ozone co-exposure not associated with enhanced lung inflammation in allergic mice. Inhal Toxicol. 2010;22:33-41 pubmed publisher
    ..Thus, O(3) and DEP co-exposure exacerbated airways hyperresponsiveness, a response that was not associated with parallel increases in pulmonary inflammation and one that may be mediated by a unique mechanism. ..
  2. Farraj A, Hazari M, Haykal Coates N, Lamb C, Winsett D, Ge Y, et al. ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. Am J Respir Cell Mol Biol. 2011;44:185-96 pubmed publisher
  3. Martin W, Tennant A, Conolly R, Prince K, Stevens J, DeMarini D, et al. High-Throughput Video Processing of Heart Rate Responses in Multiple Wild-type Embryonic Zebrafish per Imaging Field. Sci Rep. 2019;9:145 pubmed publisher
    ..As all code and executable files are publicly available, this approach may expedite cardiotoxicity screening of compounds as diverse as small molecule drugs and complex chemical mixtures. ..
  4. Martin B, Thompson L, Kim Y, Williams W, Snow S, Schladweiler M, et al. Acute peat smoke inhalation sensitizes rats to the postprandial cardiometabolic effects of a high fat oral load. Sci Total Environ. 2018;643:378-391 pubmed publisher
  5. Farraj A, Walsh L, Haykal Coates N, Malik F, McGee J, Winsett D, et al. Cardiac effects of seasonal ambient particulate matter and ozone co-exposure in rats. Part Fibre Toxicol. 2015;12:12 pubmed publisher
    ..These findings suggest that a single ambient PM metric alone is not sufficient to predict potential for interactive health effects with other air pollutants. ..
  6. Farraj A, Haykal Coates N, Winsett D, Hazari M, Carll A, Rowan W, et al. Increased non-conducted P-wave arrhythmias after a single oil fly ash inhalation exposure in hypertensive rats. Environ Health Perspect. 2009;117:709-15 pubmed publisher
    ..These results suggest that cardiac arrhythmias may be an early sensitive indicator of the propensity for PM inhalation to modify cardiovascular function. ..
  7. Farraj A, Hazari M, Winsett D, Kulukulualani A, Carll A, Haykal Coates N, et al. Overt and latent cardiac effects of ozone inhalation in rats: evidence for autonomic modulation and increased myocardial vulnerability. Environ Health Perspect. 2012;120:348-54 pubmed publisher
  8. Kurhanewicz N, McIntosh Kastrinsky R, Tong H, Walsh L, Farraj A, Hazari M. Ozone co-exposure modifies cardiac responses to fine and ultrafine ambient particulate matter in mice: concordance of electrocardiogram and mechanical responses. Part Fibre Toxicol. 2014;11:54 pubmed publisher
    ..Additionally, the mode of toxicity underlying this effect may be subtle given none of the exposures described here impaired post-ischemia recovery. ..
  9. Thompson L, Ledbetter A, Haykal Coates N, Cascio W, Hazari M, Farraj A. Acrolein Inhalation Alters Myocardial Synchrony and Performance at and Below Exposure Concentrations that Cause Ventilatory Responses. Cardiovasc Toxicol. 2017;17:97-108 pubmed publisher

More Information


  1. request reprint
    Farraj A, Haykal Coates N, Ledbetter A, Evansky P, Gavett S. Inhibition of pan neurotrophin receptor p75 attenuates diesel particulate-induced enhancement of allergic airway responses in C57/B16J mice. Inhal Toxicol. 2006;18:483-91 pubmed
    ..The DEP-induced exacerbation of allergic airway responses may, in part, be mediated by neurotrophins. ..
  2. Farraj A, Hazari M, Cascio W. The utility of the small rodent electrocardiogram in toxicology. Toxicol Sci. 2011;121:11-30 pubmed publisher
    ..This review will discuss the utility of the small rodent ECG, various methodologies used to derive ECG data in rats and mice, and various applications in toxicology. ..