Research Topics
| S ZisookSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
The bereavement exclusion and DSM-5Sidney Zisook
Department of Psychiatry, University of California, San Diego, CA 92093, USA
Depress Anxiety 29:425-43. 2012....
Depressive symptom patterns in patients with chronic schizophrenia and subsyndromal depressionSidney Zisook
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Schizophr Res 86:226-33. 2006..The purpose of this study is to learn more about the occurrence, pattern of symptoms and associated features of subsyndromal depressive symptoms in patients with chronic schizophrenia or schizoaffective disorder...
Clinical correlates of the worsening or emergence of suicidal ideation during SSRI treatment of depression: an examination of citalopram in the STAR*D studySidney Zisook
Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, California, USA
J Affect Disord 117:63-73. 2009..The purpose of this study was to determine whether, and in whom, treatment of MDD is associated with increased or emergent SI...
Sequenced Treatment Alternatives to Relieve Depression (STAR*D): lessons learnedSidney Zisook
Department of Psychiatry, UCSD, La Jolla, CA 92093, USA
J Clin Psychiatry 69:1184-5. 2008
Teaching psychopharmacology: what works and what doesn'tSidney Zisook
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
J Clin Psychopharmacol 28:96-100. 2008....
Factors that differentiate early vs. later onset of major depression disorderSidney Zisook
Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, 9500 Gilman Dr, 0603R, La Jolla, CA 92093, USA
Psychiatry Res 129:127-40. 2004..Thus, pre-adulthood onset MDD is a particularly severe and chronic condition...
Subsyndromal depressive symptoms in middle-aged and older persons with schizophreniaSidney Zisook
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
Am J Geriatr Psychiatry 15:1005-14. 2007....
Effect of age at onset on the course of major depressive disorderSidney Zisook
Department of Psychiatry, University of California, San Diego, CA 92093, USA
Am J Psychiatry 164:1539-46. 2007..This report assesses whether age at onset defines a specific subgroup of major depressive disorder in 4,041 participants who entered the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study...
Alternate methods of teaching psychopharmacologySidney Zisook
University of California San Diego School of Medicine, 9500 Gillman Dr, 0603R, La Jolla, California 92093, USA
Acad Psychiatry 29:141-54. 2005....
Psychiatry residency training around the worldSidney Zisook
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Acad Psychiatry 31:309-25. 2007..The authors compare and contrast psychiatry residency training in the United States to that in Canada and selected countries in South America, Europe, and Asia...
Is bereavement-related depression different than non-bereavement-related depression?Sidney Zisook
Department of Psychiatry, University of California, San Diego, CA 92093, USA
Psychol Med 37:779-94. 2007....
Preadult onset vs. adult onset of major depressive disorder: a replication studyS Zisook
Department of Psychiatry, University of California, San Diego, San Diego VA Medical Center, San Diego, CA, USA
Acta Psychiatr Scand 115:196-205. 2007..This study seeks to replicate these findings...
Psychopharmacology curriculum field testSidney Zisook
Department of Psychiatry at University of California, 0603 R, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
Acad Psychiatry 33:358-63. 2009..This article describes the module, its development, and the results of a field trial to test its feasibility and usefulness...
Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trialSidney Zisook
Department of Psychiatry, University of California San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
J Clin Psychiatry 71:915-22. 2010..To examine the effects of citalopram augmentation of antipsychotics on suicidal ideation in middle-aged and older people with schizophrenia and subthreshold depressive symptoms...
Do psychiatry residents identify as psychotherapists? A multisite surveyNicole M Lanouette
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 9116, USA
Ann Clin Psychiatry 23:30-9. 2011..We examined psychiatry residents' attitudes towards learning psychotherapy, practicing psychotherapy in the future, and overall identification as psychotherapists...
Treatment of major depression in HIV-seropositive men. HIV Neurobehavioral Research Center GroupS Zisook
University of California, San Diego, La Jolla 92093 0603, USA
J Clin Psychiatry 59:217-24. 1998..C.2) who had been diagnosed with major depressive disorder (DSM-III-R)...
Depression in late life. Diagnosis, course, and consequencesS Zisook
Department of Psychiatry, University of California, San Diego, School of Medicine 92093, USA
Postgrad Med 100:143-8, 150, 156. 1996....
PTSD following bereavementS Zisook
University of California, San Diego, La Jolla 92093 0603, USA
Ann Clin Psychiatry 10:157-63. 1998..The results suggested that PTSD may occur after bereavement, and, by extension, other stressors not recognized by official diagnostic systems. The "A" criterion needs further examination...
Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trialSidney Zisook
University of California, San Diego, Department of Psychiatry, San Diego, CA 92161, USA
J Clin Psychiatry 70:562-71. 2009..We describe a randomized placebo-controlled trial of citalopram in 198 patients...
Depressive symptoms in schizophreniaS Zisook
Department of Psychiatry, University of California, San Diego, and the San Diego VA Healthcare System, 92161, USA
Am J Psychiatry 156:1736-43. 1999....
Nefazodone in patients with treatment-refractory posttraumatic stress disorderS Zisook
Department of Psychiatry, University of California San Diego, La Jolla 92093 0603, USA
J Clin Psychiatry 61:203-8. 2000..e., intrusive recollections, avoidance/numbing, and hyperarousal). This open-label study evaluated the use of nefazodone in a group of Vietnam veterans with chronic, treatment-refractory symptoms of PTSD...
Psychiatric residents' interest in psychotherapy and training stage: a multi-site surveySidney Zisook
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, 116A, La Jolla, CA 92093 116A, USA
Am J Psychother 65:47-59. 2011..Most psychiatric residents enter training intent on learning both psychopharmacologic and psychotherapeutic interventions. After graduation, however, many emphasize pharmacotherapy over psychotherapy...
Effect of antidepressant medication treatment on suicidal ideation and behavior in a randomized trial: an exploratory report from the Combining Medications to Enhance Depression Outcomes StudySidney Zisook
VA Healthcare System, San Diego, CA 92161, USA
J Clin Psychiatry 72:1322-32. 2011..To explore relationships between baseline sociodemographic and clinical features and baseline suicidal ideation, and treatment effects on suicidal ideation and behavior, in depressed outpatients...
Depression in late life. Special considerations in treatmentS Zisook
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla 92093, USA
Postgrad Med 100:161-2, 165-7, 171-2. 1996..Treatment must be geared toward not only helping patients get well but helping them keep well...
A placebo-controlled randomized clinical trial of nortriptyline for chronic low back painJ H Atkinson
Department of Psychiatry, San Diego VA Healthcare System, CA 92161, USA
Pain 76:287-96. 1998..This modest reduction in pain intensity suggests that physicians should carefully weigh the risks and benefits of nortriptyline in chronic back pain without depression...
Bupropion sustained release for bereavement: results of an open trialS Zisook
Department of Psychiatry, University of California San Diego, La Jolla 92093, USA
J Clin Psychiatry 62:227-30. 2001..The present study was conducted to assess whether DSM-IV-defined bereavement responds to bupropion sustained release (SR)...
Association of depressive symptoms with worse functioning in schizophrenia: a study in older outpatientsH Jin
Department of Psychiatry, University of California, and VA San Diego Healthcare System, 92161, USA
J Clin Psychiatry 62:797-803. 2001..Effectiveness of adjunct treatment of depressive symptoms with antidepressants and psychosocial management in improving functioning of schizophrenia patients deserves further study...
Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensityJ H Atkinson
Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
Pain 83:137-45. 1999..These results suggest that at standard dosages noradrenergic agents may provide more effective analgesia in back pain than do selective serotonergic reuptake inhibitors...
A comparison of community-dwelling older schizophrenia patients by residential statusL A Auslander
Department of Psychiatry, University of California, San Diego, CA, USA
Acta Psychiatr Scand 103:380-6. 2001..CONCLUSION: Among schizophrenia out-patients, one needs to consider residential status in evaluating heterogeneity in cognitive performance or quality of wellbeing...
Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trialEdward S Friedman
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
Depress Anxiety 26:612-21. 2009..But nonresponse can include depression that worsened over the course of treatment, an outcome that has received scant attention...
An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorderJ C Gillin
University of California and VA San Diego Healthcare System, 92161, USA
J Clin Psychiatry 62:789-96. 2001..To our knowledge, this is the first polysomnographic study of treatment in patients with PTSD...
Does pretreatment insomnia or anxiety predict acute response to bupropion SR?A John Rush
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390 9086, USA
Ann Clin Psychiatry 17:1-9. 2005..This retrospective analysis was conducted to determine whether pretreatment levels of insomnia or anxiety were associated with likelihood of or time to antidepressant response with bupropion sustained release (SR)...
Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D reportDiane Warden
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9086, USA
Am J Psychiatry 164:1189-97. 2007..The purpose of this study was to identify the pretreatment predictors of attrition during acute treatment with citalopram in a large, "real world" clinical trial...
Depression in the context of human immunodeficiency virus infection: implications for treatmentS Hintz
Department of Psychiatry, University of California, San Diego
J Clin Psychiatry 51:497-501. 1990..Among the HIV-positive patients, the asymptomatic group had a better response to treatment with antidepressant medications than either the ARC or AIDS patient groups...
Depression outcomes of Spanish- and english-speaking Hispanic outpatients in STAR*DIra Lesser
Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Psychiatr Serv 59:1273-84. 2008....
Challenges and opportunities in teaching psychopharmacology during residency trainingSidney Zisook
University of California, San Diego, California, USA
J Clin Psychiatry 66:948. 2005
Anxious depression: clinical features and treatmentSanjai Rao
University of California, San Diego, 3350 La Jolla Village Drive 116A, San Diego, CA 92161, USA
Curr Psychiatry Rep 11:429-36. 2009..Well-conceived, randomized controlled treatment trials are necessary to make further gains in the management of patients with anxious depression...
Psychiatric residents' views of quality of psychotherapy training and psychotherapy competencies: a multisite surveyChristina Calabrese
University of California, San Francisco, Psychiatry, 401 Parnassus Ave, Box 0984 F, San Francisco, CA 94143, USA
Acad Psychiatry 34:13-20. 2010..The authors examined residents' perceptions of the quality of their training, support for training, their own competence levels, and associations between self-perceived competence and perceptions of the training environment...
Is there a therapeutic window with some antidepressants for analgesic response?J Hampton Atkinson
VA San Diego Healthcare System, 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, USA
Curr Pain Headache Rep 13:93-9. 2009..This article reviews the strengths, limitations, and potential of therapeutic drug monitoring of antidepressants and anticonvulsants as analgesics for selected chronic pain syndromes...
Suicide among patients with schizophrenia: a consideration of risk and protective factorsLori P Montross
University of California San Diego, Department of Psychiatry, Division of Geriatric Psychiatry, San Diego, CA 92161, USA
Ann Clin Psychiatry 17:173-82. 2005..This review serves to expand on the literature pertaining to suicide risk factors by additionally outlining how protective factors may shield against suicide within this unique patient population...
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trialJ Hampton Atkinson
Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA 92161, USA
J Clin Psychopharmacol 27:135-42. 2007....
The influence of HIV-related support groups on survival in women who lived with HIV. A pilot studyJ Summers
University of California, Berkeley UCB School of Social Welfare, USA
Psychosomatics 41:262-8. 2000..0002). Factors related to group participation and ways in which support groups might promote longevity are discussed...
Is unrecognized bipolar disorder a frequent contributor to apparent treatment resistant depression?R Correa
Department of Psychiatry, University of California San Diego UCSD, USA
J Affect Disord 127:10-8. 2010..This review attempts to assess the degree to which prevailing empirical data supports that view...
Treatment outcomes for older depressed patients with earlier versus late onset of first depressive episode: a Sequenced Treatment Alternatives to Relieve Depression (STAR*D) reportF Andrew Kozel
Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Am J Geriatr Psychiatry 16:58-64. 2008..In this study of older depressed outpatients, the authors evaluated whether the age at onset of the first major depressive episode (MDE) was related to clinical outcomes...
Suicidal ideation and suicide attempts among middle-aged and older patients with schizophrenia spectrum disorders and concurrent subsyndromal depressionLori P Montross
Argosy University, San Diego Campus, Psychology Program, San Diego, California, USA
J Nerv Ment Dis 196:884-90. 2008..The impact of hopelessness and general psychopathology, as well as the insignificance of demographic characteristics and medical illness severity warrant further investigation...
Psychopharmacologic approaches to the borderline patientS Zisook
University of California, San Diego, La Jolla 92093
Hillside J Clin Psychiatry 10:55-70. 1988..The importance of looking for and recognizing drug treatable syndromes within the wide array of patients who satisfy DSM-III criteria for Borderline Disorders is discussed...
Use of bupropion in combination with serotonin reuptake inhibitorsSidney Zisook
Department of Psychiatry, University of California, San Diego, La Jolla, USA
Biol Psychiatry 59:203-10. 2006..Additional randomized controlled studies are needed to answer important questions, such as those regarding optimal dose and duration of treatment...
Depression and grief reactions in hospice caregivers: from pre-death to 1 year afterwardsYulia Chentsova-Dutton
Department of Psychiatry, University of California at San Diego and VA Healthcare Systems, 0603-R, 9500 Gilman Drive, La Jolla, CA 92093-0603, USA
J Affect Disord 69:53-60. 2002..LIMITATIONS: The large dropout rate, reliance on self-report ratings and demographically homogeneous sample may limit generalizability of findings...
The challenge of teaching psychopharmacology in the new millennium: the role of curriculaIra D Glick
Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine, Stanford, California, USA
Acad Psychiatry 29:134-40. 2005....
Depression in Asian-American and Caucasian undergraduate studentsChristina B Young
Department of Psychology, University of California, San Diego, La Jolla, CA, United States
J Affect Disord 125:379-82. 2010..Little is known about ethnic differences in prevalence of depression in US college campuses. This study compares depression severity in Asian-American and Caucasian undergraduate students at the University of California San Diego (UCSD)...
Subthreshold depression and successful aging in older womenIpsit V Vahia
Department of Psychiatry, University of California, San Diego, CA, USA
Am J Geriatr Psychiatry 18:212-20. 2010....
Late-life depression. How to identify its symptoms and provide effective treatmentJeremy A Sable
Department of Psychiatry, University of California, San Diego, USA
Geriatrics 57:18-9, 22-3, 26 passim. 2002..Older patients may respond more slowly to treatment than younger patients and may more readily experience chronicity and recurrence...
Rationale for a posttraumatic stress spectrum disorderCharles Moreau
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0603 R, USA
Psychiatr Clin North Am 25:775-90. 2002..The future undoubtedly will bring a refinement of the current understanding of PTSD and improved treatments...
The challenge of teaching psychopharmacology and improving clinical practiceIra D Glick
J Clin Psychopharmacol 25:203-5. 2005
Gender, AIDS, and bereavement: a comparison of women and men living with HIVJacquelyn Summers
Department of Psychology, The University of Auckland, Auckland, New Zealand
Death Stud 28:225-41. 2004..It is critical that adequate mental health support services be available to this growing risk group of bereaved individuals...
Functioning in middle aged and older patients with schizophrenia and depressive symptoms: relationship to psychopathologyJohn Kasckow
VA Pittsburgh Health Care System MIRECC and Behavioral Health Service 7180 Highland Dr, Pittsburgh, PA 15206, USA
Am J Geriatr Psychiatry 16:660-3. 2008..Depressive symptoms are common in middle aged and older patients with schizophrenia. The authors hypothesized that worse functioning in these patients would be associated with worse psychopathology...
Clinical differences among depressed patients with and without a history of suicide attempts: findings from the STAR*D trialCynthia A Claassen
Department of Psychiatry and Division of Clinical Psychology, University of Texas Southwestern Medical School, Dallas, Texas 75235 9119, United States
J Affect Disord 97:77-84. 2007....
Difference in treatment outcome in outpatients with anxious versus nonanxious depression: a STAR*D reportMaurizio Fava
Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 165:342-51. 2008..The authors conducted a secondary data analysis to compare antidepressant treatment outcomes for patients with anxious and nonanxious major depression in Levels 1 and 2 of the STAR*D study...
Does bereavement-related major depression differ from major depression associated with other stressful life events?Kenneth S Kendler
Departments of Psychiatry and Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
Am J Psychiatry 165:1449-55. 2008..A depressive episode that is bereavement-related and has clinical features and course characteristic of normal grief is not diagnosed as major depression. This study evaluates the empirical validity of this exclusion criterion...
Improving the pedagogy associated with the teaching of psychopharmacologyIra D Glick
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
Acad Psychiatry 31:211-7. 2007..The focus was on whether "improving the teaching-learning process" in psychiatric residency programs could improve clinical practice...
Insight in schizophrenia: a review of etiological models and supporting researchKaterine Osatuke
Cincinnati VA Medical Center, Cincinnati, OH, USA
Compr Psychiatry 49:70-7. 2008
Adaptation to bereavementYulia Chentsova Dutton
Department of Psychology, Stanford University, Building 420, Jordan Hall, Stanford, CA 94305, USA
Death Stud 29:877-903. 2005..Each dimension of adaptation is illustrated with quotes from participants of the San Diego Widowhood Study...
Research Grants
- Citalopram Augmentation in Older Schizophrenia PatientsSidney Zisook; Fiscal Year: 2005....
- 4/4-Optimizing Treatment of Complicated GriefSidney Zisook; Fiscal Year: 2010..We will explore mediator and moderator hypotheses to answer questions about how these treatments work and who might benefit most from each approach. Answers to these questions have important public health significance. ..
