Ming Hui Zou

Summary

Affiliation: University of Tennessee Graduate School of Medicine
Country: USA

Publications

  1. ncbi Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus
    Ming Hui Zou
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920, USA
    Endothelium 11:89-97. 2004
  2. ncbi Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite
    Ming Hui Zou
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, The University of Tennessee, Knoxville, Tennessee 37920, USA
    J Biol Chem 278:34003-10. 2003
  3. ncbi Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species
    Ming Hui Zou
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville 37920, USA
    J Biol Chem 279:43940-51. 2004
  4. ncbi Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    Bradley J Davis
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, USA
    Diabetes 55:496-505. 2006
  5. ncbi Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress
    Zhibo An
    Vascular Biology Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37922, USA
    J Biol Chem 282:26793-801. 2007
  6. ncbi CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivo
    Bradley Davis
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Circulation 112:2184-92. 2005
  7. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
  8. ncbi Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circulation 116:1585-95. 2007
  9. pmc Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
    Philip Wenzel
    Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Atherosclerosis 198:65-76. 2008
  10. pmc Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide
    Miao Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Circ Res 102:328-37. 2008

Collaborators

Detail Information

Publications29

  1. ncbi Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus
    Ming Hui Zou
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920, USA
    Endothelium 11:89-97. 2004
    ..The authors' studies indicate that in diabetes the synthetic enzymes of the two major endogenous vasodilators undergo oxidative inactivation by different mechanisms, which are, however, tightly interdependent...
  2. ncbi Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite
    Ming Hui Zou
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, The University of Tennessee, Knoxville, Tennessee 37920, USA
    J Biol Chem 278:34003-10. 2003
    ....
  3. ncbi Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species
    Ming Hui Zou
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville 37920, USA
    J Biol Chem 279:43940-51. 2004
    ....
  4. ncbi Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase
    Bradley J Davis
    Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, USA
    Diabetes 55:496-505. 2006
    ..Taken together, our results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK-dependent, hsp90-mediated eNOS activation...
  5. ncbi Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stress
    Zhibo An
    Vascular Biology Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37922, USA
    J Biol Chem 282:26793-801. 2007
    ..Taken together, our results strongly suggest that nicotine, via ONOO(-) activates AMPK, resulting in enhanced threonine phosphorylation and consequent inhibition of FAS...
  6. ncbi CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivo
    Bradley Davis
    Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Circulation 112:2184-92. 2005
    ....
  7. ncbi Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus
    Jian Xu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 116:944-53. 2007
    ....
  8. ncbi Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circulation 116:1585-95. 2007
    ..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood...
  9. pmc Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
    Philip Wenzel
    Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Atherosclerosis 198:65-76. 2008
    ....
  10. pmc Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxide
    Miao Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Circ Res 102:328-37. 2008
    ..We conclude that TPr stimulation triggers reactive oxygen species-mediated LKB1-dependent AMPK activation, which in return inhibits cellular protein synthesis in VSMCs...
  11. ncbi High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cel
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Diabetes 51:198-203. 2002
    ....
  12. pmc AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function
    Ming Hui Zou
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Clin Exp Pharmacol Physiol 35:535-45. 2008
    ..We further hypothesize that AMPK is a dual sensor for energy and redox status within a cell and AMPK may be a therapeutic target for protecting vascular endothelial function...
  13. pmc Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Circulation 117:952-62. 2008
    ..The objective of the present study was to determine how metformin activates AMPK in endothelial cells...
  14. pmc Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA
    J Biol Chem 283:12446-55. 2008
    ..Finally, ONOO(-) enhanced PKCzeta nuclear import and LKB1 nuclear export. We conclude that PKCzeta mediates LKB1-dependent Akt inhibition in response to ONOO(-), resulting in endothelial apoptosis...
  15. pmc Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo
    Hyoung Chul Choi
    Sections of Endocrinology and Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Biol Chem 283:20186-97. 2008
    ..Taken together, our data suggest that AMPK activation by statin is peroxynitrite-mediated but PKC-zeta-dependent...
  16. pmc Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure
    Shuangxi Wang
    Department of Medicine, Division of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Hypertension 52:484-90. 2008
    ..In conclusion, GTPCH1 via BH4 maintains normal BP and endothelial function in vivo by preserving NO synthesis by eNOS...
  17. ncbi Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase
    Yong Wu
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 282:9777-88. 2007
    ..Taken together, we conclude that palmitate inhibits the phosphorylation of both AMPK and endothelial nitric-oxide synthase in endothelial cells via ceramide-dependent PP2A activation...
  18. pmc Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells
    Junhua Zhang
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 283:27452-61. 2008
    ..Taken together, we conclude that NO might act as an endogenous AMPK activator...
  19. ncbi Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulation
    Markus Bachschmid
    Faculty of Biology, University of Konstanz, 78457 Konstanz, Germany
    FASEB J 17:914-6. 2003
    ..PGE2 together with a lack of NO and PGI2 is known to promote the adhesion of white blood cells and their immigration to the inflammatory locus...
  20. ncbi Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidney
    Wei Guo
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University Medical Center, Boston, MA 02118, USA
    Am J Physiol Heart Circ Physiol 285:H1396-403. 2003
    ..Angiotensin II-induced hypertension is accompanied by increased tyrosine nitration of MnSOD, which, because it inactivates the enzyme, may contribute to increased oxidant stress in the kidney...
  21. pmc Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
    J Clin Invest 109:817-26. 2002
    ..in diabetes, contributing further to endothelial cell oxidant stress. Regulation of the zinc-thiolate center of NOS by ONOO(-) provides a novel mechanism for modulation of the enzyme function in disease...
  22. ncbi Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    Eberhard Schulz
    Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
    Circulation 111:3473-80. 2005
    ..We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation...
  23. ncbi Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells
    Zhonglin Xie
    Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    J Biol Chem 281:6366-75. 2006
    ..Taken together, we conclude that PKCzeta can regulate AMPK activity by increasing the Ser428 phosphorylation of LKB1, resulting in association of LKB1 with AMPK and consequent AMPK Thr172 phosphorylation by LKB1...
  24. pmc Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
    Xueliang Du
    Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 116:1071-80. 2006
    ..These studies identify what we believe to be a novel mechanism contributing to the accelerated atherogenesis and increased cardiovascular disease risk occurring in people with insulin resistance...
  25. ncbi Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite
    Jian Xu
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Arterioscler Thromb Vasc Biol 26:2688-95. 2006
    ....
  26. ncbi Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo
    Hong Nie
    BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Diabetes 55:3133-41. 2006
    ..We conclude that diabetes increases PGIS nitration in vivo, likely via dysfunctional eNOS...
  27. ncbi Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase
    Ming Hui Zou
    Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:32552-7. 2002
    ..We conclude that ONOO(-) inhibits Akt and increases AMPK-dependent Ser(1179) phosphorylation of eNOS resulting in enhanced O(2)() release...
  28. ncbi Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate tolerance
    Ulrich Hink
    University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    J Am Coll Cardiol 42:1826-34. 2003
    ..We tested whether in vivo nitroglycerin (NTG) treatment causes tyrosine nitration of prostacyclin synthase (PGI(2)-S), one of the nitration targets of peroxynitrite, and whether this may contribute to nitrate tolerance...
  29. ncbi Peroxynitrite and protein tyrosine nitration of prostacyclin synthase
    Ming Hui Zou
    BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
    Prostaglandins Other Lipid Mediat 82:119-27. 2007
    ....