MARK ZYLKA

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain
    Julie K Hurt
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, CB 7545, Chapel Hill, NC 27599, USA
    Mol Pain 8:28. 2012
  2. ncbi Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, CB 7545, Chapel Hill, North Carolina 27599, USA
    Mol Pain 6:20. 2010
  3. ncbi PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine
    Sarah E Street
    Department of Cell and Molecular Physiology, University of North Carolina, CB 7545, Chapel Hill, North Carolina 27599, USA
    Mol Pain 7:80. 2011
  4. ncbi Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine
    Mark J Zylka
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, CB 7545, Chapel Hill, NC 27599, USA
    Neuron 60:111-22. 2008
  5. ncbi Pain-relieving prospects for adenosine receptors and ectonucleotidases
    Mark J Zylka
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Mol Med 17:188-96. 2011
  6. ncbi Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center and Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:2235-44. 2010
  7. ncbi Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS ONE 4:e4248. 2009
  8. ncbi Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:10282-93. 2010
  9. ncbi Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons
    Hong Wang
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 29:13202-9. 2009
  10. ncbi Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2
    Luke Campagnola
    Department of Cell and Molecular Physiology, 5109A NRB, CB 7545, 115 Mason Farm Road, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, United States
    J Neurosci Methods 169:27-33. 2008

Research Grants

  1. Harnessing ectonucleotidases to treat chronic pain
    MARK JOHN ZYLKA; Fiscal Year: 2010
  2. Biochemical Modulation of Nociceptive Circuits
    MARK ZYLKA; Fiscal Year: 2007
  3. Biochemical Modulation of Nociceptive Circuits
    MARK JOHN ZYLKA; Fiscal Year: 2010

Collaborators

  • Kunjumon I Vadakkan
  • Nathaniel A Sowa
  • Sarah E Street
  • Hong Wang
  • Julie K Hurt
  • Bonnie Taylor-Blake
  • Pirkko Vihko
  • Luke Campagnola
  • Thomas S Guillot
  • Paul L Walsh
  • R Mark Wightman
  • Meagen K Voss

Detail Information

Publications11

  1. ncbi PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain
    Julie K Hurt
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, The University of North Carolina at Chapel Hill, CB 7545, Chapel Hill, NC 27599, USA
    Mol Pain 8:28. 2012
    ....
  2. ncbi Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, CB 7545, Chapel Hill, North Carolina 27599, USA
    Mol Pain 6:20. 2010
    ..Since adenosine has antinociceptive effects in rodents and humans, we hypothesized that NT5E, an enzyme that generates adenosine, might also have antinociceptive effects in vivo...
  3. ncbi PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine
    Sarah E Street
    Department of Cell and Molecular Physiology, University of North Carolina, CB 7545, Chapel Hill, North Carolina 27599, USA
    Mol Pain 7:80. 2011
    ....
  4. ncbi Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine
    Mark J Zylka
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, CB 7545, Chapel Hill, NC 27599, USA
    Neuron 60:111-22. 2008
    ..Our studies reveal molecular and physiological functions for PAP in purine nucleotide metabolism and nociception and suggest a novel use for PAP in the treatment of chronic pain...
  5. ncbi Pain-relieving prospects for adenosine receptors and ectonucleotidases
    Mark J Zylka
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Trends Mol Med 17:188-96. 2011
    ..Collectively, these studies suggest the possibility of treating chronic pain in humans by targeting specific adenosine receptor subtypes in anatomically defined regions with agonists or with ectonucleotidases that generate adenosine...
  6. ncbi Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center and Curriculum in Neurobiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:2235-44. 2010
    ..Moreover, our data suggest NT5E is well localized to regulate nucleotide signaling between skin cells and sensory axons...
  7. ncbi Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina, USA
    PLoS ONE 4:e4248. 2009
    ..Lastly, our studies demonstrate that recombinant PAP protein can be used to treat chronic pain in animal models...
  8. ncbi Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate
    Nathaniel A Sowa
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, Chapel Hill, North Carolina 27599, USA
    J Neurosci 30:10282-93. 2010
    ..This tone regulates how effectively acute nociceptive insults promote the transition to chronic pain...
  9. ncbi Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons
    Hong Wang
    Department of Cell and Molecular Physiology, University of North Carolina Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 29:13202-9. 2009
    ..Our findings set broad constraints on the types of spinal neurons that process afferent input from Mrgprd(+) polymodal nociceptors...
  10. ncbi Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2
    Luke Campagnola
    Department of Cell and Molecular Physiology, 5109A NRB, CB 7545, 115 Mason Farm Road, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7545, United States
    J Neurosci Methods 169:27-33. 2008
    ..This scalable fiber-coupled LED system can be used to deliver light independent of the microscope objective and could, in principle, deliver light in parallel to multiple brain regions or to multiple genetically engineered animals...
  11. ncbi Nonpeptidergic circuits feel your pain
    Mark J Zylka
    Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Neuron 47:771-2. 2005
    ..They found that these neurons give rise to a specialized multisynaptic circuit that links pain signals in the periphery to limbic/affective regions of the brain...

Research Grants6

  1. Harnessing ectonucleotidases to treat chronic pain
    MARK JOHN ZYLKA; Fiscal Year: 2010
    ..In addition, these studies have the potential to transform how we treat pain in millions of patients with fewer side effects. ..
  2. Biochemical Modulation of Nociceptive Circuits
    MARK ZYLKA; Fiscal Year: 2007
    ..Finally, we will test the hypothesis that this phosphatase modulates neuropathic pain behaviors in wild-type and phosphatase knockout mice. ..
  3. Biochemical Modulation of Nociceptive Circuits
    MARK JOHN ZYLKA; Fiscal Year: 2010
    ..Finally, we will test the hypothesis that this phosphatase modulates neuropathic pain behaviors in wild-type and phosphatase knockout mice. ..