Fuad Ziyadeh

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Overview: combating diabetic nephropathy
    Fuad N Ziyadeh
    Renal Electrolyte and Hypertension Division, 700 Clinical Research Building, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104 6144, USA
    J Am Soc Nephrol 14:1355-7. 2003
  2. ncbi request reprint Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator
    Fuad N Ziyadeh
    Penn Center for Molecular Studies of Kidney Diseases, Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Soc Nephrol 15:S55-7. 2004
  3. pmc Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
    F N Ziyadeh
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
    Proc Natl Acad Sci U S A 97:8015-20. 2000
  4. ncbi request reprint The renal TGF-beta system in the db/db mouse model of diabetic nephropathy
    M P Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Exp Nephrol 6:226-33. 1998
  5. ncbi request reprint The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy
    S Chen
    Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia 19104-6144, USA
    Ren Fail 23:471-81. 2001
  6. pmc TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy
    S Goldfarb
    Renal Electrolyte and Hypertension Division, and Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, 100 Centrex, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Trans Am Clin Climatol Assoc 112:27-32; discussion 33. 2001
  7. pmc Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse
    S W Hong
    Renal Electrolyte and Hypertension Division of the Department of Medicine and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 158:1653-63. 2001
  8. ncbi request reprint Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression
    D C Han
    Renal-Electrolyte and Hypertension Division and Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA
    Kidney Int 59:1315-23. 2001
  9. ncbi request reprint Increased renal production of transforming growth factor-beta1 in patients with type II diabetes
    K Sharma
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Diabetes 46:854-9. 1997
  10. ncbi request reprint Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose
    A Mogyorosi
    Renal Electrolyte and Hypertension Division, Department of Medicine, and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol 275:F827-32. 1998

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Overview: combating diabetic nephropathy
    Fuad N Ziyadeh
    Renal Electrolyte and Hypertension Division, 700 Clinical Research Building, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104 6144, USA
    J Am Soc Nephrol 14:1355-7. 2003
  2. ncbi request reprint Mediators of diabetic renal disease: the case for tgf-Beta as the major mediator
    Fuad N Ziyadeh
    Penn Center for Molecular Studies of Kidney Diseases, Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Soc Nephrol 15:S55-7. 2004
    ..These studies argue strongly in support of the hypothesis that overactivity of the TGF-beta system in the kidney is a crucial mediator of diabetic renal hypertrophy and mesangial matrix expansion...
  3. pmc Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice
    F N Ziyadeh
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, PA 19104 6144, USA
    Proc Natl Acad Sci U S A 97:8015-20. 2000
    ..We conclude that chronic inhibition of the biologic actions of TGF-beta with a neutralizing monoclonal antibody in db/db mice prevents the glomerulosclerosis and renal insufficiency resulting from type 2 diabetes...
  4. ncbi request reprint The renal TGF-beta system in the db/db mouse model of diabetic nephropathy
    M P Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, USA
    Exp Nephrol 6:226-33. 1998
    ....
  5. ncbi request reprint The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy
    S Chen
    Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia 19104-6144, USA
    Ren Fail 23:471-81. 2001
    ..The data we review here strongly support the hypothesis that elevated production or activity of the TGF-beta system mediates diabetic renal hypertrophy and extracellular matrix expansion...
  6. pmc TGF-beta: a crucial component of the pathogenesis of diabetic nephropathy
    S Goldfarb
    Renal Electrolyte and Hypertension Division, and Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, 100 Centrex, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Trans Am Clin Climatol Assoc 112:27-32; discussion 33. 2001
    ..Nevertheless, it is hoped that further studies to elucidate the efficacy of novel interventions to intercept the activity of the renal TGF-beta system will prove useful for effectively halting the progression of diabetic nephropathy...
  7. pmc Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse
    S W Hong
    Renal Electrolyte and Hypertension Division of the Department of Medicine and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Pathol 158:1653-63. 2001
    ..Our findings suggest that the profibrotic effects of TGF-beta may underlie the progression to glomerulosclerosis and tubulointerstitial fibrosis that characterize diabetic nephropathy...
  8. ncbi request reprint Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression
    D C Han
    Renal-Electrolyte and Hypertension Division and Penn Center for Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA
    Kidney Int 59:1315-23. 2001
    ....
  9. ncbi request reprint Increased renal production of transforming growth factor-beta1 in patients with type II diabetes
    K Sharma
    Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Diabetes 46:854-9. 1997
    ..Increased renal TGF-beta production may be an important manifestation of diabetic kidney disease...
  10. ncbi request reprint Increased decorin mRNA in diabetic mouse kidney and in mesangial and tubular cells cultured in high glucose
    A Mogyorosi
    Renal Electrolyte and Hypertension Division, Department of Medicine, and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6144, USA
    Am J Physiol 275:F827-32. 1998
    ....
  11. ncbi request reprint Glycated albumin stimulates TGF-beta 1 production and protein kinase C activity in glomerular endothelial cells
    S Chen
    Renal-Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6144, USA
    Kidney Int 59:673-81. 2001
    ....
  12. ncbi request reprint Captopril-induced reduction of serum levels of transforming growth factor-beta1 correlates with long-term renoprotection in insulin-dependent diabetic patients
    K Sharma
    Thomas Jefferson University, Philadelphia, PA 19107, USA
    Am J Kidney Dis 34:818-23. 1999
    ..69, P = 0.03) and captopril groups (n = 21, r = -0.73, P = 0.0001). Our data suggest that captopril decreases TGF-beta1 levels in diabetic nephropathy and that changes in TGF-beta1 levels may predict the course of diabetic nephropathy...
  13. ncbi request reprint Attenuated expression of epithelial cell adhesion molecules in murine polycystic kidney disease
    M V Rocco
    Department of Medicine, University of Pennsylvania, Philadelphia 19104
    Am J Physiol 262:F679-86. 1992
    ....
  14. ncbi request reprint Evidence linking glycated albumin to altered glomerular nephrin and VEGF expression, proteinuria, and diabetic nephropathy
    Margo P Cohen
    University City Science Center, Institute of Metalboic Research, Philadelphia, Pennsylania 19104, USA
    Kidney Int 68:1554-61. 2005
    ....
  15. ncbi request reprint Angiotensin II stimulates alpha3(IV) collagen production in mouse podocytes via TGF-beta and VEGF signalling: implications for diabetic glomerulopathy
    Sheldon Chen
    Renal Electrolyte and Hypertension Division of the University of Pennsylvania, Philadelphia, PA, USA
    Nephrol Dial Transplant 20:1320-8. 2005
    ..Podocyte expression of alpha3(IV) collagen may involve the transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) systems...
  16. ncbi request reprint Podocyte-derived vascular endothelial growth factor mediates the stimulation of alpha3(IV) collagen production by transforming growth factor-beta1 in mouse podocytes
    Sheldon Chen
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4218, USA
    Diabetes 53:2939-49. 2004
    ..The TGF-beta1-stimulated endogenous VEGF may have significant implications for podocyte dysfunction in diabetic glomerulopathy, manifesting as GBM thickening and altered macromolecular permeability...
  17. ncbi request reprint Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria
    Amy Wang
    Division of Nephrology, Northwestern University, 303 E Chicago Ave, Tarry 4 755, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 293:F1657-65. 2007
    ..In conclusion, the effects of the Smad3-KO mirror the effects of anti-TGF-beta therapy in diabetes, suggesting that the chief component of TGF-beta signaling that is relevant to kidney disease is the Smad3 pathway...
  18. ncbi request reprint Regulation of inducible class II MHC, costimulatory molecules, and cytokine expression in TGF-beta1 knockout renal epithelial cells: effect of exogenous TGF-beta1
    Nazifa Banu
    Renal Electrolyte and Hypertension Division, Department of Medicine, Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Exp Nephrol 10:320-31. 2002
    ....
  19. ncbi request reprint Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells
    Motohide Isono
    Renal Electrolyte and Hypertension Division, Department of Medicine and the Penn Center for the Molecular Studies of Kidney Diseases, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, 19104 4218, Philadelphia, PA, USA
    Biochem Biophys Res Commun 296:1356-65. 2002
    ..We conclude that hyperglycemia activates the intrarenal TGF-beta/Smad signaling pathway, which then promotes mesangial matrix gene expression in diabetic nephropathy...
  20. ncbi request reprint Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes
    M Carmen Iglesias-de la Cruz
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104 4218, USA
    Kidney Int 62:901-13. 2002
    ..Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes...
  21. ncbi request reprint Cellular and molecular mechanisms of proteinuria in diabetic nephropathy
    Gunter Wolf
    Klinik fur Innere Medizin III, University of Jena, Jena, Germany
    Nephron Physiol 106:p26-31. 2007
    ..Good control of hyperglycemia and hypertension and maximal inhibition of ANG II are essential steps in preventing the development and progression of diabetic nephropathy...
  22. ncbi request reprint Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice
    Sun Hee Sung
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Soc Nephrol 17:3093-104. 2006
    ..By impeding these pathophysiologic processes, VEGF receptor inhibition by SU5416 might become a useful adjunct to anti-albuminuria therapy in diabetic nephropathy...
  23. ncbi request reprint Leptin and renal fibrosis
    Gunter Wolf
    Department of Internal Medicine III, Friedrich Schiller University, Jena, Germany
    Contrib Nephrol 151:175-83. 2006
    ..These findings collectively suggest that the kidney is a target organ for leptin and that this hormone might play an important role in renal pathophysiology...
  24. ncbi request reprint Assessment of 115 candidate genes for diabetic nephropathy by transmission/disequilibrium test
    Kathryn Gogolin Ewens
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6145, USA
    Diabetes 54:3305-18. 2005
    ..In addition, our results provide modest support for a number of candidate genes previously studied by others...
  25. ncbi request reprint Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
    ....
  26. ncbi request reprint From the periphery of the glomerular capillary wall toward the center of disease: podocyte injury comes of age in diabetic nephropathy
    Gunter Wolf
    Renal Electrolyte and Hypertension Division, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Blvd, Philadelphia, PA 19104 4218, USA
    Diabetes 54:1626-34. 2005
    ..The mainstays of therapy, glycemic control and inhibition of ANG II, are key measures to prevent early podocyte injury and the subsequent development of diabetic nephropathy...
  27. ncbi request reprint Inhibiting albumin glycation in vivo ameliorates glomerular overexpression of TGF-beta1
    Margo P Cohen
    Institute of Metabolic Research and Exocell, University City Science Center, Philadelphia, PA 19104, USA
    Kidney Int 61:2025-32. 2002
    ..Whether glycated albumin modulates glomerular TGF-beta1 expression in vivo is not known. To address this issue, we assessed glomerular TGF-beta1 expression and pathology in response to reducing the burden of glycated albumin in vivo...
  28. ncbi request reprint Albumin up-regulates the type II transforming growth factor-beta receptor in cultured proximal tubular cells
    Gunter Wolf
    Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany
    Kidney Int 66:1849-58. 2004
    ..We studied in an in vitro system using a well-defined mouse proximal tubular cell line (MCT cells) whether fatty acid-free bovine albumin modulates expression of specific receptors for TGF-beta...
  29. ncbi request reprint Cultured tubule cells from TGF-beta1 null mice exhibit impaired hypertrophy and fibronectin expression in high glucose
    Sheldon Chen
    Renal Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Kidney Int 65:1191-204. 2004
    ....
  30. ncbi request reprint Diabetic nephropathy and transforming growth factor-beta: transforming our view of glomerulosclerosis and fibrosis build-up
    Sheldon Chen
    Department of Medicine, University of Philadelphia, PA 19104, USA
    Semin Nephrol 23:532-43. 2003
    ..The data presented here strongly support the consensus that the TGF-beta system mediates the renal hypertrophy, glomerulosclerosis, and tubulointerstitial fibrosis of diabetic kidney disease...
  31. ncbi request reprint Why should an angiogenic factor modulate tubular structure in diabetic nephropathy? Some answers, more questions
    Fuad N Ziyadeh
    Kidney Int 64:758-9. 2003
  32. ncbi request reprint Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice
    Sheldon Chen
    Renal Electrolyte and Hypertension Division, Penn Center for the Molecular Studies of Kidney Diseases, Department of Medicine, University of Pennsylvania, 700 Clinical Research Building, 415 Curie Boulevard, Philadelphia 19104, USA
    Biochem Biophys Res Commun 300:16-22. 2003
    ..Anti-TGF-beta regimens would be useful in the treatment of diabetic nephropathy...

Research Grants15

  1. AMADORI-MODIFIED ALBUMIN IN DIABETIC NEPHROPATHY
    Fuad Ziyadeh; Fiscal Year: 2002
    ....
  2. TUBULOINTERSTITIAL KIDNEY CELLS AND RESPONSE TO GLUCOSE
    Fuad Ziyadeh; Fiscal Year: 2000
    ..These studies should provide a detailed mechanistic understanding of the untoward effects of hyperglycemia in diabetic nephropathy that may lead to novel therapeutic interventions even in the face of suboptimal glycemic control. ..
  3. TUBULOINTERSTITIAL KIDNEY CELLS & REPONSE TO GLUCOSE
    Fuad Ziyadeh; Fiscal Year: 1993
    ..The results of these studies should provide new insights into the effects of hyperglycemia on the ultimate progression of renal failure in diabetes with a particular emphasis on the effects of altered matrix synthesis...
  4. Angiotensin II, TGF-beta, and the podocyte in diabetes
    Fuad Ziyadeh; Fiscal Year: 2006
    ..Selectively ablating the ability of glomerular podocytes to respond to each of these relevant stimuli will allow us to dissect the relative contribution of these systems to podocyte dysfunction in diabetes. ..