Berislav V Zlokovic

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. pmc Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    Berislav V Zlokovic
    Department of Physiology and Biophysics, and Center for Neurodegeneration and Regeneration at the Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, California 90089, USA
    Nat Rev Neurosci 12:723-38. 2011
  2. pmc Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice
    Ethan A Winkler
    Zilkha Neurogenetic Institute, Center for Neurodegeneration and Regeneration, Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA 90089
    Proc Natl Acad Sci U S A 111:E1035-42. 2014
  3. pmc A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain
    Abhay P Sagare
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 288:15154-66. 2013
  4. pmc Pericyte loss influences Alzheimer-like neurodegeneration in mice
    Abhay P Sagare
    1 Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA 2
    Nat Commun 4:2932. 2013
  5. pmc Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats
    Yaoming Wang
    From the Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA Y W, Z Z, B V Z ZZ Biotech Research Laboratory, Rochester, NY N C Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA P S R, P D L and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA J H G
    Stroke 44:3529-36. 2013
  6. pmc Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease
    Jesse D Sengillo
    Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, USA
    Brain Pathol 23:303-10. 2013
  7. pmc Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
    Ethan A Winkler
    Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, University of Southern California, Room 101, 1501 San Pablo Street, Los Angeles, CA 90089, USA
    Acta Neuropathol 125:111-20. 2013
  8. ncbi Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease
    Abhay P Sagare
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    J Alzheimers Dis 33:S87-100. 2013
  9. doi Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease
    Berislav V Zlokovic
    Zilkha Neurogenetic Institute, 1501 San Pablo St, Room 101, Los Angeles, CA 90089, USA
    JAMA Neurol 70:440-4. 2013
  10. ncbi Blood-brain barrier: a dual life of MFSD2A?
    Zhen Zhao
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Neuron 82:728-30. 2014

Collaborators

  • Min Wang
  • Su Wang
  • Jenny S Henkel
  • Stanley H Appel
  • Rashid Deane
  • Jorge Ghiso
  • Abhay P Sagare
  • Ethan A Winkler
  • Zhen Zhao
  • Jesse D Sengillo
  • Yaoming Wang
  • Robert D Bell
  • John H Griffin
  • John S Sullivan
  • Nienwen Chow
  • Qingyi Ma
  • Huang Guo
  • Ranjit K Giri
  • Edward Zuniga
  • Jasmina B Mackic
  • Zhihui Zhong
  • Don W Cleveland
  • Laurent O Mosnier
  • Ranjeet Kumar Sinha
  • Mahlon Johnson
  • Qi Yang
  • Alaka Srivastava
  • Thomas P Davis
  • Itender Singh
  • Steven A Goldman
  • Padmesh S Rajput
  • Yoichiro Nishida
  • Corey T Walker
  • Anita Ramanathan
  • Patrick D Lyden
  • Joseph Wang
  • Vijay K Kalra
  • Shweta Shahi
  • Vikram Rajagopal
  • James Bading
  • Larry Walker
  • Thomas Wisniewski
  • Blas Frangione

Detail Information

Publications16

  1. pmc Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    Berislav V Zlokovic
    Department of Physiology and Biophysics, and Center for Neurodegeneration and Regeneration at the Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, California 90089, USA
    Nat Rev Neurosci 12:723-38. 2011
    ..This article examines mechanisms of BBB dysfunction in neurodegenerative disorders, notably Alzheimer's disease, and highlights therapeutic opportunities relating to these neurovascular deficits...
  2. pmc Blood-spinal cord barrier disruption contributes to early motor-neuron degeneration in ALS-model mice
    Ethan A Winkler
    Zilkha Neurogenetic Institute, Center for Neurodegeneration and Regeneration, Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA 90089
    Proc Natl Acad Sci U S A 111:E1035-42. 2014
    ..Our data suggest that BSCB breakdown contributes to early motor-neuron degeneration in ALS mice and that restoring BSCB integrity during an early disease phase retards the disease process. ..
  3. pmc A lipoprotein receptor cluster IV mutant preferentially binds amyloid-β and regulates its clearance from the mouse brain
    Abhay P Sagare
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 288:15154-66. 2013
    ..Thus, LRPIV-D3674G is an efficient new Aβ clearance therapy...
  4. pmc Pericyte loss influences Alzheimer-like neurodegeneration in mice
    Abhay P Sagare
    1 Department of Physiology and Biophysics, Keck School of Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California 90033, USA 2
    Nat Commun 4:2932. 2013
    ..Therefore, pericytes may represent a novel therapeutic target to modify disease progression in AD. ..
  5. pmc Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats
    Yaoming Wang
    From the Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA Y W, Z Z, B V Z ZZ Biotech Research Laboratory, Rochester, NY N C Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA P S R, P D L and Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA J H G
    Stroke 44:3529-36. 2013
    ..Here, we studied the effects of delayed 3KA-APC therapy alone and with tissue-type plasminogen activator (tPA) in aged female mice and spontaneously hypertensive rats...
  6. pmc Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease
    Jesse D Sengillo
    Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, USA
    Brain Pathol 23:303-10. 2013
    ..86 (P < 0.01) and -0.98 (P < 0.01) in the hippocampus, respectively. Thus, deficiency in mural vascular cells may contribute to disrupted vascular barrier properties and resultant neuronal dysfunction during AD pathogenesis...
  7. pmc Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis
    Ethan A Winkler
    Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute, University of Southern California, Room 101, 1501 San Pablo Street, Los Angeles, CA 90089, USA
    Acta Neuropathol 125:111-20. 2013
    ..75, p < 0.01). Thus, the BSCB disruption with erythrocyte extravasation and pericyte reductions is present in ALS. Whether similar findings occur in motor cortex and affected brainstem motor nuclei remain to be seen...
  8. ncbi Neurovascular defects and faulty amyloid-β vascular clearance in Alzheimer's disease
    Abhay P Sagare
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
    J Alzheimers Dis 33:S87-100. 2013
    ..We aim to provide a summary of recent research findings implicated in neurovascular defects and faulty Aβ vascular clearance contributing to AD pathogenesis...
  9. doi Cerebrovascular effects of apolipoprotein E: implications for Alzheimer disease
    Berislav V Zlokovic
    Zilkha Neurogenetic Institute, 1501 San Pablo St, Room 101, Los Angeles, CA 90089, USA
    JAMA Neurol 70:440-4. 2013
    ....
  10. ncbi Blood-brain barrier: a dual life of MFSD2A?
    Zhen Zhao
    Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Neuron 82:728-30. 2014
    ..Two recent papers in Nature, Ben-Zvi et al. (2014) and Nguyen et al. (2014), report a surprising dual role for the blood-brain barrier transporter MFSD2A in both establishing BBB integrity and in uptake of the fatty acid DHA...
  11. pmc Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice
    Yaoming Wang
    Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA
    Blood Cells Mol Dis 51:104-8. 2013
    ..Our data emphasize that APC's cytoprotective activities, but not its anticoagulant activity, are key for APC neuroprotection after transient ischemic stroke...
  12. pmc An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway
    Huang Guo
    Center for Neurodegeneration and Regeneration, Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, Los Angeles, California 90089, USA
    J Neurosci 33:6181-90. 2013
    ..Therefore, APC and its pharmacological analogs, by influencing PAR and S1PR signals in resident neural progenitor cells, may be potent modulators of both development and repair in the human CNS...
  13. pmc Blood-spinal cord barrier pericyte reductions contribute to increased capillary permeability
    Ethan A Winkler
    Department of Physiology and Biophysics, University of Southern California, Zilkha Neurogenetic Institute, Center for Neurodegeneration and Regeneration, Los Angeles, California 90089, USA
    J Cereb Blood Flow Metab 32:1841-52. 2012
    ..Regional reductions in spinal cord pericytes may provide a cellular basis for heightened spinal cord barrier capillary permeability and motor neuron loss...
  14. pmc Low-density lipoprotein receptor-related protein 1: a physiological Aβ homeostatic mechanism with multiple therapeutic opportunities
    Abhay P Sagare
    Department of Physiology and Biophysics, and Center for Neurodegeneration and Regeneration at the Zilkha Neurogenetic Institute, University of Southern California, Keck School of Medicine, 1501 San Pablo Street, Los Angeles, CA 90089, USA
    Pharmacol Ther 136:94-105. 2012
    ....
  15. ncbi Mechanism of amyloid peptide induced CCR5 expression in monocytes and its inhibition by siRNA for Egr-1
    Ranjit K Giri
    Department of Biochemistry and Molecular Biology, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    Am J Physiol Cell Physiol 289:C264-76. 2005
    ..We suggest that inhibition of Egr-1 by either Egr-1 siRNA or pharmacological agents may reduce activation of monocytes/microglia and possibly ameliorate the inflammation and progression of AD...
  16. ncbi Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer's disease lesions
    Jasmina B Mackic
    Department of Neurological Surgery, USC School of Medicine, Los Angeles, CA 90033, USA
    Vascul Pharmacol 38:303-13. 2002
    ..Negligible capillary binding, rapid systemic and brain degradation, and accelerated body elimination of blood-borne A beta, may prevent the development of CAA in rhesus in contrast to squirrel monkeys...