William K Boyes

Summary

Affiliation: U.S. Environmental Protection Agency
Country: USA

Publications

  1. ncbi request reprint Integrating epidemiology and toxicology in neurotoxicity risk assessment
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Hum Exp Toxicol 26:283-93. 2007
  2. ncbi request reprint Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual function
    William K Boyes
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 76:121-30. 2003
  3. doi request reprint The neurotoxic potential of engineered nanomaterials
    William K Boyes
    US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 33:902-10. 2012
  4. ncbi request reprint Acute toluene exposure and rat visual function in proportion to momentary brain concentration
    William K Boyes
    Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 99:572-81. 2007
  5. ncbi request reprint Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Risk Anal 25:677-86. 2005
  6. doi request reprint Acute perchloroethylene exposure alters rat visual-evoked potentials in relation to brain concentrations
    William K Boyes
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 108:159-72. 2009
  7. ncbi request reprint Momentary brain concentration of trichloroethylene predicts the effects on rat visual function
    William K Boyes
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 87:187-96. 2005
  8. doi request reprint Essentiality, toxicity, and uncertainty in the risk assessment of manganese
    William K Boyes
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 73:159-65. 2010
  9. doi request reprint Acute inhalation of 2,2,4-trimethylpentane alters visual evoked potentials and signal detection behavior in rats
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 32:525-35. 2010
  10. ncbi request reprint Approaches to extrapolating animal toxicity data on organic solvents to public health
    Philip J Bushnell
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 28:221-6. 2007

Detail Information

Publications26

  1. ncbi request reprint Integrating epidemiology and toxicology in neurotoxicity risk assessment
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Hum Exp Toxicol 26:283-93. 2007
    ..An appropriate blend of scientific information from toxicology and epidemiology studies is necessary to evaluate potential human risks of exposure to neurotoxic substances...
  2. ncbi request reprint Dose-based duration adjustments for the effects of inhaled trichloroethylene on rat visual function
    William K Boyes
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 76:121-30. 2003
    ..However, an estimate of the brain TCE concentration at the time of VEP testing predicted the effects of TCE across exposure concentrations and durations...
  3. doi request reprint The neurotoxic potential of engineered nanomaterials
    William K Boyes
    US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 33:902-10. 2012
    ..Each of these topics is discussed fully in sections of the manuscript. The promising benefits of ENM technology can be best realized if the potential risks are first understood and then minimized in product and system designs...
  4. ncbi request reprint Acute toluene exposure and rat visual function in proportion to momentary brain concentration
    William K Boyes
    Neurotoxicology Division, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 99:572-81. 2007
    ..In general, however, the neurophysiological deficits caused by acute toluene exposure could be described by estimates of the momentary concentration of toluene in the brain at the time of VEP evaluation...
  5. ncbi request reprint Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Risk Anal 25:677-86. 2005
    ..89 mg/l for AEGL-1, 18.7 mg/l for AEGL-2, and 310 mg/l for AEGL-3. Duration adjustments based on equivalent target tissue doses should provide similar degrees of toxicity protection at different exposure durations...
  6. doi request reprint Acute perchloroethylene exposure alters rat visual-evoked potentials in relation to brain concentrations
    William K Boyes
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 108:159-72. 2009
    ....
  7. ncbi request reprint Momentary brain concentration of trichloroethylene predicts the effects on rat visual function
    William K Boyes
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 87:187-96. 2005
    ....
  8. doi request reprint Essentiality, toxicity, and uncertainty in the risk assessment of manganese
    William K Boyes
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 73:159-65. 2010
    ..The work accomplished in response to the test rule, in combination with other scientific evidence, will enable future manganese risk assessments to consider tissue dosimetry more comprehensively than was previously possible...
  9. doi request reprint Acute inhalation of 2,2,4-trimethylpentane alters visual evoked potentials and signal detection behavior in rats
    William K Boyes
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 32:525-35. 2010
    ....
  10. ncbi request reprint Approaches to extrapolating animal toxicity data on organic solvents to public health
    Philip J Bushnell
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicology 28:221-6. 2007
    ....
  11. ncbi request reprint Quantitative comparisons of the acute neurotoxicity of toluene in rats and humans
    Vernon A Benignus
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 100:146-55. 2007
    ....
  12. doi request reprint Neurobehavioral effects of acute exposure to four solvents: meta-analyses
    Vernon A Benignus
    Human Studies Division, Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 109:296-305. 2009
    ..No human data were found to test whether species differed under strong motivation. Dose-equivalence curves were derived for extrapolating to human effects from rat data...
  13. doi request reprint Transcriptional responses in rat brain associated with sub-chronic toluene inhalation are not predicted by effects of acute toluene inhalation
    Susan D Hester
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 34:530-3. 2012
    ..Based on the current data, long-term gene expression changes after toluene inhalation cannot be readily predicted by acute responses...
  14. ncbi request reprint Evaluating the NMDA-glutamate receptor as a site of action for toluene, in vivo
    Ambuja S Bale
    Neurotoxicology Division, MD B105 05, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 98:159-66. 2007
    ..These data support the hypothesis that acute actions of toluene on pattern-elicited VEPs involve NMDA receptors...
  15. doi request reprint Estimated rate of fatal automobile accidents attributable to acute solvent exposure at low inhaled concentrations
    Vernon A Benignus
    Integrated Systems Toxicology Division, Systems Biology Branch, Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Risk Anal 31:1935-48. 2011
    ..This approach could also be applied to other potentially adverse consequences of acute exposure to solvents (e.g., nonfatal car crashes, property damage, and workplace accidents), if appropriate data were available...
  16. pmc Human neurobehavioral effects of long-term exposure to styrene: a meta-analysis
    Vernon A Benignus
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 113:532-8. 2005
    ..The same exposure history was predicted to increase the color confusion index as much as 1.7 additional years of age in men...
  17. ncbi request reprint Toward cost-benefit analysis of acute behavioral effects of toluene in humans
    Vernon A Benignus
    U S Environmental Protection Agency, Office of Research and Development, National Health and Environmental Health Effects Laboratory, Human Studies Division, Research Triangle Park, NC 27711, USA
    Risk Anal 25:447-56. 2005
    ..The resulting function has the potential to estimate the monetary values of behavioral deficits caused by a range of exposures to toluene from existing monetized information on ethanol...
  18. doi request reprint Long-term perchloroethylene exposure: a meta-analysis of neurobehavioral deficits in occupationally and residentially exposed groups
    Vernon A Benignus
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    J Toxicol Environ Health A 72:824-31. 2009
    ....
  19. ncbi request reprint Role of NMDA, nicotinic, and GABA receptors in the steady-state visual-evoked potential in rats
    Ambuja S Bale
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Pharmacol Biochem Behav 82:635-45. 2005
    ..5 mg/kg, i.p.; n = 8-10 rats/dose) did not significantly alter either F1 or F2 amplitudes. Results indicate important roles for glutamate and nicotinic acetylcholine receptors in both F1 and F2, while GABA receptors contribute to F1...
  20. ncbi request reprint Moving from external exposure concentration to internal dose: duration extrapolation based on physiologically based pharmacokinetic derived estimates of internal dose
    Jane Ellen Simmons
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Toxicol Environ Health A 68:927-50. 2005
    ..For TCE, this PBPK modeling approach has allowed determination of dose metrics predictive of the acute neurotoxic effects of TCE and dose-duration adjustments based on estimates of internal dose...
  21. doi request reprint Development of multi-route physiologically-based pharmacokinetic models for ethanol in the adult, pregnant, and neonatal rat
    Sheppard A Martin
    Neurotoxicology Branch, Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency Research Triangle Park, NC 27711, USA
    Inhal Toxicol 24:698-722. 2012
    ....
  22. ncbi request reprint Epilepsy and medication effects on the pattern visual evoked potential
    Andrew M Geller
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Doc Ophthalmol 110:121-31. 2005
    ....
  23. doi request reprint Acute toluene exposure alters expression of genes in the central nervous system associated with synaptic structure and function
    Susan D Hester
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Neurotoxicol Teratol 33:521-9. 2011
    ..This report provides the first global genomic evidence that CNS pathways affected by toluene are strongly associated with neurological processes participating in synaptic transmission and plasticity...
  24. doi request reprint In vitro phototoxicity and hazard identification of nano-scale titanium dioxide
    Kristen Sanders
    Toxicity Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Appl Pharmacol 258:226-36. 2012
    ..LC(50) values under UVA were correlated with TBARS reactivity, particle size, and surface area...
  25. ncbi request reprint Behavioral test methods workshop
    William Slikker
    National Center for Toxicological Research FDA, Division of Neurotoxicology, 3900 NCTR Rd Jefferson 72079, United States
    Neurotoxicol Teratol 27:417-27. 2005
    ....
  26. ncbi request reprint Retinal degeneration and other eye disorders in wives of farmer pesticide applicators enrolled in the agricultural health study
    Ellen F Kirrane
    CODA, Inc, Durham, NC 27709, USA
    Am J Epidemiol 161:1020-9. 2005
    ..These findings suggest that exposure to some fungicides and other pesticides may increase the risk of retinal degeneration and warrant further investigation...