D M Demarini

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Influence of DNA repair on mutation spectra in Salmonella
    D M Demarini
    Environmental Carcinogenesis Division, US Environmental Protection Agency, MD 68, 86 Alexander Drive, Research Triangle Park, NC 27711, USA
    Mutat Res 450:5-17. 2000
  2. ncbi request reprint Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates
    David M DeMarini
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 650:15-29. 2008
  3. ncbi request reprint Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations
    Andrew D Kligerman
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 42:192-205. 2003
  4. ncbi request reprint Biomedicine. Do airborne particles induce heritable mutations?
    Jonathan M Samet
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Science 304:971-2. 2004
  5. doi request reprint Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review
    David M DeMarini
    Integrated Systems Toxicology Division, US Environmental Protection Agency, B105 03, Research Triangle Park, NC 27711, USA
    Mutagenesis 28:485-505. 2013
  6. doi request reprint Declaring the existence of human germ-cell mutagens
    David M DeMarini
    Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 53:166-72. 2012
  7. pmc Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of MX-treated Salmonella
    William O Ward
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    BMC Bioinformatics 8:378. 2007
  8. ncbi request reprint Mutagenicity in lung of big Blue((R)) mice and induction of tandem-base substitutions in Salmonella by the air pollutant peroxyacetyl nitrate (PAN): predicted formation of intrastrand cross-links
    D M Demarini
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA
    Mutat Res 457:41-55. 2000
  9. pmc Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particles
    David M DeMarini
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:814-9. 2004
  10. ncbi request reprint Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions
    D M Demarini
    Environmental Carcinogenesis Division MD 68, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Cancer Res 61:6679-81. 2001

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Influence of DNA repair on mutation spectra in Salmonella
    D M Demarini
    Environmental Carcinogenesis Division, US Environmental Protection Agency, MD 68, 86 Alexander Drive, Research Triangle Park, NC 27711, USA
    Mutat Res 450:5-17. 2000
    ..Thus, a mutagen induces the same primary class of base substitution in most organisms, reflecting the conserved nature of DNA replication and repair processes...
  2. ncbi request reprint Genotoxicity of 10 cigarette smoke condensates in four test systems: comparisons between assays and condensates
    David M DeMarini
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 650:15-29. 2008
    ....
  3. ncbi request reprint Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: induction of chromosomal mutations but not gene mutations
    Andrew D Kligerman
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 42:192-205. 2003
    ..We suggest that the clastogenicity of the other arsenicals is due to their metabolism by cells to MMA(III) or DMA(III)...
  4. ncbi request reprint Biomedicine. Do airborne particles induce heritable mutations?
    Jonathan M Samet
    Department of Epidemiology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Science 304:971-2. 2004
  5. doi request reprint Genotoxicity biomarkers associated with exposure to traffic and near-road atmospheres: a review
    David M DeMarini
    Integrated Systems Toxicology Division, US Environmental Protection Agency, B105 03, Research Triangle Park, NC 27711, USA
    Mutagenesis 28:485-505. 2013
    ....
  6. doi request reprint Declaring the existence of human germ-cell mutagens
    David M DeMarini
    Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Mol Mutagen 53:166-72. 2012
    ..I suggest that the long search for human germ-cell mutagens is about to end, and a demonstration of the much-anticipated linkage between heritable disease and environmental factors is poised to begin...
  7. pmc Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of MX-treated Salmonella
    William O Ward
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    BMC Bioinformatics 8:378. 2007
    ....
  8. ncbi request reprint Mutagenicity in lung of big Blue((R)) mice and induction of tandem-base substitutions in Salmonella by the air pollutant peroxyacetyl nitrate (PAN): predicted formation of intrastrand cross-links
    D M Demarini
    National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 27711, Research Triangle Park, NC, USA
    Mutat Res 457:41-55. 2000
    ..Thus, PAN may pose a mutagenic and possible carcinogenic risk to humans, especially at the high concentrations at which it is present in some urban environments...
  9. pmc Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particles
    David M DeMarini
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 112:814-9. 2004
    ....
  10. ncbi request reprint Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions
    D M Demarini
    Environmental Carcinogenesis Division MD 68, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Cancer Res 61:6679-81. 2001
    ..These results show that mutations in the TP53 and KRAS genes can reflect a specific environmental exposure...
  11. ncbi request reprint Mutation spectra in Salmonella of analogues of MX: implications of chemical structure for mutational mechanisms
    D M Demarini
    Environmental Carcinogenesis Division MD 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 453:51-65. 2000
    ..To our knowledge, this is the first study in which such analyses have been applied to structural analogues for which both mutagenic potency and mutation spectra date were available...
  12. ncbi request reprint Genotoxicity of tobacco smoke and tobacco smoke condensate: a review
    David M DeMarini
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Mutat Res 567:447-74. 2004
    ..Thus, their relevance to humans cannot be denied, and their explanatory powers not easily dismissed. Tobacco smoke is now the most extreme example of a systemic human mutagen...
  13. pmc Outdoor air pollution and DNA damage
    D M Demarini
    Environmental Carcinogenesis Division B143 06, US Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Occup Environ Med 63:227-9. 2006
  14. doi request reprint What's in a name? The argument for changing the name of IAEMS and its affiliated societies
    David M DeMarini
    U S Environmental Protection Agency, B105 03, RTP, NC 27711, USA
    Mutat Res 705:201-4. 2010
    ....
  15. doi request reprint Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene
    David M DeMarini
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 714:17-25. 2011
    ..Our results leave open a possible role for unstable DNA adducts in the mutational specificity of BP but not for DBP...
  16. ncbi request reprint Induction of genetic damage in human lymphocytes and mutations in Salmonella by trihalomethanes: role of red blood cells and GSTT1-1 polymorphism
    S Landi
    Environmental Carcinogenesis Division MD 68 and Experimental Toxicology Division MD 74, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutagenesis 14:479-82. 1999
    ..Such a proposal is reasonably consistent with the organ specificity of drinking water-associated cancer in humans, which shows slightly elevated risks for cancer of the colon and bladder but not of the liver...
  17. ncbi request reprint Glutathione S-transferase-mediated induction of GC-->AT transitions by halomethanes in Salmonella
    D M Demarini
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 30:440-7. 1997
    ..The implications of these findings are discussed in relation to previous experimental work on the GST-mediated bioactivation of dihalomethanes, which includes the possible formation of GSH intermediates and/or GSH-DNA adducts...
  18. ncbi request reprint Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3, 4-diepoxybutane in mouse, rat and human lymphocytes following in vitro G0 exposures
    A D Kligerman
    Environmental Carcinogenesis Division MD 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 439:13-23. 1999
    ..However, additional factors also appear to influence the genotoxic response of humans to DEB. This study is the first direct comparison of the genotoxicity of EB and DEB in the cells from all three species...
  19. pmc Spectra of spontaneous frameshift mutations at the hisD3052 allele of Salmonella typhimurium in four DNA repair backgrounds
    D M Demarini
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Genetics 149:17-36. 1998
    ..The mechanisms may involve (1) the potential of direct and inverted repeats to undergo slippage and misalignment and to form quasi-palindromes and (2) the interaction of these sequences with DNA replication and repair proteins...
  20. doi request reprint Induction of abasic sites by the drinking-water mutagen MX in Salmonella TA100
    Leon C King
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Chem Biol Interact 180:340-3. 2009
    ..001). These results provide some evidence for the ability of MX to induce abasic sites in cellular DNA. However, the lack of a dose response makes it unclear whether this DNA damage underlies the mutagenic activity of MX...
  21. pmc Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice
    Pramila Singh
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 112:820-5. 2004
    ..Key words: automobile, diesel exhaust particles, forklift, mice, pulmonary toxicity, SRM 2975...
  22. ncbi request reprint Mutation spectrum of a binary mixture of mutagens (methapyrilene and sodium azide) in strain TA1535 of Salmonella
    M L Shelton
    U S Environmental Protection Agency, Research Triangle Park, NC 27711
    Mutat Res 323:35-9. 1994
    ..Such a mechanism might be the basis for the carcinogenic and cocarcinogenic activities of MP. To our knowledge, this is the first report of the molecular analysis of mutants produced by exposure of cells to a binary mixture of mutagens...
  23. ncbi request reprint Pilot study of free and conjugated urinary mutagenicity during consumption of pan-fried meats: possible modulation by cruciferous vegetables, glutathione S-transferase-M1, and N-acetyltransferase-2
    D M Demarini
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 381:83-96. 1997
    ....
  24. ncbi request reprint Mutation spectra of complex mixtures
    D M Demarini
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 411:11-8. 1998
    ..Such information should be useful in the interpretation of mutation spectra in molecular epidemiological studies where the exposure is primarily to a complex mixture...
  25. ncbi request reprint Induction of sister chromatid exchanges in human peripheral blood lymphocytes by bromoform: investigation of the role of GSTT1-1 polymorphism
    S Landi
    Environmental Carcinogenesis Division MD 68, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 429:261-7. 1999
    ..9.57+/-0.07), or the 24th h (8.21+/-0.61 vs. 8.29+/-0.24) of cell growth. Although GSTT1-1 is expressed in the erythrocytes, the lack of expression of the GSTT1-1 gene in the target cells (lymphocytes) may account for this observation...
  26. ncbi request reprint Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: a review and roadmap for research
    Susan D Richardson
    National Exposure Research Laboratory, US Environmental Protection Agency, Athens, GA 30605, USA
    Mutat Res 636:178-242. 2007
    ..The categories of DBPs described here, the identified data gaps, and the emerging role of dermal/inhalation exposure provide guidance for drinking water and public health research...
  27. doi request reprint Mutagen structure and transcriptional response: induction of distinct transcriptional profiles in Salmonella TA100 by the drinking-water mutagen MX and its homologues
    William O Ward
    Integrated Systems Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Mol Mutagen 51:69-79. 2010
    ..Ultimately, explanations for varying transcriptional responses induced by compounds with similar structures await an improved understanding of the interactions between small molecules and the cellular machinery...
  28. ncbi request reprint Metabolism and mutagenicity of source water contaminants 1,3-dichloropropane and 2,2-dichloropropane
    Rogelio Tornero-Velez
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, USA
    Drug Metab Dispos 32:123-31. 2004
    ....
  29. ncbi request reprint Induction of DNA strand breaks by trihalomethanes in primary human lung epithelial cells
    Stefano Landi
    US Environmental Protection Agency, National Health and Environmental, Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Mutat Res 538:41-50. 2003
    ....
  30. ncbi request reprint Transcriptional responses to complex mixtures: a review
    Banalata Sen
    National Center for Environmental Assessment, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 636:144-77. 2007
    ..We suggest critical components of study design and reporting that will achieve this goal...
  31. ncbi request reprint Do arsenosugars pose a risk to human health? The comparative toxicities of a trivalent and pentavalent arsenosugar
    Paul Andrewes
    U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Environ Sci Technol 38:4140-8. 2004
    ....
  32. ncbi request reprint Dietary interventions of human carcinogenesis
    D M Demarini
    Environmental Carcinogenesis Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Mutat Res 400:457-65. 1998
    ..have generally not. Estimates suggest that appropriate dietary changes could reduce the percentage of deaths due to prostate, colorectal, pancreatic, and breast cancer by >/=50%...
  33. ncbi request reprint Specific-locus mutations induced in eukaryotes (especially mammalian cells) by radiation and chemicals: a perspective
    D M Demarini
    Genetic Toxicology Division, U S Environmental Protection Agency, Research Triangle Park, NC 27711
    Mutat Res 220:11-29. 1989
    ....
  34. ncbi request reprint Enhanced mutagenesis of Salmonella tester strains due to deletion of genes other than uvrB
    Carol D Swartz
    Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA
    Environ Mol Mutagen 48:694-705. 2007
    ..This enhanced sensitivity may underlay the severe health effects in humans who have mutations in molybdenum cofactor biosynthesis genes...
  35. ncbi request reprint Urinary mutagenicity and colorectal adenoma risk
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland 20892 7273, USA
    Cancer Epidemiol Biomarkers Prev 12:1253-6. 2003
    ..2-13.9, comparing the highest with the lowest quintile). In our study population, diet may have contributed to mutagenic exposure, which was positively associated with colorectal adenoma risk...
  36. ncbi request reprint Mutation spectra of smoky coal combustion emissions in Salmonella reflect the TP53 and KRAS mutations in lung tumors from smoky coal-exposed individuals
    Courtney A Granville
    Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
    Mutat Res 525:77-83. 2003
    ..The mutation spectra of the extract reflect the presence of PAHs in the mixture and support a role for PAHs in the induction of the mutations and tumors due to exposure to smoky coal emissions...
  37. ncbi request reprint Mutagenicity in Salmonella of halonitromethanes: a recently recognized class of disinfection by-products in drinking water
    Bijit Kundu
    Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
    Mutat Res 562:39-65. 2004
    ..Because the HNMs are mutagenic in Salmonella (present study) and potent clastogens in mammalian cells [Environ. Sci. Technol. 38 (2004) 62], their presence in drinking water warrants further research on their potential health effects...
  38. ncbi request reprint Urinary biomarkers in charcoal workers exposed to wood smoke in Bahia State, Brazil
    Mina Kato
    FUNDACENTRO CRBA, CEP 41280 770, Salvador BA, Brzail
    Cancer Epidemiol Biomarkers Prev 13:1005-12. 2004
    ..This is the first reported measurement of internal exposure to wood smoke among charcoal workers, and the results showed that these workers receive a systemic exposure to genotoxic compounds...
  39. ncbi request reprint Genotoxicity and metabolism of the source-water contaminant 1,1-dichloropropene: activation by GSTT1-1 and structure-activity considerations
    Courtney A Granville
    Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill, NC 27599, USA
    Mutat Res 572:98-112. 2005
    ..Occurrence data for 1,1-DCPe in finished drinking water are needed to estimate human exposure to, and possible health risks from, this mutagenic compound...
  40. ncbi request reprint K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China
    Phouthone Keohavong
    Department of Environmental and Occupational Health, University of Pittsburgh, 3343 Forbes Avenue, Pittsburgh, PA 15260, USA
    Lung Cancer 41:21-7. 2003
    ....
  41. ncbi request reprint Mutagenic characteristics of river waters flowing through large metropolitan areas in North America
    Takeshi Ohe
    Department of Food and Nutrition, Kyoto Women s University, Japan
    Mutat Res 534:101-12. 2003
    ..g. XAD and blue rayon), will be needed to clarify the observed differences between North American blue rayon values and published values for European and Asian river systems...
  42. ncbi request reprint Urinary mutagenesis and fried red meat intake: influence of cooking temperature, phenotype, and genotype of metabolizing enzymes in a controlled feeding study
    Ulrike Peters
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland 20892 7273, USA
    Environ Mol Mutagen 43:53-74. 2004
    ..The data from this study indicate that urinary mutagenicity correlates with mutagenic exposure from cooked meat and can potentially be used as a marker in etiological studies on cancer...
  43. ncbi request reprint Oxidative damage-related genes AKR1C3 and OGG1 modulate risks for lung cancer due to exposure to PAH-rich coal combustion emissions
    Qing Lan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
    Carcinogenesis 25:2177-81. 2004
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and other populations with substantial exposure to PAHs...
  44. pmc Antimutagenicity of cinnamaldehyde and vanillin in human cells: Global gene expression and possible role of DNA damage and repair
    Audrey A King
    The Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mutat Res 616:60-9. 2007
    ..These and other data lead us to propose that VAN and CIN may induce DNA damage that elicits recombinational DNA repair, which reduces spontaneous mutations...
  45. ncbi request reprint Evidence for the presence of mutagenic arylamines in human breast milk and DNA adducts in exfoliated breast ductal epithelial cells
    Patricia A Thompson
    College of Medicine, Department of Pathology, The University of Arizona Health Sciences Center, Tucson, Arizona, USA
    Environ Mol Mutagen 39:134-42. 2002
    ....
  46. ncbi request reprint Biomarkers of exposure, effect, and susceptibility in workers exposed to nitrotoluenes
    Gabriele Sabbioni
    Institute of Environmental and Occupational Toxicology, Casella Postale 108, 6780 Airolo, Switzerland
    Cancer Epidemiol Biomarkers Prev 15:559-66. 2006
    ....
  47. ncbi request reprint Unrecognized or potential risk factors for childhood cancer
    Nicolas A van Larebeke
    Study Center for Carcinogenesis and Primary Prevention of Cancer, Ghent University, Ghent, Belgium
    Int J Occup Environ Health 11:199-201. 2005
    ..That environmental exposures may be important causes of childhood cancers is indicated by associations of enzyme polymorphisms with risk...
  48. ncbi request reprint Smoking while pregnant: transplacental mutagenesis of the fetus by tobacco smoke
    David M DeMarini
    JAMA 293:1264-5. 2005
  49. ncbi request reprint Comparative mutagenicity of halomethanes and halonitromethanes in Salmonella TA100: structure-activity analysis and mutation spectra
    Bijit Kundu
    Department of Environmental Science and Engineering, University of North Carolina, Chapel Hill 27599, USA
    Mutat Res 554:335-50. 2004
    ..Sci. Technol. 38 (2004) 62] and are more mutagenic and 10x more cytotoxic in Salmonella than the HMs, whose levels are regulated in drinking water, further study of their occurrence and potential health effects is warranted...
  50. ncbi request reprint Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China
    Min Shen
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 7240, USA
    Int J Cancer 116:768-73. 2005
    ..However, due to the small sample size, additional studies are needed to evaluate these associations within Xuan Wei and in other populations with substantial environmental exposure to PAHs...