GEORGE ZUBENKO

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Effects of previous major depressive illness on cognition in Alzheimer disease patients
    H Eleanor Cannon-Spoor
    Geriatric Psychiatry Branch, NIMH, Bethesda, MD 20892 1274, USA
    Am J Geriatr Psychiatry 13:312-8. 2005
  2. pmc No evidence of non-homologous insertions in mouse model of MDD created by replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 159:1-4. 2012
  3. ncbi request reprint Reduced age-related cataracts among elderly persons who reach age 90 with preserved cognition: a biomarker of successful aging?
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:500-6. 2007
  4. pmc Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress
    G S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 14:390-7. 2009
  5. ncbi request reprint Genome survey for loci that influence successful aging: results at 10-cM resolution
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA
    Am J Geriatr Psychiatry 15:184-93. 2007
  6. pmc Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments?
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 150:12-23. 2009
  7. pmc Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Genomics 93:376-82. 2009
  8. ncbi request reprint Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 129:47-54. 2004
  9. pmc D10S1423 identifies a susceptibility locus for Alzheimer's disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: results at 14 years
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 153:359-64. 2010
  10. ncbi request reprint Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 123:1-18. 2003

Detail Information

Publications25

  1. ncbi request reprint Effects of previous major depressive illness on cognition in Alzheimer disease patients
    H Eleanor Cannon-Spoor
    Geriatric Psychiatry Branch, NIMH, Bethesda, MD 20892 1274, USA
    Am J Geriatr Psychiatry 13:312-8. 2005
    ....
  2. pmc No evidence of non-homologous insertions in mouse model of MDD created by replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 159:1-4. 2012
    ..No evidence of insertions of targeting vector sequence was observed at regions other than the mouse Creb1 gene...
  3. ncbi request reprint Reduced age-related cataracts among elderly persons who reach age 90 with preserved cognition: a biomarker of successful aging?
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Gerontol A Biol Sci Med Sci 62:500-6. 2007
    ..Our findings suggest that the progressive development of lens opacities may be reflective of degenerative events occurring more generally throughout the body...
  4. pmc Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress
    G S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Psychiatry 14:390-7. 2009
    ..Furthermore, exaggeration of these effects during a simulated stress condition may be relevant to reported gene-environment interactions that contribute to the emergence of MDD in clinical populations...
  5. ncbi request reprint Genome survey for loci that influence successful aging: results at 10-cM resolution
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA
    Am J Geriatr Psychiatry 15:184-93. 2007
    ..A systematic genome survey was initiated to identify loci that affect the likelihood of reaching age 90 with preserved cognition (successful aging)...
  6. pmc Identification of a CREB-dependent serotonergic pathway and neuronal circuit regulating foraging behavior in Caenorhabditis elegans: a useful model for mental disorders and their treatments?
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 150:12-23. 2009
    ....
  7. pmc Predicted gene sequence C10orf112 is transcribed, exhibits tissue-specific expression, and may correspond to AD7
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Genomics 93:376-82. 2009
    ..Northern blots revealed 1.2 kb and 3.2 kb mRNA species that hybridize to a cDNA probe consisting of contiguous exons 23-26. Expression of these C10orf112 mRNA species was limited to a subset of brain regions and heart tissue...
  8. ncbi request reprint Genome-wide linkage survey for genetic loci that affect the risk of suicide attempts in families with recurrent, early-onset, major depression
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 129:47-54. 2004
    ....
  9. pmc D10S1423 identifies a susceptibility locus for Alzheimer's disease (AD7) in a prospective, longitudinal, double-blind study of asymptomatic individuals: results at 14 years
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 153:359-64. 2010
    ..06). Recent evidence that D10S1423 resides within open reading frame C10orf112, whose predicted product resembles a low-density lipoprotein receptor, suggests a molecular mechanism for this gene-gene interaction...
  10. ncbi request reprint Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 123:1-18. 2003
    ....
  11. ncbi request reprint Sequence variations in CREB1 cosegregate with depressive disorders in women
    G S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Mol Psychiatry 8:611-8. 2003
    ..These findings implicate the cAMP signaling pathway in the pathophysiology of Mood Disorders and related conditions...
  12. ncbi request reprint A collaborative study of the emergence and clinical features of the major depressive syndrome of Alzheimer's disease
    George S Zubenko
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Room E1230, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 160:857-66. 2003
    ....
  13. pmc Effects of the A(-115)G variant on CREB1 promoter activity in two brain cell lines: Interactions with gonadal steroids
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 153:1365-72. 2010
    ..2010 Wiley-Liss, Inc...
  14. pmc Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 156:517-31. 2011
    ..Human promoter variants that have highly penetrant effects on disease expression provide an attractive opportunity for creating etiology-based mouse models of human diseases, with minimal disruption of the mouse genome...
  15. ncbi request reprint Genetic linkage of region containing the CREB1 gene to depressive disorders in women from families with recurrent, early-onset, major depression
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Am J Med Genet 114:980-7. 2002
    ..The sex-specificity of the susceptibility locus identified by our study may result from reported synergistic interactions of CREB with nuclear estrogen receptors...
  16. ncbi request reprint Genome survey for loci that influence successful aging: sample characterization, method validation, and initial results for the Y chromosome
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Geriatr Psychiatry 10:619-30. 2002
    ..This communication describes the clinical characterization and comparison of the experimental groups, validation of the experimental method, and results for the Y chromosome...
  17. ncbi request reprint D2S2944 identifies a likely susceptibility locus for recurrent, early-onset, major depression in women
    G S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA, USA
    Mol Psychiatry 7:460-7. 2002
    ....
  18. ncbi request reprint Genome survey for susceptibility loci for recurrent, early-onset major depression: results at 10cM resolution
    George S Zubenko
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet 114:413-22. 2002
    ..Alternatively, our findings may reflect the existence of sex-specific differences in the molecular mechanisms that determine resilience to endogenous or environmental depressogenic stimuli...
  19. doi request reprint Effects of the G(-656)A variant on CREB1 promoter activity in a glial cell line: interactions with gonadal steroids and stress
    George S Zubenko
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet B Neuropsychiatr Genet 147:579-85. 2008
    ..The results of in silico analysis revealed four putative binding sites for transcription factors that are affected by the G to A transition at position -656, of which CP2 best fit the experimental observations...
  20. ncbi request reprint Genetic segregation analysis of recurrent, early-onset major depression: evidence for single major locus transmission
    Brion S Maher
    Division of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania, USA
    Am J Med Genet 114:214-21. 2002
    ..Our findings illustrate the advantage of employing families identified by probands with RE-MDD in studies designed to detect susceptibility loci for unipolar MDD and related disorders...
  21. ncbi request reprint Genetic segregation analysis of alcohol and other substance-use disorders in families with recurrent, early-onset major depression
    Brion S Maher
    Division of Oral Biology, University of Pittsburgh, School of Dental Medicine, Pittsburgh, Pennsylvania, USA
    Am J Drug Alcohol Abuse 28:711-31. 2002
    ..The goal of this study was to conduct a complex segregation analysis of alcohol and other substance-use disorders in families identified by probands with recurrent, early-onset major depression (RE-MDD)...
  22. ncbi request reprint Research agenda for DSM-V: diagnostic categories and criteria for neuropsychiatric syndromes in dementia
    Dilip V Jeste
    Division of Geriatric Psychiatry, Department of Psychiatry, University of California, San Diego, CA 92161, USA
    J Geriatr Psychiatry Neurol 19:160-71. 2006
    ..The high emotional and economic costs of neuropsychiatric symptoms in dementia implore diagnostic refinement to facilitate improved treatment...
  23. ncbi request reprint Genetics of recurrent early-onset major depression (GenRED): final genome scan report
    Peter Holmans
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 701A Welch Rd, Suite 3325, Palo Alto, CA 94304 5797, USA
    Am J Psychiatry 164:248-58. 2007
    ....
  24. pmc Genomewide significant linkage to recurrent, early-onset major depressive disorder on chromosome 15q
    Peter Holmans
    Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Cardiff, United Kingdom
    Am J Hum Genet 74:1154-67. 2004
    ..Chromosome 15q25.3-26.2 deserves further study as a candidate region for susceptibility to MDD...
  25. ncbi request reprint Genetics of recurrent early-onset depression (GenRED): design and preliminary clinical characteristics of a repository sample for genetic linkage studies
    Douglas F Levinson
    Department of Psychiatry and Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 3309, USA
    Am J Med Genet B Neuropsychiatr Genet 119:118-30. 2003
    ..This suggests comparability of our cases to those in earlier large family studies. This dataset should prove useful for genetic studies of a highly familial form of major depressive disorder...

Research Grants28

  1. MORPHOLOGIC/NEUROCHEMICAL CORRELATES OF DEPRESSION IN AD
    GEORGE ZUBENKO; Fiscal Year: 2009
    ..abstract_text> ..
  2. GENETICS OF RECURRENT EARLY-ONSET DEPRESSION (GENRED)
    GEORGE ZUBENKO; Fiscal Year: 2002
    ..A timetable is proposed for rapid sharing of all biological materials, blinded clinical data, genotypes and linkage analyses with the scientific community through the NIMH-sponsored Center for Genetic Studies. ..
  3. MORPHOLOGIC/NEUROCHEMICAL CORRELATES OF DEPRESSION IN AD
    GEORGE ZUBENKO; Fiscal Year: 2002
    ....
  4. BIOLOGICAL MARKER FOR PRIMARY DEMENTIA IN THE ELDERLY
    GEORGE ZUBENKO; Fiscal Year: 2003
    ....
  5. MORPHOLOGIC/NEUROCHEMICAL CORRELATES OF DEPRESSION IN AD
    GEORGE ZUBENKO; Fiscal Year: 2007
    ..abstract_text> ..
  6. BIOLOGICAL MARKER FOR PRIMARY DEMENTIA IN THE ELDERLY
    GEORGE ZUBENKO; Fiscal Year: 1993
    ....
  7. BIOLOGICAL MARKER FOR PRIMARY DEMENTIA IN THE ELDERLY
    GEORGE ZUBENKO; Fiscal Year: 1992
    ....
  8. MORPHOLOGIC/NEUROCHEMICAL CORRELATES OF DEPRESSION IN AD
    GEORGE ZUBENKO; Fiscal Year: 1993
    ..As an ancillary specific aim, we will also test the hypothesis that a family history of major depressive disorder among first-degree relatives is a risk factor for the emergence of major depression in probands with AD...