Danny Zipris

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. doi request reprint Innate immunity and its role in type 1 diabetes
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 15:326-31. 2008
  2. doi request reprint Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Clin Immunol 131:11-23. 2009
  3. doi request reprint The role of the intestinal microbiota in type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Clin Immunol 146:112-9. 2013
  4. doi request reprint Prevention of virus-induced type 1 diabetes with antibiotic therapy
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:3805-14. 2012
  5. doi request reprint Innate immunity in type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:824-9. 2011
  6. doi request reprint Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, 80045, USA
    J Mol Med (Berl) 92:93-102. 2014
  7. doi request reprint Toll-like receptors and type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Adv Exp Med Biol 654:585-610. 2010
  8. doi request reprint Brief dexamethasone treatment during acute infection prevents virus-induced autoimmune diabetes
    Pilar Londono
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Clin Immunol 135:401-11. 2010
  9. doi request reprint DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes
    Travis R Wolter
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, 1775 Aurora Ct, Mail Stop B 140, Aurora, CO 80045, USA
    Clin Immunol 132:103-15. 2009
  10. ncbi request reprint TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:693-701. 2007

Collaborators

  • Charles A Dinarello
  • Aldo Rossini
  • Naoko Hara
  • Aimon K Alkanani
  • Charles E Robertson
  • Diana Ir
  • Brandie D Wagner
  • Daniel N Frank
  • Pilar Londono
  • Travis R Wolter
  • Akiko Komura
  • Suparna A Sarkar
  • Randall Wong

Detail Information

Publications12

  1. doi request reprint Innate immunity and its role in type 1 diabetes
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, Colorado 80045 6511, USA
    Curr Opin Endocrinol Diabetes Obes 15:326-31. 2008
    ..This review focuses on recent studies on the role of Toll-like receptors and innate pathways in triggering type 1 diabetes...
  2. doi request reprint Epidemiology of type 1 diabetes and what animal models teach us about the role of viruses in disease mechanisms
    Danny Zipris
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045 6511, USA
    Clin Immunol 131:11-23. 2009
    ..Understanding the link between environmental agents and innate immune pathways involved in early stages of diabetes may advance the design of immune interventions to prevent disease in genetically susceptible individuals...
  3. doi request reprint The role of the intestinal microbiota in type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Clin Immunol 146:112-9. 2013
    ..A better understanding of the interplay between microbes and innate immune pathways in early disease stages holds promise for the design of immune interventions and disease prevention in genetically susceptible individuals...
  4. doi request reprint Prevention of virus-induced type 1 diabetes with antibiotic therapy
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 189:3805-14. 2012
    ..The data suggest that gut microbiota may be involved in promoting virus-induced T1D in the LEW1.WR1 rat model...
  5. doi request reprint Innate immunity in type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA
    Diabetes Metab Res Rev 27:824-9. 2011
    ..We have used the biobreeding diabetes resistant and LEW1.WR1 rat models to identify the role of virus-induced innate immunity in the mechanism of type 1 diabetes...
  6. doi request reprint Histone deacetylase inhibitor suppresses virus-induced proinflammatory responses and type 1 diabetes
    Naoko Hara
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, 80045, USA
    J Mol Med (Berl) 92:93-102. 2014
    ..The data suggest that targeting innate immune pathways with inhibitors of HDAC might represent an efficient therapeutic strategy for preventing T1D...
  7. doi request reprint Toll-like receptors and type 1 diabetes
    Danny Zipris
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Adv Exp Med Biol 654:585-610. 2010
    ..The new knowledge about the role of innate immune pathways in triggering islet destruction could lead to the discovery of new molecules that may be targeted for disease prevention...
  8. doi request reprint Brief dexamethasone treatment during acute infection prevents virus-induced autoimmune diabetes
    Pilar Londono
    Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO 80045, USA
    Clin Immunol 135:401-11. 2010
    ....
  9. doi request reprint DNA microarray analysis for the identification of innate immune pathways implicated in virus-induced autoimmune diabetes
    Travis R Wolter
    Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, 1775 Aurora Ct, Mail Stop B 140, Aurora, CO 80045, USA
    Clin Immunol 132:103-15. 2009
    ..Our findings provide new insights into KRV-induced innate immune pathways that may play a role in early mechanisms leading to islet inflammation and diabetes...
  10. ncbi request reprint TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat
    Danny Zipris
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    J Immunol 178:693-701. 2007
    ..Our data implicate the TLR9-signaling pathway in KRV-induced innate immune activation and autoimmune diabetes in the BBDR rat...
  11. ncbi request reprint Infections that induce autoimmune diabetes in BBDR rats modulate CD4+CD25+ T cell populations
    Danny Zipris
    Program in Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 170:3592-602. 2003
    ....
  12. ncbi request reprint A single treatment with IL-4 via retrovirally transduced lymphocytes partially protects against diabetes in BioBreeding (BB) rats
    Danny Zipris
    The Institute of Endocrinology, Diabetes, and Metabolism, Rambam Medical Center B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    JOP 3:76-82. 2002
    ..The BioBreeding rat is used as an animal model for the study of human Type 1 diabetes. In spite of a severe lymphopenia, these animals develop spontaneous diabetes at the age of 10-12 weeks...