I H Zucker


Affiliation: University of Nebraska Medical Center
Country: USA


  1. Wang H, Wang W, Cornish K, Rozanski G, Zucker I. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension. 2014;64:745-55 pubmed publisher
    ..These data suggest a potential new paradigm and therapeutic potential in the management of CHF. ..
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    Zucker I, Hackley J, Cornish K, Hiser B, Anderson N, Kieval R, et al. Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure. Hypertension. 2007;50:904-10 pubmed
    ..6 pg/mL in control dogs versus 10.1+/-14.0 pg/mL in dogs receiving activation therapy; P<0.02). We conclude that chronic activation of the carotid BR improves survival and suppresses neurohormonal activation in chronic heart failure. ..
  3. Zucker I, Schultz H, Patel K, Wang W, Gao L. Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure. Am J Physiol Heart Circ Physiol. 2009;297:H1557-66 pubmed publisher
    ..Finally, exercise training reduces both central oxidative stress and AT(1)R expression in animals with CHF. These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF. ..
  4. Zucker I, Patel K, Schultz H. Neurohumoral stimulation. Heart Fail Clin. 2012;8:87-99 pubmed publisher
    ..It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF. ..
  5. Haack K, Zucker I. Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure. Auton Neurosci. 2015;188:44-50 pubmed publisher
    ..These enzymes appear to be normalized following exercise training in CHF. Understanding the precise molecular mechanisms by which exercise training is sympatho-inhibitory will uncover new targets for therapy. ..
  6. Zucker I, Schultz H, Patel K, Wang H. Modulation of angiotensin II signaling following exercise training in heart failure. Am J Physiol Heart Circ Physiol. 2015;308:H781-91 pubmed publisher
  7. Becker B, Wang H, Tian C, Zucker I. BDNF contributes to angiotensin II-mediated reductions in peak voltage-gated K+ current in cultured CATH.a cells. Physiol Rep. 2015;3: pubmed publisher
    ..We therefore propose that BDNF may be a necessary component of the mechanism by which Ang II reduces IA in CATH.a cells. ..
  8. Schiller A, Pellegrino P, Zucker I. Renal nerves dynamically regulate renal blood flow in conscious, healthy rabbits. Am J Physiol Regul Integr Comp Physiol. 2016;310:R156-66 pubmed publisher
    ..Cumulatively, these data suggest that the renal nerves mediate LF renal sympathetic vasomotion, which buffers RBF from LF AP oscillations in conscious, healthy rabbits. ..
  9. Pügge C, Mediratta J, Marcus N, Schultz H, Schiller A, Zucker I. Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: role of the α1-adrenergic receptor. J Appl Physiol (1985). 2016;120:334-43 pubmed publisher
    ..Nonetheless, α1-adrenergic receptors play an important role in the beneficial effects of ExT in the kidney. ..

More Information


  1. de Morais S, Shanks J, Zucker I. Integrative Physiological Aspects of Brain RAS in Hypertension. Curr Hypertens Rep. 2018;20:10 pubmed publisher
  2. Wang H, Cahoon R, Cahoon E, Zheng H, Patel K, Zucker I. Glutamatergic receptor dysfunction in spinal cord contributes to the exaggerated exercise pressor reflex in heart failure. Am J Physiol Heart Circ Physiol. 2015;308:H447-55 pubmed publisher
    ..980 ± 65 nM in sham vs. CHF rats, n = 4, P < 0.01). These data indicate that the spinal glutamate system contributes to the exaggerated EPR in the CHF state. ..
  3. Schiller A, Pellegrino P, Zucker I. Eppur Si Muove: The dynamic nature of physiological control of renal blood flow by the renal sympathetic nerves. Auton Neurosci. 2017;204:17-24 pubmed publisher
    ..Clinically, renal sympathetic vasomotion may be important for solving the problems facing the field of therapeutic renal denervation. ..
  4. Pellegrino P, Schiller A, Haack K, Zucker I. Central Angiotensin-II Increases Blood Pressure and Sympathetic Outflow via Rho Kinase Activation in Conscious Rabbits. Hypertension. 2016;68:1271-1280 pubmed
  5. Gao L, Zimmerman M, Biswal S, Zucker I. Selective Nrf2 Gene Deletion in the Rostral Ventrolateral Medulla Evokes Hypertension and Sympathoexcitation in Mice. Hypertension. 2017;69:1198-1206 pubmed publisher
    ..These data suggest that Nrf2 gene deletion in the RVLM elevates blood pressure, increases sympathetic outflow, and impairs baroreflex function potentially by impaired antioxidant enzyme expression. ..
  6. Becker B, Wang H, Zucker I. Central TrkB blockade attenuates ICV angiotensin II-hypertension and sympathetic nerve activity in male Sprague-Dawley rats. Auton Neurosci. 2017;205:77-86 pubmed publisher