Michael C Cimino

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes
    Michael C Cimino
    Risk Assessment Division, Science Support Branch, Office of Pollution Prevention and Toxics, U S Environmental Protection Agency, Washington, District of Columbia 20460 0001, USA
    Environ Mol Mutagen 47:362-90. 2006
  2. doi request reprint Follow-up actions from positive results of in vitro genetic toxicity testing
    Kerry L Dearfield
    U S Department of Agriculture, Food Safety and Inspection Service, Washington, District of Columbia, USA
    Environ Mol Mutagen 52:177-204. 2011
  3. ncbi request reprint Genotoxicity risk assessment: a proposed classification strategy
    Kerry L Dearfield
    US Environmental Protection Agency, Office of Research and Development 8103R, 1200 Pennsylvanian Ave, N W, Washington, DC 20460, USA
    Mutat Res 521:121-35. 2002
  4. ncbi request reprint An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods
    Edwin J Matthews
    US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff ICSAS, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Regul Toxicol Pharmacol 44:97-110. 2006
  5. ncbi request reprint An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
    Edwin J Matthews
    US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff ICSAS, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Regul Toxicol Pharmacol 44:83-96. 2006

Detail Information

Publications5

  1. ncbi request reprint Comparative overview of current international strategies and guidelines for genetic toxicology testing for regulatory purposes
    Michael C Cimino
    Risk Assessment Division, Science Support Branch, Office of Pollution Prevention and Toxics, U S Environmental Protection Agency, Washington, District of Columbia 20460 0001, USA
    Environ Mol Mutagen 47:362-90. 2006
    ..When testing for regulatory purposes, it is advisable to verify the testing program with the specific regulatory body or bodies responsible forregulatory oversight before beginning testing...
  2. doi request reprint Follow-up actions from positive results of in vitro genetic toxicity testing
    Kerry L Dearfield
    U S Department of Agriculture, Food Safety and Inspection Service, Washington, District of Columbia, USA
    Environ Mol Mutagen 52:177-204. 2011
    ..The Review Subgroup also examined the characteristics, strengths, and limitations of each of the existing in vitro and in vivo genotoxicity assays to determine their usefulness in any follow-up testing...
  3. ncbi request reprint Genotoxicity risk assessment: a proposed classification strategy
    Kerry L Dearfield
    US Environmental Protection Agency, Office of Research and Development 8103R, 1200 Pennsylvanian Ave, N W, Washington, DC 20460, USA
    Mutat Res 521:121-35. 2002
    ..The final level of concern and characterized genotoxicity risk assessment are communicated to decision makers for possible regulatory action(s) and to the public...
  4. ncbi request reprint An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods
    Edwin J Matthews
    US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff ICSAS, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Regul Toxicol Pharmacol 44:97-110. 2006
    ..Results also showed that when Salmonella mutagenic carcinogens were removed from the 12 correlated, expanded data sets, only 7 endpoints showed added value by detecting significantly more additional carcinogens than non-carcinogens...
  5. ncbi request reprint An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
    Edwin J Matthews
    US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Pharmaceutical Science, Informatics and Computational Safety Analysis Staff ICSAS, 10903 New Hampshire Avenue, Silver Spring, MD 20993, USA
    Regul Toxicol Pharmacol 44:83-96. 2006
    ....