Research Topics
Genomes and GenesSpecies | Elad ZivSummaryAffiliation: University of California Country: USA Publications
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Publications
Genetics of breast cancer: applications to the Mexican populationElad Ziv
Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics, San Francisco, California, USA
Salud Publica Mex 53:415-9. 2011..The pace of discovery is accelerating as genetic technology and computational methods improve. These discoveries will change the way that breast cancer risk is understood in Mexico over the next few decades...
Genetic variation in insulin/IGF-1 signaling pathways and longevityElad Ziv
Department of Medicine, Institute for Human Genetics, Helen Diller Comprehensive Cancer Center, University of California, San Francisco, 94143 3116, United States
Ageing Res Rev 10:201-4. 2011..One gene, FOXO3A, a transcriptional factor homologous to daf-16, has been repeatedly associated with increased lifespan in several studies in different ethnic populations...- Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay AreaElad Ziv
Division of General Internal Medicine, University of California San Francisco, Box 1732, San Francisco, CA 94143, USA
Cancer Epidemiol Biomarkers Prev 15:1878-85. 2006..We reasoned that if genetic ancestry is associated with known breast cancer risk factors, then the results of genetic association studies would be confounded... 
Ancestry-related assortative mating in Latino populationsNeil Risch
Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Genome Biol 10:R132. 2009..While spouse correlations have been documented for numerous traits, no prior studies have assessed assortative mating for genetic ancestry in admixed populations...- Population stratification confounds genetic association studies among LatinosShweta Choudhry
University of California, San Francisco, 94143-0833, USA
Hum Genet 118:652-64. 2006..Our findings suggest that empirical assessment of the effects of stratification is critical to appropriately interpret the results of case-control studies in admixed populations... - Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthmaHarriet Corvol
Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
Pharmacogenet Genomics 19:489-96. 2009..Therefore, we reasoned that interactions between the IL6 and IL6R genes might be associated with bronchodilator drug responsiveness to albuterol in asthmatic patients... - Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmaticsKeyan Salari
Department of Medicine, University of California, San Francisco, California 94143-1732, USA
Genet Epidemiol 29:76-86. 2005..These results suggest that asthma severity may be influenced by genetic factors differentiating Europeans and Native Americans in Mexican Americans, although differing results for Puerto Ricans require further investigation... - CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthmaShweta Choudhry
University of California San Francisco, DNA Bank Lung Biology Center, San Francisco General Hospital, Bldg 30, 5th Floor, Room 3501H, 1001 Potrero Avenue, San Francisco, CA 94110, USA
Am J Respir Crit Care Med 172:173-82. 2005..A recent family-based genomewide screen revealed linkage between the 5q31 region and the diagnosis of asthma, but only in those exposed to environmental tobacco smoke (ETS). Among the candidate genes in this region is CD14... - Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthmaShweta Choudhry
University of California San Francisco, San Francisco, CA 94143 0833, USA
Am J Respir Crit Care Med 171:563-70. 2005..We tested the association of beta(2)AR genotypes with asthma severity and bronchodilator response to albuterol in Puerto Ricans and Mexicans with asthma... - European ancestry is positively associated with breast cancer risk in Mexican womenLaura Fejerman
Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics, University of California, San Francisco, California, USA
Cancer Epidemiol Biomarkers Prev 19:1074-82. 2010.... - Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US LatinasLaura Fejerman
Department of Medicine, Division of General Internal Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94158, USA
Hum Mol Genet 21:1907-17. 2012..Fine-mapping within the 6q25 and possibly the 11p15 loci will lead to the discovery of the biologically functional variant/s behind this association... - Genetic ancestry and risk of breast cancer among U.S. LatinasLaura Fejerman
Division of General Internal Medicine and Lung Biology Center, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
Cancer Res 68:9723-8. 2008..39; 95% CI, 1.06-2.11; P=0.013). Further work is needed to determine if the association is due to genetic differences between populations or possibly due to environmental factors not measured... - The Association of African Ancestry and elevated creatinine in the Coronary Artery Risk Development in Young Adults (CARDIA) StudyCarmen A Peralta
Department of Medicine, University of California San Francisco, USA
Am J Nephrol 31:202-8. 2010..05 (4.81-17.02) for black men with >80% African ancestry. Genetic factors common to African ancestry may be associated with increased risk of early kidney dysfunction in a young, healthy population, particularly among black men... - Ancestry-environment interactions and asthma risk among Puerto RicansShweta Choudhry
University of California, San Francisco, San Francisco, CA 94143-2911, USA
Am J Respir Crit Care Med 174:1088-93. 2006..CONCLUSIONS: The observed interaction may help to explain the unique pattern of risk for asthma in Puerto Ricans and the lack of association with SES observed in previous studies when not accounting for varying proportions of ancestry... - Dissecting complex diseases in complex populations: asthma in latino americansShweta Choudhry
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 2911, USA
Proc Am Thorac Soc 4:226-33. 2007.... - Comparison of three methods to estimate genetic ancestry and control for stratification in genetic association studies among admixed populationsHui Ju Tsai
Department of Medicine, University of California, Box 0833, San Francisco, CA, 94143 0833, USA
Hum Genet 118:424-33. 2005..These simulations are meant to provide some practical guidelines for investigators conducting association studies in admixed populations... - Are breast density and bone mineral density independent risk factors for breast cancer?Karla Kerlikowske
Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
J Natl Cancer Inst 97:368-74. 2005..We determined whether mammographic breast density and BMD of the hip and spine are correlated and independently associated with breast cancer risk... - Mammographic breast density and the Gail model for breast cancer risk prediction in a screening populationJeffrey A Tice
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, CA 94143 1732, USA
Breast Cancer Res Treat 94:115-22. 2005..Although the current standard, the Gail model, is well calibrated in populations, it performs poorly for individuals. Mammographic breast density (BD) may improve the predictive accuracy of the Gail model... - Genome-wide screen for asthma in Puerto Ricans: evidence for association with 5q23 regionShweta Choudhry
Institute for Human Genetics, University of California, San Francisco, CA, USA
Hum Genet 123:455-68. 2008..3 region. Our results provide strong evidence that the previously linked 5q23 region is associated with asthma in Puerto Ricans. The detection of causative variants in this region will require fine mapping and functional validation... - The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injuryKirsten Neudoerffer Kangelaris
Department of Medicine, Division of General Internal Medicine, University of California, San Francisco, San Francisco, CA 94143 0131, USA
Chest 141:1160-9. 2012..We sought to determine the effect of the functional rs2814778 polymorphism, C/C genotype (Duffy null state), on clinical outcomes in African Americans with acute lung injury... - Clinical and biomarker predictors of side effects from tamoxifenWendy Lorizio
Division of General Internal Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
Breast Cancer Res Treat 132:1107-18. 2012..The association between endoxifen levels and side effects is consistent with the data that suggest that endoxifen is the most highly active metabolite of tamoxifen... - Latino populations: a unique opportunity for the study of race, genetics, and social environment in epidemiological researchEsteban Gonzalez Burchard
Department of Medicine, University of California, San Francisco, CA 94143 0833, USA
Am J Public Health 95:2161-8. 2005.... - Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthmaEsteban Gonzalez Burchard
University of California, San Francisco, 94143 0833, USA
Am J Respir Crit Care Med 169:386-92. 2004..We conclude that Puerto Ricans with asthma respond less to albuterol than do Mexicans with asthma. These findings underscore the need for additional research on racial/ethnic differences in asthma morbidity and response to therapy... - Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevityLudmila Pawlikowska
Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
Aging Cell 8:460-72. 2009..35, 95%CI = 1.15-1.57, adjusted P = 0.0093). These results demonstrate that common variants in several genes in the insulin/IGF1 pathway are associated with human lifespan... - Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition StudyDonglei Hu
Department of Medicine, University of California at San Francisco, San Francisco, California, USA
J Am Geriatr Soc 57:1213-8. 2009..To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults... - Admixture-matched case-control study: a practical approach for genetic association studies in admixed populationsHui Ju Tsai
Department of Medicine, Study of African American, Asthma, Genes and Environments, SAGE, University of California, 0833, San Francisco, 94143 0833, USA
Hum Genet 118:626-39. 2006..Our present work demonstrates that admixture-matched case-control strategies can efficiently control population stratification confounding in admixed populations... - Mammographic density and estrogen receptor status of breast cancerElad Ziv
Department of Medicine, University of California at San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 04115, USA
Cancer Epidemiol Biomarkers Prev 13:2090-5. 2004..We determined if mammographic density is associated more strongly with ER-positive breast cancer than with ER-negative breast cancer... - Estimation of tamoxifen metabolite concentrations in the blood of breast cancer patients through CYP2D6 genotype activity scoreAlan H B Wu
Department of Laboratory Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
Breast Cancer Res Treat 133:677-83. 2012..If endoxifen levels are confirmed to be predictive of tamoxifen benefit, then this algorithm may be helpful to determine which women warrant endoxifen testing... - An admixture scan in 1,484 African American women with breast cancerLaura Fejerman
Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California 94143, USA
Cancer Epidemiol Biomarkers Prev 18:3110-7. 2009..However, we found little evidence that genetic ancestry at any one region contributes significantly to breast cancer risk or hormone receptor status... - African ancestry, socioeconomic status, and kidney function in elderly African Americans: a genetic admixture analysisCarmen A Peralta
Department of Medicine, University of California at San Francisco, San Francisco, California 94124, USA
J Am Soc Nephrol 17:3491-6. 2006..Rather, kidney dysfunction in elderly African Americans seems more attributable to differences in environmental and social factors... - Confounding in genetic association studies and its solutionsDonglei Hu
Institute for Human Genetics, Comprehensive Cancer Center, Department of Medicine, University of California San Francisco, San Francisco, California, USA
Methods Mol Biol 448:31-9. 2008..Confounding can be detected and adjusted. Major methods that adjust for population stratification are described and explained in this chapter. Their advantages and disadvantages are discussed... - ADAM33 is not associated with asthma in Puerto Rican or Mexican populationsDenise L Lind
University of California at San Francisco, San Francisco, CA 94143-0833, USA
Am J Respir Crit Care Med 168:1312-6. 2003..We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans... - Development of a panel of genome-wide ancestry informative markers to study admixture throughout the AmericasJoshua Mark Galanter
University of California San Francisco, San Francisco, California, United States of America
PLoS Genet 8:e1002554. 2012.... - Population differences in breast cancer severityLaura Fejerman
Division of General Internal Medicine, Department of Medicine, Institute for Human Genetics and Helen Diller Family Comprehensive Cancer Center at UCSF, 2200 Post Street, San Francisco, CA 94143 1732, USA
Pharmacogenomics 9:323-33. 2008..Studies evaluating the risk for particular tumor subtypes combining genetic and environmental variables and analyzing cases from different populations are needed to understand population differences in the severity of breast cancer... - Methylenetetrahydrofolate reductase C677T polymorphism and cognitive function in older womenJacob S Elkins
Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
Am J Epidemiol 166:672-8. 2007..035). Although the strength of the observed associations was modest, these results lend some support to the theory that an elevated homocysteine level contributes to cognitive decline... - The importance of race and ethnic background in biomedical research and clinical practiceEsteban Gonzalez Burchard
Lung Biology Center, University of California, San Francisco, CA 94143 0833, USA
N Engl J Med 348:1170-5. 2003 - History shaped the geographic distribution of genomic admixture on the island of Puerto RicoMarc Via
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e16513. 2011..More generally, our results demonstrate the importance of incorporating social and geographic data with genetics when studying contemporary admixed populations... - Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition studyChristina L Wassel Fyr
Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 1015, USA
Hum Genet 121:615-24. 2007..The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin... - Human population structure and genetic association studiesElad Ziv
Division of General Internal Medicine and Division of Pulmonary Medicine, Department of Medicine, University of California, San Francisco, CA 94115, USA
Pharmacogenomics 4:431-41. 2003..Unlinked genetic markers may be used to detect confounding in association studies. In addition, the information from unlinked markers may be used to adjust genetic associations... - The genetics of human longevityWarren S Browner
California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
Am J Med 117:851-60. 2004..Despite the challenges in study design and analysis that face investigators in this area, the identification of genetic pathways that regulate longevity may suggest potential targets for therapy... - No association between the TGF-beta 1 Leu10Pro polymorphism and osteoporosis among white women in the United StatesElad Ziv
Department of Medicine, University of California, San Francisco, San Francisco, California, USA
Am J Med 114:227-31. 2003 - CD36 repression activates a multicellular stromal program shared by high mammographic density and tumor tissuesRosa Anna DeFilippis
Department of Pathology, Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Cancer Discov 2:826-39. 2012..Levels of CD36 and extent of mammographic density are both modifiable factors that provide potential for intervention... - Mammographic breast density and family history of breast cancerElad Ziv
Division of General Internal Medicine and Department of Medicine, University of California, San Francisco, USA
J Natl Cancer Inst 95:556-8. 2003..37, 95% confidence interval [CI] = 0.96 to 1.89; BI-RADS 3, OR = 1.70, 95% CI = 1.19 to 2.40; BI-RADS 4, OR = 1.70, 95% CI = 1.05 to 2.71). Thus, the genetic factors that determine breast density may determine breast cancer risk... - Pharmacogenetic testing affects choice of therapy among women considering tamoxifen treatmentWendy Lorizio
Division of General Internal Medicine, Department of Medicine, University of California San Francisco, 1545 Divisadero Street, Suite 322, San Francisco, CA 94143 0320, USA
Genome Med 3:64. 2011..We evaluated the effect of CYP2D6 testing in clinical practice to determine whether genotype results affected choice of hormone therapy in a prospective cohort study... - Potential public health impact of new tuberculosis vaccinesElad Ziv
University of California-San Francisco, San Francisco, California, USA
Emerg Infect Dis 10:1529-35. 2004..Even widely deployed and highly effective (50%-90% efficacy) pre- or postexposure vaccines would only be able to reduce the number of TB cases by one third. We discuss the health policy implications of our analyses... - Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health StudyLucia A Hindorff
Department of Epidemiology, University of Washington, Seattle, WA, United States
Atherosclerosis 197:922-30. 2008..If confirmed, CRP genetic variants may be weakly associated with CV and non-CV mortality in older adults, particularly in self-identified blacks... - Comparing genetic ancestry and self-described race in african americans born in the United States and in AfricaRona Yaeger
Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York, USA
Cancer Epidemiol Biomarkers Prev 17:1329-38. 2008..Genetic classifications of ancestry may provide a more objective and accurate method of defining homogenous populations for the investigation of specific population-disease associations... - Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health StudyAlexander P Reiner
Department of Epidemiology, University of Washington, Seattle, WA 98101 1448, USA
Am J Hum Genet 76:463-77. 2005..Complementary methods that identify discrete subgroups on the basis of genetic similarity may help to further characterize the complex biodemographic structure of human populations... - Association of estrogen receptor alpha polymorphisms with breast cancer risk in older Caucasian womenFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
Int J Cancer 116:984-91. 2005..60 vs. 1.12 for nulliparous vs. parous women; interaction p = 0.03). ESR1 polymorphisms in combination with lifestyle factors may be associated with breast cancer risk in older Caucasian women... - Estrogen metabolizing polymorphisms and breast cancer risk among older white womenFrancesmary Modugno
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA
Breast Cancer Res Treat 93:261-70. 2005..To investigate breast cancer risk according to metabolizing genes polymorphisms in older women... - Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian womenJun Wang
Human Genetics Department, Roche Molecular Systems, Inc, 1145 Atlantic Ave, Alameda, CA 94555, USA
Breast Cancer Res Treat 106:273-80. 2007..001% in cases and controls). No other statistically significant associations were observed between ESR1 haplotypes from the same four SNPs and the risk of breast cancer in older Caucasian women... - Genetic ancestry, population sub-structure, and cardiovascular disease-related traits among African-American participants in the CARDIA StudyAlexander P Reiner
Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195, USA
Hum Genet 121:565-75. 2007..These results demonstrate the potential for confounding of genetic associations with some cardiovascular disease-related traits in large studies involving US African-Americans... - Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levelsDavid Reich
Department of Genetics, Harvard Medical School, New Research Building, Boston, MA 02115, USA
Am J Hum Genet 80:716-26. 2007..0x10-12 for IL-6 SR, and P<2.0x10-9 for IL-6. These results also serve as an important proof of principle, showing that admixture mapping can not only coarsely localize but can also fine map a phenotypically important variant... - Tracing sub-structure in the European American population with PCA-informative markersPeristera Paschou
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
PLoS Genet 4:e1000114. 2008..Furthermore, our redundancy removal algorithm can be applied on sets of ancestry informative markers selected with any method in order to select the most uncorrelated SNPs, and significantly decreases genotyping costs... - Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studiesMichael A Nalls
Laboratory of Epidemiology, Demography and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892, USA
Am J Hum Genet 82:81-7. 2008..Additional studies are needed to determine the biological mechanism for this effect and its clinical implications... - Categorization of humans in biomedical research: genes, race and diseaseNeil Risch
Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 5120, USA
Genome Biol 3:comment2007. 2002..An epidemiologic perspective on the issue of human categorization in biomedical and genetic research strongly supports the continued use of self-identified race and ethnicity... - PCA-correlated SNPs for structure identification in worldwide human populationsPeristera Paschou
Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupoli, Greece
PLoS Genet 3:1672-86. 2007....
Research Grants
- Admixture Mapping for Breast Cancer in LatinasElad Ziv; Fiscal Year: 2007..The total population that will be available for analysis will include 1000 Latina cases and 1000 controls. ..
- Breast Cancer, Breast Density & Admixture Among LatinasElad Ziv; Fiscal Year: 2006..In addition, this project will test the feasibility of using the increased linkage disequilibrium in admixed populations to identify genetic variations associated with breast cancer among Latinas. ..
- Admixture Mapping for Breast Cancer in LatinasElad Ziv; Fiscal Year: 2010..The total population that will be available for analysis will include 1000 Latina cases and 1000 controls. ..