David J Dix

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint A framework for the use of genomics data at the EPA
    David J Dix
    Office of Research and Development, US Environmental Protection Agency, National Center for Computational Toxicology D343 03, Research Triangle Park, North Carolina 27711, USA
    Nat Biotechnol 24:1108-11. 2006
  2. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
  3. ncbi request reprint The ToxCast program for prioritizing toxicity testing of environmental chemicals
    David J Dix
    National Center for Computational Toxicology D343 03, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:5-12. 2007
  4. ncbi request reprint Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides
    Amber K Goetz
    Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 215:274-84. 2006
  5. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
  6. ncbi request reprint Effect of conazole fungicides on reproductive development in the female rat
    John C Rockett
    Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 22:647-58. 2006
  7. ncbi request reprint Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice
    Guobin Sun
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Lett 164:44-53. 2006
  8. ncbi request reprint Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides
    Douglas B Tully
    Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 215:260-73. 2006
  9. doi request reprint Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals
    Amber K Goetz
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:449-62. 2009
  10. doi request reprint Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011

Detail Information

Publications54

  1. ncbi request reprint A framework for the use of genomics data at the EPA
    David J Dix
    Office of Research and Development, US Environmental Protection Agency, National Center for Computational Toxicology D343 03, Research Triangle Park, North Carolina 27711, USA
    Nat Biotechnol 24:1108-11. 2006
  2. pmc Environmental impact on vascular development predicted by high-throughput screening
    Nicole C Kleinstreuer
    National Center for Computational Toxiciology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1596-603. 2011
    ....
  3. ncbi request reprint The ToxCast program for prioritizing toxicity testing of environmental chemicals
    David J Dix
    National Center for Computational Toxicology D343 03, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:5-12. 2007
    ..The resulting multidimensional data set provides an informatics challenge requiring appropriate computational methods for integrating various chemical, biological, and toxicological data into profiles and models predicting toxicity...
  4. ncbi request reprint Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides
    Amber K Goetz
    Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 215:274-84. 2006
    ..Based on these results, we expanded on our original hypothesis that triazole hepatotoxicity was mediated by CYP induction, to include additional XME genes, many of which are modulated by CAR and PXR...
  5. doi request reprint Predictive models of prenatal developmental toxicity from ToxCast high-throughput screening data
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 124:109-27. 2011
    ..This work indicates the utility of HTS assays for developing pathway-level models predictive of developmental toxicity...
  6. ncbi request reprint Effect of conazole fungicides on reproductive development in the female rat
    John C Rockett
    Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 22:647-58. 2006
    ..It is concluded that exposure to P, M and T adversely impacted female rodent reproductive development...
  7. ncbi request reprint Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice
    Guobin Sun
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Lett 164:44-53. 2006
    ..In summary, these results indicated that fluconazole, a triazole-containing conazole, clearly induced CYP2B and CYP3A families of isoforms in rat liver and Cyp2b and Cyp3a families of isoforms in mouse liver...
  8. ncbi request reprint Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides
    Douglas B Tully
    Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 215:260-73. 2006
    ..Triazoles also affected expression of multiple genes involved in steroid hormone metabolism in the two tissues. Thus, gene expression profiles helped identify possible toxicological mechanisms of the triazole fungicides...
  9. doi request reprint Mode of action for reproductive and hepatic toxicity inferred from a genomic study of triazole antifungals
    Amber K Goetz
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:449-62. 2009
    ..These toxicogenomic effects describe a plausible series of key events contributing to the disruption in steroid homeostasis and reproductive toxicity of select triazole antifungals...
  10. doi request reprint Predictive model of rat reproductive toxicity from ToxCast high throughput screening
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Biol Reprod 85:327-39. 2011
    ....
  11. ncbi request reprint Toxicogenomic study of triazole fungicides and perfluoroalkyl acids in rat livers predicts toxicity and categorizes chemicals based on mechanisms of toxicity
    Matthew T Martin
    National Center for Computational Toxicology, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Sci 97:595-613. 2007
    ..The concordance of in vivo observations and gene expression findings demonstrated the ability of genomics to accurately categorize chemicals, identify toxic mechanisms of action, and predict subsequent pathological responses...
  12. doi request reprint Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment
    Barbara A Wetmore
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709 2137, USA
    Toxicol Sci 125:157-74. 2012
    ..The incorporation of dosimetry and exposure provide necessary context for interpretation of in vitro toxicity screening data and are important considerations in determining chemical testing priorities...
  13. ncbi request reprint Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole blood
    Sung Jae Kim
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Clin Chem 53:1038-45. 2007
    ..In addition, characterization of interindividual and sex-based variation in gene expression is needed to understand sources and extent of variability...
  14. doi request reprint In vitro perturbations of targets in cancer hallmark processes predict rodent chemical carcinogenesis
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 131:40-55. 2013
    ..This model represents a chemical carcinogenicity prioritization tool supporting targeted testing and functional validation of cancer pathways...
  15. doi request reprint Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals
    Daniel M Rotroff
    US Environmental Protection Agency, Office of Research and Development, National Center for Computational Toxicology, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health B Crit Rev 13:329-46. 2010
    ..Significant relative risk associations with rodent in vivo chronic toxicity effects are reported for the five major receptor pathways. These gene expression data are being incorporated into the larger ToxCast predictive modeling effort...
  16. doi request reprint Estimating toxicity-related biological pathway altering doses for high-throughput chemical risk assessment
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Chem Res Toxicol 24:451-62. 2011
    ....
  17. pmc In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:485-92. 2010
    ..The U.S. Environmental Protection Agency's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches...
  18. doi request reprint Inhibition of rat and human steroidogenesis by triazole antifungals
    Amber K Goetz
    Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Syst Biol Reprod Med 55:214-26. 2009
    ..This discordance could be due to higher concentrations of triazoles tested in vitro, and differences within an in vitro model system lacking hepatic metabolism and neuroendocrine control...
  19. pmc Evaluation of 309 environmental chemicals using a mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay
    Kelly J Chandler
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e18540. 2011
    ..Taken together, these results provide an initial characterization of metabolic and regulatory pathways by which some environmental chemicals may act to disrupt ES cell growth and differentiation...
  20. doi request reprint Economic benefits of using adaptive predictive models of reproductive toxicity in the context of a tiered testing program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Syst Biol Reprod Med 58:3-9. 2012
    ....
  21. doi request reprint Toxicogenomic effects common to triazole antifungals and conserved between rats and humans
    Amber K Goetz
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 238:80-9. 2009
    ..Modulation of hepatic sterol and steroid metabolism is a plausible mode of action for changes in serum testosterone and adverse reproductive outcomes observed in rat studies, and may be relevant to human risk assessment...
  22. doi request reprint Activity profiles of 309 ToxCastâ„¢ chemicals evaluated across 292 biochemical targets
    Thomas B Knudsen
    National Center for Computational Toxicology B205 01, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicology 282:1-15. 2011
    ..The primary dataset, summary data and details on quality control checks are available for download at http://www.epa.gov/ncct/toxcast/...
  23. pmc Endocrine profiling and prioritization of environmental chemicals using ToxCast data
    David M Reif
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 118:1714-20. 2010
    ..S. EPA's Endocrine Disruptor Screening Program (EDSP) has been charged with screening pesticide chemicals and environmental contaminants for their potential to affect the endocrine systems of humans and wildlife...
  24. pmc Using nuclear receptor activity to stratify hepatocarcinogens
    Imran Shah
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America
    PLoS ONE 6:e14584. 2011
    ..Here we report on a systematic analysis of new in vitro human NR activity data on 309 environmental chemicals in relationship to their liver cancer-related chronic outcomes in rodents...
  25. ncbi request reprint Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms
    Nicole C Kleinstreuer
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Nat Biotechnol 32:583-91. 2014
    ..Our results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways. ..
  26. pmc Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays
    Nisha S Sipes
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 26:878-95. 2013
    ..Results from this large inventory of chemical-biological interactions can inform read-across methods as well as link potential targets to molecular initiating events in adverse outcome pathways for diverse toxicities...
  27. ncbi request reprint A database for tracking toxicogenomic samples and procedures
    Wenjun Bao
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 19:411-9. 2005
    ..The user-friendly interface provides easy procedures for researchers to add, edit, save, delete, and navigate different records. Finally, TSP facilitates exporting microarray data into public databases...
  28. ncbi request reprint Profiling the activity of environmental chemicals in prenatal developmental toxicity studies using the U.S. EPA's ToxRefDB
    Thomas B Knudsen
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Reprod Toxicol 28:209-19. 2009
    ..This novel data model provides an important public resource for cross-scale modeling and predictive understanding of developmental processes and toxicities...
  29. doi request reprint Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Chem Res Toxicol 23:578-90. 2010
    ....
  30. pmc Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:392-9. 2009
    ..These data are now accessible and mineable within ToxRefDB and are serving as a primary source of validation for U.S. EPA's ToxCast research program in predictive toxicology...
  31. pmc Informing selection of nanomaterial concentrations for ToxCast in vitro testing based on occupational exposure potential
    Sumit Gangwal
    National Center for Computational Toxicology, Offce of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 119:1539-46. 2011
    ..Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable...
  32. doi request reprint Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening
    Daniel M Rotroff
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 117:348-58. 2010
    ..Importantly, these tools are necessary to move beyond hazard rankings to estimates of possible in vivo responses based on in vitro screens...
  33. pmc Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity
    Richard S Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 44:5979-85. 2010
    ..Two dispersants, JD 2000 and SAF-RON GOLD, were significantly less cytotoxic than the others with LC50 values approaching or exceeding 1000 ppm...
  34. ncbi request reprint Reproductive and genomic effects in testes from mice exposed to the water disinfectant byproduct bromochloroacetic acid
    Douglas B Tully
    National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA
    Reprod Toxicol 19:353-66. 2005
    ..Modulated expression of these genes, particularly the 15 expressed in Sertoli cells and spermatids, offers new insights into potential mechanisms of BCA toxicity in the mouse testis...
  35. ncbi request reprint Gene expression in head hair follicles plucked from men and women
    Sung Jae Kim
    Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Ann Clin Lab Sci 36:115-26. 2006
    ..The differentially expressed genes could be involved in producing gender and interindividual differences in hair growth...
  36. doi request reprint Profiling bioactivity of the ToxCast chemical library using BioMAP primary human cell systems
    Keith A Houck
    National Center for Computational Toxicology, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Biomol Screen 14:1054-66. 2009
    ..This data set is being combined with additional ToxCast data sets for development of predictive toxicity models at the EPA...
  37. ncbi request reprint Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells
    John C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 194:189-99. 2004
    ..Also discussed are some of the challenges that must be overcome if the utility of STA is to be proven, and thus permit researchers to move this concept from the laboratory to the clinical environment...
  38. doi request reprint Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database
    Matthew T Martin
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:181-90. 2009
    ..Capturing this reproductive toxicity data in ToxRefDB supports ongoing retrospective analyses, test guideline revisions, and computational toxicology research...
  39. pmc The toxicity data landscape for environmental chemicals
    Richard Judson
    National Center for Computational Toxicology, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Health Perspect 117:685-95. 2009
    ..The main objective of this analysis is to define a list of environmental chemicals that are candidates for the U.S. EPA screening and prioritization process, and to catalog the available toxicology information...
  40. doi request reprint Inducible 70 kDa heat shock proteins protect embryos from teratogen-induced exencephaly: Analysis using Hspa1a/a1b knockout mice
    Marianne Barrier
    Birth Defects Research Laboratory, Division of Genetics and Development, Department of Pediatrics, University of Washington, Seattle, Washington, USA
    Birth Defects Res A Clin Mol Teratol 85:732-40. 2009
    ..Previously, our laboratory has shown that embryos overexpressing the 70-Da heat shock proteins (HSPs) Hspa1a and Hspa1b were partially protected from the deleterious effects of exposure to hyperthermia in vitro...
  41. pmc Advancing the next generation of health risk assessment
    Ila Cote
    U S Environmental Protection Agency, Washington, DC 20460, USA
    Environ Health Perspect 120:1499-502. 2012
    ..Over the past 20 years, knowledge of the genome and its function has increased dramatically, but risk assessment methodologies using such knowledge have not advanced accordingly...
  42. ncbi request reprint Gene expression patterns associated with infertility in humans and rodent models
    John C Rockett
    Reproductive Toxicology Division MD 72, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 549:225-40. 2004
    ....
  43. ncbi request reprint Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver
    Guobin Sun
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Lett 155:277-87. 2005
    ..In summary, these results indicated that propiconazole induced CYP1A2 in rat liver and CYP2B and CYP3A families of isoforms in rat and mouse liver...
  44. ncbi request reprint Raman spectroscopy-based metabolomics for differentiating exposures to triazole fungicides using rat urine
    Daniel P Cherney
    U S Environmental Protection Agency, Office of Research and Development, National Exposure Research Laboratory, Athens, Georgia 30605, USA
    Anal Chem 79:7324-32. 2007
    ..Results from multivariate data analysis demonstrated that the Raman method compares favorably with NMR in regard to the ability to differentiate responses from these three contaminants...
  45. ncbi request reprint DNA arrays to monitor gene expression in rat blood and uterus following 17beta-estradiol exposure: biomonitoring environmental effects using surrogate tissues
    John C Rockett
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 69:49-59. 2002
    ....
  46. ncbi request reprint Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs
    Adrian E Platts
    Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA
    Hum Mol Genet 16:763-73. 2007
    ..The origin of the perturbation could be traced as far back as the pachytene stage of spermatogenesis. It is anticipated that this diagnostic strategy will prove valuable for understanding male factor infertility...
  47. ncbi request reprint A bioinformatic strategy to rapidly characterize cDNA libraries
    G Charles Ostermeier
    Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, and Institute for Scientific Computing, Wayne State University, USA
    Bioinformatics 18:949-52. 2002
    ..Complementary DNA libraries can define the genetic constituents of specific cells and/or tissues. Their sequencing will illuminate the transcriptome but it is a monumental task requiring considerable resources...
  48. pmc The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
    Leming Shi
    National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Nat Biotechnol 24:1151-61. 2006
    ..This study provides a resource that represents an important first step toward establishing a framework for the use of microarrays in clinical and regulatory settings...
  49. ncbi request reprint HSP70.1 and -70.3 are required for late-phase protection induced by ischemic preconditioning of mouse hearts
    Craig R Hampton
    Department of Surgery, University of Washington, 1959 N E Pacific Street, Box 356410, Seattle, WA 98195, USA
    Am J Physiol Heart Circ Physiol 285:H866-74. 2003
    ..1/3(-/-) mice. We conclude that inducible HSP70.1 and HSP70.3 are required for late-phase protection against infarction following IP in mice...
  50. ncbi request reprint Spermatozoal RNA profiles of normal fertile men
    G Charles Ostermeier
    Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, and Institute for Scientific Computing, Wayne State University, Detroit, MI, USA
    Lancet 360:772-7. 2002
    ..Our aim was to determine whether we could use spermatozoal mRNAs to generate a genetic fingerprint of normal fertile men...
  51. ncbi request reprint Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy
    Yun Kyung Kim
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0618, USA
    Circulation 113:2589-97. 2006
    ..Hspa1a and Hspa1b genes encode stress-inducible 70-kDa heat shock proteins (Hsp70) that protect cells from insults such as ischemia. Mice with null mutations of both genes (KO) were generated, and their cardiac phenotype was explored...
  52. ncbi request reprint Toward using stable spermatozoal RNAs for prognostic assessment of male factor fertility
    G Charles Ostermeier
    Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA
    Fertil Steril 83:1687-94. 2005
    ..To establish the stability of spermatozoal RNAs as a means to validate their use as a male fertility marker...
  53. ncbi request reprint Genomic identification of potential risk factors during acetaminophen-induced liver disease in susceptible and resistant strains of mice
    Kevin D Welch
    Molecular and Cellular Toxicology Section, Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Chem Res Toxicol 19:223-33. 2006
    ..Our findings suggest that comparative gene expression analysis of susceptible and resistant mouse strains may lead to the identification of factors that could have a role in determining the susceptibility of individuals to DILD...
  54. pmc Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice
    Clayton R Hunt
    Department of Oncology, Radiation, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Mol Cell Biol 24:899-911. 2004
    ..1/3(-/-) cells in comparison to Hsp70.1/3(+/+) cells. Both in vivo and in vitro studies demonstrate for the first time that Hsp70.1 and Hsp70.3 have an essential role in maintaining genomic stability under stress conditions...