Barbara D Abbott
Affiliation: U.S. Environmental Protection Agency
Abbott B, Buckalew A. Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, Ang-1, and Tie-2. Dev Dyn. 2000;219:526-38 pubmed
..5. Published 2000 Wiley-Liss, Inc. ..
Abbott B. Review of the expression of peroxisome proliferator-activated receptors alpha (PPAR alpha), beta (PPAR beta), and gamma (PPAR gamma) in rodent and human development. Reprod Toxicol. 2009;27:246-57 pubmed publisher
..The features of the PPAR nuclear receptor family are introduced and what is known or inferred about their roles in development is discussed relative to insights from genetically modified mice and studies in the adult. ..
Abbott B, Buckalew A, DeVito M, Ross D, Bryant P, Schmid J. EGF and TGF-alpha expression influence the developmental toxicity of TCDD: dose response and AhR phenotype in EGF, TGF-alpha, and EGF + TGF-alpha knockout mice. Toxicol Sci. 2003;71:84-95 pubmed
..In conclusion, the EGFR pathway is mechanistically important in responses of the embryo to TCDD. Specific ligands confer sensitivity or resistance that are target tissue-dependent. ..
Das K, Wood C, Lin M, Starkov A, Lau C, Wallace K, et al
. Perfluoroalkyl acids-induced liver steatosis: Effects on genes controlling lipid homeostasis. Toxicology. 2017;378:37-52 pubmed publisher
Rosen M, Das K, Rooney J, Abbott B, Lau C, Corton J. PPAR?-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling. Toxicology. 2017;387:95-107 pubmed publisher
..These results indicate that, in addition to activating PPAR? as a primary target, PFAAs also have the potential to activate CAR, PPAR?, and ER? as well as suppress STAT5B. ..
Lee J, Ward W, Knapp G, Ren H, Vallanat B, Abbott B, et al
. Transcriptional ontogeny of the developing liver. BMC Genomics. 2012;13:33 pubmed publisher
..Overall, these findings reveal the complexity of gene expression changes during liver development and maturation, and provide a foundation to predict responses to chemical and drug exposure as a function of early life-stages. ..
Abbott B, Lin T, Rasmussen N, Albrecht R, Schmid J, Peterson R. Lack of expression of EGF and TGF-alpha in the fetal mouse alters formation of prostatic epithelial buds and influences the response to TCDD. Toxicol Sci. 2003;76:427-36 pubmed
..In conclusion, EGF and TGF-alpha expression are important for the formation of ADLBs and VBs, and expression of EGF and TGF-alpha affects the ability of TCDD to inhibit prostatic bud formation in a region-specific manner. ..
Abbott B, Wolf C, Schmid J, Das K, Zehr R, Helfant L, et al
. Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha. Toxicol Sci. 2007;98:571-81 pubmed
..PPARalpha was required for PFOA-induced postnatal lethality and expression of one copy of the gene was sufficient to mediate this effect...
Abbott B, Wood C, Watkins A, Tatum Gibbs K, Das K, Lau C. Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-1 mouse tissues. Reprod Toxicol. 2012;33:491-505 pubmed publisher
..The metabolic disruption produced by PFOA may contribute to poor postnatal survival and persistent weight deficits of CD-1 mouse neonates. ..