Jon Kar Zubieta

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Altered central micro-opioid receptor binding after psychological trauma
    Israel Liberzon
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0118, USA
    Biol Psychiatry 61:1030-8. 2007
  2. pmc Short-term hormone treatment modulates emotion response circuitry in postmenopausal women
    Tiffany Love
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Fertil Steril 93:1929-37. 2010
  3. pmc Reduced basal ganglia μ-opioid receptor availability in trigeminal neuropathic pain: a pilot study
    Marcos Fabio Dossantos
    Headache and Orofacial Pain Effort H O P E, Department of Biologic and Materials Sciences and MCOHR, School of Dentistry, University of Michigan, Michigan, Ann Arbor, MI 48109 5720, USA
    Mol Pain 8:74. 2012
  4. ncbi request reprint Two year follow-up of atypical depression
    J K Zubieta
    Department of Psychiatry, The University of Michigan, Ann Arbor 48104 1678, USA
    J Psychiatr Res 33:23-9. 1999
  5. pmc Neurobiological mechanisms of placebo responses
    Jon Kar Zubieta
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Maryland, Baltimore, USA
    Ann N Y Acad Sci 1156:198-210. 2009
  6. ncbi request reprint Placebo effects mediated by endogenous opioid activity on mu-opioid receptors
    Jon Kar Zubieta
    Department of Psychiatry, Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 25:7754-62. 2005
  7. ncbi request reprint Belief or Need? Accounting for individual variations in the neurochemistry of the placebo effect
    Jon Kar Zubieta
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, USA
    Brain Behav Immun 20:15-26. 2006
  8. ncbi request reprint Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 60:1145-53. 2003
  9. ncbi request reprint COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Science 299:1240-3. 2003
  10. ncbi request reprint Regional cerebral blood flow responses to smoking in tobacco smokers after overnight abstinence
    Jon Kar Zubieta
    Department of Psychiatry, Mental Health Research Institute, 205 Zina Pitcher Pl, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Am J Psychiatry 162:567-77. 2005

Research Grants

Detail Information

Publications85

  1. ncbi request reprint Altered central micro-opioid receptor binding after psychological trauma
    Israel Liberzon
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 0118, USA
    Biol Psychiatry 61:1030-8. 2007
    ..The mu-opioid neurotransmitter system, implicated in responses to stress and suppression of pain, is distributed in and is thought to regulate the function of brain regions that are implicated in affective processing...
  2. pmc Short-term hormone treatment modulates emotion response circuitry in postmenopausal women
    Tiffany Love
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Fertil Steril 93:1929-37. 2010
    ..To study the effects of combination hormone therapy (HT) on emotional processing in postmenopausal women with use of functional neuroimaging...
  3. pmc Reduced basal ganglia μ-opioid receptor availability in trigeminal neuropathic pain: a pilot study
    Marcos Fabio Dossantos
    Headache and Orofacial Pain Effort H O P E, Department of Biologic and Materials Sciences and MCOHR, School of Dentistry, University of Michigan, Michigan, Ann Arbor, MI 48109 5720, USA
    Mol Pain 8:74. 2012
    ..Understanding these processes is crucial to determine the systems involved in the development and persistence of TNP...
  4. ncbi request reprint Two year follow-up of atypical depression
    J K Zubieta
    Department of Psychiatry, The University of Michigan, Ann Arbor 48104 1678, USA
    J Psychiatr Res 33:23-9. 1999
    ..Conversely, social functioning and overall outcome appear more favorable in AD...
  5. pmc Neurobiological mechanisms of placebo responses
    Jon Kar Zubieta
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Maryland, Baltimore, USA
    Ann N Y Acad Sci 1156:198-210. 2009
    ..These data confirm that specific neural circuits and neurotransmitter systems respond to the expectation of benefit during placebo administration, inducing measurable physiological changes...
  6. ncbi request reprint Placebo effects mediated by endogenous opioid activity on mu-opioid receptors
    Jon Kar Zubieta
    Department of Psychiatry, Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 25:7754-62. 2005
    ..These data demonstrate that cognitive factors (e.g., expectation of pain relief) are capable of modulating physical and emotional states through the site-specific activation of mu-opioid receptor signaling in the human brain...
  7. ncbi request reprint Belief or Need? Accounting for individual variations in the neurochemistry of the placebo effect
    Jon Kar Zubieta
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, USA
    Brain Behav Immun 20:15-26. 2006
    ..Further examination of individual variations in placebo responding will need to take into account the underlying process for which relief is required...
  8. ncbi request reprint Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 60:1145-53. 2003
    ..The mu-opioid neurotransmitter system is distributed in, and thought to regulate the function of, brain regions centrally implicated in affective processing...
  9. ncbi request reprint COMT val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Science 299:1240-3. 2003
    ..The COMT val158met polymorphism thus influences the human experience of pain and may underlie interindividual differences in the adaptation and responses to pain and other stressful stimuli...
  10. ncbi request reprint Regional cerebral blood flow responses to smoking in tobacco smokers after overnight abstinence
    Jon Kar Zubieta
    Department of Psychiatry, Mental Health Research Institute, 205 Zina Pitcher Pl, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Am J Psychiatry 162:567-77. 2005
    ..The purpose of the study was to determine the effects of cigarette smoking on brain regional function in a group of chronic smokers by using cerebral blood flow (CBF) measures and positron emission tomography (PET)...
  11. ncbi request reprint Medial frontal cortex involvement in PTSD symptoms: a SPECT study
    J K Zubieta
    Department of Psychiatry, and Mental Health Research Institute, The University of Michigan, Ann Arbor, USA
    J Psychiatr Res 33:259-64. 1999
    ..These data support the involvement of the medial prefrontal cortex in the pathophysiology of PTSD, possibly mediating some of its symptoms...
  12. ncbi request reprint High vesicular monoamine transporter binding in asymptomatic bipolar I disorder: sex differences and cognitive correlates
    J K Zubieta
    Department of Psychiatry, University of Michigan, Ann Arbor, 48104 1687, USA
    Am J Psychiatry 157:1619-28. 2000
    ..In this study the authors examined the possibility that trait-related abnormalities in the concentration of monoaminergic synaptic terminals may be present in patients with asymptomatic bipolar disorder type I...
  13. ncbi request reprint Assessment of muscarinic receptor concentrations in aging and Alzheimer disease with [11C]NMPB and PET
    J K Zubieta
    Department of Psychiatry, The University of Michigan, Neuroscience Building, 1103 East Huron Street, Ann Arbor, MI 48104 1687, USA
    Synapse 39:275-87. 2001
    ..After normalization, no regional changes in muscarinic receptor concentrations were observed in AD...
  14. ncbi request reprint Cognitive function in euthymic bipolar I disorder
    J K Zubieta
    Department of Psychiatry, Mental Health Research Institute, Neuroscience Building, 1103 E Huron St, Ann Arbor, MI 48104 1687, USA
    Psychiatry Res 102:9-20. 2001
    ..Some of these deficits appear to be associated with a more severe course of illness and poorer social and occupational functioning...
  15. ncbi request reprint Regional mu opioid receptor regulation of sensory and affective dimensions of pain
    J K Zubieta
    Department of Psychiatry and Mental Health Research Institute, Medical School, The University of Michigan, Ann Arbor, MI 48104 1687, USA
    Science 293:311-5. 2001
    ..These data demonstrate the central role of the mu-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience...
  16. ncbi request reprint Smoking modulation of mu-opioid and dopamine D2 receptor-mediated neurotransmission in humans
    David J Scott
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 32:450-7. 2007
    ....
  17. ncbi request reprint Regional cerebral blood flow and plasma nicotine after smoking tobacco cigarettes
    Edward F Domino
    Department of Pharmacology, University of Michigan, Box 0632, Ann Arbor, MI 48109 0632, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:319-27. 2004
    ..Nicotine delivery by tobacco smoking is only one of the factors, which contribute to changes in rCBF...
  18. pmc Emotion processing, major depression, and functional genetic variation of neuropeptide Y
    Brian J Mickey
    Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 5720, USA
    Arch Gen Psychiatry 68:158-66. 2011
    ..Functional genetic variation of neuropeptide Y (NPY) was recently identified as a source of individual differences in emotion. Low NPY levels have been reported in major depressive disorder (MDD)...
  19. pmc DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience
    Marta Peciña
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
    Cortex 49:877-90. 2013
    ..As such, it contributes to normal variation and potentially to vulnerability to psychopathology associated with those functions, such as risk for mood and substance use disorders...
  20. pmc Accumbens functional connectivity during reward mediates sensation-seeking and alcohol use in high-risk youth
    Barbara J Weiland
    Department of Psychiatry, The University of Michigan, Ann Arbor, MI, United States Addiction Research Center, The University of Michigan, Ann Arbor, MI, USA
    Drug Alcohol Depend 128:130-9. 2013
    ....
  21. pmc Hormonal environment affects cognition independent of age during the menopause transition
    Alison Berent-Spillson
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48104, USA
    J Clin Endocrinol Metab 97:E1686-94. 2012
    ..Cognitive decline is prevalent in aging populations, and cognitive complaints are common during menopause. However, the extent of hormonal influence is unclear, particularly when considered independent of the aging process...
  22. pmc Valence-specific effects of BDNF Val66Met polymorphism on dopaminergic stress and reward processing in humans
    Marta Peciña
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109, Research Institute on Health Sciences Institut Universitari d Investigació en Ciencies de la Salut IUNICS, Palma de Mallorca 07122, Spain, College of Dental Medicine, Columbia University, New York, New York 10032, and National Institute of Alcohol Abuse and Alcoholism, Rockville, Maryland 20852
    J Neurosci 34:5874-81. 2014
    ..Our results are of relevance to the neurobiology of stress and reward interactions and the pathophysiology of stress-related disorders. ..
  23. doi request reprint Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses
    David J Scott
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Arch Gen Psychiatry 65:220-31. 2008
    ..They are also an example of cognitive processes, particularly expectations, capable of influencing physiology...
  24. ncbi request reprint mu-opioid receptor-mediated antinociceptive responses differ in men and women
    Jon Kar Zubieta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 22:5100-7. 2002
    ..These data demonstrate that at matched levels of pain intensity, men and women during their follicular phase differ in the magnitude and direction of response of the mu-opioid system in distinct brain nuclei...
  25. pmc Impact of combined estradiol and norethindrone therapy on visuospatial working memory assessed by functional magnetic resonance imaging
    Yolanda R Smith
    Department of Obstetrics and Gynecology, School of Public Health, University of Michigan Health Systems, Women s Hospital, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 91:4476-81. 2006
    ..Hormones regulate neuronal function in brain regions critical to cognition; however, the cognitive effects of postmenopausal hormone therapy are controversial...
  26. pmc Oxytocin gene polymorphisms influence human dopaminergic function in a sex-dependent manner
    Tiffany M Love
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Biol Psychiatry 72:198-206. 2012
    ..As such, we examined how OXT variation is associated with stress-induced dopaminergic neurotransmission in a healthy human sample...
  27. pmc Postmenopausal hormone use impact on emotion processing circuitry
    Tal Shafir
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, United States
    Behav Brain Res 226:147-53. 2012
    ..These fMRI effects were more prominent than those observed for behavioral measures and involved brain regions implicated in cognitive-emotional integration...
  28. pmc Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in children of alcoholics
    Mary M Heitzeg
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 68:287-95. 2010
    ..However, it remains controversial whether these alterations reflect preexisting traits predisposing to problem alcohol use or are secondary to alcohol involvement...
  29. pmc Indirect effect of corticotropin-releasing hormone receptor 1 gene variation on negative emotionality and alcohol use via right ventrolateral prefrontal cortex
    Yi G Glaser
    Department of Psychiatry, Addiction Research Center, and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109
    J Neurosci 34:4099-107. 2014
    ..This work provides support for a model in which CRHR1 gene variation modulates the risk of problem drinking via an internalizing/negative affect pathway involving rVLPFC and reappraisal of negative emotion. ..
  30. pmc Alterations in endogenous opioid functional measures in chronic back pain
    Ilkka K Martikainen
    Molecular and Behavioral Neuroscience Institute, and Departments of Psychiatry, Anesthesiology, Obstetrics and Gynecology, and Radiology, University of Michigan, Ann Arbor, Michigan 48109, Neuroscience Graduate Program, University of Michigan, Ann Arbor, Michigan 48104, Department of Health Management and Policy, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, and School of Dentistry, University of Maryland, Baltimore, Maryland 21201
    J Neurosci 33:14729-37. 2013
    ....
  31. ncbi request reprint Dysregulation of endogenous opioid emotion regulation circuitry in major depression in women
    Susan E Kennedy
    Department of Psychiatry, University of Michigan, Ann Arbor 48109 0720, USA
    Arch Gen Psychiatry 63:1199-208. 2006
    ..Endogenous opioid neurotransmission activating mu-opioid receptors is involved in stress and emotion regulatory processes and has been further implicated in MDD...
  32. ncbi request reprint Individual differences in reward responding explain placebo-induced expectations and effects
    David J Scott
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, MI 48109 0720, USA
    Neuron 55:325-36. 2007
    ..Individual variations in NAC response to reward expectation accounted for 28% of the variance in the formation of placebo analgesia...
  33. pmc Impact of chronic hypercortisolemia on affective processing
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, 2101 Commonwealth Blvd, Suite C, Ann Arbor, MI 48105, USA
    Neuropharmacology 62:217-25. 2012
    ..This article is part of a Special Issue entitled 'Anxiety and Depression'...
  34. pmc Early initiation of hormone therapy in menopausal women is associated with increased hippocampal and posterior cingulate cholinergic activity
    Yolanda R Smith
    Department of Obstetrics and Gynecology, University of Michigan Health Systems, 1500 East Medical Center Drive, Room L4224 Women s Hospital, Ann Arbor, Michigan 48109 0276, USA
    J Clin Endocrinol Metab 96:E1761-70. 2011
    ..The role of ovarian hormones in maintaining neuronal integrity and cognitive function is still debated. This study was undertaken to clarify the potential relationship between postmenopausal hormone use and the cholinergic system...
  35. ncbi request reprint Time-course of change in [11C]carfentanil and [11C]raclopride binding potential after a nonpharmacological challenge
    David J Scott
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Synapse 61:707-14. 2007
    ..These may reflect varying levels of change in receptor affinity, receptor internalization, and recycling depending on the type of challenge employed...
  36. ncbi request reprint Variations in the human pain stress experience mediated by ventral and dorsal basal ganglia dopamine activity
    David J Scott
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 26:10789-95. 2006
    ....
  37. ncbi request reprint Face emotion perception and executive functioning deficits in depression
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Exp Neuropsychol 27:320-33. 2005
    ..Measures of emotion perception and executive functioning may be of assistance in objectively measuring functional capability of the ventral and dorsal neural systems, respectively, as well as in the diagnosis of depression...
  38. pmc Denicotinized versus average nicotine tobacco cigarette smoking differentially releases striatal dopamine
    Edward F Domino
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
    Nicotine Tob Res 15:11-21. 2013
    ..This study examined venous plasma concentrations effects of nicotine in cigarette smoking after overnight abstinence to release striatal dopamine (DA)...
  39. doi request reprint Tobacco smoking produces greater striatal dopamine release in G-allele carriers with mu opioid receptor A118G polymorphism
    Edward F Domino
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
    Prog Neuropsychopharmacol Biol Psychiatry 38:236-40. 2012
    ..To determine if carriers of the allelic expression of the G variant of the human mu opioid receptor (OPRM1) A118G polymorphism have greater increases in striatal dopamine (DA) release after tobacco smoking...
  40. pmc Leptin regulates dopamine responses to sustained stress in humans
    Paul R Burghardt
    Molecular and Behavioral Neuroscience Institute, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:15369-76. 2012
    ..The capacity for leptin to influence stress-induced dopaminergic function is of importance for pathological states where dopamine is thought to play an integral role, such as mood, substance-use disorders, eating disorders, and obesity...
  41. pmc fMRI BOLD responses to negative stimuli in the prefrontal cortex are dependent on levels of recent negative life stress in major depressive disorder
    David T Hsu
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Psychiatry Res 183:202-8. 2010
    ..The severity of recent negative life stressors is an important modifier of neurobiological and cognitive function in MDD and may help explain heterogeneity in the disorder...
  42. pmc Insulin resistance influences central opioid activity in polycystic ovary syndrome
    Alison Berent-Spillson
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Fertil Steril 95:2494-8. 2011
    ....
  43. pmc Frontal and limbic activation during inhibitory control predicts treatment response in major depressive disorder
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Biol Psychiatry 62:1272-80. 2007
    ..Inhibitory control is addressed specifically by using a task devoid of affectively-laden stimuli, to disentangle the effects of altered affect and altered inhibitory processes in MDD...
  44. pmc Pronociceptive and antinociceptive effects of estradiol through endogenous opioid neurotransmission in women
    Yolanda R Smith
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 26:5777-85. 2006
    ..These data demonstrate a significant role of estrogen in modulating endogenous opioid neurotransmission and associated psychophysical responses to a pain stressor in humans...
  45. pmc Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study
    Courtney A Marsh
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan 48109 0276, USA
    Fertil Steril 100:200-7.e1. 2013
    ..To evaluate emotional processing in women with insulin-resistant polycystic ovary syndrome (IR-PCOS) and its relationship to glucose regulation and the mu-opioid system...
  46. pmc Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing
    David T Hsu
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:3253-60. 2012
    ....
  47. ncbi request reprint Decreased central mu-opioid receptor availability in fibromyalgia
    Richard E Harris
    Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 27:10000-6. 2007
    ..These findings indicate altered endogenous opioid analgesic activity in FM and suggest a possible reason for why exogenous opiates appear to have reduced efficacy in this population...
  48. pmc Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood
    Barbara J Weiland
    Department of Psychiatry, The University of Michigan, Ann Arbor, 48109, USA
    Alcohol Clin Exp Res 36:1355-64. 2012
    ..Cortical-striatal connectivity has been proposed to underlie adaptive switches between cautious and risky behaviors...
  49. pmc Striatal dopamine release and genetic variation of the serotonin 2C receptor in humans
    Brian J Mickey
    Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 5720, USA
    J Neurosci 32:9344-50. 2012
    ..Mesoaccumbal stress sensitivity may mediate the effects of HTR2C variation on risk of neuropsychiatric disorders...
  50. pmc Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans
    Tiffany M Love
    The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Pl, Ann Arbor, MI 48109 0720, USA
    Arch Gen Psychiatry 66:1124-34. 2009
    ....
  51. pmc Reduced emotion processing efficiency in healthy males relative to females
    Sara L Weisenbach
    Department of Psychiatry, University of Michigan Medical School, 2101 Commonwealth Boulevard, Suite C, Ann Arbor, MI, USA
    Soc Cogn Affect Neurosci 9:316-25. 2014
    ..With one exception in females, performance was not associated with activation. Results suggest that females and males process emotions using different neural pathways, and these differences cannot be explained by performance variations. ..
  52. pmc Personality trait predictors of placebo analgesia and neurobiological correlates
    Marta Peciña
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 38:639-46. 2013
    ....
  53. ncbi request reprint The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, C480 Med Inn Building, 1500 East Medical Center, Ann Arbor, MI 48109, USA
    Psychiatry Res 152:143-54. 2007
    ..Developing valid and reliable measures of cognitive signs in mood disorders creates excellent opportunities for tracking cognitive status prior to initiation of treatment, and allows for reliable retest following treatment...
  54. ncbi request reprint Interface of physical and emotional stress regulation through the endogenous opioid system and mu-opioid receptors
    Saulo C Ribeiro
    University of Michigan, Department of Psychiatry and Molecular and Behavioral Neuroscience Institute, MBNI, 205 Zine Pitcher Place, 48109 0720, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:1264-80. 2005
    ..Possible future areas of study at the interface of "mind" (cognitive-emotional) and "body" (physical) functions are delineated in this context...
  55. pmc Modality-specific alterations in the perception of emotional stimuli in Bipolar Disorder compared to Healthy Controls and Major Depressive Disorder
    Aaron C Vederman
    The University of Michigan Medical Center, Department of Psychiatry, MI, USA
    Cortex 48:1027-34. 2012
    ..Demographic and clinical variables, in addition to medications were also investigated...
  56. pmc Early menopausal hormone use influences brain regions used for visual working memory
    Alison Berent-Spillson
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI, USA
    Menopause 17:692-9. 2010
    ..We examined the effects of early-initiation hormone use on visual working memory, hypothesizing that long-term hormone use is associated with greater brain activation during visual working memory...
  57. doi request reprint Dysregulation of regional endogenous opioid function in borderline personality disorder
    Alan R Prossin
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan, 4250 Plymouth Rd, Ann Arbor, MI 48109 2700, USA
    Am J Psychiatry 167:925-33. 2010
    ..The authors investigated the role of the endogenous opioid system and mu-opioid receptors in emotion regulation in borderline personality disorder...
  58. ncbi request reprint Changes in craving for a cigarette and arterial nicotine plasma concentrations in abstinent smokers
    Sally K Guthrie
    College of Pharmacy, University of Michigan, Ann Arbor 48109 1065, USA
    Prog Neuropsychopharmacol Biol Psychiatry 28:617-23. 2004
    ..Both the psychology and pharmacology of nicotine/tobacco smoking are involved in craving reduction...
  59. pmc Nucleus accumbens response to incentive stimuli anticipation in children of alcoholics: relationships with precursive behavioral risk and lifetime alcohol use
    Wai Ying Wendy Yau
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 32:2544-51. 2012
    ..Moreover, the results suggest that a close association between motivational responses, alcohol consumption, and behavioral risk may underlie addiction vulnerability in COAs...
  60. ncbi request reprint A task to manipulate attentional load, set-shifting, and inhibitory control: convergent validity and test-retest reliability of the Parametric Go/No-Go Test
    Scott A Langenecker
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    J Clin Exp Neuropsychol 29:842-53. 2007
    ..Learning effects were significantly less than those for the Trail Making Test. The present results provide solid initial support for the validity and reliability of the PGNG...
  61. ncbi request reprint BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects
    Joshua A Bueller
    Mental Health Research Institute, The University of Michigan, Ann Arbor, Michigan, USA
    Biol Psychiatry 59:812-5. 2006
    ....
  62. pmc Human Mu Opioid Receptor (OPRM1 A118G) polymorphism is associated with brain mu-opioid receptor binding potential in smokers
    Riju Ray
    Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:9268-73. 2011
    ..Future translational investigations can elucidate the role of MORs in nicotine addiction, which may lead to development of novel therapeutics...
  63. pmc Venous plasma nicotine correlates of hormonal effects of tobacco smoking
    Yue Xue
    Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 5632, USA
    Pharmacol Biochem Behav 95:209-15. 2010
    ..Increases in maximal plasma beta-endorphin levels following tobacco smoking were barely statistically significant with insufficient data to obtain a correlation coefficient...
  64. doi request reprint Association of plasma interleukin-18 levels with emotion regulation and μ-opioid neurotransmitter function in major depression and healthy volunteers
    Alan R Prossin
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109 2700, USA
    Biol Psychiatry 69:808-12. 2011
    ..We examined the relationship between μ-opioid receptor (OR)-mediated neurotransmission and a proinflammatory cytokine (interleukin [IL]-18)...
  65. pmc Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors (MORs)
    Richard E Harris
    Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA
    Neuroimage 47:1077-85. 2009
    ..These findings suggest that divergent MOR processes may mediate clinically relevant analgesic effects for acupuncture and sham acupuncture...
  66. pmc Monoamine oxidase A genotype predicts human serotonin 1A receptor availability in vivo
    Brian J Mickey
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 28:11354-9. 2008
    ..These results demonstrate a sex-specific interaction between two key molecules of the human serotonergic system, and suggest a neurobiological basis for sexual dimorphism in serotonin-modulated phenotypes...
  67. ncbi request reprint Priority actions to improve the care of persons with co-occurring substance abuse and other mental disorders: a call to action
    CHARLES P O'BRIEN
    Department of Psychiatry, University of Pennsylvania School of Medicine, 3900 Chestnut Street, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 56:703-13. 2004
  68. pmc Sex differences in anterior cingulate cortex activation during impulse inhibition and behavioral correlates
    Jing Liu
    University of Michigan, Ann Arbor, MI, USA
    Psychiatry Res 201:54-62. 2012
    ..We also found that the activation/deactivation in males and females correlates with personality ratings in a sex-specific manner...
  69. pmc Real-time functional MRI using pseudo-continuous arterial spin labeling
    Luis Hernandez-Garcia
    Functional MRI Laboratory, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48105, USA
    Magn Reson Med 65:1570-7. 2011
    ..This method is demonstrated by two functional imaging experiments: a simultaneous finger-tapping and visual stimulation paradigm, and a bimanual finger-tapping task...
  70. ncbi request reprint HPA axis activation in major depression and response to fluoxetine: a pilot study
    Elizabeth A Young
    Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
    Psychoneuroendocrinology 29:1198-204. 2004
    ..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response...
  71. pmc Pain imaging in the emerging era of molecular medicine
    Christian S Stohler
    University of Maryland Dental School, Baltimore, MD, USA
    Methods Mol Biol 617:517-37. 2010
    ..Imaging has become an indispensable tool in pain research...
  72. pmc Affective circuitry and risk for alcoholism in late adolescence: differences in frontostriatal responses between vulnerable and resilient children of alcoholic parents
    Mary M Heitzeg
    Department of Psychiatry, The University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Alcohol Clin Exp Res 32:414-26. 2008
    ....
  73. pmc mu-Opioid receptors and limbic responses to aversive emotional stimuli
    Israel Liberzon
    Department of Psychiatry, Veterans Administration Medical Center, University of Michigan, Ann Arbor, MI 48105, USA
    Proc Natl Acad Sci U S A 99:7084-9. 2002
    ..This is consistent with an inhibitory/anxiolytic role of the endogenous opioid system in limbic regions of the temporal lobe and basal forebrain...
  74. pmc Neural correlates of visual motion prediction
    Daniel Cheong
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 7:e39854. 2012
    ..Our results set the stage for the examination of the effects of deficiencies in these networks, such as those caused by aging and mental disorders, on visual motion prediction and its consequences on mobility related daily activities...
  75. ncbi request reprint The role of the endogenous opioid system in polycystic ovary syndrome
    Aimee D Eyvazzadeh
    Department of Obstetrics and Gynecology, School of Medicine and School of Public Health, University of Michigan, 1500 East Medical Center Drive, Women s Hospital, Ann Arbor, MI 48109 0276, USA
    Fertil Steril 92:1-12. 2009
    ....
  76. pmc Gender-specific disruptions in emotion processing in younger adults with depression
    Sara L Wright
    Department of Psychiatry, University of Michigan Medical Center, Ann Arbor, Michigan 48105, USA
    Depress Anxiety 26:182-9. 2009
    ..This study sought to explore how gender and depression status relate to emotion processing...
  77. pmc Enhanced neuroactivation during verbal memory processing in postmenopausal women receiving short-term hormone therapy
    Carol C Persad
    Department of Psychiatry, University of Michigan Health Systems, 2101 Commonwealth, Ann Arbor, MI 48105, USA
    Fertil Steril 92:197-204. 2009
    ..To study the effects of hormone therapy on brain activation patterns during verbal memory in postmenopausal women...
  78. pmc Practical aspects of in vivo detection of neuropeptides by microdialysis coupled off-line to capillary LC with multistage MS
    Qiang Li
    Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA
    Anal Chem 81:2242-50. 2009
    ..The improvements over previous approaches using capillary LC-MS(n) make in vivo neuropeptide monitoring more practical and feasible for a variety of neuropeptides...
  79. ncbi request reprint Neuroreceptor imaging of stress and mood disorders
    Susan E Kennedy
    Neuroscience Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    CNS Spectr 9:292-301. 2004
    ..As new radiotracers with higher selectivity for the various receptors and transporters are developed, imaging techniques may provide new insights into the pathophysiology of mood disorders, leading to improved diagnosis and treatment...
  80. pmc Placebo effects on human mu-opioid activity during pain
    Tor D Wager
    Department of Psychology, Columbia University, 1190 Amsterdam Avenue, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 104:11056-61. 2007
    ..Overall, the results suggest that endogenous opioid release in core affective brain regions is an integral part of the mechanism whereby expectancies regulate affective and nociceptive circuits...
  81. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  82. ncbi request reprint Buprenorphine duration of action: mu-opioid receptor availability and pharmacokinetic and behavioral indices
    Mark Greenwald
    Substance Abuse Research Division, Department of Psychiatry and Behavioral Neurosciences Wayne State University, Detroit, Michigan 48207, USA
    Biol Psychiatry 61:101-10. 2007
    ..This study examined the duration of action of BUP at microORs and correlations with pharmacokinetic and pharmacodynamic outcomes in 10 heroin-dependent volunteers...
  83. ncbi request reprint Neurobiological mechanisms of the placebo effect
    Fabrizio Benedetti
    Department of Neuroscience, University of Turin Medical School, 10125 Turin, Italy
    J Neurosci 25:10390-402. 2005
  84. ncbi request reprint Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    ..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions...
  85. ncbi request reprint Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers
    Mark K Greenwald
    Department of Psychiatry and Behavioral Neurosciences and Addiction Research Institute, Wayne State University, Detroit, MI 48207, USA
    Neuropsychopharmacology 28:2000-9. 2003
    ....

Research Grants18

  1. Neurochemical mediation of placebo responses in humans
    Jon Kar Zubieta; Fiscal Year: 2003
    ..abstract_text> ..
  2. Predicting Placebo Responses Across Disease States
    Jon Kar Zubieta; Fiscal Year: 2010
    ..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
  3. STRESS AND REPRODUCTIVE HORMONES IN DEPRESSION
    Jon Kar Zubieta; Fiscal Year: 2010
    ..This project will evaluate whether women with depression show low estrogen levels and if the changes in estrogen are accompanied by changes in serotonin binding in the brains of women with major depression ..
  4. Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic Levels
    Jon Kar Zubieta; Fiscal Year: 2009
    ..Neural responses will then be related to the individual pain report and severity of nicotine addiction. ..
  5. Predicting Placebo Responses Across Disease States
    Jon Kar Zubieta; Fiscal Year: 2009
    ..The proposed studies benefit from unique features of the scientific environment, subject populations, or employ useful collaborative arrangements. There is evidence of institutional support. ..
  6. STRESS AND REPRODUCTIVE HORMONES IN DEPRESSION
    Jon Kar Zubieta; Fiscal Year: 2009
    ..This project will evaluate whether women with depression show low estrogen levels and if the changes in estrogen are accompanied by changes in serotonin binding in the brains of women with major depression ..
  7. Neurochemistry of Opiate Abuse Risk in Chronic Pain
    Jon Kar Zubieta; Fiscal Year: 2010
    ..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
  8. Neurochemistry of Opiate Abuse Risk in Chronic Pain
    Jon Kar Zubieta; Fiscal Year: 2007
    ..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
  9. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2007
    ....
  10. Neurochemistry of Opiate Abuse Risk in Chronic Pain
    Jon Kar Zubieta; Fiscal Year: 2006
    ..g., pain variability, distress in responses to variations in pain, impulsive choice and rewarding responses to acute opiate administration). ..
  11. Mu Opioid Mediated Stress Regulation in BPD
    Jon Kar Zubieta; Fiscal Year: 2006
    ..This information is critical for the understanding of the biological mechanisms underlying the symptomatology of BPD, and to guide future research and treatment interventions in this common but poorly understood illness. ..
  12. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2006
    ....
  13. Neurochemical mediation of placebo responses in humans
    Jon Kar Zubieta; Fiscal Year: 2006
    ..abstract_text> ..
  14. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2005
    ....
  15. Neurochemical mediation of placebo responses in humans
    Jon Kar Zubieta; Fiscal Year: 2005
    ..abstract_text> ..
  16. Neurochemical Endophenotype Responses to Pain-Stress
    Jon Kar Zubieta; Fiscal Year: 2004
    ....
  17. Neurochemical mediation of placebo responses in humans
    Jon Kar Zubieta; Fiscal Year: 2004
    ..abstract_text> ..
  18. Interaction of Smoking and Chronic Pain at Neurochemical and Phenotypic Levels
    Jon Kar Zubieta; Fiscal Year: 2010
    ..Neural responses will then be related to the individual pain report and severity of nicotine addiction. ..