R Thomas Zoeller

Summary

Affiliation: University of Massachusetts
Country: USA

Publications

  1. ncbi request reprint 4-Hydroxy-PCB106 acts as a direct thyroid hormone receptor agonist in rat GH3 cells
    Seo Hee You
    Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Mol Cell Endocrinol 257:26-34. 2006
  2. pmc Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society
    R Thomas Zoeller
    Biology Department, University of Massachusetts, 611 North Pleasant Street, Amherst, Massachusetts 01003, USA
    Endocrinology 153:4097-110. 2012
  3. ncbi request reprint Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil
    R Thomas Zoeller
    University of Massachusetts Amherst, Department of Biology, Morrill Science Center, 01003, USA
    Crit Rev Toxicol 35:771-81. 2005
  4. ncbi request reprint Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain
    R T Zoeller
    Biology Department, University of Massachusetts, Morrill Science Center, Amherst 01003, USA
    Endocrinology 141:181-9. 2000
  5. ncbi request reprint Collision of basic and applied approaches to risk assessment of thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Ann N Y Acad Sci 1076:168-90. 2006
  6. ncbi request reprint General background on the hypothalamic-pituitary-thyroid (HPT) axis
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:11-53. 2007
  7. ncbi request reprint Current and potential rodent screens and tests for thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:55-95. 2007
  8. ncbi request reprint Implications of research on assays to characterize thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:195-210. 2007
  9. ncbi request reprint Environmental chemicals impacting the thyroid: targets and consequences
    R Thomas Zoeller
    Biology Department, Program in Molecular and Cellular Biology, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Thyroid 17:811-7. 2007
  10. ncbi request reprint Environmental chemicals targeting thyroid
    Thomas R Zoeller
    Biology Department and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, USA
    Hormones (Athens) 9:28-40. 2010

Research Grants

  1. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2011
  2. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2010
  3. PCB Disruption of Thyroid Hormone Action during Development
    Robert Zoeller; Fiscal Year: 2009
  4. PCB DISRUPTION OF THYROID HORMONE
    Robert Zoeller; Fiscal Year: 2004
  5. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2010

Detail Information

Publications29

  1. ncbi request reprint 4-Hydroxy-PCB106 acts as a direct thyroid hormone receptor agonist in rat GH3 cells
    Seo Hee You
    Program in Molecular and Cellular Biology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Mol Cell Endocrinol 257:26-34. 2006
    ..These effects were directly parallel to effects of T(3), indicating that 4-OH-CB106 exerts a direct agonistic effect on the TRbeta1...
  2. pmc Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society
    R Thomas Zoeller
    Biology Department, University of Massachusetts, 611 North Pleasant Street, Amherst, Massachusetts 01003, USA
    Endocrinology 153:4097-110. 2012
    ....
  3. ncbi request reprint Mode of action: developmental thyroid hormone insufficiency--neurological abnormalities resulting from exposure to propylthiouracil
    R Thomas Zoeller
    University of Massachusetts Amherst, Department of Biology, Morrill Science Center, 01003, USA
    Crit Rev Toxicol 35:771-81. 2005
    ....
  4. ncbi request reprint Developmental exposure to polychlorinated biphenyls exerts thyroid hormone-like effects on the expression of RC3/neurogranin and myelin basic protein messenger ribonucleic acids in the developing rat brain
    R T Zoeller
    Biology Department, University of Massachusetts, Morrill Science Center, Amherst 01003, USA
    Endocrinology 141:181-9. 2000
    ..These data clearly demonstrate that the developmental effects of PCB exposure are not simply a function of PCB-induced hypothyroidism...
  5. ncbi request reprint Collision of basic and applied approaches to risk assessment of thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Ann N Y Acad Sci 1076:168-90. 2006
    ..As testing paradigms are designed by regulatory agencies, these age-dependent differences in thyroid endocrinology must be considered...
  6. ncbi request reprint General background on the hypothalamic-pituitary-thyroid (HPT) axis
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:11-53. 2007
    ..This review provides the background necessary to review the current assays and endpoints described in the following articles for rodents, fishes, amphibians, and birds...
  7. ncbi request reprint Current and potential rodent screens and tests for thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:55-95. 2007
    ..Finally, the importance of understanding the relationship between timing of exposure, duration of dose, and time of acquisition of the endpoints in interpreting the results of the in vivo assays is emphasized...
  8. ncbi request reprint Implications of research on assays to characterize thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Crit Rev Toxicol 37:195-210. 2007
    ..It is our hope that this series of thyroid articles will provide regulators and research scientists the information needed for each individual to identify the assays and endpoints most suited for their specific purposes...
  9. ncbi request reprint Environmental chemicals impacting the thyroid: targets and consequences
    R Thomas Zoeller
    Biology Department, Program in Molecular and Cellular Biology, Morrill Science Center, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Thyroid 17:811-7. 2007
    ....
  10. ncbi request reprint Environmental chemicals targeting thyroid
    Thomas R Zoeller
    Biology Department and Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, USA
    Hormones (Athens) 9:28-40. 2010
    ..The goal of this review is therefore to identify the issues that must be clearly resolved before effective risk assessment can be performed...
  11. ncbi request reprint Environmental chemicals as thyroid hormone analogues: new studies indicate that thyroid hormone receptors are targets of industrial chemicals?
    R Thomas Zoeller
    Biology Department and Program in Molecular and Cellular Biology, Morrill Science Center, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Mol Cell Endocrinol 242:10-5. 2005
    ....
  12. pmc Transplacental thyroxine and fetal brain development
    R Thomas Zoeller
    Department of Biology, University of Massachusetts Amherst, Morrill Science Center, Amherst, Massachusetts 01003, USA
    J Clin Invest 111:954-7. 2003
  13. ncbi request reprint Timing of thyroid hormone action in the developing brain: clinical observations and experimental findings
    R T Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, MA 10003, USA
    J Neuroendocrinol 16:809-18. 2004
    ....
  14. ncbi request reprint Thyroid hormone action in fetal brain development and potential for disruption by environmental chemicals
    R T Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst 01003, USA
    Neurotoxicology 21:935-45. 2000
    ..In the final section, we review the endocrinology of thyroid disruption with an emphasis on disruption of thyroid hormone action...
  15. ncbi request reprint Bisphenol-A, an environmental contaminant that acts as a thyroid hormone receptor antagonist in vitro, increases serum thyroxine, and alters RC3/neurogranin expression in the developing rat brain
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 146:607-12. 2005
    ....
  16. pmc Thyroid hormone, brain development, and the environment
    Thomas R Zoeller
    Biology Department, Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, MA 10003, USA
    Environ Health Perspect 110:355-61. 2002
    ....
  17. ncbi request reprint Challenges confronting risk analysis of potential thyroid toxicants
    R Thomas Zoeller
    Biology Department, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Risk Anal 23:143-62. 2003
    ....
  18. ncbi request reprint Maternal thyroid hormone increases HES expression in the fetal rat brain: an effect mimicked by exposure to a mixture of polychlorinated biphenyls (PCBs)
    Ruby Bansal
    Department of Biology, University of Massachusetts Amherst, Morrill Science Center, Amherst, MA 01003, USA
    Brain Res Dev Brain Res 156:13-22. 2005
    ..However, considering the role of HES proteins in fate specification of cortical neurons, these findings suggest that thyroid hormone, and PCB exposure, may influence fate specification of cortical neurons...
  19. pmc Individual polychlorinated biphenyl (PCB) congeners produce tissue- and gene-specific effects on thyroid hormone signaling during development
    Stefanie Giera
    Molecular and Cellular Biology Program, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    Endocrinology 152:2909-19. 2011
    ..These are essential mechanisms to consider when evaluating the health risks of contaminant exposures, for both PCB and other polycyclic compounds known to interact with nuclear hormone receptors...
  20. pmc Polychlorinated biphenyls (PCBs) exert thyroid hormone-like effects in the fetal rat brain but do not bind to thyroid hormone receptors
    Kelly J Gauger
    Biology Department, Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Environ Health Perspect 112:516-23. 2004
    ..These findings indicate that PCBs can interfere with TH signaling in the fetal brain by direct actions on the fetus rather than by producing maternal hypothyroidism...
  21. ncbi request reprint Polychlorinated biphenyls exert selective effects on cellular composition of white matter in a manner inconsistent with thyroid hormone insufficiency
    David S Sharlin
    Molecular and Cellular Biology Program, University of Massachusetts Amherst, Morrill Science Center, 01003, USA
    Endocrinology 147:846-58. 2006
    ..Thus, PCB exposure mimicked some, but not all, of the effects of hypothyroidism on white matter composition...
  22. pmc Polychlorinated biphenyls (Aroclor 1254) do not uniformly produce agonist actions on thyroid hormone responses in the developing rat brain
    Ruby Bansal
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:4001-8. 2008
    ..However, neither did PCBs mimic T(4) in hypothyroid animals on all end points measured. Thus, PCBs exert a complex action on TH signaling in the developing brain...
  23. pmc Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells
    Kelly J Gauger
    Molecular and Cellular Biology Program, University of Massachusetts Amherst, Massachusetts 01003, USA
    Environ Health Perspect 115:1623-30. 2007
    ..Polychlorinated biphenyls (PCBs) may interfere with thyroid hormone (TH) signaling by reducing TH levels in blood, by exerting direct effects on TH receptors (TRs), or both...
  24. doi request reprint The balance between oligodendrocyte and astrocyte production in major white matter tracts is linearly related to serum total thyroxine
    David S Sharlin
    Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    Endocrinology 149:2527-36. 2008
    ..Moreover, these findings indicate that major white matter tracts may differ in their sensitivity to TH insufficiency...
  25. ncbi request reprint Thyroid hormone exerts site-specific effects on SRC-1 and NCoR expression selectively in the neonatal rat brain
    Eric A Iannacone
    Biology Department and Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Mol Cell Endocrinol 186:49-59. 2002
    ....
  26. pmc Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
    Laura N Vandenberg
    Tufts University, Center for Regenerative and Developmental Biology, Department of Biology, 200 Boston Avenue, Suite 4600, Medford, Massachusetts 02155, USA
    Endocr Rev 33:378-455. 2012
    ..Thus, fundamental changes in chemical testing and safety determination are needed to protect human health...
  27. ncbi request reprint Differential display identifies neuroendocrine-specific protein-A (NSP-A) and interferon-inducible protein 10 (IP-10) as ethanol-responsive genes in the fetal rat brain
    Jun Yang
    Biology Department and Molecular and Cellular Biology Program, Morrill Science Center, University of Massachusetts, Amherst, MA 01003, USA
    Brain Res Dev Brain Res 138:117-33. 2002
    ..A critical analysis of the approaches used in the present study may be important for future studies in this field...
  28. pmc Analyzing in situ gene expression in the mouse brain with image registration, feature extraction and block clustering
    Manjunatha Jagalur
    Department of Computer Science, University of Massachusetts Amherst, Amherst, MA 01003, USA
    BMC Bioinformatics 8:S5. 2007
    ..Solutions to these and other challenges will lead to a richer understanding of the complex system aspects of gene regulation in heterogeneous tissue...
  29. doi request reprint Environmental neuroendocrine and thyroid disruption: relevance for reproductive medicine?
    R Thomas Zoeller
    Biology Department, University of Massachusetts Amherst, Morrill Science Center, Amherst, Massachusetts 01003, USA
    Fertil Steril 89:e99-e100. 2008
    ..However, important new information is appearing concerning the association between thyroid hormone levels and fertility in humans, as well as animal studies focused on its role in testis development...

Research Grants10

  1. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2011
    ..These studies will provide important new information about the toxicity of PCBs, and perhaps other common contaminants in the human population. ..
  2. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2010
    ..These studies will provide important new information about the toxicity of PCBs, and perhaps other common contaminants in the human population. ..
  3. PCB Disruption of Thyroid Hormone Action during Development
    Robert Zoeller; Fiscal Year: 2009
    ..These studies will provide important new information about the toxicity of PCBs, and perhaps other common contaminants in the human population. ..
  4. PCB DISRUPTION OF THYROID HORMONE
    Robert Zoeller; Fiscal Year: 2004
    ..These studies have the potential to identify individual PCB congeners with thyroid hormone agonist or antagonist actions. In addition, these studies will identify adverse neurological effects and the doses required for these effects. ..
  5. PCB Disruption of Thyroid Hormone Action during Development
    ROBERT THOMAS ZOELLER; Fiscal Year: 2010
    ..Because of the highly integrated nature of this work, requiring efforts from all three labs for successful completion of the work, we are proposing only 2 aims and designate the part of the work that is performed in each lab. ..