J M Zmuda

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Recent progress in understanding the genetic susceptibility to osteoporosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Genet Epidemiol 16:356-67. 1999
  2. pmc Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older women
    S P Moffett
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    J Clin Endocrinol Metab 93:2002-8. 2008
  3. pmc Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
    A L Kuipers
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Osteoporos Int 23:1521-31. 2012
  4. pmc The effects of adiponectin and leptin on changes in bone mineral density
    K E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 23:1699-710. 2012
  5. pmc Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men
    J M Zmuda
    Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 22:1079-90. 2011
  6. pmc Age-related decline in bone density among ethnically diverse older men
    Y Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Osteoporos Int 22:599-605. 2011
  7. ncbi request reprint Bone mass and breast cancer risk in older women: differences by stage at diagnosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Natl Cancer Inst 93:930-6. 2001
  8. pmc Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men
    I Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 21:1900-7. 2013
  9. ncbi request reprint Update on the epidemiology of osteoporosis
    R L Wolf
    University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Curr Rheumatol Rep 2:74-86. 2000
  10. pmc Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women
    K Lian
    Department of Epidemiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Osteoarthritis Cartilage 15:972-8. 2007

Detail Information

Publications30

  1. ncbi request reprint Recent progress in understanding the genetic susceptibility to osteoporosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    Genet Epidemiol 16:356-67. 1999
    ..The improved understanding of osteoporosis that will emerge from these genetic studies should lead to better diagnosis of this disease and new treatment and prevention strategies...
  2. pmc Osteoprotegerin Lys3Asn polymorphism and the risk of fracture in older women
    S P Moffett
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    J Clin Endocrinol Metab 93:2002-8. 2008
    ..Osteoprotegerin (OPG) is a soluble decoy receptor for receptor activator nuclear factor kappa-beta that blocks osteoclastic bone resorption...
  3. pmc Genetic analysis of serum osteocalcin and bone mineral in multigenerational Afro-Caribbean families
    A L Kuipers
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Osteoporos Int 23:1521-31. 2012
    ..Osteocalcin is a major component of bone matrix. Concentrations of total, carboxylated, and uncarboxylated osteocalcin, are highly heritable and genetically correlated with bone mineral content (BMC) within African ancestry families...
  4. pmc The effects of adiponectin and leptin on changes in bone mineral density
    K E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 23:1699-710. 2012
    ..Results suggest that adiponectin, but not leptin, is a risk factor for bone loss in women...
  5. pmc Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men
    J M Zmuda
    Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 22:1079-90. 2011
    ..SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p < 0.005)...
  6. pmc Age-related decline in bone density among ethnically diverse older men
    Y Sheu
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto St, Pittsburgh, PA 15261, USA
    Osteoporos Int 22:599-605. 2011
    ..We compared rates of BMD decline in older men of diverse ethnic background. The rate of bone loss was statistically equivalent between men of African and Caucasian descent...
  7. ncbi request reprint Bone mass and breast cancer risk in older women: differences by stage at diagnosis
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    J Natl Cancer Inst 93:930-6. 2001
    ..Older women with low bone mineral density (BMD) have a decreased incidence of breast cancer. It is not known whether this association is confined to early-stage, slow-growing tumors...
  8. pmc Skeletal muscle adiposity is associated with serum lipid and lipoprotein levels in Afro-Caribbean men
    I Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 21:1900-7. 2013
    ..A comprehensive array of factors potentially related to fasting serum lipid and lipoprotein levels in African ancestry men was evaluated...
  9. ncbi request reprint Update on the epidemiology of osteoporosis
    R L Wolf
    University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Curr Rheumatol Rep 2:74-86. 2000
    ..New studies linking osteoporosis to several other important diseases in women including breast cancer, osteoarthritis, and stroke are also reviewed...
  10. pmc Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women
    K Lian
    Department of Epidemiology, University of California at San Francisco, San Francisco, CA 94143, USA
    Osteoarthritis Cartilage 15:972-8. 2007
    ....
  11. pmc Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry
    I Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Lipid Res 51:1823-31. 2010
    ..Future sequencing and functional studies of these loci may advance our understanding of genetic factors contributing to LDL-C in African ancestry populations...
  12. pmc The association of serum 25-hydroxyvitamin D with indicators of bone quality in men of Caucasian and African ancestry
    K E Barbour
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 22:2475-85. 2011
    ....
  13. ncbi request reprint The search for human osteoporosis genes
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Musculoskelet Neuronal Interact 6:3-15. 2006
    ..The new insight that will emerge from this ongoing research should lead to new ways of diagnosing, preventing and treating the growing clinical and public health problem of osteoporosis...
  14. ncbi request reprint Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk
    F Modugno
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Cancer Res 7:3092-6. 2001
    ....
  15. ncbi request reprint Timing of estrogen replacement therapy for optimal osteoporosis prevention
    J A Cauley
    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 86:5700-5. 2001
    ....
  16. ncbi request reprint Tumor necrosis factor-alpha polymorphism, bone strength phenotypes, and the risk of fracture in older women
    S P Moffett
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, USA
    J Clin Endocrinol Metab 90:3491-7. 2005
    ..The G-308A polymorphism was not associated with a reduced risk of other fractures. These results suggest a potential role of genetic variation in TNFalpha in the etiology of osteoporosis...
  17. ncbi request reprint A common promotor variant in the cytochrome P450c17alpha (CYP17) gene is associated with bioavailability testosterone levels and bone size in men
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 16:911-7. 2001
    ..These results suggest that allelic variation at the CYP17 locus may contribute to the genetic influence on stature and femoral size in men...
  18. ncbi request reprint Genetic markers for ancestry are correlated with body composition traits in older African Americans
    J R Shaffer
    Graduate School of Public Health, University of Pittsburgh, PA 15261, USA
    Osteoporos Int 18:733-41. 2007
    ..We found significant correlations between proportion of European ancestry and several musculoskeletal traits, indicating that admixture mapping may be a useful strategy for locating genes affecting these traits...
  19. pmc Successful skeletal aging: a marker of low fracture risk and longevity. The Study of Osteoporotic Fractures (SOF)
    Jane A Cauley
    University of Pittsburgh, Department of Epidemiology, Pittsburgh, Pennsylvania 15261, USA
    J Bone Miner Res 24:134-43. 2009
    ..These women experienced a lower risk of fractures, disability, and mortality, suggesting that this phenotype may be a marker of successful aging...
  20. ncbi request reprint Correlates of bone mineral density in men of African ancestry: the Tobago bone health study
    D D Hill
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Osteoporos Int 19:227-34. 2008
    ..These models explained 25-27% of the variability in total hip and femoral neck BMD, respectively, and 13% of the variability in estimated volumetric BMD...
  21. ncbi request reprint Higher 1,25-dihydroxyvitamin D3 concentrations associated with lower fall rates in older community-dwelling women
    K A Faulkner
    University of Pittsburgh, 130 DeSoto Street, Parran 509, Pittsburgh, PA 15261, USA
    Osteoporos Int 17:1318-28. 2006
    ..The purpose of this study was to examine the relationships of vitamin D supplementation and serum concentrations of vitamin D metabolites and parathyroid hormone (PTH) with neuromuscular function and falls in older community-dwelling women...
  22. ncbi request reprint Molecular epidemiology of vitamin D receptor gene variants
    J M Zmuda
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, 130 DeSoto Street, Pittsburgh, PA 15261, USA
    Epidemiol Rev 22:203-17. 2000
  23. ncbi request reprint Enhanced cardiovascular hemodynamics in endurance-trained postmenopausal women athletes
    S D McCole
    Division of Cardiology, University of Pittsburgh, PA 15213, USA
    Med Sci Sports Exerc 32:1073-9. 2000
    ..We sought to determine whether older women athletes who had habitually performed vigorous endurance exercise training had higher stroke volumes and cardiac outputs than sedentary postmenopausal women during maximal exercise...
  24. ncbi request reprint FABP2 genotype is associated with insulin sensitivity in older women
    M D Brown
    Cardiovascular Institute and Division of Endocrinology, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Metabolism 50:1102-5. 2001
    ..It was concluded that FABP2 genotype influences insulin sensitivity independent of body composition, habitual physical activity levels, and HRT status in postmenopausal white women...
  25. ncbi request reprint Association of body composition and physical activity with proximal femur geometry in middle-aged and elderly Afro-Caribbean men: the Tobago bone health study
    L M Semanick
    Department of Radiology, Johns Hopkins University, USA
    Calcif Tissue Int 77:160-6. 2005
    ....
  26. ncbi request reprint Physical activity, hormone replacement therapy and plasma lipoprotein-lipid levels in postmenopausal women
    J M Hagberg
    Division of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Int J Sports Med 24:22-9. 2003
    ....
  27. ncbi request reprint Moderate physical activity is associated with higher bone mineral density in postmenopausal women
    J M Hagberg
    Division of Cardiology, University of Pittsburgh Medical Center, PA, USA
    J Am Geriatr Soc 49:1411-7. 2001
    ....
  28. ncbi request reprint Obesity gene variant and elite endurance performance
    G E Moore
    University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, PA, USA
    Metabolism 50:1391-2. 2001
    ..4 +/- 1.1 v 32.4 +/- 1.5 and 29.1 +/- 1.7 mL/kg/min, P <.05). We conclude that the Glu27Glu ADRB2 genotype may dissociate from and the Gln27Gln and Gln27Glu genotypes may associate with elite endurance performance in older women...
  29. ncbi request reprint Type I collagen alpha1 Sp1 transcription factor binding site polymorphism is associated with reduced risk of hip osteoarthritis defined by severe joint space narrowing in elderly women
    K Lian
    University of California at San Francisco, USA
    Arthritis Rheum 52:1431-6. 2005
    ..The purpose of this study was to examine whether there is an association between COL1A1 Sp1 polymorphism and radiographic osteoarthritis (OA) of the hip in elderly women in the Study of Osteoporotic Fractures...
  30. ncbi request reprint Frizzled-related protein variants are risk factors for hip osteoarthritis
    N E Lane
    University of California at San Francisco, USA
    Arthritis Rheum 54:1246-54. 2006
    ....