Research Topics
| D M DemariniSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
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Detail Information
Publications
Influence of DNA repair on mutation spectra in SalmonellaD M Demarini
Environmental Carcinogenesis Division, US Environmental Protection Agency, MD 68, 86 Alexander Drive, Research Triangle Park, NC 27711, USA
Mutat Res 450:5-17. 2000..Thus, a mutagen induces the same primary class of base substitution in most organisms, reflecting the conserved nature of DNA replication and repair processes...- Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutationsAndrew D Kligerman
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Mol Mutagen 42:192-205. 2003..We suggest that the clastogenicity of the other arsenicals is due to their metabolism by cells to MMA(III) or DMA(III)... - Biomedicine. Do airborne particles induce heritable mutations?Jonathan M Samet
Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
Science 304:971-2. 2004 - Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensatesDavid M DeMarini
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 650:15-29. 2008.... 
Declaring the existence of human germ-cell mutagensDavid M DeMarini
Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Mol Mutagen 53:166-72. 2012..I suggest that the long search for human germ-cell mutagens is about to end, and a demonstration of the much-anticipated linkage between heritable disease and environmental factors is poised to begin...
Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of MX-treated SalmonellaWilliam O Ward
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
BMC Bioinformatics 8:378. 2007....- Mutagenicity in lung of big Blue((R)) mice and induction of tandem-base substitutions in Salmonella by the air pollutant peroxyacetyl nitrate (PAN): predicted formation of intrastrand cross-linksD M Demarini
National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA
Mutat Res 457:41-55. 2000..Thus, PAN may pose a mutagenic and possible carcinogenic risk to humans, especially at the high concentrations at which it is present in some urban environments... - Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyreneDavid M DeMarini
U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 714:17-25. 2011..Our results leave open a possible role for unstable DNA adducts in the mutational specificity of BP but not for DBP... - Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissionsD M Demarini
Environmental Carcinogenesis Division MD 68, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Cancer Res 61:6679-81. 2001..These results show that mutations in the TP53 and KRAS genes can reflect a specific environmental exposure... - What's in a name? The argument for changing the name of IAEMS and its affiliated societiesDavid M DeMarini
U S Environmental Protection Agency, B105 03, RTP, NC 27711, USA
Mutat Res 705:201-4. 2010.... 
Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particlesDavid M DeMarini
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Health Perspect 112:814-9. 2004....- Outdoor air pollution and DNA damageD M Demarini
Environmental Carcinogenesis Division (B143-06, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Occup Environ Med 63:227-9. 2006 - Genotoxicity of tobacco smoke and tobacco smoke condensate: a reviewDavid M DeMarini
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Mutat Res 567:447-74. 2004..Thus, their relevance to humans cannot be denied, and their explanatory powers not easily dismissed. Tobacco smoke is now the most extreme example of a systemic human mutagen... - Mutation spectra in Salmonella of analogues of MX: implications of chemical structure for mutational mechanismsD M Demarini
Environmental Carcinogenesis Division MD 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 453:51-65. 2000..To our knowledge, this is the first study in which such analyses have been applied to structural analogues for which both mutagenic potency and mutation spectra date were available... - Induction of genetic damage in human lymphocytes and mutations in Salmonella by trihalomethanes: role of red blood cells and GSTT1-1 polymorphismS Landi
Environmental Carcinogenesis Division MD 68 and Experimental Toxicology Division MD 74, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutagenesis 14:479-82. 1999..Such a proposal is reasonably consistent with the organ specificity of drinking water-associated cancer in humans, which shows slightly elevated risks for cancer of the colon and bladder but not of the liver... - Glutathione S-transferase-mediated induction of GC-->AT transitions by halomethanes in SalmonellaD M Demarini
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Mol Mutagen 30:440-7. 1997..The implications of these findings are discussed in relation to previous experimental work on the GST-mediated bioactivation of dihalomethanes, which includes the possible formation of GSH intermediates and/or GSH-DNA adducts... - Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3, 4-diepoxybutane in mouse, rat and human lymphocytes following in vitro G0 exposuresA D Kligerman
Environmental Carcinogenesis Division MD 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 439:13-23. 1999..However, additional factors also appear to influence the genotoxic response of humans to DEB. This study is the first direct comparison of the genotoxicity of EB and DEB in the cells from all three species... - Spectra of spontaneous frameshift mutations at the hisD3052 allele of Salmonella typhimurium in four DNA repair backgroundsD M Demarini
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Genetics 149:17-36. 1998..The mechanisms may involve (1) the potential of direct and inverted repeats to undergo slippage and misalignment and to form quasi-palindromes and (2) the interaction of these sequences with DNA replication and repair proteins... - Induction of abasic sites by the drinking-water mutagen MX in Salmonella TA100Leon C King
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Chem Biol Interact 180:340-3. 2009..001). These results provide some evidence for the ability of MX to induce abasic sites in cellular DNA. However, the lack of a dose response makes it unclear whether this DNA damage underlies the mutagenic activity of MX... - Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in micePramila Singh
National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA
Environ Health Perspect 112:820-5. 2004..Key words: automobile, diesel exhaust particles, forklift, mice, pulmonary toxicity, SRM 2975... - Mutation spectrum of a binary mixture of mutagens (methapyrilene and sodium azide) in strain TA1535 of SalmonellaM L Shelton
U S Environmental Protection Agency, Research Triangle Park, NC 27711
Mutat Res 323:35-9. 1994..Such a mechanism might be the basis for the carcinogenic and cocarcinogenic activities of MP. To our knowledge, this is the first report of the molecular analysis of mutants produced by exposure of cells to a binary mixture of mutagens... - Pilot study of free and conjugated urinary mutagenicity during consumption of pan-fried meats: possible modulation by cruciferous vegetables, glutathione S-transferase-M1, and N-acetyltransferase-2D M Demarini
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 381:83-96. 1997.... - Mutation spectra of complex mixturesD M Demarini
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 411:11-8. 1998..Such information should be useful in the interpretation of mutation spectra in molecular epidemiological studies where the exposure is primarily to a complex mixture... - Induction of sister chromatid exchanges in human peripheral blood lymphocytes by bromoform: investigation of the role of GSTT1-1 polymorphismS Landi
Environmental Carcinogenesis Division MD 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 429:261-7. 1999..9.57+/-0.07), or the 24th h (8.21+/-0.61 vs. 8.29+/-0.24) of cell growth. Although GSTT1-1 is expressed in the erythrocytes, the lack of expression of the GSTT1-1 gene in the target cells (lymphocytes) may account for this observation... - Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropaneRogelio Tornero-Velez
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, USA
Drug Metab Dispos 32:123-31. 2004.... - Mutagen structure and transcriptional response: induction of distinct transcriptional profiles in Salmonella TA100 by the drinking-water mutagen MX and its homologuesWilliam O Ward
Integrated Systems Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Mol Mutagen 51:69-79. 2010..Ultimately, explanations for varying transcriptional responses induced by compounds with similar structures await an improved understanding of the interactions between small molecules and the cellular machinery... - Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for researchSusan D Richardson
National Exposure Research Laboratory, US Environmental Protection Agency, Athens, GA 30605, USA
Mutat Res 636:178-242. 2007..The categories of DBPs described here, the identified data gaps, and the emerging role of dermal/inhalation exposure provide guidance for drinking water and public health research... - Induction of DNA strand breaks by trihalomethanes in primary human lung epithelial cellsStefano Landi
US Environmental Protection Agency, National Health and Environmental, Effects Research Laboratory, Research Triangle Park, NC 27711, USA
Mutat Res 538:41-50. 2003.... - Transcriptional responses to complex mixtures: a reviewBanalata Sen
National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 636:144-77. 2007..We suggest critical components of study design and reporting that will achieve this goal... - Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugarPaul Andrewes
U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Environ Sci Technol 38:4140-8. 2004.... - Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspectiveD M Demarini
Genetic Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711
Mutat Res 220:11-29. 1989.... - Dietary interventions of human carcinogenesisD M Demarini
Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Mutat Res 400:457-65. 1998..have generally not. Estimates suggest that appropriate dietary changes could reduce the percentage of deaths due to prostate, colorectal, pancreatic, and breast cancer by >/=50%... - Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrBCarol D Swartz
Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA
Environ Mol Mutagen 48:694-705. 2007..This enhanced sensitivity may underlay the severe health effects in humans who have mutations in molybdenum cofactor biosynthesis genes... - Urinary mutagenicity and colorectal adenoma riskUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7273, USA
Cancer Epidemiol Biomarkers Prev 12:1253-6. 2003..2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk... - Mutation spectra of smoky coal combustion emissions in Salmonella reflect the TP53 and KRAS mutations in lung tumors from smoky coal-exposed individualsCourtney A Granville
Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
Mutat Res 525:77-83. 2003..The mutation spectra of the extract reflect the presence of PAHs in the mixture and support a role for PAHs in the induction of the mutations and tumors due to exposure to smoky coal emissions... - Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerationsCourtney A Granville
Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
Mutat Res 572:98-112. 2005..Occurrence data for 1,1-DCPe in finished drinking water are needed to estimate human exposure to, and possible health risks from, this mutagenic compound... - Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking waterBijit Kundu
Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
Mutat Res 562:39-65. 2004..Because the HNMs are mutagenic in Salmonella (present study) and potent clastogens in mammalian cells [Environ. Sci. Technol. 38 (2004) 62], their presence in drinking water warrants further research on their potential health effects... - Urinary biomarkers in charcoal workers exposed to wood smoke in Bahia State, BrazilMina Kato
FUNDACENTRO-CRBA, CEP 41280-770, Salvador/BA, Brzail
Cancer Epidemiol Biomarkers Prev 13:1005-12. 2004..This is the first reported measurement of internal exposure to wood smoke among charcoal workers, and the results showed that these workers receive a systemic exposure to genotoxic compounds... - K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in ChinaPhouthone Keohavong
Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
Lung Cancer 41:21-7. 2003.... - Mutagenic characteristics of river waters flowing through large metropolitan areas in North AmericaTakeshi Ohe
Department of Food and Nutrition, Kyoto Women s University, Japan
Mutat Res 534:101-12. 2003..g. XAD and blue rayon), will be needed to clarify the observed differences between North American blue rayon values and published values for European and Asian river systems... - Evidence for the presence of mutagenic arylamines in human breast milk and DNA adducts in exfoliated breast ductal epithelial cellsPatricia A Thompson
College of Medicine, Department of Pathology, The University of Arizona Health Sciences Center, Tucson, Arizona, USA
Environ Mol Mutagen 39:134-42. 2002.... - Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repairAudrey A King
The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
Mutat Res 616:60-9. 2007..These and other data lead us to propose that VAN and CIN may induce DNA damage that elicits recombinational DNA repair, which reduces spontaneous mutations... - Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding studyUlrike Peters
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7273, USA
Environ Mol Mutagen 43:53-74. 2004..The data from this study indicate that urinary mutagenicity correlates with mutagenic exposure from cooked meat and can potentially be used as a marker in etiological studies on cancer... - Unrecognized or potential risk factors for childhood cancerNicolas A van Larebeke
Study Center for Carcinogenesis and Primary Prevention of Cancer, Ghent University, Ghent, Belgium
Int J Occup Environ Health 11:199-201. 2005..That environmental exposures may be important causes of childhood cancers is indicated by associations of enzyme polymorphisms with risk... - Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, ChinaMin Shen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
Int J Cancer 116:768-73. 2005..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs... - Smoking while pregnant: transplacental mutagenesis of the fetus by tobacco smokeDavid M DeMarini
JAMA 293:1264-5. 2005 - Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectraBijit Kundu
Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill 27599, USA
Mutat Res 554:335-50. 2004..Sci. Technol. 38 (2004) 62] and are more mutagenic and 10x more cytotoxic in Salmonella than the HMs, whose levels are regulated in drinking water, further study of their occurrence and potential health effects is warranted... - Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissionsQing Lan
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
Carcinogenesis 25:2177-81. 2004..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs... - Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenesGabriele Sabbioni
Institute of Environmental and Occupational Toxicology, Casella Postale 108, 6780 Airolo, Switzerland
Cancer Epidemiol Biomarkers Prev 15:559-66. 2006....