Danny Zipris

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations
    Danny Zipris
    Program in Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3592-602. 2003
  2. ncbi TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:693-701. 2007
  3. ncbi TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:131-42. 2005
  4. ncbi Innate immune pathways in virus-induced autoimmune diabetes
    Anjali Nair
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1150:139-42. 2008
  5. ncbi Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes
    Rita Bortell
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1150:112-22. 2008
  6. ncbi The role of Toll-like receptor pathways in the mechanism of type 1 diabetes
    Egil Lien
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Mol Med 9:52-68. 2009
  7. ncbi A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats
    Danny Zipris
    The Institute of Endocrinology, Diabetes, and Metabolism, Rambam Medical Center B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    JOP 3:76-82. 2002
  8. ncbi Innate immunity and its role in type 1 diabetes
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 15:326-31. 2008

Research Grants

  1. Modulation of CD4+cd25+ Cells in Autoimmune Diabetes
    Danny Zipris; Fiscal Year: 2004

Collaborators

Detail Information

Publications8

  1. ncbi Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations
    Danny Zipris
    Program in Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3592-602. 2003
    ....
  2. ncbi TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:693-701. 2007
    ..Our data implicate the TLR9-signaling pathway in KRV-induced innate immune activation and autoimmune diabetes in the BBDR rat...
  3. ncbi TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:131-42. 2005
    ..Our results suggest that the degree to which the innate immune system is activated by TLRs is important for expression of virus-induced diabetes in genetically susceptible hosts...
  4. ncbi Innate immune pathways in virus-induced autoimmune diabetes
    Anjali Nair
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA
    Ann N Y Acad Sci 1150:139-42. 2008
    ..Our data may implicate TLR9-induced STAT-1 signaling pathways in KRV-induced innate immune activation in the BBDR rat and raise the possibility that these pathways are involved in mediating autoimmune diabetes...
  5. ncbi Closing the circle between the bedside and the bench: Toll-like receptors in models of virally induced diabetes
    Rita Bortell
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Ann N Y Acad Sci 1150:112-22. 2008
    ..These investigations may uncover new therapies and strategies to prevent type 1A diabetes...
  6. ncbi The role of Toll-like receptor pathways in the mechanism of type 1 diabetes
    Egil Lien
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Curr Mol Med 9:52-68. 2009
    ..The potential link between TLR upregulation and autoimmunity emphasizes the need for caution in using new therapies involving TLR agonists as vaccine adjuvants...
  7. ncbi A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats
    Danny Zipris
    The Institute of Endocrinology, Diabetes, and Metabolism, Rambam Medical Center B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    JOP 3:76-82. 2002
    ..The BioBreeding rat is used as an animal model for the study of human Type 1 diabetes. In spite of a severe lymphopenia, these animals develop spontaneous diabetes at the age of 10-12 weeks...
  8. ncbi Innate immunity and its role in type 1 diabetes
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 15:326-31. 2008
    ..This review focuses on recent studies on the role of Toll-like receptors and innate pathways in triggering type 1 diabetes...

Research Grants1

  1. Modulation of CD4+cd25+ Cells in Autoimmune Diabetes
    Danny Zipris; Fiscal Year: 2004
    ..This may lead to the development of new clinical approaches to combat diabetes in humans. ..