I H Zucker
Affiliation: University of Nebraska Medical Center
Wang H, Wang W, Cornish K, Rozanski G, Zucker I. Cardiac sympathetic afferent denervation attenuates cardiac remodeling and improves cardiovascular dysfunction in rats with heart failure. Hypertension. 2014;64:745-55 pubmed publisher
..These data suggest a potential new paradigm and therapeutic potential in the management of CHF. ..
Zucker I, Hackley J, Cornish K, Hiser B, Anderson N, Kieval R, et al
. Chronic baroreceptor activation enhances survival in dogs with pacing-induced heart failure. Hypertension. 2007;50:904-10 pubmed
..6 pg/mL in control dogs versus 10.1+/-14.0 pg/mL in dogs receiving activation therapy; P<0.02). We conclude that chronic activation of the carotid BR improves survival and suppresses neurohormonal activation in chronic heart failure. ..
Zucker I, Schultz H, Patel K, Wang W, Gao L. Regulation of central angiotensin type 1 receptors and sympathetic outflow in heart failure. Am J Physiol Heart Circ Physiol. 2009;297:H1557-66 pubmed publisher
..Finally, exercise training reduces both central oxidative stress and AT(1)R expression in animals with CHF. These data strongly suggest that multiple central and peripheral influences dynamically alter AT(1)R expression in CHF. ..
Zucker I, Patel K, Schultz H. Neurohumoral stimulation. Heart Fail Clin. 2012;8:87-99 pubmed publisher
..It also sheds light on some of the important central mechanisms that contribute to the increase in sympathetic nerve activity in CHF. ..
Haack K, Zucker I. Central mechanisms for exercise training-induced reduction in sympatho-excitation in chronic heart failure. Auton Neurosci. 2015;188:44-50 pubmed publisher
..These enzymes appear to be normalized following exercise training in CHF. Understanding the precise molecular mechanisms by which exercise training is sympatho-inhibitory will uncover new targets for therapy. ..
Zucker I, Schultz H, Patel K, Wang H. Modulation of angiotensin II signaling following exercise training in heart failure. Am J Physiol Heart Circ Physiol. 2015;308:H781-91 pubmed publisher
Becker B, Wang H, Tian C, Zucker I. BDNF contributes to angiotensin II-mediated reductions in peak voltage-gated K+ current in cultured CATH.a cells. Physiol Rep. 2015;3: pubmed publisher
..We therefore propose that BDNF may be a necessary component of the mechanism by which Ang II reduces IA in CATH.a cells. ..
Schiller A, Pellegrino P, Zucker I. Renal nerves dynamically regulate renal blood flow in conscious, healthy rabbits. Am J Physiol Regul Integr Comp Physiol. 2016;310:R156-66 pubmed publisher
..Cumulatively, these data suggest that the renal nerves mediate LF renal sympathetic vasomotion, which buffers RBF from LF AP oscillations in conscious, healthy rabbits. ..
PÃ¼gge C, Mediratta J, Marcus N, Schultz H, Schiller A, Zucker I. Exercise training normalizes renal blood flow responses to acute hypoxia in experimental heart failure: role of the Î±1-adrenergic receptor. J Appl Physiol (1985). 2016;120:334-43 pubmed publisher
..Nonetheless, Î±1-adrenergic receptors play an important role in the beneficial effects of ExT in the kidney. ..