Kimberly A Zuhlke
Affiliation: University of Michigan
- Identification of a novel NBN truncating mutation in a family with hereditary prostate cancerKimberly A Zuhlke
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
Fam Cancer 11:595-600. 2012..The S706X mutation truncates the protein in a highly conserved region of NBN near the MRE11 binding site, thus suggesting a role for rare NBN mutations in prostate cancer susceptibility...
- Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control studyJennifer L Beebe-Dimmer
Program of Population Studies and Disparities Research, Karmanos Cancer Institute, 4100 John R, Detroit, MI 48201, USA
Environ Health 11:43. 2012..Therefore, we examined the association between genes thought to play a role in the metabolism of arsenic and bladder cancer...
- Identification of a novel germline SPOP mutation in a family with hereditary prostate cancerKimberly A Zuhlke
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan
Prostate 74:983-90. 2014..SPOP (Speckle-type POZ protein) maps to the 17q21-22 candidate linkage region and is one of the most frequently mutated genes in sporadic prostate cancers...
- Chromosome 17q12 variants contribute to risk of early-onset prostate cancerAlbert M Levin
Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109 5618, USA
Cancer Res 68:6492-5. 2008..Thus, there likely exist one or more additional independent prostate cancer susceptibility loci in this region...
- Prevalence of the HOXB13 G84E prostate cancer risk allele in men treated with radical prostatectomyJennifer L Beebe-Dimmer
Department of Oncology, Wayne State University, Detroit, MI, USA Barbara Ann Karmanos Cancer Institute, Population Studies and Disparities Research Program, Detroit, MI, USA
BJU Int 113:830-5. 2014..To determine the prevalence and clinical correlates of the G84E mutation in the homeobox transcription factor, or HOXB13, gene using DNA samples from 9559 men with prostate cancer undergoing radical prostatectomy...
- HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular surveySteven C Smith
Departments of Pathology Internal Medicine Urology Michigan Center for Translational Pathology Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI Howard Hughes Medical Institute, Chevy Chase, MD
Am J Surg Pathol 38:615-26. 2014..These findings suggest that novel molecular pathways may drive disease in HOXB13 G84E carriers. ..
- Sequence variation in the mitochondrial gene cytochrome c oxidase subunit I and prostate cancer in African American menAnna M Ray
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
Prostate 69:956-60. 2009..Here we examine the association between COI mutations and PCa in African American men...
- Chromosome 8q24 markers: risk of early-onset and familial prostate cancerJennifer L Beebe-Dimmer
Karmanos Cancer Institute and Wayne State University, Detroit, MI, USA
Int J Cancer 122:2876-9. 2008..In addition, our results suggest that the increased risk associated with these SNPs is approximately doubled in individuals predisposed to develop early onset or clinically aggressive disease...
- Testing for the recurrent HOXB13 G84E germline mutation in men with clinical indications for prostate biopsyFlorian R Schroeck
Division of Health Services Research, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
J Urol 189:849-53. 2013..We estimated the prevalence of this mutation in a clinical population of men at risk for prostate cancer who were scheduled to undergo prostate biopsy...
- Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancerAlbert M Levin
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109 0618, USA
Prostate 67:1507-13. 2007..An initial study has also suggested that the risk of familial (but not sporadic) prostate cancer may be associated with germline variation in the AMACR gene...