Research Topics
| Glinda S CooperSummaryAffiliation: U.S. Environmental Protection Agency Country: USA Publications
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Detail Information
Publications
Recent advances and opportunities in research on lupus: environmental influences and mechanisms of diseaseGlinda S Cooper
National Center for Environmental Assessment, US Environmental Protection Agency, Washington, DC 20460, USA
Environ Health Perspect 116:695-702. 2008....
The prevalence and accuracy of self-reported history of 11 autoimmune diseasesGlinda S Cooper
United States Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC 20460, USA
J Rheumatol 35:2001-4. 2008..To determine the prevalence and confirmation rate of autoimmune diseases reported by relatives of patients with lupus and controls...- Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humansGlinda S Cooper
National Center for Environmental Assessment, U S Environmental Protection Agency, Washington, DC 20460, USA
Environ Health Perspect 117:696-702. 2009..Our objective was to examine experimental and epidemiologic studies pertaining to immune-related, and specifically autoimmune-related, effects of trichloroethylene (TCE)... - Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseasesGlinda S Cooper
Department of Environmental and Occupational Health, George Washington University School of Public Health and Health Services, Washington, DC 20052, USA
J Autoimmun 33:197-207. 2009..Multiple sclerosis and rheumatoid arthritis is one disease pair that appears to have a decreased chance of coexistence... 
The ghost of public health journalism: past, present, and futureGlinda S Cooper
Department of Environmental and Occupational Health, George Washington University School of Public Health and Health Services, Washington, DC, USA
Epidemiology 21:263-6. 2010..Continued efforts to promote interest in and skills needed for high-quality public health and environmental reporting are needed...- Occupational and environmental exposures and risk of systemic lupus erythematosus: silica, sunlight, solventsGlinda S Cooper
Department of Environmental and Occupational Health, The George Washington University, School of Public Health and Health Services, Washington, DC, USA
Rheumatology (Oxford) 49:2172-80. 2010..We examined occupational and non-occupational exposures in relation to risk of SLE in a case-control study conducted through the Canadian Network for Improved Outcomes in SLE (CaNIOS)... - Insights from epidemiology into dichloromethane and cancer riskGlinda S Cooper
National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, Washington, DC 20460, USA
Int J Environ Res Public Health 8:3380-98. 2011.... - Pentachlorophenol and cancer risk: focusing the lens on specific chlorophenols and contaminantsGlinda S Cooper
National Center for Environmental Assessment, US Environmental Protection Agency, Washington, DC 20460, USA
Environ Health Perspect 116:1001-8. 2008..We reviewed currently available data to determine the extent to which recent studies assist in distinguishing the effect of pentachlorophenol from that of its contaminants (e.g., dioxins and other chlorophenols)... - A review of potential neurotoxic mechanisms among three chlorinated organic solventsAmbuja S Bale
National Center for Environmental Assessment, Office of Research and Development, United States Environmental Protection Agency, Washington, DC 20460, USA
Toxicol Appl Pharmacol 255:113-26. 2011..Given this mechanistic information and available studies for TCE, DCM, and PERC, we provide hypotheses on primary targets (e.g. ion channel targets) that appear to be most influential in producing the resultant neurological effects... - Human health effects of trichloroethylene: key findings and scientific issuesWeihsueh A Chiu
National Center for Environmental Assessment, U S Environmental Protection Agency EPA, Washington, DC, USA
Environ Health Perspect 121:303-11. 2013..S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years... - Sociodemographic associations with early disease damage in patients with systemic lupus erythematosusGlinda S Cooper
US Environmental Protection Agency, Washington, DC 20460, USA
Arthritis Rheum 57:993-9. 2007..To examine the extent of organ damage among recently diagnosed patients with systemic lupus erythematosus (SLE), and to assess the association between sociodemographic variables and total damage and organ-specific damage scores... - Renal effects of exposure to natural and depleted uranium: a review of the epidemiologic and experimental dataXabier Arzuaga
National Center for Environmental Assessment, U S Environmental Protection Agency, Washington, DC 20460, USA
J Toxicol Environ Health B Crit Rev 13:527-45. 2010..The interpretation and importance of the observed changes in biomarkers of proximal tubule function are important questions that indicate the need for additional clinical, epidemiological, and experimental research... - Use of epidemiologic data in Integrated Risk Information System (IRIS) assessmentsAmanda S Persad
Office of Research and Development 8601 P, U S Environmental Protection Agency, 1200 Pennsylvania Ave NW Washington, DC 20460, USA
Toxicol Appl Pharmacol 233:137-45. 2008.... - Rheumatoid arthritis among women in the Agricultural Health Study: risk associated with farming activities and exposuresAnneclaire J De Roos
University of Washington Department of Epidemiology and Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Ann Epidemiol 15:762-70. 2005..We studied risk factors for RA in the Agricultural Health Study, a cohort of over 57,000 licensed pesticide applicators and their spouses... - Occupational silica and solvent exposures and risk of systemic lupus erythematosus in urban womenAxel Finckh
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arthritis Rheum 54:3648-54. 2006..To assess the risk of systemic lupus erythematosus (SLE) associated with occupational exposure to silica dust and organic solvents in an urban population... - Vitamin D deficiency in systemic lupus erythematosusDiane L Kamen
Medical University of South Carolina, Charleston, SC, USA
Autoimmun Rev 5:114-7. 2006..9, p<0.01). These results suggest vitamin D deficiency as a possible risk factor for SLE and provide guidance for future studies looking at a potential role of vitamin D in the prevention and/or treatment of SLE... - Occupational and environmental associations with antinuclear antibodies in a general population sampleGlinda S Cooper
National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Durham, North Carolina 27709, USA
J Toxicol Environ Health A 69:2063-9. 2006..Larger studies addressing these exposures may provide insights into the mechanisms by which various environmental factors affect the development of autoantibodies and the progression to clinical disease... - Effect of glutathione S-transferase polymorphisms and proximity to hazardous waste sites on time to systemic lupus erythematosus diagnosis: results from the Roxbury lupus projectElizabeth W Karlson
Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 56:244-54. 2007..Our goal was to assess association of residential proximity to hazardous waste sites and genetic variation in 3 glutathione Stransferase (GST) genes (GSTM1, GSTT1, and GSTP1) with age at diagnosis of SLE... - Personal and family medical history correlates of rheumatoid arthritisAnneclaire J De Roos
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and Department of Epidemiology, University of Washington, Seattle, WA 98109, USA
Ann Epidemiol 18:433-9. 2008..We studied personal and family medical history correlates of incident and prevalent RA in women... - Association of Epstein-Barr virus with systemic lupus erythematosus: effect modification by race, age, and cytotoxic T lymphocyte-associated antigen 4 genotypeChristine G Parks
National Institute of Environmental Health Sciences, Durham, North Carolina, USA
Arthritis Rheum 52:1148-59. 2005..This study examined the seroprevalence of EBV in a population-based study of SLE patients from the southeastern United States, and potential interactions with CTLA-4 polymorphisms were assessed... - Occupational exposure to crystalline silica and risk of systemic lupus erythematosus: a population-based, case-control study in the southeastern United StatesChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina 27709, USA
Arthritis Rheum 46:1840-50. 2002..We undertook this population-based study to examine the association between occupational silica exposure and SLE in the southeastern US... - Occupational and environmental exposures as risk factors for systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch MDA3 05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
Curr Rheumatol Rep 6:367-74. 2004..There are numerous avenues with respect to environmental factors in SLE that need additional research... - Comparing questionnaire-based methods to assess occupational silica exposureChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Epidemiology 15:433-41. 2004.... - Polychlorinated biphenyls and menstrual cycle characteristicsGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Epidemiology 16:191-200. 2005..Few studies have examined these associations in humans... - The epidemiology of autoimmune diseasesGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA
Autoimmun Rev 2:119-25. 2003..Thus although there are commonalities, there are also important demographic differences between diseases. Disease-specific research, as well as studies that focus on potentially related diseases, needs to be conducted... - Assessing exposure to crystalline silica from farm work: a population-based study in the Southeastern United StatesChristine G Parks
Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Ann Epidemiol 13:385-92. 2003..This study examines aspects of farm work that were used to estimate potential silica dust exposure in a population-based study conducted in the southeastern United States... - Employment and disability issues in systemic lupus erythematosus: a reviewLacie Scofield
National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Arthritis Rheum 59:1475-9. 2008..To summarize research pertaining to work disability in lupus patients, discuss challenges patients face applying for federal disability assistance in the US, and make recommendations for clinical and health policy research... - Glutathione S-transferase M null homozygosity and risk of systemic lupus erythematosus associated with sun exposure: a possible gene-environment interaction for autoimmunityPatricia A Fraser
Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
J Rheumatol 30:276-82. 2003..We hypothesized that risk of SLE associated with occupational sun exposure is modulated by GSTM1, GSTT1, and GSTP1 genotypes... - Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americansJim C Oates
Department of Medicine, Ralph H Johnson VA Medical Center VAMC and Medical University of South Carolina, Charleston 29425, USA
J Rheumatol 30:60-7. 2003..This study was designed to determine if these polymorphisms are associated with SLE... - A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patientsJianming Wu
Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama, Birmingham, AL 35294 0006, USA
J Immunol 170:132-8. 2003..This functionally significant SNP demonstrates the potential importance of SNPs in regulatory regions and suggests that differences in the regulation of FasL expression may contribute to the development of the autoimmune phenotype... - Hormone replacement following early menopauseGlinda S Cooper
JAMA 288:2824-5; author reply 2825. 2002 - Risk factors for development of systemic lupus erythematosus: allergies, infections, and family historyGlinda S Cooper
Epidemiology Branch A3 05, National Institute of Environmental Health Sciences, PO Box 12233, Durham, NC 27709, USA
J Clin Epidemiol 55:982-9. 2002..3, 95% CI 1.2-8.6). Further research is needed to clarify whether medication allergies and specific infectious agents are involved in the etiology of SLE. Published by Elsevier Science Inc... - Organochlorine exposure and age at natural menopauseGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA
Epidemiology 13:729-33. 2002..The effect of potential endocrine-modulating organochlorines on menopause has not been extensively examined... - A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signalingXiaoli Li
University of Alabama at Birmingham, AL 35294 0006, USA
Arthritis Rheum 48:3242-52. 2003..The transmembrane domain of FcgammaRIIb may also contribute to receptor signaling. Therefore, we investigated the biologic significance of single-nucleotide polymorphisms (SNPs) throughout the coding region... - Two aspects of the clinical and humanistic burden of systemic lupus erythematosus: mortality risk and quality of life early in the course of diseaseRobert Campbell
Medical University of South Carolina, Charleston, SC, USA
Arthritis Rheum 59:458-64. 2008..To evaluate mortality risk and predictors among recently diagnosed systemic lupus erythematosus (SLE) patients... - N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 31:76-80. 2004..To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE)... - Occupational risk factors for the development of systemic lupus erythematosusGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina 27709, USA
J Rheumatol 31:1928-33. 2004..We examined the association between the risk of SLE and occupational exposures (mercury, solvents, and pesticides), specific jobs (ever worked in teaching, healthcare, and cosmetology), and working night or rotating shifts... - Associations between plasma DDE levels and immunologic measures in African-American farmers in North CarolinaGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA
Environ Health Perspect 112:1080-4. 2004..32-11.3; for > or = 12.0 microg/L compared with < 3.0 microg/L p,p'-DDE), but this difference was not statistically significant. These analyses provide evidence that p,p'-DDE modulates immune responses in humans... - Occupational exposures and risk of systemic lupus erythematosusChristine G Parks
Biostatistics and Epidemiology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Autoimmunity 38:497-506. 2005..g. high-titer autoantibodies) in occupational cohorts with well-characterized exposure histories may reveal occupational risk factors for autoimmunity, and may also provide baseline data for studies of determinants of progression to SLE... - Pesticide exposure and timing of menopause: the Agricultural Health StudySherry L Farr
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Epidemiol 163:731-42. 2006..78, 0.97) and by approximately 5 months for women who used hormonally active pesticides (hazard ratio = 0.77, 95% confidence interval: 0.65, 0.92). Pesticide use may be associated with a later age at menopause... - Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphismChristine G Parks
National Institute of Environmental Health Sciences, Durham, NC, USA
Hum Immunol 65:622-31. 2004..0, p < 0.00001) for the combined "HLA-DR3, TNF-alpha -308A, IL-1alpha -889C/C" genotype. These findings provide evidence of cytokine gene epistasis in SLE susceptibility... - Cancer screening in patients with systemic lupus erythematosusSasha R Bernatsky
Montreal General Hospital Research Institute, the Department of Rheumatology and the Divisions of Clinical Immunology and Allergy and Clinical Epidemiology, Montreal General Hospital, McGill University Health Centre, Montreal, Canada
J Rheumatol 33:45-9. 2006..CONCLUSION: These data suggest that appropriate cancer screening may be overlooked in patients with SLE... - A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosusKaihong Su
Division of Clinical Immunology and Rheumatology, Departments of Medicine and Microbiology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 172:7186-91. 2004..72; p = 0.0083). These results suggest that an expression variant of FCGR2B is a risk factor for human lupus and implicate FCGR2B in disease pathogenesis... - Ovarian cancer risk and use of phenolphthalein-containing laxativesGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC 27709, USA
Pharmacoepidemiol Drug Saf 13:35-9. 2004..Ovarian cancer was one of the cancers observed in these studies. We examined the association between epithelial ovarian cancer and use of phenolphthalein-containing laxatives in a population-based case-control study... - Association of silica exposure with anti-neutrophil cytoplasmic autoantibody small-vessel vasculitis: a population-based, case-control studySusan L Hogan
UNC Kidney Center and Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7155, USA
Clin J Am Soc Nephrol 2:290-9. 2007..Exposure to silica from specific farming tasks related to harvesting may be of particular importance in the southeastern United States. Interval of time since last exposure did not influence development of ANCA-SVV... - Childbearing and the risk of scleroderma: a population-based study in SwedenMats Lambe
Department of Epidemiology, Karolinska Institutet, Stockholm, Sweden
Am J Epidemiol 159:162-6. 2004.... - Hormonal and reproductive risk factors for development of systemic lupus erythematosus: results of a population-based, case-control studyGlinda S Cooper
Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina 27709, USA
Arthritis Rheum 46:1830-9. 2002..In humans, 85% of lupus patients are women, which also suggests the importance of hormonal factors in disease pathogenesis. The purpose of this study was to examine hormonal and reproductive risk factors for lupus among women...