Frank Zufall

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Role of cyclic GMP in olfactory transduction and adaptation
    F Zufall
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 855:199-204. 1998
  2. ncbi request reprint The cellular and molecular basis of odor adaptation
    F Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Chem Senses 25:473-81. 2000
  3. ncbi request reprint From odor and pheromone transduction to the organization of the sense of smell
    F Zufall
    Dept of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Trends Neurosci 24:191-3. 2001
  4. ncbi request reprint The TRPC2 ion channel and pheromone sensing in the accessory olfactory system
    F Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201 1509, USA
    Naunyn Schmiedebergs Arch Pharmacol 371:245-50. 2005
  5. ncbi request reprint Neurobiology of TRPC2: from gene to behavior
    Frank Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201 1509, USA
    Pflugers Arch 451:61-71. 2005
  6. ncbi request reprint Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing
    Kevin R Kelliher
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore MD 21201, USA
    Eur J Neurosci 23:3385-90. 2006
  7. ncbi request reprint Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:1961-70. 2006
  8. ncbi request reprint A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction
    Philippe Lucas
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neuron 40:551-61. 2003
  9. pmc An olfactory subsystem that detects carbon disulfide and mediates food-related social learning
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Biol 20:1438-44. 2010
  10. pmc Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation
    S D Munger
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 294:2172-5. 2001

Research Grants

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Role of cyclic GMP in olfactory transduction and adaptation
    F Zufall
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 855:199-204. 1998
    ....
  2. ncbi request reprint The cellular and molecular basis of odor adaptation
    F Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Chem Senses 25:473-81. 2000
    ..Identification of these molecular steps may help to elucidate how the olfactory system extracts temporal and intensity information and to which extent odor perception is influenced by the different mechanisms underlying adaptation...
  3. ncbi request reprint From odor and pheromone transduction to the organization of the sense of smell
    F Zufall
    Dept of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Trends Neurosci 24:191-3. 2001
    ..Such approaches should enable researchers to examine the role that each of these subsystems could play in chemosensory-dependent behaviors...
  4. ncbi request reprint The TRPC2 ion channel and pheromone sensing in the accessory olfactory system
    F Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201 1509, USA
    Naunyn Schmiedebergs Arch Pharmacol 371:245-50. 2005
    ..The TRPC2 gene has become an important marker for the evolution of VNO-dependent pheromone signaling in primates...
  5. ncbi request reprint Neurobiology of TRPC2: from gene to behavior
    Frank Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201 1509, USA
    Pflugers Arch 451:61-71. 2005
    ..The experimental strategy employed in the mouse VNO now serves as a powerful model for examining the native functions of other TRP genes...
  6. ncbi request reprint Pheromonal recognition memory induced by TRPC2-independent vomeronasal sensing
    Kevin R Kelliher
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore MD 21201, USA
    Eur J Neurosci 23:3385-90. 2006
    ..This indicates that a previously unrecognized TRPC2-independent signal transduction mechanism in the VNO underlies the sensing of cues required for the formation of this pheromonal recognition memory...
  7. ncbi request reprint Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands
    Marc Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 26:1961-70. 2006
    ..These results suggest a general role for MHC peptides in chemical communication even in those vertebrates that lack a functional VNO...
  8. ncbi request reprint A diacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction
    Philippe Lucas
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neuron 40:551-61. 2003
    ..Thus, a previously unanticipated mechanism involving direct channel opening by DAG underlies the transduction of sensory cues in the accessory olfactory system...
  9. pmc An olfactory subsystem that detects carbon disulfide and mediates food-related social learning
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Curr Biol 20:1438-44. 2010
    ..Our findings indicate that GC-D(+) OSNs detect chemosignals that facilitate food-related social interactions...
  10. pmc Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation
    S D Munger
    Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Science 294:2172-5. 2001
    ..Thus, the CNGA4 subunit accelerates the Ca2+-mediated negative feedback in olfactory signaling and allows rapid adaptation in this sensory system...
  11. ncbi request reprint MHC class I peptides as chemosensory signals in the vomeronasal organ
    Trese Leinders-Zufall
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 306:1033-7. 2004
    ..MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior...
  12. pmc Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice
    Kevin R Kelliher
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 100:4299-304. 2003
    ....
  13. doi request reprint Subsystem organization of the mammalian sense of smell
    Steven D Munger
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Annu Rev Physiol 71:115-40. 2009
    ..An integrative approach that includes gene targeting methods, optical and electrophysiological recording, and behavioral analysis has helped to elucidate the functional significance of this subsystem organization for the sense of smell...
  14. ncbi request reprint Impaired odor adaptation in olfactory receptor neurons after inhibition of Ca2+/calmodulin kinase II
    T Leinders-Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 19:RC19. 1999
    ..The results indicate that CaMKII controls the temporal response properties of ORNs during odor adaptation. We propose that CaMKII plays a prominent role in odor perception...
  15. pmc Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice
    Hyun J Kwon
    Department of Anatomy and Neurobiology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 4:e4260. 2009
    ..The electrophysiological and behavioral phenotypes of OMP knockout mice indicated that OMP influences olfactory signal transduction. However, the mechanism by which this occurs remained unknown...
  16. doi request reprint Functional analysis of the guanylyl cyclase type D signaling system in the olfactory epithelium
    Renee E Cockerham
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1170:173-6. 2009
    ..Together, these findings suggest that neurons expressing GC-D are part of a specialized olfactory subsystem that is responsive to semiochemicals...
  17. ncbi request reprint Pheromone detection by mammalian vomeronasal neurons
    Frank Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201 1509, USA
    Microsc Res Tech 58:251-60. 2002
    ..These advances offer the opportunity to decipher the logic of mammalian pheromonal communication...
  18. ncbi request reprint Visualizing odor detection in olfactory cilia by calcium imaging
    T Leinders-Zufall
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 855:205-7. 1998
    ..This novel approach enables us to monitor the initial steps leading to olfactory perception in a spatially and temporally resolved manner...
  19. ncbi request reprint Parallel processing of social signals by the mammalian main and accessory olfactory systems
    M Spehr
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD, 21201, USA
    Cell Mol Life Sci 63:1476-84. 2006
    ..Together with previous work, this model will lead to a better understanding of the general organization of chemical communication in mammals and give a new direction for future experiments...
  20. pmc The receptor guanylyl cyclase type D (GC-D) ligand uroguanylin promotes the acquisition of food preferences in mice
    Hiroyuki Arakawa
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Chem Senses 38:391-7. 2013
    ....
  21. ncbi request reprint Connexins and olfactory synchronicity: toward the olfactory code
    Frank Zufall
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, 20 Penn Street, Baltimore, Maryland 21201, USA
    Neuron 46:693-4. 2005
    ..In this issue of Neuron, Christie et al. use mice deficient for the gap junction protein connexin36 (Cx36) to demonstrate that Cx36-mediated electrical coupling underlies such synchrony...
  22. ncbi request reprint Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task
    Scott R Wersinger
    Section on Neural Gene Expression, National Institute of Mental Health, NIH, DHHS, Bethesda, MD 20892, USA
    Horm Behav 46:638-45. 2004
    ..We propose that the V1bR plays an important role in social motivation, perhaps by coupling the processing, integration, and/or interpretation of chemosensory cues with the appropriate behavioral response...
  23. ncbi request reprint Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes
    Karina Del Punta
    The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nature 419:70-4. 2002
    ..Electrophysiologically, the epithelium of the VNO of such mice does not respond detectably to specific pheromonal ligands. The behavioural impairment and chemosensory deficit support a role of V1r receptors as pheromone receptors...
  24. pmc Altered sexual and social behaviors in trp2 mutant mice
    Bradley G Leypold
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 99:6376-81. 2002
    ..These results suggest that the cation channel trp2 is required in the VNO to detect male-specific pheromones that elicit aggressive behaviors and dictate the choice of sexual partners...
  25. ncbi request reprint MHC peptides and the sensory evaluation of genotype
    Thomas Boehm
    Department of Developmental Immunology, Max Planck Institute of Immunobiology, D 79108 Freiburg, Germany
    Trends Neurosci 29:100-7. 2006
    ..These findings provide a molecular mechanism by which an individual can sense the composition and compatibility of vital immune system molecules of a conspecific, with direct consequences for social behavior...
  26. ncbi request reprint Pheromonal communication in vertebrates
    Peter A Brennan
    Department of Physiology, University of Bristol, Medical School Building, University Walk, Bristol BS8 1TD, UK
    Nature 444:308-15. 2006
    ..Future developments could show how the functions of the different chemosensory systems are integrated to regulate innate and learned behavioural and physiological responses to pheromones...
  27. ncbi request reprint Mammalian pheromone sensing
    Frank Zufall
    Department of Physiology, University of Saarland School of Medicine, Kirrberger Strasse, 66421 Homburg Saar, Germany
    Curr Opin Neurobiol 17:483-9. 2007
    ..Selective genetic targeting of these subsystems should help to unravel their biological role in pheromone-mediated behavioral responses...
  28. ncbi request reprint Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined V1r or V2r receptor: ionic mechanisms underlying persistent firing
    Kirill Ukhanov
    Whitney Laboratory for Marine Bioscience, Center for Smell and Taste, and the McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Neurophysiol 98:2357-69. 2007
    ..Collectively, these results suggest a novel mechanism for regulating and encoding neuronal activity in the accessory olfactory system...

Research Grants10

  1. MEMBRANE MECHANISMS OF OLFACTORY TRANSDUCTION
    Frank Zufall; Fiscal Year: 2006
    ..abstract_text> ..
  2. MEMBRANE MECHANISMS OF OLFACTORY TRANSDUCTION
    Frank Zufall; Fiscal Year: 2001
    ....
  3. Encoding Immune System Signals by the Mammalian Nose
    Frank Zufall; Fiscal Year: 2006
    ..A potential application of this reseach is in the development of olfactory sensors that can identify an individual based on genetically-determined odors. ..