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Genomes and GenesSpecies | Jon Kar ZubietaSummaryAffiliation: University of Michigan Country: USA Publications
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Publications
Altered central micro-opioid receptor binding after psychological traumaIsrael Liberzon
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0118, USA
Biol Psychiatry 61:1030-8. 2007..The mu-opioid neurotransmitter system, implicated in responses to stress and suppression of pain, is distributed in and is thought to regulate the function of brain regions that are implicated in affective processing...
Short-term hormone treatment modulates emotion response circuitry in postmenopausal womenTiffany Love
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
Fertil Steril 93:1929-37. 2010..To study the effects of combination hormone therapy (HT) on emotional processing in postmenopausal women with use of functional neuroimaging...- Two year follow-up of atypical depressionJ K Zubieta
Department of Psychiatry, The University of Michigan, Ann Arbor 48104 1678, USA
J Psychiatr Res 33:23-9. 1999..Conversely, social functioning and overall outcome appear more favorable in AD... - Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmissionJon Kar Zubieta
Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
Arch Gen Psychiatry 60:1145-53. 2003..The mu-opioid neurotransmitter system is distributed in, and thought to regulate the function of, brain regions centrally implicated in affective processing... - Regional cerebral blood flow responses to smoking in tobacco smokers after overnight abstinenceJon Kar Zubieta
Department of Psychiatry, Mental Health Research Institute, 205 Zina Pitcher Pl, University of Michigan, Ann Arbor, MI 48109 0720, USA
Am J Psychiatry 162:567-77. 2005..The purpose of the study was to determine the effects of cigarette smoking on brain regional function in a group of chronic smokers by using cerebral blood flow (CBF) measures and positron emission tomography (PET)... - COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressorJon Kar Zubieta
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
Science 299:1240-3. 2003..The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli... - Placebo effects mediated by endogenous opioid activity on mu-opioid receptorsJon Kar Zubieta
Department of Psychiatry, Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
J Neurosci 25:7754-62. 2005..These data demonstrate that cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of mu-opioid receptor signaling in the human brain... - Belief or Need? Accounting for individual variations in the neurochemistry of the placebo effectJon Kar Zubieta
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, USA
Brain Behav Immun 20:15-26. 2006..Further examination of individual variations in placebo responding will need to take into account the underlying process for which relief is required... - Regional mu opioid receptor regulation of sensory and affective dimensions of painJ K Zubieta
Department of Psychiatry and Mental Health Research Institute, Medical School, The University of Michigan, Ann Arbor, MI 48104 1687, USA
Science 293:311-5. 2001..These data demonstrate the central role of the mu-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience... - Cognitive function in euthymic bipolar I disorderJ K Zubieta
Department of Psychiatry, Mental Health Research Institute, Neuroscience Building, 1103 E Huron St, Ann Arbor, MI 48104 1687, USA
Psychiatry Res 102:9-20. 2001..Some of these deficits appear to be associated with a more severe course of illness and poorer social and occupational functioning... - Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [11C]NMPB and PETJ K Zubieta
Department of Psychiatry, The University of Michigan, Neuroscience Building, 1103 East Huron Street, Ann Arbor, MI 48104 1687, USA
Synapse 39:275-87. 2001..After normalization, no regional changes in muscarinic receptor concentrations were observed in AD... - High vesicular monoamine transporter binding in asymptomatic bipolar I disorder: sex differences and cognitive correlatesJ K Zubieta
Department of Psychiatry, University of Michigan, Ann Arbor, 48104 1687, USA
Am J Psychiatry 157:1619-28. 2000..In this study the authors examined the possibility that trait-related abnormalities in the concentration of monoaminergic synaptic terminals may be present in patients with asymptomatic bipolar disorder type I... - Medial frontal cortex involvement in PTSD symptoms: a SPECT studyJ K Zubieta
Department of Psychiatry, and Mental Health Research Institute, The University of Michigan, Ann Arbor, USA
J Psychiatr Res 33:259-64. 1999..These data support the involvement of the medial prefrontal cortex in the pathophysiology of PTSD, possibly mediating some of its symptoms... - Neurobiological mechanisms of placebo responsesJon Kar Zubieta
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Maryland, Baltimore, USA
Ann N Y Acad Sci 1156:198-210. 2009..These data confirm that specific neural circuits and neurotransmitter systems respond to the expectation of benefit during placebo administration, inducing measurable physiological changes... - Smoking modulation of mu-opioid and dopamine D2 receptor-mediated neurotransmission in humansDavid J Scott
Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
Neuropsychopharmacology 32:450-7. 2007.... - Regional cerebral blood flow and plasma nicotine after smoking tobacco cigarettesEdward F Domino
Department of Pharmacology, University of Michigan, Box 0632, Ann Arbor, MI 48109 0632, USA
Prog Neuropsychopharmacol Biol Psychiatry 28:319-27. 2004..Nicotine delivery by tobacco smoking is only one of the factors, which contribute to changes in rCBF... - Emotion processing, major depression, and functional genetic variation of neuropeptide YBrian J Mickey
Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 5720, USA
Arch Gen Psychiatry 68:158-66. 2011..Functional genetic variation of neuropeptide Y (NPY) was recently identified as a source of individual differences in emotion. Low NPY levels have been reported in major depressive disorder (MDD)... - Hormonal environment affects cognition independent of age during the menopause transitionAlison Berent-Spillson
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48104, USA
J Clin Endocrinol Metab 97:E1686-94. 2012..Cognitive decline is prevalent in aging populations, and cognitive complaints are common during menopause. However, the extent of hormonal influence is unclear, particularly when considered independent of the aging process... - Impact of combined estradiol and norethindrone therapy on visuospatial working memory assessed by functional magnetic resonance imagingYolanda R Smith
Department of Obstetrics and Gynecology, School of Public Health, University of Michigan Health Systems, Women s Hospital, Ann Arbor, Michigan 48109 0276, USA
J Clin Endocrinol Metab 91:4476-81. 2006..Hormones regulate neuronal function in brain regions critical to cognition; however, the cognitive effects of postmenopausal hormone therapy are controversial... 
Placebo and nocebo effects are defined by opposite opioid and dopaminergic responsesDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor 48109 0720, USA
Arch Gen Psychiatry 65:220-31. 2008..They are also an example of cognitive processes, particularly expectations, capable of influencing physiology...- Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent mannerTiffany M Love
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
Biol Psychiatry 72:198-206. 2012..As such, we examined how OXT variation is associated with stress-induced dopaminergic neurotransmission in a healthy human sample... - Postmenopausal hormone use impact on emotion processing circuitryTal Shafir
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States
Behav Brain Res 226:147-53. 2012..These fMRI effects were more prominent than those observed for behavioral measures and involved brain regions implicated in cognitive-emotional integration... - Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in children of alcoholicsMary M Heitzeg
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 68:287-95. 2010..However, it remains controversial whether these alterations reflect preexisting traits predisposing to problem alcohol use or are secondary to alcohol involvement... - Individual differences in reward responding explain placebo-induced expectations and effectsDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, MI 48109 0720, USA
Neuron 55:325-36. 2007..Individual variations in NAC response to reward expectation accounted for 28% of the variance in the formation of placebo analgesia... - Impact of chronic hypercortisolemia on affective processingScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, 2101 Commonwealth Blvd, Suite C, Ann Arbor, MI 48105, USA
Neuropharmacology 62:217-25. 2012..This article is part of a Special Issue entitled 'Anxiety and Depression'... - Early initiation of hormone therapy in menopausal women is associated with increased hippocampal and posterior cingulate cholinergic activityYolanda R Smith
Department of Obstetrics and Gynecology, University of Michigan Health Systems, 1500 East Medical Center Drive, Room L4224 Women s Hospital, Ann Arbor, Michigan 48109 0276, USA
J Clin Endocrinol Metab 96:E1761-70. 2011..The role of ovarian hormones in maintaining neuronal integrity and cognitive function is still debated. This study was undertaken to clarify the potential relationship between postmenopausal hormone use and the cholinergic system... - Face emotion perception and executive functioning deficits in depressionScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
J Clin Exp Neuropsychol 27:320-33. 2005..Measures of emotion perception and executive functioning may be of assistance in objectively measuring functional capability of the ventral and dorsal neural systems, respectively, as well as in the diagnosis of depression... - Time-course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challengeDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
Synapse 61:707-14. 2007..These may reflect varying levels of change in receptor affinity, receptor internalization, and recycling depending on the type of challenge employed... - Leptin regulates dopamine responses to sustained stress in humansPaul R Burghardt
Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, and Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892, and University of Maryland School of Dentistry, Baltimore, Maryland 21201
J Neurosci 32:15369-76. 2012..The capacity for leptin to influence stress-induced dopaminergic function is of importance for pathological states where dopamine is thought to play an integral role, such as mood, substance-use disorders, eating disorders, and obesity... - Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorderScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
Biol Psychiatry 62:1272-80. 2007..Inhibitory control is addressed specifically by using a task devoid of affectively-laden stimuli, to disentangle the effects of altered affect and altered inhibitory processes in MDD... - fMRI BOLD responses to negative stimuli in the prefrontal cortex are dependent on levels of recent negative life stress in major depressive disorderDavid T Hsu
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
Psychiatry Res 183:202-8. 2010..The severity of recent negative life stressors is an important modifier of neurobiological and cognitive function in MDD and may help explain heterogeneity in the disorder... - Insulin resistance influences central opioid activity in polycystic ovary syndromeAlison Berent-Spillson
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
Fertil Steril 95:2494-8. 2011.... - Tobacco smoking produces greater striatal dopamine release in G-allele carriers with mu opioid receptor A118G polymorphismEdward F Domino
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
Prog Neuropsychopharmacol Biol Psychiatry 38:236-40. 2012..To determine if carriers of the allelic expression of the G variant of the human mu opioid receptor (OPRM1) A118G polymorphism have greater increases in striatal dopamine (DA) release after tobacco smoking... - Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processingDavid T Hsu
Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 32:3253-60. 2012.... - Decreased central mu-opioid receptor availability in fibromyalgiaRichard E Harris
Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 27:10000-6. 2007..These findings indicate altered endogenous opioid analgesic activity in FM and suggest a possible reason for why exogenous opiates appear to have reduced efficacy in this population... - Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthoodBarbara J Weiland
Department of Psychiatry, The University of Michigan, Ann Arbor, 48109, USA
Alcohol Clin Exp Res 36:1355-64. 2012..Cortical-striatal connectivity has been proposed to underlie adaptive switches between cautious and risky behaviors... - Striatal dopamine release and genetic variation of the serotonin 2C receptor in humansBrian J Mickey
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 5720, USA
J Neurosci 32:9344-50. 2012..Mesoaccumbal stress sensitivity may mediate the effects of HTR2C variation on risk of neuropsychiatric disorders... - Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humansTiffany M Love
The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 0720, USA
Arch Gen Psychiatry 66:1124-34. 2009.... - The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinicScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, C480 Med Inn Building, 1500 East Medical Center, Ann Arbor, MI 48109, USA
Psychiatry Res 152:143-54. 2007..Developing valid and reliable measures of cognitive signs in mood disorders creates excellent opportunities for tracking cognitive status prior to initiation of treatment, and allows for reliable retest following treatment... - Modality-specific alterations in the perception of emotional stimuli in Bipolar Disorder compared to Healthy Controls and Major Depressive DisorderAaron C Vederman
The University of Michigan Medical Center, Department of Psychiatry, MI, USA
Cortex 48:1027-34. 2012..Demographic and clinical variables, in addition to medications were also investigated... - Dysregulation of regional endogenous opioid function in borderline personality disorderAlan R Prossin
Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109 2700, USA
Am J Psychiatry 167:925-33. 2010..The authors investigated the role of the endogenous opioid system and mu-opioid receptors in emotion regulation in borderline personality disorder... - Early menopausal hormone use influences brain regions used for visual working memoryAlison Berent-Spillson
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
Menopause 17:692-9. 2010..We examined the effects of early-initiation hormone use on visual working memory, hypothesizing that long-term hormone use is associated with greater brain activation during visual working memory... - Changes in craving for a cigarette and arterial nicotine plasma concentrations in abstinent smokersSally K Guthrie
College of Pharmacy, University of Michigan, Ann Arbor 48109 1065, USA
Prog Neuropsychopharmacol Biol Psychiatry 28:617-23. 2004..Both the psychology and pharmacology of nicotine/tobacco smoking are involved in craving reduction... - Nucleus accumbens response to incentive stimuli anticipation in children of alcoholics: relationships with precursive behavioral risk and lifetime alcohol useWai Ying Wendy Yau
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 32:2544-51. 2012..Moreover, the results suggest that a close association between motivational responses, alcohol consumption, and behavioral risk may underlie addiction vulnerability in COAs... - BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjectsJoshua A Bueller
Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, USA
Biol Psychiatry 59:812-5. 2006.... - A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go TestScott A Langenecker
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
J Clin Exp Neuropsychol 29:842-53. 2007..Learning effects were significantly less than those for the Trail Making Test. The present results provide solid initial support for the validity and reliability of the PGNG... - Association of plasma interleukin-18 levels with emotion regulation and μ-opioid neurotransmitter function in major depression and healthy volunteersAlan R Prossin
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 2700, USA
Biol Psychiatry 69:808-12. 2011..We examined the relationship between μ-opioid receptor (OR)-mediated neurotransmission and a proinflammatory cytokine (interleukin [IL]-18)... - Venous plasma nicotine correlates of hormonal effects of tobacco smokingYue Xue
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
Pharmacol Biochem Behav 95:209-15. 2010..Increases in maximal plasma beta-endorphin levels following tobacco smoking were barely statistically significant with insufficient data to obtain a correlation coefficient... - Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokersRiju Ray
Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Proc Natl Acad Sci U S A 108:9268-73. 2011..Future translational investigations can elucidate the role of MORs in nicotine addiction, which may lead to development of novel therapeutics... - Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs)Richard E Harris
Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA
Neuroimage 47:1077-85. 2009..These findings suggest that divergent MOR processes may mediate clinically relevant analgesic effects for acupuncture and sham acupuncture... - Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivoBrian J Mickey
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
J Neurosci 28:11354-9. 2008..These results demonstrate a sex-specific interaction between two key molecules of the human serotonergic system, and suggest a neurobiological basis for sexual dimorphism in serotonin-modulated phenotypes... - Dysregulation of endogenous opioid emotion regulation circuitry in major depression in womenSusan E Kennedy
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0720, USA
Arch Gen Psychiatry 63:1199-208. 2006..These data demonstrate that endogenous opioid neurotransmission on mu-opioid receptors, a system implicated in stress responses and emotional regulation, is altered in patients diagnosed with MDD... - Accumbens functional connectivity during reward mediates sensation-seeking and alcohol use in high-risk youthBarbara J Weiland
Department of Psychiatry, The University of Michigan, Ann Arbor, MI, United States Addiction Research Center, The University of Michigan, Ann Arbor, MI, USA
Drug Alcohol Depend 128:130-9. 2013.... - Denicotinized versus average nicotine tobacco cigarette smoking differentially releases striatal dopamineEdward F Domino
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
Nicotine Tob Res 15:11-21. 2013..This study examined venous plasma concentrations effects of nicotine in cigarette smoking after overnight abstinence to release striatal dopamine (DA)... - Sex differences in anterior cingulate cortex activation during impulse inhibition and behavioral correlatesJing Liu
University of Michigan, Ann Arbor, MI, USA
Psychiatry Res 201:54-62. 2012..We also found that the activation/deactivation in males and females correlates with personality ratings in a sex-specific manner... - Real-time functional MRI using pseudo-continuous arterial spin labelingLuis Hernandez-Garcia
Functional MRI Laboratory, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48105, USA
Magn Reson Med 65:1570-7. 2011..This method is demonstrated by two functional imaging experiments: a simultaneous finger-tapping and visual stimulation paradigm, and a bimanual finger-tapping task... - Pain imaging in the emerging era of molecular medicineChristian S Stohler
University of Maryland Dental School, Baltimore, MD, USA
Methods Mol Biol 617:517-37. 2010..Imaging has become an indispensable tool in pain research... - HPA axis activation in major depression and response to fluoxetine: a pilot studyElizabeth A Young
Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
Psychoneuroendocrinology 29:1198-204. 2004..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response... - Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parentsMary M Heitzeg
Department of Psychiatry, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
Alcohol Clin Exp Res 32:414-26. 2008.... - mu-opioid receptor-mediated antinociceptive responses differ in men and womenJon-Kar Zubieta
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109-0720, USA
J Neurosci 22:5100-7. 2002..These data demonstrate that at matched levels of pain intensity, men and women during their follicular phase differ in the magnitude and direction of response of the mu-opioid system in distinct brain nuclei... - mu-Opioid receptors and limbic responses to aversive emotional stimuliIsrael Liberzon
Department of Psychiatry, Veterans Administration Medical Center, University of Michigan, Ann Arbor, MI 48105, USA
Proc Natl Acad Sci U S A 99:7084-9. 2002..This is consistent with an inhibitory/anxiolytic role of the endogenous opioid system in limbic regions of the temporal lobe and basal forebrain... - Personality trait predictors of placebo analgesia and neurobiological correlatesMarta Peciña
1 Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA 2 Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
Neuropsychopharmacology 38:639-46. 2013.... - Neural correlates of visual motion predictionDaniel Cheong
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
PLoS ONE 7:e39854. 2012..Our results set the stage for the examination of the effects of deficiencies in these networks, such as those caused by aging and mental disorders, on visual motion prediction and its consequences on mobility related daily activities... - Gender-specific disruptions in emotion processing in younger adults with depressionSara L Wright
Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA
Depress Anxiety 26:182-9. 2009..This study sought to explore how gender and depression status relate to emotion processing... - The role of the endogenous opioid system in polycystic ovary syndromeAimee D Eyvazzadeh
Department of Obstetrics and Gynecology, School of Medicine and School of Public Health, University of Michigan, 1500 East Medical Center Drive, Women s Hospital, Ann Arbor, MI 48109 0276, USA
Fertil Steril 92:1-12. 2009.... - Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activityDavid J Scott
Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109-0720, USA
J Neurosci 26:10789-95. 2006.... - Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapyCarol C Persad
Department of Psychiatry, University of Michigan Health Systems, 2101 Commonwealth, Ann Arbor, MI 48105, USA
Fertil Steril 92:197-204. 2009..To study the effects of hormone therapy on brain activation patterns during verbal memory in postmenopausal women... - Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MSQiang Li
Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA
Anal Chem 81:2242-50. 2009..The improvements over previous approaches using capillary LC-MS(n) make in vivo neuropeptide monitoring more practical and feasible for a variety of neuropeptides... - Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in womenYolanda R Smith
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
J Neurosci 26:5777-85. 2006..These data demonstrate a significant role of estrogen in modulating endogenous opioid neurotransmission and associated psychophysical responses to a pain stressor in humans... - Interface of physical and emotional stress regulation through the endogenous opioid system and mu-opioid receptorsSaulo C Ribeiro
University of Michigan, Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, MBNI, 205 Zine Pitcher Place, 48109-0720, USA
Prog Neuropsychopharmacol Biol Psychiatry 29:1264-80. 2005..Possible future areas of study at the interface of "mind" (cognitive-emotional) and "body" (physical) functions are delineated in this context... - Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to actionDennis S Charney
Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104-6178, USA
Biol Psychiatry 56:703-13. 2004 - Neuroreceptor imaging of stress and mood disordersSusan E Kennedy
Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
CNS Spectr 9:292-301. 2004..As new radiotracers with higher selectivity for the various receptors and transporters are developed, imaging techniques may provide new insights into the pathophysiology of mood disorders, leading to improved diagnosis and treatment... - Genetic variation in human NPY expression affects stress response and emotionZhifeng Zhou
Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
Nature 452:997-1001. 2008..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases... - Neurobiological mechanisms of the placebo effectFabrizio Benedetti
Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
J Neurosci 25:10390-402. 2005 - Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indicesMark Greenwald
Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences Wayne State University, Detroit, Michigan 48207, USA
Biol Psychiatry 61:101-10. 2007..This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic outcomes in 10 heroin-dependent volunteers... - Placebo effects on human mu-opioid activity during painTor D Wager
Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027, USA
Proc Natl Acad Sci U S A 104:11056-61. 2007..Overall, the results suggest that endogenous opioid release in core affective brain regions is an integral part of the mechanism whereby expectancies regulate affective and nociceptive circuits... - Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteersMark K Greenwald
Department of Psychiatry and Behavioral Neurosciences and Addiction Research Institute, Wayne State University, Detroit, MI 48207, USA
Neuropsychopharmacology 28:2000-9. 2003.... - Human brain mechanisms of pain perception and regulation in health and diseaseA Vania Apkarian
Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
Eur J Pain 9:463-84. 2005..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions...
Research Grants
- Predicting Placebo Responses Across Disease StatesJon Kar Zubieta; Fiscal Year: 2010..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
- STRESS AND REPRODUCTIVE HORMONES IN DEPRESSIONJon Kar Zubieta; Fiscal Year: 2010..This project will evaluate whether women with depression show low estrogen levels and if the changes in estrogen are accompanied by changes in serotonin binding in the brains of women with major depression ..
- Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic LevelsJon Kar Zubieta; Fiscal Year: 2009..Neural responses will then be related to the individual pain report and severity of nicotine addiction. ..
- STRESS AND REPRODUCTIVE HORMONES IN DEPRESSIONJon Kar Zubieta; Fiscal Year: 2009..This project will evaluate whether women with depression show low estrogen levels and if the changes in estrogen are accompanied by changes in serotonin binding in the brains of women with major depression ..
- Neurochemistry of Opiate Abuse Risk in Chronic PainJon Kar Zubieta; Fiscal Year: 2010..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
- Neurochemistry of Opiate Abuse Risk in Chronic PainJon Kar Zubieta; Fiscal Year: 2007..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
- Neurochemical Endophenotype Responses to Pain-StressJon Kar Zubieta; Fiscal Year: 2007....
- Mu Opioid Mediated Stress Regulation in BPDJon Kar Zubieta; Fiscal Year: 2006..This information is critical for the understanding of the biological mechanisms underlying the symptomatology of BPD, and to guide future research and treatment interventions in this common but poorly understood illness. ..
- Neurochemical mediation of placebo responses in humansJon Kar Zubieta; Fiscal Year: 2006..abstract_text> ..
- Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic LevelsJon Kar Zubieta; Fiscal Year: 2010..Neural responses will then be related to the individual pain report and severity of nicotine addiction. ..