Research Topics
Genomes and Genes | Ming Hui ZouSummaryAffiliation: University of Tennessee Graduate School of Medicine Country: USA Publications
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Publications
Peroxynitrite and vascular endothelial dysfunction in diabetes mellitusMing Hui Zou
Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37920, USA
Endothelium 11:89-97. 2004..The authors' studies indicate that in diabetes the synthetic enzymes of the two major endogenous vasodilators undergo oxidative inactivation by different mechanisms, which are, however, tightly interdependent...- Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitriteMing Hui Zou
Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, The University of Tennessee, Knoxville, Tennessee 37920, USA
J Biol Chem 278:34003-10. 2003.... - Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen speciesMing Hui Zou
Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville 37920, USA
J Biol Chem 279:43940-51. 2004.... - Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthaseBradley J Davis
Vascular Research Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, USA
Diabetes 55:496-505. 2006..Taken together, our results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK-dependent, hsp90-mediated eNOS activation... - Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: a role for oxidant stressZhibo An
Vascular Biology Laboratory, Department of Surgery, Graduate School of Medicine, University of Tennessee, Knoxville, TN 37922, USA
J Biol Chem 282:26793-801. 2007..Taken together, our results strongly suggest that nicotine, via ONOO(-) activates AMPK, resulting in enhanced threonine phosphorylation and consequent inhibition of FAS... - CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivoBradley Davis
Vascular Research Laboratory, Graduate School of Medicine, University of Tennessee, Knoxville, Tennessee, USA
Circulation 112:2184-92. 2005.... - Proteasome-dependent degradation of guanosine 5'-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitusJian Xu
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Circulation 116:944-53. 2007.... - Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent mannerPing Song
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Circulation 116:1585-95. 2007..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood... 
Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitusPhilip Wenzel
Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
Atherosclerosis 198:65-76. 2008....- Thromboxane receptor activates the AMP-activated protein kinase in vascular smooth muscle cells via hydrogen peroxideMiao Zhang
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Circ Res 102:328-37. 2008..We conclude that TPr stimulation triggers reactive oxygen species-mediated LKB1-dependent AMPK activation, which in return inhibits cellular protein synthesis in VSMCs... - High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H(2) receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial celMing Hui Zou
Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Diabetes 51:198-203. 2002.... - AMP-activated protein kinase activation as a strategy for protecting vascular endothelial functionMing Hui Zou
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Clin Exp Pharmacol Physiol 35:535-45. 2008..We further hypothesize that AMPK is a dual sensor for energy and redox status within a cell and AMPK may be a therapeutic target for protecting vascular endothelial function... - Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cellsZhonglin Xie
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Circulation 117:952-62. 2008..The objective of the present study was to determine how metformin activates AMPK in endothelial cells... - Protein kinase Czeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cellsPing Song
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, 73104, USA
J Biol Chem 283:12446-55. 2008..Finally, ONOO(-) enhanced PKCzeta nuclear import and LKB1 nuclear export. We conclude that PKCzeta mediates LKB1-dependent Akt inhibition in response to ONOO(-), resulting in endothelial apoptosis... - Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivoHyoung Chul Choi
Sections of Endocrinology and Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
J Biol Chem 283:20186-97. 2008..Taken together, our data suggest that AMPK activation by statin is peroxynitrite-mediated but PKC-zeta-dependent... - Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressureShuangxi Wang
Department of Medicine, Division of Endocrinology and Diabetes, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
Hypertension 52:484-90. 2008..In conclusion, GTPCH1 via BH4 maintains normal BP and endothelial function in vivo by preserving NO synthesis by eNOS... - Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinaseYong Wu
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 282:9777-88. 2007..Taken together, we conclude that palmitate inhibits the phosphorylation of both AMPK and endothelial nitric-oxide synthase in endothelial cells via ceramide-dependent PP2A activation... - Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cellsJunhua Zhang
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 283:27452-61. 2008..Taken together, we conclude that NO might act as an endogenous AMPK activator... - Endothelial cell activation by endotoxin involves superoxide/NO-mediated nitration of prostacyclin synthase and thromboxane receptor stimulationMarkus Bachschmid
Faculty of Biology, University of Konstanz, 78457 Konstanz, Germany
FASEB J 17:914-6. 2003..PGE2 together with a lack of NO and PGI2 is known to promote the adhesion of white blood cells and their immigration to the inflammatory locus... - Quantitative assessment of tyrosine nitration of manganese superoxide dismutase in angiotensin II-infused rat kidneyWei Guo
Vascular Biology Unit, Whitaker Cardiovascular Institute, Boston University Medical Center, Boston, MA 02118, USA
Am J Physiol Heart Circ Physiol 285:H1396-403. 2003..Angiotensin II-induced hypertension is accompanied by increased tyrosine nitration of MnSOD, which, because it inactivates the enzyme, may contribute to increased oxidant stress in the kidney... - Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitriteMing Hui Zou
Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, 650 Albany Street, Boston, MA 02118, USA
J Clin Invest 109:817-26. 2002..in diabetes, contributing further to endothelial cell oxidant stress. Regulation of the zinc-thiolate center of NOS by ONOO(-) provides a novel mechanism for modulation of the enzyme function in disease... - Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinaseEberhard Schulz
Evans Memorial Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass 02118, USA
Circulation 111:3473-80. 2005..We therefore investigated whether AMPK is activated by estradiol in endothelial cells and plays a role in estradiol-induced eNOS activation... - Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cellsZhonglin Xie
Division of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
J Biol Chem 281:6366-75. 2006..Taken together, we conclude that PKCzeta can regulate AMPK activity by increasing the Ser428 phosphorylation of LKB1, resulting in association of LKB1 with AMPK and consequent AMPK Thr172 phosphorylation by LKB1... - Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidationXueliang Du
Diabetes Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
J Clin Invest 116:1071-80. 2006..These studies identify what we believe to be a novel mechanism contributing to the accelerated atherogenesis and increased cardiovascular disease risk occurring in people with insulin resistance... - Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitriteJian Xu
Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Sciences Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Arterioscler Thromb Vasc Biol 26:2688-95. 2006.... - Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivoHong Nie
BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
Diabetes 55:3133-41. 2006..We conclude that diabetes increases PGIS nitration in vivo, likely via dysfunctional eNOS... - Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthaseMing Hui Zou
Vascular Biology Unit, Whitaker Cardiovascular Institute, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
J Biol Chem 277:32552-7. 2002..We conclude that ONOO(-) inhibits Akt and increases AMPK-dependent Ser(1179) phosphorylation of eNOS resulting in enhanced O(2)() release... - Role for peroxynitrite in the inhibition of prostacyclin synthase in nitrate toleranceUlrich Hink
University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
J Am Coll Cardiol 42:1826-34. 2003..CONCLUSIONS: Nitroglycerin-induced vascular peroxynitrite formation inhibits the activity of PGI(2)-S as well as NO, cGMP, and cGK-I signaling, which may contribute to vascular dysfunction in the setting of tolerance... - Peroxynitrite and protein tyrosine nitration of prostacyclin synthaseMing Hui Zou
BSEB 325, Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, 941 Stanton L Young Blvd, Oklahoma City, OK 73104, USA
Prostaglandins Other Lipid Mediat 82:119-27. 2007....