Bruce L Zuraw

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Clinical practice. Hereditary angioedema
    Bruce L Zuraw
    University of California at San Diego and the Veterans Affairs Medical Center, San Diego, USA
    N Engl J Med 359:1027-36. 2008
  2. ncbi request reprint US Hereditary Angioedema Association Medical Advisory Board 2013 recommendations for the management of hereditary angioedema due to C1 inhibitor deficiency
    Bruce L Zuraw
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif Medicine Service, San Diego Veterans Administration Healthcare, San Diego, Calif Electronic address
    J Allergy Clin Immunol Pract 1:458-67. 2013
  3. ncbi request reprint Rare disease partnership: the role of the US HAEA in angioedema care
    Bruce L Zuraw
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92014, USA Department of Medicine, San Diego VA Healthcare, 3350 La Jolla Village Dr, San Diego, CA 92161, USA Electronic address
    Immunol Allergy Clin North Am 33:545-53. 2013
  4. pmc The pathophysiology of hereditary angioedema
    Bruce L Zuraw
    From the Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, Cal
    World Allergy Organ J 3:S25-8. 2010
  5. doi request reprint Hereditary angioedema with normal C1 inhibitor function: consensus of an international expert panel
    Bruce L Zuraw
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0732, USA
    Allergy Asthma Proc 33:S145-56. 2012
  6. ncbi request reprint Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema
    Bruce L Zuraw
    University of California, San Diego, La Jolla, USA
    Am J Med 125:938.e1-7. 2012
  7. doi request reprint Pathophysiology of hereditary angioedema
    Bruce L Zuraw
    Department of Medicine, University of California, San Diego, and San Diego Veteran s Affairs Medical Center, La Jolla, California, USA
    Am J Rhinol Allergy 25:373-8. 2011
  8. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
  9. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
  10. ncbi request reprint Pathogenesis and laboratory diagnosis of hereditary angioedema
    Bruce L Zuraw
    Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, California, USA
    Allergy Asthma Proc 30:487-92. 2009

Collaborators

Detail Information

Publications41

  1. doi request reprint Clinical practice. Hereditary angioedema
    Bruce L Zuraw
    University of California at San Diego and the Veterans Affairs Medical Center, San Diego, USA
    N Engl J Med 359:1027-36. 2008
  2. ncbi request reprint US Hereditary Angioedema Association Medical Advisory Board 2013 recommendations for the management of hereditary angioedema due to C1 inhibitor deficiency
    Bruce L Zuraw
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, La Jolla, Calif Medicine Service, San Diego Veterans Administration Healthcare, San Diego, Calif Electronic address
    J Allergy Clin Immunol Pract 1:458-67. 2013
    ..Although several consensus papers have been published concerning the diagnosis and treatment of HAE, guidelines for a comprehensive management plan have not been developed...
  3. ncbi request reprint Rare disease partnership: the role of the US HAEA in angioedema care
    Bruce L Zuraw
    Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92014, USA Department of Medicine, San Diego VA Healthcare, 3350 La Jolla Village Dr, San Diego, CA 92161, USA Electronic address
    Immunol Allergy Clin North Am 33:545-53. 2013
    ..The dedication and unique structure of this patient advocacy organization has allowed it to make a substantial contribution to improving hereditary angioedema diagnosis and care. ..
  4. pmc The pathophysiology of hereditary angioedema
    Bruce L Zuraw
    From the Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, Cal
    World Allergy Organ J 3:S25-8. 2010
    ..HAE results from mutations in the SERPING1 gene that lead to a loss of functional C1 inhibitor. Attacks of angioedema result from generation of bradykinin, which acts on bradykinin B2 receptors to enhance vascular permeability...
  5. doi request reprint Hereditary angioedema with normal C1 inhibitor function: consensus of an international expert panel
    Bruce L Zuraw
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0732, USA
    Allergy Asthma Proc 33:S145-56. 2012
    ..In addition, potential therapeutic strategies are discussed. The consensus criteria developed during this symposium will allow physicians to better diagnose and treat patients with HAE with normal C1INH...
  6. ncbi request reprint Safety and efficacy of prophylactic nanofiltered C1-inhibitor in hereditary angioedema
    Bruce L Zuraw
    University of California, San Diego, La Jolla, USA
    Am J Med 125:938.e1-7. 2012
    ..Nanofiltered C1-inhibitor (C1INH-nf) is approved for prophylactic treatment of hereditary angioedema. This study assessed the efficacy and safety of C1INH-nf as prophylactic therapy in a large cohort of patients with hereditary angioedema...
  7. doi request reprint Pathophysiology of hereditary angioedema
    Bruce L Zuraw
    Department of Medicine, University of California, San Diego, and San Diego Veteran s Affairs Medical Center, La Jolla, California, USA
    Am J Rhinol Allergy 25:373-8. 2011
    ..This study describes the clinical characteristics and pathophysiology of bradykinin-mediated angioedema...
  8. pmc HAE international home therapy consensus document
    Hilary J Longhurst
    Department of Immunology, Barts and The London NHS Trust, London, UK
    Allergy Asthma Clin Immunol 6:22. 2010
    ..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE...
  9. pmc 2010 International consensus algorithm for the diagnosis, therapy and management of hereditary angioedema
    Tom Bowen
    Departments of Medicine and Paediatrics, University of Calgary, Calgary, Alberta, Canada
    Allergy Asthma Clin Immunol 6:24. 2010
    ....
  10. ncbi request reprint Pathogenesis and laboratory diagnosis of hereditary angioedema
    Bruce L Zuraw
    Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, California, USA
    Allergy Asthma Proc 30:487-92. 2009
    ..The knowledge gained concerning the underlying mechanisms of the different types of HAE allow the clinician to approach the laboratory diagnosis with confidence and provides opportunities for novel therapeutic strategies...
  11. pmc HAE therapies: past present and future
    Bruce L Zuraw
    Department of Medicine, University of California San Diego and San Diego Veteran s Affairs Medical Center, La Jolla, CA, USA
    Allergy Asthma Clin Immunol 6:23. 2010
    ..This review will recap the past treatment options, review the new current treatment options, and discuss potential future treatment options for patients with HAE...
  12. ncbi request reprint Ecallantide
    Bruce Zuraw
    Bruce Zuraw is at the Allergy and Immunology Section, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92037 0635, USA
    Nat Rev Drug Discov 9:189-90. 2010
    ..In December 2009, ecallantide (Kalbitor; Dyax) - a recombinant protein inhibitor of plasma kallikrein - was approved by the US FDA for the treatment of acute attacks of hereditary angioedema...
  13. doi request reprint Nanofiltered C1 inhibitor concentrate for treatment of hereditary angioedema
    Bruce L Zuraw
    University of California, San Diego, USA
    N Engl J Med 363:513-22. 2010
    ..Hereditary angioedema due to C1 inhibitor deficiency is characterized by recurrent acute attacks of swelling that can be painful and sometimes life-threatening...
  14. ncbi request reprint New promise and hope for treating hereditary angioedema
    Bruce L Zuraw
    Veterans Medical Research Foundation, University of California San Diego, La Jolla, CA 92093 0732, USA
    Expert Opin Investig Drugs 17:697-706. 2008
    ..While there is no approved effective therapy for the treatment of acute attacks of hereditary angioedema in the USA, four different drugs are completing or have recently completed Phase III clinical trials...
  15. ncbi request reprint Hereditary angiodema: a current state-of-the-art review, IV: short- and long-term treatment of hereditary angioedema: out with the old and in with the new?
    Bruce L Zuraw
    Veterans Affairs Medical Center, San Diego, California, USA
    Ann Allergy Asthma Immunol 100:S13-8. 2008
    ..To provide a context to understand the opportunity for novel therapeutic modalities to transform the treatment of hereditary angioedema (HAE)...
  16. ncbi request reprint Novel therapies for hereditary angioedema
    Bruce L Zuraw
    University of California San Diego, La Jolla, CA 92093 0732, USA
    Immunol Allergy Clin North Am 26:691-708. 2006
    ..This article reviews the rationale, development, and potential use of these novel therapeutics...
  17. pmc TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids
    Astrid M Doerner
    Veterans Medical Research Foundation, La Jolla, California, USA
    Respir Res 10:100. 2009
    ....
  18. ncbi request reprint Bradykinin increases the in vivo expression of the CXC chemokine receptors CXCR1 and CXCR2 in patients with allergic rhinitis
    Jane Eddleston
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif 92037, USA
    J Allergy Clin Immunol 111:106-12. 2003
    ..Increased levels of bradykinin and IL-8 have been detected within the airways of individuals with active symptoms of allergic rhinitis and asthma...
  19. ncbi request reprint Current and future therapy for hereditary angioedema
    Bruce L Zuraw
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    Clin Immunol 114:10-6. 2005
    ..This article will review both the current and the future therapeutic options for the treatment of HAE...
  20. ncbi request reprint Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediators
    Jane Eddleston
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:6445-51. 2002
    ..This may lead to enhanced activation of intracellular signaling pathways resulting in the release of mediators involved in inflammatory allergic airway disease...
  21. pmc Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection
    Jane Eddleston
    Veterans Medical Research Foundation, and Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0732, USA
    Am J Respir Cell Mol Biol 44:118-26. 2011
    ..A diminished, early epithelial-initiated antiviral response to rhinovirus infection could contribute to the increased susceptibility of subjects to prolonged respiratory viral infections after exposure to cigarette smoke...
  22. ncbi request reprint Update on therapeutic developments for hereditary angioedema
    Sandra C Christiansen
    Department of Allergy, Kaiser Permanente and Department of Medicine, University of California San Diego, La Jolla, California, USA
    Allergy Asthma Proc 30:500-5. 2009
    ..The arrival of these novel therapies promises to transform the future management of HAE...
  23. doi request reprint Hereditary angioedema: management of laryngeal attacks
    Sandra C Christiansen
    Department of Allergy, Kaiser Permanente and University of California, San Diego, California, USA
    Am J Rhinol Allergy 25:379-82. 2011
    ..Acute therapy had been relegated to supportive care, intubation, and consideration of fresh frozen plasma (FFP)--the latter with the potential for actually accelerating the speed and severity of the swelling...
  24. doi request reprint Experimental rhinovirus infection increases human tissue kallikrein activation in allergic subjects
    Sandra C Christiansen
    Southern California Kaiser Permanente Medical Group, San Diego, Calif, USA
    Int Arch Allergy Immunol 147:299-304. 2008
    ..In this report we investigate the effect of experimental rhinovirus infection on hTK activity in the airways of atopic subjects with and without asthma...
  25. ncbi request reprint Diagnosis and management of hereditary angioedema: an American approach
    Bruce L Zuraw
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA
    Transfus Apher Sci 29:239-45. 2003
    ..Areas in which the diagnostic or therapeutic tools are deficient are discussed, and the prospects for improved therapeutic modalities highlighted...
  26. ncbi request reprint The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells
    Jane Eddleston
    Veterans Medical Research Foundation, La Jolla, CA, USA
    J Allergy Clin Immunol 119:115-22. 2007
    ..A recently described anti-inflammatory protein, glucocorticoid-induced leucine zipper (GILZ), interferes with NF-kappaB-mediated gene transcription in T cells and macrophages...
  27. pmc Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM
    Sumanta Mukherjee
    Department of Medicine, University of Toledo Medical Center, Toledo, Ohio 43614, USA
    J Biol Chem 284:29391-8. 2009
    ..These findings suggest a novel function of LPS and the signaling pathways in the induction of IL-4 gene expression...
  28. ncbi request reprint Current update on cellular and molecular mechanisms of hereditary angioedema
    Hannah H Walford
    Department of Medicine, University of California San Diego, La Jolla, California
    Ann Allergy Asthma Immunol 112:413-8. 2014
    ..To provide an update on the molecular mechanisms of hereditary angioedema (HAE)...
  29. doi request reprint The association of obesity and asthma severity and control in children
    Kenneth B Quinto
    Department of Allergy and Immunology, University of California, San Diego, La Jolla, Calif 92111, USA
    J Allergy Clin Immunol 128:964-9. 2011
    ..The association between obesity and asthma severity and control in children is not well understood...
  30. ncbi request reprint IL-1 receptor-associated kinase and low molecular weight GTPase RhoA signal molecules are required for bacterial lipopolysaccharide-induced cytokine gene transcription
    Ling Yu Chen
    Department of Molecular and Experimental Medicine and Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:3934-9. 2002
    ..These results indicate that RhoA and IL-1R-associated kinase are novel signal transducers for LPS-induced Toll-like receptor 4-mediated proinflammatory cytokine synthesis in human monocytes...
  31. doi request reprint Recognizing and managing hereditary angioedema
    Kevin Tse
    Division of Rheumatology, Allergy, and Immunology, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Cleve Clin J Med 80:297-308. 2013
    ..Prompt recognition is critical so that treatment can be started to minimize morbidity and the risk of death. Drugs have recently become available to prevent and treat acute attacks...
  32. ncbi request reprint Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow
    Savita P Rao
    Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, CA 92121, USA
    J Immunol 179:7800-7. 2007
    ..These findings suggest that Gal-3 functions as a cell surface adhesion molecule to support eosinophil rolling and adhesion under conditions of flow...
  33. pmc Safety and efficacy of physician-supervised self-managed C1 inhibitor replacement therapy
    Louanne M Tourangeau
    University of California, San Diego, La Jolla, CA 92093 0732, USA
    Int Arch Allergy Immunol 157:417-24. 2012
    ..Home infusion of C1INH allows for the earliest possible intervention since patients can initiate therapy at the first sign of symptoms...
  34. ncbi request reprint Serving the underserved: school-based asthma intervention programs
    Sandra C Christiansen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    J Asthma 39:463-72. 2002
    ..Strategies are required that can specifically address the needs of underserved communities. We review the underlying rationale and progress of school-based programs designed to assist asthmatic children...
  35. ncbi request reprint Up-regulation of functional kinin B1 receptors in allergic airway inflammation
    Sandra C Christiansen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 169:2054-60. 2002
    ..Taken together, these results show that functional B1 receptors are induced in the airway during allergic inflammation and suggest that they participate in the regulation of gene expression...
  36. pmc The tumor necrosis factor family member LIGHT is a target for asthmatic airway remodeling
    Taylor A Doherty
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA
    Nat Med 17:596-603. 2011
    ....
  37. ncbi request reprint Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release
    Ichiro Kuwabara
    Divisions of Allergy and Cellular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Biol Chem 277:3487-97. 2002
    ..Some of them are potentially contributory to this lectin's proapoptotic function and these include redox-related genes monoamine oxidase B, ryanodine receptor 2, and glutathione S-transferase Mu 3...
  38. ncbi request reprint Involvement of protein tyrosine kinase in Toll-like receptor 4-mediated NF-kappa B activation in human peripheral blood monocytes
    Ling Yu Chen
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla 92037, California 92121, USA
    Am J Physiol Lung Cell Mol Physiol 284:L607-13. 2003
    ..These findings provide evidence that LPS-induced NF-kappaB activation and IL-8 gene expression use a signaling pathway requiring protein tyrosine kinase and that such regulation may occur through tyrosine phosphorylation of TLR4...
  39. ncbi request reprint A Rho exchange factor mediates fMet-Leu-Phe-induced NF-kappaB activation in human peripheral blood monocytes
    Ling Yu Chen
    Department of Microbiology and Immunology, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 279:7208-12. 2004
    ..These results indicate that guanine nucleotide exchange factor Lbc is a novel signal transducer for RhoA-mediated NF-kappaB activation in human peripheral blood monocytes stimulated with bacterial products...
  40. pmc Kinin receptor expression during Staphylococcus aureus infection
    Sara H Bengtson
    Department of Clinical Sciences, Section for Clinical and Experimental Infection Medicine, Lund University, Tornavagen 10, SE 221 84 Lund, Sweden
    Blood 108:2055-63. 2006
    ..The data of the present study implicate an important and previously unknown role for kinin receptor regulation in S aureus infections...

Research Grants10

  1. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2007
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  2. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2006
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  3. INITIATION AND PROPAGATION OF ASTHMATIC INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2004
    ..Efforts to elucidate and then modify key events leading to asthmatic inflammation may ultimately be exploited for prevention of asthmatic disease. ..
  4. GILZ Controls TLR-Induced NF-kB Activity In Acute Asthma
    Bruce Zuraw; Fiscal Year: 2005
    ..We anticipate that this proposal will provide novel and clinically relevant data regarding the mechanisms of acute asthma exacerbations. ..
  5. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2002
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  6. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2001
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  7. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 2000
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..
  8. RHINOVIRUS MEDIATED TRANSCRIPTION IN AIRWAY INFLAMMATION
    Bruce Zuraw; Fiscal Year: 1999
    ..These results will provide a necessary foundation for additional investigations into downstream inflammatory consequences of rhinovirus infection as well as potential targets for new intervention strategies. ..