Weiping Zou

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 203:871-81. 2006
  2. ncbi request reprint Regulatory T cells, tumour immunity and immunotherapy
    Weiping Zou
    Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0346, USA
    Nat Rev Immunol 6:295-307. 2006
  3. ncbi request reprint Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 181:5842-6. 2008
  4. ncbi request reprint IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:4388-95. 2011
  5. ncbi request reprint Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 67:8900-5. 2007
  6. ncbi request reprint Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    Ke Wu
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 69:8067-75. 2009
  7. pmc Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis
    Ilona Kryczek
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 181:4733-41. 2008
  8. ncbi request reprint Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression
    Ilona Kryczek
    Department of Surgery, University of Mechigan, Ann Arbor, MI 48109, USA
    J Immunol 179:1423-6. 2007
  9. pmc Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
    Blood 114:1141-9. 2009
  10. ncbi request reprint Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinoma
    Shuang Wei
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 67:7487-94. 2007

Research Grants

  1. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2003
  2. Human Tregs in Ovarian Cancer
    Weiping Zou; Fiscal Year: 2010
  3. Novel immunosupressive macrophages in human ovarian tumor
    Weiping Zou; Fiscal Year: 2010
  4. Regulatory T Cells and Tumor Bone Marrow Metastasis
    Weiping Zou; Fiscal Year: 2009
  5. Novel immunosupressive macrophages in human ovarian tumor
    Weiping Zou; Fiscal Year: 2007
  6. Human Tregs in Ovarian Cancer
    Weiping Zou; Fiscal Year: 2007
  7. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2006
  8. Tumor environmental CD4+CD25+ T cells
    Weiping Zou; Fiscal Year: 2006
  9. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2005
  10. Human Tregs in Ovarian Cancer
    Weiping Zou; Fiscal Year: 2006

Detail Information

Publications47

  1. pmc B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Exp Med 203:871-81. 2006
    ..Blocking B7-H4 or depleting B7-H4+ tumor macrophages may represent novel strategies to enhance T cell tumor immunity in cancer...
  2. ncbi request reprint Regulatory T cells, tumour immunity and immunotherapy
    Weiping Zou
    Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0346, USA
    Nat Rev Immunol 6:295-307. 2006
    ..Strategies for therapeutic targeting of regulatory T cells and the effect of regulatory T cells on current immunotherapeutic and vaccine regimens are discussed...
  3. ncbi request reprint Cutting edge: IFN-gamma enables APC to promote memory Th17 and abate Th1 cell development
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 181:5842-6. 2008
    ..Our study challenges the dogma that IFN-gamma suppresses Th17 and enhances Th1 development...
  4. ncbi request reprint IL-17+ regulatory T cells in the microenvironments of chronic inflammation and cancer
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 186:4388-95. 2011
    ..Our data therefore challenge commonly held beliefs of the anti-inflammatory role of Treg cells and suggest a more complex Treg cell biology, at least in the context of human chronic inflammation and associated carcinoma...
  5. ncbi request reprint Relationship between B7-H4, regulatory T cells, and patient outcome in human ovarian carcinoma
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Cancer Res 67:8900-5. 2007
    ..Altogether, our data support the concept that there is a mechanistic interaction between Treg cells and macrophage, and that Treg cells may convey the suppressive activity to APCs through B7-H4 induction in human ovarian cancer...
  6. ncbi request reprint Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions
    Ke Wu
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 69:8067-75. 2009
    ..Our data indicate that the B7-H1/PD-1 axis contributes to immune suppression in human HCC, with blockade of this pathway carrying important therapeutic implications...
  7. pmc Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis
    Ilona Kryczek
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48105, USA
    J Immunol 181:4733-41. 2008
    ....
  8. ncbi request reprint Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression
    Ilona Kryczek
    Department of Surgery, University of Mechigan, Ann Arbor, MI 48109, USA
    J Immunol 179:1423-6. 2007
    ..Thus, the IL-17(+) T cell pool may be controlled by the local cytokine profile in the microenvironment...
  9. pmc Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
    Blood 114:1141-9. 2009
    ..This study thus provides scientific and clinical rationale for developing novel immune-boosting strategies based on promoting the Th17 cell population in cancer patients...
  10. ncbi request reprint Interleukin-2 administration alters the CD4+FOXP3+ T-cell pool and tumor trafficking in patients with ovarian carcinoma
    Shuang Wei
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 67:7487-94. 2007
    ..These data provide an important insight in evaluating the clinical benefit and therapeutic prediction of IL-2 treatment in patients with cancer...
  11. pmc Bone marrow and the control of immunity
    Ende Zhao
    Department of Surgery, University of Michigan School of Medicine, 1150 W Medical Center Dr, Ann Arbor, MI 48109 0669, USA
    Cell Mol Immunol 9:11-9. 2012
    ..We suggest that bone marrow is an immune regulatory organ capable of fine tuning immunity and may be a potential therapeutic target for immunotherapy and immune vaccination...
  12. pmc Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease
    Cailin M Wilke
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    J Transl Med 9:217. 2011
    ..Th17 cells play a role in inflammation. Interleukin (IL)-10 is a potent anti-inflammatory cytokine. However, it is poorly understood whether and how endogenous IL-10 impacts the development of Th17 cells in human pathologies...
  13. pmc Myeloid-derived suppressor cells enhance stemness of cancer cells by inducing microRNA101 and suppressing the corepressor CtBP2
    Tracy X Cui
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Immunity 39:611-21. 2013
    ..Collectively, our work identifies an immune-associated cellular, molecular, and clinical network involving MDSCs-microRNA101-CtBP2-stem cell core genes, which extrinsically controls cancer stemness and impacts patient outcome. ..
  14. pmc IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L
    Ilona Kryczek
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Immunity 40:772-84. 2014
    ..Thus, IL-22(+) cells promote colon cancer stemness via regulation of stemness genes that negatively affects patient outcome. Efforts to target this network might be a strategy in treating colorectal cancer patients...
  15. pmc Endogenous IL-17 contributes to reduced tumor growth and metastasis
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI, USA
    Blood 114:357-9. 2009
    ....
  16. pmc A crucial role for host APCs in the induction of donor CD4+CD25+ regulatory T cell-mediated suppression of experimental graft-versus-host disease
    Isao Tawara
    Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109, USA
    J Immunol 185:3866-72. 2010
    ..This requirement was independent of their effect on the maintenance of Treg numbers and the production of IL-10 or IDO by the host APCs...
  17. pmc Tumor-induced immune suppression of in vivo effector T-cell priming is mediated by the B7-H1/PD-1 axis and transforming growth factor beta
    Shuang Wei
    University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, USA
    Cancer Res 68:5432-8. 2008
    ..These results show a major role for the B7-H1/PD-1 axis and TGF-beta as synergistic suppressive mechanisms in cTDLN. Our data have clinical relevance in the generation of effector T cells in the tumor-bearing host...
  18. ncbi request reprint Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells
    Ilona Kryczek
    Department of Surgery, University of Michigan, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    J Immunol 177:40-4. 2006
    ..Altogether, our data provide a novel cellular and molecular mechanism for Treg cell-mediated immunosuppression at the level of APCs, and suggest a plausible mechanism for the suppressive effect of IL-10 in Treg cell-mediated suppression...
  19. pmc Human TH17 cells are long-lived effector memory cells
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Sci Transl Med 3:104ra100. 2011
    ..Targeting TH17-associated signaling pathway would be therapeutically meaningful for treating patients with autoimmune disease and advanced tumor...
  20. pmc Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109 0669, USA
    Int J Cancer 130:29-39. 2012
    ..Altogether, the data suggest that ALDH+ and CD133+ cells are enriched with ovarian cancer-initiating (stem) cells and that ALDH and CD133 may be widely used as reliable markers to investigate ovarian cancer stem cell biology...
  21. pmc Th17 cells in cancer: help or hindrance?
    Cailin Moira Wilke
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    Carcinogenesis 32:643-9. 2011
    ..In this review, we will describe the phenotype of tumor-associated Th17 cells, review those studies that have examined the population directly, and finally, briefly discuss the studies involving Th17-associated signature cytokines...
  22. ncbi request reprint Cutting edge: Th17 and regulatory T cell dynamics and the regulation by IL-2 in the tumor microenvironment
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 178:6730-3. 2007
    ....
  23. pmc Helicobacter pylori immune escape is mediated by dendritic cell-induced Treg skewing and Th17 suppression in mice
    John Y Kao
    Department of Internal Medicine, Division of Gastroenterology, University of Michigan Health System, 6520A MSRB I, SPC 5682, 1150 West Medical Center Drive, Ann Arbor, MI 48109 5682, USA
    Gastroenterology 138:1046-54. 2010
    ..We hypothesize that H pylori directs Treg skewing by way of dendritic cells (DCs) and thus inhibits interleukin-17(+) helper T cells (Th17) immunity...
  24. doi request reprint FOXP3 defines regulatory T cells in human tumor and autoimmune disease
    Ilona Kryczek
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Cancer Res 69:3995-4000. 2009
    ..We suggest that the combination of FOXP3 and cytokine profile is useful for further functionally distinguishing primary Tregs from activated conventional T cells...
  25. doi request reprint Antigen-presenting cell (APC) subsets in ovarian cancer
    Cailin Moira Wilke
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, Michigan 48109 0669, USA
    Int Rev Immunol 30:120-6. 2011
    ..In this review, we summarize the nature, cellular interactions, and prognostic significance of the main APC populations in ovarian cancer, and discuss the relevance of manipulating APC subsets for patient treatment...
  26. pmc Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
    Huijun Wei
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, USA
    Genes Dev 25:1510-27. 2011
    ..Together, these data provide strong evidence for a protumorigenesis role of autophagy in oncogene-induced tumors in vivo and suggest FIP200 as a potential target for cancer therapy...
  27. pmc Interleukin-10 ablation promotes tumor development, growth, and metastasis
    Takashi Tanikawa
    Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Cancer Res 72:420-9. 2012
    ....
  28. pmc Effects of tumor irradiation on host T-regulatory cells and systemic immunity in the context of adoptive T-cell therapy in mice
    Shuang Wei
    Department of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI 48109 5932, USA
    J Immunother 36:124-32. 2013
    ..Altogether, our data indicate that local tumor irradiation has a distinct modulatory effect on Tregs and can enhance systemic antitumor immunity associated with adoptive T-cell therapy...
  29. pmc T(H)17 cells in tumour immunity and immunotherapy
    Weiping Zou
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, 48109 0669, USA
    Nat Rev Immunol 10:248-56. 2010
    ..Understanding the nature of T(H)17 cell responses in the tumour microenvironment will be important for the design of more efficacious cancer immunotherapies...
  30. pmc Role of T cell TGFbeta signaling and IL-17 in allograft acceptance and fibrosis associated with chronic rejection
    Susan M Faust
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 183:7297-306. 2009
    ..Thus, IL-17 may provide a therapeutic target for preventing graft fibrosis, a measure of CR, while sparing the immunosuppressive activity of TGFbeta...
  31. ncbi request reprint Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis
    Ilona Kryczek
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109 0669, USA
    Am J Physiol Cell Physiol 292:C987-95. 2007
    ..In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed...
  32. doi request reprint Inhibitory B7-family molecules in the tumour microenvironment
    Weiping Zou
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Rev Immunol 8:467-77. 2008
    ..We also discuss novel therapeutic strategies that target these inhibitory B7 molecules and their signalling pathways to treat human cancer...
  33. pmc Deciphering the role of Th17 cells in human disease
    Cailin Moira Wilke
    Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Trends Immunol 32:603-11. 2011
    ..Also discussed is how the in vivo plasticity of Th17 cells may be an important feature of Th17 cell biology in human disease...
  34. doi request reprint Dual biological effects of the cytokines interleukin-10 and interferon-γ
    Cailin Moira Wilke
    Department of Surgery, University of Michigan School of Medicine, Ann Arbor, USA
    Cancer Immunol Immunother 60:1529-41. 2011
    ..Our progressive understanding of the dual effects of these cytokines is important for dissecting cytokine-associated pathology and provides new avenues for developing effective immune therapy against human diseases, including cancer...
  35. pmc T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
    Joel Crespo
    Department of Surgery, Ann Arbor, MI, United States
    Curr Opin Immunol 25:214-21. 2013
    ..We suggest that targeting T cell dysfunctional mechanisms and introducing/promoting T cell stemness are important approaches to treat patients with cancer...
  36. doi request reprint Prognostic significance of regulatory T cells in tumor
    Cailin Moira Wilke
    Graduate Program in Immunology, University of Michigan, Ann Arbor, MI 48109 0669, USA
    Int J Cancer 127:748-58. 2010
    ....
  37. doi request reprint Elevated serum IL-8 is associated with the presence of hepatocellular carcinoma and independently predicts survival
    Theodore H Welling
    Departments of Surgery and Medicine, Sections of Transplantation and Hepatology, University of Michigan Health System, MI 48109, USA
    Cancer Invest 30:689-97. 2012
    ..15; 95%CI:1.21-3.74) and stage (HR 1.92; 95%CI:1.22-3.97) independently predicted mortality; while viral etiology was protective (HR 0.69; 95%CI:0.41-0.98). Therefore, HCC IL-8 mediated events may be worthy of future investigation...
  38. pmc Regulatory T-cell compartmentalization and trafficking
    Shuang Wei
    Department of Surgery, University of Michigan, Ann Arbor, USA
    Blood 108:426-31. 2006
    ..In this review, the cellular and molecular signals that control specialized migration and retention of Treg cells are discussed...
  39. doi request reprint The B7 homologues and their receptors in hematologic malignancies
    Ryan A Wilcox
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan, Ann Arbor, MI 48109 5948, USA
    Eur J Haematol 88:465-75. 2012
    ..Herein, we will review recent evidence that supports the therapeutic targeting of the B7 homologues in hematologic malignancies...
  40. pmc Regulatory T cells in human ovarian cancer
    Dong Jun Peng
    Department of Surgery, University of Michigan, Ann Arbor, MI 48109, USA
    J Oncol 2012:345164. 2012
    ..We will briefly review the development of manipulation of T(Reg) cells in preclinical and clinical settings...
  41. ncbi request reprint Modeling dynamic changes in type 1 diabetes progression: quantifying beta-cell variation after the appearance of islet-specific autoimmune responses
    Patrick Nelson
    University of Michigan, Department of Mathematics, Center for Computational Medicine and Bioinformatics, 100 Washtenaw Ave, Ann Arbor, MI 48109 2218, USA
    Math Biosci Eng 6:753-78. 2009
    ..Finally, we discuss the robustness of the model and its ability to assist experimentalists in designing studies to test complicated theories about the disease...
  42. ncbi request reprint Immunosuppressive networks in the tumour environment and their therapeutic relevance
    Weiping Zou
    Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112 2699, USA
    Nat Rev Cancer 5:263-74. 2005
    ..Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity...
  43. ncbi request reprint Plasmacytoid dendritic cells induce CD8+ regulatory T cells in human ovarian carcinoma
    Shuang Wei
    Tulane University Health Science Center, New Orleans, Louisiana 70112 2699, USA
    Cancer Res 65:5020-6. 2005
    ..The data are relevant to understanding tumor immunopathology as well as reevaluating tumor immunotherapeutic strategies...
  44. ncbi request reprint Regulatory T cells in ovarian cancer: biology and therapeutic potential
    Brian Barnett
    Department of Medicine Hematology and Medical Oncology, Tulane Medical School, New Orleans, LA 70112, USA
    Am J Reprod Immunol 54:369-77. 2005
    ..We discuss Tregs in this regard in human ovarian cancer and present evidence that depleting Treg in human cancer, including ovarian cancer, using denileukin diftitox (Ontak), improves immunity and may be therapeutic...
  45. ncbi request reprint Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Tyler J Curiel
    Tulane University Health Science Center, New Orleans, Louisiana, USA
    Nat Med 9:562-7. 2003
    ..Therefore, upregulation of B7-H1 on MDCs in the tumor microenvironment downregulates T-cell immunity. Blockade of B7-H1 represents one approach for cancer immunotherapy...
  46. doi request reprint Regulatory T cells: a new frontier in cancer immunotherapy
    Brian G Barnett
    Center for Research on the Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia 19104, USA
    Adv Exp Med Biol 622:255-60. 2008
  47. doi request reprint Inhibitory B7 family members in human ovarian carcinoma
    Shuang Wei
    Center for Research on the Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia 19104, USA
    Adv Exp Med Biol 622:261-71. 2008

Research Grants17

  1. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2003
    ..Tumor PDC highly express B7-H1 whose regulation and functional significance is unknown. Aim 3 is to test our hypothesis that tumor PDC B7-HI contributes to induce TAA-specific suppressive CD8+ T cell immunity. ..
  2. Human Tregs in Ovarian Cancer
    Weiping Zou; Fiscal Year: 2010
    ....
  3. Novel immunosupressive macrophages in human ovarian tumor
    Weiping Zou; Fiscal Year: 2010
    ....
  4. Regulatory T Cells and Tumor Bone Marrow Metastasis
    Weiping Zou; Fiscal Year: 2009
    ..Our specific aims are: Aim 1: To test the hypothesis that Tregs expand in the tumor associated BM in mouse model Aim 2: To test the hypothesis that tumor associated BM DCs induce Treg expansion in mouse model ..
  5. Novel immunosupressive macrophages in human ovarian tumor
    Weiping Zou; Fiscal Year: 2007
    ....
  6. Human Tregs in Ovarian Cancer
    Weiping Zou; Fiscal Year: 2007
    ..Test the hypothesis that tumor-associated DC induce Tregs. 3. Test the hypothesis that tumor-associated DC induced Tregs are detrimental to tumor immunity. 4. Test the hypothesis that B7 family members are critical for Treg induction. ..
  7. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2006
    ..Tumor PDC highly express B7-H1 whose regulation and functional significance is unknown. Aim 3 is to test our hypothesis that tumor PDC B7-HI contributes to induce TAA-specific suppressive CD8+ T cell immunity. ..
  8. Tumor environmental CD4+CD25+ T cells
    Weiping Zou; Fiscal Year: 2006
    ..We hypothesize that MDC plus IL-2 are beneficial to tumor immunity by modifying the regulatory function ofCD4 + Tr cells. We predict that MDC plus IL-2, not MDC alone may be a strategy for treating cancer patients. ..
  9. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2005
    ..Tumor PDC highly express B7-H1 whose regulation and functional significance is unknown. Aim 3 is to test our hypothesis that tumor PDC B7-HI contributes to induce TAA-specific suppressive CD8+ T cell immunity. ..
  10. Human Tregs in Ovarian Cancer
    Weiping Zou; Fiscal Year: 2006
    ..Test the hypothesis that tumor-associated DC induce Tregs. 3. Test the hypothesis that tumor-associated DC induced Tregs are detrimental to tumor immunity. 4. Test the hypothesis that B7 family members are critical for Treg induction. ..
  11. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2007
    ..Tumor PDC highly express B7-H1 whose regulation and functional significance is unknown. Aim 3 is to test our hypothesis that tumor PDC B7-HI contributes to induce TAA-specific suppressive CD8+ T cell immunity. ..
  12. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2005
    ..Tumor PDC highly express B7-H1 whose regulation and functional significance is unknown. Aim 3 is to test our hypothesis that tumor PDC B7-HI contributes to induce TAA-specific suppressive CD8+ T cell immunity. ..
  13. Regulatory T Cells and Tumor Bone Marrow Metastasis
    Weiping Zou; Fiscal Year: 2010
    ..Our specific aims are: Aim 1: To test the hypothesis that Tregs expand in the tumor associated BM in mouse model Aim 2: To test the hypothesis that tumor associated BM DCs induce Treg expansion in mouse model ..
  14. Novel immunosupressive macrophages in human ovarian tumor
    Weiping Zou; Fiscal Year: 2009
    ....
  15. Tumor plasmacytoid dendritic cells and tumor immunity
    Weiping Zou; Fiscal Year: 2004
    ..Tumor PDC highly express B7-H1 whose regulation and functional significance is unknown. Aim 3 is to test our hypothesis that tumor PDC B7-HI contributes to induce TAA-specific suppressive CD8+ T cell immunity. ..