N Chernoff

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. doi request reprint Reproductive effects of maternal and pre-weaning undernutrition in rat offspring: age at puberty, onset of female reproductive senescence and intergenerational pup growth and viability
    N Chernoff
    U S Environmental Protection Agency, NHEERL, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 28:489-94. 2009
  2. pmc Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin
    N Chernoff
    US EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    J Appl Toxicol 31:242-54. 2011
  3. doi request reprint The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the "no observed adverse effect level"
    N Chernoff
    US EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 25:192-202. 2008
  4. ncbi request reprint Supernumerary ribs in developmental toxicity bioassays and in human populations: incidence and biological significance
    Neil Chernoff
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 7:437-49. 2004
  5. ncbi request reprint The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse after exposure late in gestation
    E H Rogers
    US EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicon 49:855-64. 2007
  6. ncbi request reprint Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin
    E H Rogers
    US Environmental Protection Agency, National Health and Ecological Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    J Appl Toxicol 25:527-34. 2005
  7. ncbi request reprint Lack of evidence for intergenerational reproductive effects due to prenatal and postnatal undernutrition in the female CD-1 mouse
    E H Rogers
    US Environmental Protection Agency, NHEERL, RTD, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 17:519-25. 2003
  8. doi request reprint Moderate developmental undernutrition: Impact on growth and cognitive function in youth and old age
    M E Gilbert
    Toxicity Assessment Division, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Neurotoxicol Teratol 32:362-72. 2010
  9. ncbi request reprint Altered axial skeletal development
    Rochelle W Tyl
    Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 80:451-72. 2007
  10. ncbi request reprint Axial skeletal and Hox expression domain alterations induced by retinoic acid, valproic acid, and bromoxynil during murine development
    C Y Kawanishi
    Reproductive Toxicology Division, NHEERL MD 67, U S Environmental Protection Agency, NC 27711, USA
    J Biochem Mol Toxicol 17:346-56. 2003

Detail Information

Publications19

  1. doi request reprint Reproductive effects of maternal and pre-weaning undernutrition in rat offspring: age at puberty, onset of female reproductive senescence and intergenerational pup growth and viability
    N Chernoff
    U S Environmental Protection Agency, NHEERL, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 28:489-94. 2009
    ..Females were bred to control males and no evidence of adverse reproductive effects was found in any F2 groups. The offspring of the F1 generation did not show an intergenerational effect as documented in humans...
  2. pmc Toxicity and recovery in the pregnant mouse after gestational exposure to the cyanobacterial toxin, cylindrospermopsin
    N Chernoff
    US EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    J Appl Toxicol 31:242-54. 2011
    ..Gene expression changes persisted up to 2 weeks post-dosing and returned to normal by 4 weeks. Responses of individual animals to CYN exposure indicated highly significant inter-animal variability within the treated groups...
  3. doi request reprint The relationship of maternal and fetal toxicity in developmental toxicology bioassays with notes on the biological significance of the "no observed adverse effect level"
    N Chernoff
    US EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 25:192-202. 2008
    ..Experimental approaches to test the hypothesis that maternal undernutrition in standard developmental toxicology bioassays may be responsible for significant term fetal weight decrements are discussed...
  4. ncbi request reprint Supernumerary ribs in developmental toxicity bioassays and in human populations: incidence and biological significance
    Neil Chernoff
    US Environmental Protection Agency, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health B Crit Rev 7:437-49. 2004
    ....
  5. ncbi request reprint The cyanobacterial toxin, cylindrospermopsin, induces fetal toxicity in the mouse after exposure late in gestation
    E H Rogers
    US EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Toxicon 49:855-64. 2007
    ..GD 13-17 exposed male pups still weighed significantly less than the controls after 15 months...
  6. ncbi request reprint Potential developmental toxicity of anatoxin-a, a cyanobacterial toxin
    E H Rogers
    US Environmental Protection Agency, National Health and Ecological Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    J Appl Toxicol 25:527-34. 2005
    ..Most notable was the occurrence of 100% mortality at the high dose in both groups 6-13 days post-exposure. The observed delay between initial exposure and death is highly unusual for anatoxin-a...
  7. ncbi request reprint Lack of evidence for intergenerational reproductive effects due to prenatal and postnatal undernutrition in the female CD-1 mouse
    E H Rogers
    US Environmental Protection Agency, NHEERL, RTD, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 17:519-25. 2003
    ..We conclude that body weight at birth in the CD-1 mouse is not correlated with growth through the period of weaning (PD28). We did not find any evidence for an intergenerational reproductive effect after developmental undernutrition...
  8. doi request reprint Moderate developmental undernutrition: Impact on growth and cognitive function in youth and old age
    M E Gilbert
    Toxicity Assessment Division, U S Environmental Protection Agency, Research Triangle Park, NC, USA
    Neurotoxicol Teratol 32:362-72. 2010
    ..These findings indicate that moderate fetal undernutrition followed by neonatal adequate nutrition does not appear to lead to obesity or neurological dysfunction in young adulthood or old age...
  9. ncbi request reprint Altered axial skeletal development
    Rochelle W Tyl
    Center for Life Sciences and Toxicology, Research Triangle Institute, Research Triangle Park, North Carolina 27709 2194, USA
    Birth Defects Res B Dev Reprod Toxicol 80:451-72. 2007
    ..Tables of the spontaneous incidence of axial anomalies in both humans and animals are provided...
  10. ncbi request reprint Axial skeletal and Hox expression domain alterations induced by retinoic acid, valproic acid, and bromoxynil during murine development
    C Y Kawanishi
    Reproductive Toxicology Division, NHEERL MD 67, U S Environmental Protection Agency, NC 27711, USA
    J Biochem Mol Toxicol 17:346-56. 2003
    ..These data suggest that xenobiotic compounds such as VA and Br may induce similar axial skeletal changes by affecting different components of the developmental processes involved in the patterning of the axial skeleton...
  11. ncbi request reprint 5-Aza-2'-deoxycytidine-induced cytotoxicity and limb reduction defects in the mouse
    Mitchell B Rosen
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Reproductive Toxicology Division, Research Triangle Park, North Carolina 27711, USA
    Teratology 65:180-90. 2002
    ..The present study tests the hypothesis that dAZA causes limb dysplasia by inducing cytotoxicity among rapidly proliferating cells in the limb bud mesenchyme...
  12. ncbi request reprint Chemically induced supernumerary lumbar ribs in CD-1 mice: size distribution and dose response
    John M Rogers
    Developmental Biology Branch, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Birth Defects Res B Dev Reprod Toxicol 71:17-25. 2004
    ..These data support the idea that extra and rudimentary SNR may reflect separate developmental phenomena, and should be considered and reported separately in developmental toxicity studies for risk assessment...
  13. ncbi request reprint Short-term exposures to dihaloacetic acids produce dysmorphogenesis in mouse conceptuses in vitro
    E Sidney Hunter
    Reproductive Toxicology Division, NHEERL, ORD, US EPA, RTP, NC 27711, USA
    Reprod Toxicol 22:443-8. 2006
    ..These studies demonstrate that for these dihaloacetic acids relatively high concentrations and long exposures are needed to alter rodent development in vitro...
  14. ncbi request reprint Bromochloro-haloacetic acids: effects on mouse embryos in vitro and QSAR considerations
    E Sidney Hunter
    Reproductive Toxicology Division, National Health and Environmental Effects Research Lab, US EPA, RTP, NC 27711, USA
    Reprod Toxicol 21:260-6. 2006
    ....
  15. ncbi request reprint Evaluation and interpretation of maternal toxicity in Segment II studies: issues, some answers, and data needs
    John M Rogers
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, MD 67, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Toxicol Appl Pharmacol 207:367-74. 2005
    ....
  16. ncbi request reprint Nicotine effects on the activity of mice exposed prenatally to the nicotinic agonist anatoxin-a
    R C MacPhail
    Neurotoxicology Division, U S Environmental Protection Agency, 109 TW Alexander Drive, MD B105 03, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 27:593-8. 2005
    ..Nicotine decreased both horizontal and vertical activity in all mice, regardless of prenatal anatoxin-a treatment. Thus, no enduring effects of prenatal anatoxin-a were obtained in adult mice following nicotine challenge...
  17. ncbi request reprint Lack of teratogenicity of microcystin-LR in the mouse and toad
    N Chernoff
    US EPA, ORD, National Health and Ecological Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    J Appl Toxicol 22:13-7. 2002
    ..These data indicate that microcystin does not appear to affect development adversely in the mouse (in vivo or in vitro) or the toad at the doses and exposure parameters used...
  18. doi request reprint Hypoxia and the Edema Syndrome: elucidation of a mechanism of teratogenesis
    Neil Chernoff
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Birth Defects Res B Dev Reprod Toxicol 89:300-3. 2010
    ..Vascular disruption is also associated with a number of birth defects in humans, including limb and digit reduction defects and urogenital defects...
  19. ncbi request reprint Periods of vertebral column sensitivity to boric acid treatment in CD-1 mice in utero
    Jana W Cherrington
    Department of Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    Reprod Toxicol 16:237-43. 2002
    ..The sensitivity of embryos to treatment on GD 8 to rib agenesis suggests that BA is affecting early processes such as gastrulation and presomitic mesoderm formation and patterning in this area...