BRIAN SCOTT ZUCKERBRAUN

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Heme oxygenase-1: a cellular Hercules
    Brian S Zuckerbraun
    Hepatology 37:742-4. 2003
  2. pmc Mitochondrial signaling: forwards, backwards, and in between
    Sean P Whelan
    Department of General Surgery, University of Pittsburgh and VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Oxid Med Cell Longev 2013:351613. 2013
  3. pmc Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver
    Evie H Carchman
    1F1200PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    FASEB J 27:4703-11. 2013
  4. pmc Isolated skeletal muscle metastasis following successful treatment of laryngeal cancer: case report
    John R Klune
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA
    Int Semin Surg Oncol 7:1. 2010
  5. pmc Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh, NW 607 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cardiovasc Res 89:542-52. 2011
  6. ncbi request reprint Carbon monoxide protects against the development of experimental necrotizing enterocolitis
    Brian S Zuckerbraun
    Dept of Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Physiol Gastrointest Liver Physiol 289:G607-13. 2005
  7. ncbi request reprint Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, NW653 MUH, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    FASEB J 21:1099-106. 2007
  8. ncbi request reprint Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation
    Brian S Zuckerbraun
    Department of Surgery, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Shock 23:527-32. 2005
  9. ncbi request reprint Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes
    Kevin P Mollen
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Shock 28:270-7. 2007
  10. ncbi request reprint Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver
    Judit K Sarady
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    FASEB J 18:854-6. 2004

Research Grants

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Heme oxygenase-1: a cellular Hercules
    Brian S Zuckerbraun
    Hepatology 37:742-4. 2003
  2. pmc Mitochondrial signaling: forwards, backwards, and in between
    Sean P Whelan
    Department of General Surgery, University of Pittsburgh and VA Pittsburgh Healthcare System, Pittsburgh, PA 15206, USA
    Oxid Med Cell Longev 2013:351613. 2013
    ..These avenues of mitochondrial signaling are discussed in this review. ..
  3. pmc Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver
    Evie H Carchman
    1F1200PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    FASEB J 27:4703-11. 2013
    ..These results suggest that hepatocyte survival and maintenance of function in sepsis is dependent on a mitochondrial homeostasis pathway marked by mitophagy and biogenesis...
  4. pmc Isolated skeletal muscle metastasis following successful treatment of laryngeal cancer: case report
    John R Klune
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, 15213, USA
    Int Semin Surg Oncol 7:1. 2010
    ..Here we discuss the incidence of distant metastases from laryngeal cancer and appropriate screening methods. Additionally, skeletal muscle metastases and treatment considerations are discussed...
  5. pmc Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh, NW 607 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Cardiovasc Res 89:542-52. 2011
    ....
  6. ncbi request reprint Carbon monoxide protects against the development of experimental necrotizing enterocolitis
    Brian S Zuckerbraun
    Dept of Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Physiol Gastrointest Liver Physiol 289:G607-13. 2005
    ..iNOS and NO production were decreased by CO both in vivo and in vitro. CO may prove to be a useful clinical adjunct in the treatment of NEC...
  7. ncbi request reprint Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, NW653 MUH, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    FASEB J 21:1099-106. 2007
    ....
  8. ncbi request reprint Carbon monoxide prevents multiple organ injury in a model of hemorrhagic shock and resuscitation
    Brian S Zuckerbraun
    Department of Surgery, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Shock 23:527-32. 2005
    ..The precise cellular mechanisms involved require further elucidation. CO may prove to be an adjunctive therapy that could be instituted rapidly and with ease as an out-of-hospital therapeutic modality for severe blood loss after trauma...
  9. ncbi request reprint Hypoxia activates c-Jun N-terminal kinase via Rac1-dependent reactive oxygen species production in hepatocytes
    Kevin P Mollen
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Shock 28:270-7. 2007
    ..Together, these data suggest that ROS generation during hypoxia in the liver directly leads to JNK activation in a Rac1-dependent process...
  10. ncbi request reprint Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver
    Judit K Sarady
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    FASEB J 18:854-6. 2004
    ....
  11. ncbi request reprint Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway
    Hoe Suk Kim
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Biochem Biophys Res Commun 344:1172-8. 2006
    ..These data indicate that CO interferes with apoptotic signaling at a proximal step...
  12. doi request reprint Carbon monoxide activates NF-kappaB via ROS generation and Akt pathways to protect against cell death of hepatocytes
    Hoe Suk Kim
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 295:G146-G152. 2008
    ..This pathway may prove to be important in maintenance of hepatic function in both physiological and pathophysiological conditions...
  13. ncbi request reprint Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    Leo E Otterbein
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
    Nat Med 9:183-90. 2003
    ..These findings demonstrate a protective role for CO in vascular injury and support its use as a therapeutic agent...
  14. doi request reprint Galantamine and carbon monoxide protect brain microvascular endothelial cells by heme oxygenase-1 induction
    Atsunori Nakao
    Department of Surgery, University of Pittsburgh Medical Center, E1551 BST, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Biochem Biophys Res Commun 367:674-9. 2008
    ..This pharmacological action of galantamine may, at least in part, account for the superior clinical efficacy of galantamine in vascular dementia and Alzheimer disease...
  15. ncbi request reprint Nitric oxide modulates vascular inflammation and intimal hyperplasia in insulin resistance and the metabolic syndrome
    Joel E Barbato
    Dept of Surgery, Univ of Pittsburgh, A1010 PUH, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Heart Circ Physiol 289:H228-36. 2005
    ..iNOS gene transfer is able to effectively inhibit this heightened injury response and reduce neointima formation in this proinflammatory environment...
  16. doi request reprint Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Circulation 121:98-109. 2010
    ..Considering the fact that nitric oxide exhibits vasoprotective properties, we examined the effects of nitrite on experimental pulmonary arterial hypertension...
  17. ncbi request reprint Vascular gene therapy: a reality of the 21st century
    Brian S Zuckerbraun
    Department of Surgery Laboratories, University of Pittsburgh School of Medicine, NW 607 Montefiore University Hospital, 3457 Fifth Ave, Pittsburgh, PA 15213, USA
    Arch Surg 137:854-61. 2002
    ..Gene therapy will serve an enhancing and adjuvant role to evolving surgical therapies...
  18. doi request reprint Heme oxygenase 1 protects against hepatic hypoxia and injury from hemorrhage via regulation of cellular respiration
    Raghuveer Vallabhaneni
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburg, PA, USA
    Shock 33:274-81. 2010
    ..In conclusion, HO-1 overexpression protects the liver against hemorrhage-induced injury. This may be secondary to the ability of HO-1 to protect against bioenergetic failure via regulation of cellular respiration...
  19. pmc HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1
    Andres I Rodriguez
    Department of Surgery, University of Pittsburgh School of Medicine, 3501 5 Ave, BST3 Room 6058, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 30:98-104. 2010
    ..Furthermore, CO decreased platelet-derived growth factor-stimulated, redox-sensitive signaling pathways...
  20. ncbi request reprint Protective functions of heme oxygenase-1 and carbon monoxide in the respiratory system
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Antioxid Redox Signal 9:2157-73. 2007
    ..This review summarizes recent findings on the functions of heme oxygenase-1 in the respiratory system, with an emphasis on possible roles in disease progression and therapies...
  21. ncbi request reprint RhoA influences the nuclear localization of extracellular signal-regulated kinases to modulate p21Waf/Cip1 expression
    Brian S Zuckerbraun
    University of Pittsburgh, Department of Surgery, Pittsburgh, PA, USA
    Circulation 108:876-81. 2003
    ..The purpose of this investigation was to examine whether RhoA regulates ERK downstream signaling and cellular proliferation through its effects on the cytoskeleton and the nuclear localization of ERK...
  22. ncbi request reprint Nitric oxide-induced inhibition of smooth muscle cell proliferation involves S-nitrosation and inactivation of RhoA
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Cell Physiol 292:C824-31. 2007
    ..Nitrosation of RhoA and other proteins likely contributes to cGMP-independent effects of NO...
  23. ncbi request reprint A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock
    Carol A McCloskey
    Department of Surgery, University of Pittsburgh Medical Center, Presbyterian University Hospital, Pennsylvania 15213, USA
    Shock 20:316-9. 2003
    ..Together, these data suggest that angiotensin II is an important stimulus for ERK 1/2 activation in the liver during HS...
  24. ncbi request reprint Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli
    Peter K M Kim
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 277:38855-62. 2002
    ..These data indicate that FADD protein expression can increase rapidly in hepatocytes exposed to broadly cytotoxic agents...
  25. ncbi request reprint Overexpression of mutated IkappaBalpha inhibits vascular smooth muscle cell proliferation and intimal hyperplasia formation
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    J Vasc Surg 38:812-9. 2003
    ....
  26. ncbi request reprint Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Surg Res 124:256-63. 2005
    ..The purpose of this work was to test the hypothesis that inhibition of geranylgeranyltransferase I (GG Tase I) reduces vascular injury by increasing vascular NO production while decreasing ROS generation...
  27. pmc Carbon monoxide protects against liver failure through nitric oxide-induced heme oxygenase 1
    Brian S Zuckerbraun
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 198:1707-16. 2003
    ....
  28. ncbi request reprint 'Til cell death do us part: nitric oxide and mechanisms of hepatotoxicity
    Peter K M Kim
    Department of Surgery, University of Pittsburgh Medical School, NW607 MUH, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Biol Chem 385:11-5. 2004
    ..Insights that we and others have gained from the liver under pathologic conditions of stress can be applied to the understanding of cellular death mechanisms in other organs and tissues...
  29. pmc Ketamine-induced hepatoprotection: the role of heme oxygenase-1
    James W Suliburk
    UT Houston Medical School, Dept of Surgery, 6431 Fannin, MSB Suite 4 264, Houston, TX 77030, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1360-9. 2009
    ..Although CO abolished the ability of LPS to diminish PPAR-gamma activity, it enhanced NF-kappaB activity. These data suggest that the hepatoprotective effects of ketamine are mediated primarily by HO-1 and its end product CO...
  30. pmc Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects
    Ruiping Song
    Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 163:231-42. 2003
    ..These data suggest that the anti-inflammatory and antiapoptotic properties of CO confer potent cytoprotection in a rat model of lung transplantation...
  31. ncbi request reprint Carbon monoxide: medicinal chemistry and biological effects
    David J Kaczorowski
    Department of Surgery, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, PA 15213, USA
    Curr Med Chem 14:2720-5. 2007
    ..Additionally, CO is produced endogenously in the breakdown of heme by heme oxygenase enzymes. Here we review the biological chemistry of CO and highlight some of the anti-inflammatory biological effects of the heme oxygenase/CO system...
  32. pmc Carbon monoxide inhalation protects rat intestinal grafts from ischemia/reperfusion injury
    Atsunori Nakao
    Thomas E Starzl Transplantation Institute, Departments of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 163:1587-98. 2003
    ..Perioperative CO inhalation at a low concentration resulted in protection against ischemia/reperfusion injury to intestinal grafts with prolonged cold preservation...
  33. ncbi request reprint IRF-1 expression induces apoptosis and inhibits tumor growth in mouse mammary cancer cells in vitro and in vivo
    Peter K M Kim
    Department of Surgery, University of Pittsburgh Medical Center, 497 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Oncogene 23:1125-35. 2004
    ..The mechanism of apoptosis may involve the transcriptional upregulation of bak, caspase-8, and caspase-7 expression. These data support the antitumor potential of IRF-1 and the use of agents that increase IRF-1 in breast cancer...
  34. ncbi request reprint Protective effect of carbon monoxide inhalation for cold-preserved small intestinal grafts
    Atsunori Nakao
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Surgery 134:285-92. 2003
    ..This study investigated cytoprotective efficacy of CO at a low concentration on cold ischemia/reperfusion (I/R) injury of transplanted intestine...
  35. pmc Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart
    David J Kaczorowski
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 87:1455-63. 2009
    ..High mobility group box 1 (HMGB1) is a putative endogenous activator of TLR4. Therefore, we also assessed the contribution of HMGB1 in cold I/R induced inflammation...
  36. ncbi request reprint Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion
    David J Kaczorowski
    Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Transplantation 84:1279-87. 2007
    ..We tested the hypothesis that TLR4 mediates the early inflammatory response in the setting of cold I/R in a murine cardiac transplant model...
  37. pmc Carbon monoxide reverses established pulmonary hypertension
    Brian S Zuckerbraun
    Department of Surgery Transplant Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 203:2109-19. 2006
    ..In conclusion, these data demonstrate that CO reverses established PAH dependent on NO generation supporting the use of CO clinically to treat pulmonary hypertension...

Research Grants1