Andrew Zinn

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Computing power of quantitative trait locus association mapping for haploid loci
    Derek Gordon
    Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA
    BMC Bioinformatics 10:261. 2009
  2. ncbi request reprint Complete SHOX deficiency causes Langer mesomelic dysplasia
    Andrew R Zinn
    McDermott Center for Human Growth and Development and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Genet 110:158-63. 2002
  3. pmc MODY-like diabetes associated with an apparently balanced translocation: possible involvement of MPP7 gene and cell polarity in the pathogenesis of diabetes
    Elizabeth J Bhoj
    McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cytogenet 2:5. 2009
  4. ncbi request reprint EFHC2 SNP rs7055196 is not associated with fear recognition in 45,X Turner syndrome
    Andrew R Zinn
    Department of Internal Medicine and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 147:507-9. 2008
  5. doi request reprint Unconventional wisdom about the obesity epidemic
    Andrew R Zinn
    McDermott Center for Human Growth and Development and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Sci 340:481-91. 2010
  6. ncbi request reprint Androgen receptor CAGn repeat length influences phenotype of 47,XXY (Klinefelter) syndrome
    Andrew R Zinn
    McDermott Center for Human Growth and Development, and Department of Internal Medicne, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8591, USA
    J Clin Endocrinol Metab 90:5041-6. 2005
  7. pmc Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    Kristen P Tolson
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:3803-12. 2010
  8. ncbi request reprint Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
    J Lloyd Holder
    Dept of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8591, USA
    Am J Physiol Endocrinol Metab 287:E105-13. 2004
  9. pmc Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genes
    Lane J Jaeckle Santos
    McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
    Hum Genet 123:469-76. 2008
  10. ncbi request reprint SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
    Bassil M Kublaoui
    Department of Pediatrics, and McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, 75390 8591, USA
    Endocrinology 147:4542-9. 2006

Collaborators

Detail Information

Publications29

  1. pmc Computing power of quantitative trait locus association mapping for haploid loci
    Derek Gordon
    Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA
    BMC Bioinformatics 10:261. 2009
    ..The purpose of this work is to mathematically derive the biometric model for haploid loci, and to compute power for QTL mapping when the loci are haploid...
  2. ncbi request reprint Complete SHOX deficiency causes Langer mesomelic dysplasia
    Andrew R Zinn
    McDermott Center for Human Growth and Development and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Genet 110:158-63. 2002
    ..These findings confirm clinical inferences that Langer mesomelic dysplasia is the homozygous form of Leri-Weill dyschondrosteosis and add to our understanding of genotype/phenotype relationships in SHOX deficiency disorders...
  3. pmc MODY-like diabetes associated with an apparently balanced translocation: possible involvement of MPP7 gene and cell polarity in the pathogenesis of diabetes
    Elizabeth J Bhoj
    McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cytogenet 2:5. 2009
    ....
  4. ncbi request reprint EFHC2 SNP rs7055196 is not associated with fear recognition in 45,X Turner syndrome
    Andrew R Zinn
    Department of Internal Medicine and McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Med Genet B Neuropsychiatr Genet 147:507-9. 2008
    ..Other variations in EFHC2 and other candidate genes should be tested for association with social cognition in 45,X TS...
  5. doi request reprint Unconventional wisdom about the obesity epidemic
    Andrew R Zinn
    McDermott Center for Human Growth and Development and Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Am J Med Sci 340:481-91. 2010
    ..These Grand Rounds reviews the background of some of these unconventional ideas and evidence for or against their roles in the obesity epidemic...
  6. ncbi request reprint Androgen receptor CAGn repeat length influences phenotype of 47,XXY (Klinefelter) syndrome
    Andrew R Zinn
    McDermott Center for Human Growth and Development, and Department of Internal Medicne, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8591, USA
    J Clin Endocrinol Metab 90:5041-6. 2005
    ....
  7. pmc Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression
    Kristen P Tolson
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:3803-12. 2010
    ....
  8. ncbi request reprint Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat in mice
    J Lloyd Holder
    Dept of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8591, USA
    Am J Physiol Endocrinol Metab 287:E105-13. 2004
    ..Our results indicate that Sim1 gene dosage modulates the homeostatic feeding response to increased dietary fat and likely plays a physiological role in the regulation of energy balance...
  9. pmc Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genes
    Lane J Jaeckle Santos
    McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
    Hum Genet 123:469-76. 2008
    ..PDR is most likely due to a mutation within the linked interval not affecting currently annotated coding exons...
  10. ncbi request reprint SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake
    Bassil M Kublaoui
    Department of Pediatrics, and McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, 75390 8591, USA
    Endocrinology 147:4542-9. 2006
    ..Our results indicate that the melanocortin 4 receptor signals through Sim1 or its transcriptional targets in controlling food intake but not energy expenditure...
  11. ncbi request reprint Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons
    Bassil M Kublaoui
    Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 8591, USA
    Mol Endocrinol 20:2483-92. 2006
    ..Our results demonstrate that Sim1 heterozygotes are resistant to hypothalamic melanocortin signaling and suggest that Sim1-expressing PVN neurons regulate feeding, but not energy expenditure, in response to melanocortin signaling...
  12. pmc Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice
    Bassil M Kublaoui
    Department of Pediatrics, Department of Internal Medicine, McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, Dallas, TX 75390 8591, USA
    Mol Endocrinol 22:1723-34. 2008
    ..Our results support the importance of Oxt neurons in feeding regulation and suggest that reduced Oxt neuropeptide is one mechanism mediating the hyperphagic obesity of Sim1(+/-) mice...
  13. ncbi request reprint Phenotypic expansion of the supernumerary derivative (22) chromosome syndrome: VACTERL and Hirschsprung's disease
    Juan C Prieto
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    J Pediatr Surg 42:1928-32. 2007
    ....
  14. pmc Sequence variation at the human FOXO3 locus: a study of premature ovarian failure and primary amenorrhea
    Teresa D Gallardo
    Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA
    Hum Reprod 23:216-21. 2008
    ..The forkhead transcription factor Foxo3 is a master regulator and potent suppressor of primordial follicle activation. Loss of Foxo3 function in the mouse leads to premature ovarian failure (POF) due to global follicle activation...
  15. pmc A serotonin and melanocortin circuit mediates D-fenfluramine anorexia
    Yong Xu
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 30:14630-4. 2010
    ..Thus, our results identify a neurochemically defined neural circuit through which D-Fen influences appetite and thereby indicate that this 5-HT(2C)R/POMC-MC4R/SIM1 circuit may yield a more refined target to exploit for weight loss...
  16. ncbi request reprint X-linked reticulate pigmentary disorder with systemic manifestations: report of a third family and literature review
    Robert C Anderson
    Department of Dermatology, University of Texas Southwestern Medical School, Dallas, Texas 75390, USA
    Pediatr Dermatol 22:122-6. 2005
    ..We present a summary of the clinical manifestations of this rare disorder and discuss efforts to identify the causative gene...
  17. doi request reprint Cryptic chromosomal abnormalities identified in children with congenital heart disease
    Ashleigh A Richards
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Pediatr Res 64:358-63. 2008
    ..We propose that children who meet these two criteria should receive more extensive genetic testing to detect potential cryptic chromosomal abnormalities...
  18. ncbi request reprint Mesomelic and rhizomelic short stature: The phenotype of combined Leri-Weill dyschondrosteosis and achondroplasia or hypochondroplasia
    Judith L Ross
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Med Genet A 116:61-5. 2003
    ..The phenotypes of combined LWD and achondroplasia or hypochondroplasia appeared to be less than additive, suggesting that SHOX and FGFR3 act on overlapping pathways of bone growth and development...
  19. doi request reprint Effect of ascertainment and genetic features on the phenotype of Klinefelter syndrome
    Martha P D Zeger
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Pediatr 152:716-22. 2008
    ..To describe the Klinefelter Syndrome (KS) phenotype during childhood in a large cohort...
  20. ncbi request reprint Compound heterozygosity of SHOX-encompassing and downstream PAR1 deletions results in Langer mesomelic dysplasia (LMD)
    Angel Campos-Barros
    Department of Endocrinology, Hospital Infantil Universitario Nino Jesus, Universidad Autonoma de Madrid, Madrid, Spain
    Am J Med Genet A 143:933-8. 2007
    ....
  21. ncbi request reprint The phenotype of short stature homeobox gene (SHOX) deficiency in childhood: contrasting children with Leri-Weill dyschondrosteosis and Turner syndrome
    Judith L Ross
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Pediatr 147:499-507. 2005
    ..To evaluate the growth disorder and phenotype in prepubertal children with Leri-Weill dyschondrosteosis (LWD), a dominantly inherited skeletal dysplasia, and to compare the findings from girls with Turner syndrome (TS)...
  22. doi request reprint Cognitive and motor development during childhood in boys with Klinefelter syndrome
    Judith L Ross
    Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Med Genet A 146:708-19. 2008
    ..These findings would also be an important component of counseling clinicians and families about this disorder...
  23. pmc Dynamic regulation of p53 subnuclear localization and senescence by MORC3
    Keiko Takahashi
    Department of Molecular Genetics and Molecular Biology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Osaka 537 8511, Japan
    Mol Biol Cell 18:1701-9. 2007
    ..These results suggest that MORC3 regulates p53 activity and localization into PML-NBs. We identified a new molecular mechanism that regulates the activity of nuclear proteins by localization to a nuclear subdomain...
  24. ncbi request reprint The physical phenotype of girls and women with Turner syndrome is not X-imprinted
    Carolyn A Bondy
    Chief Developmental Endocrinology Branch, National Institute of Child Health, NIH, Bethesda, MD 20982, USA
    Hum Genet 121:469-74. 2007
    ..We did demonstrate a selective maternal effect on final stature that was independent of X-chromosome origin, suggesting potential autosomal imprinting effects on growth revealed by X monosomy...
  25. ncbi request reprint Editorial: MC4R mutations--weight before screening!
    Bassil M Kublaoui
    J Clin Endocrinol Metab 91:1671-2. 2006
  26. pmc A second recombination hotspot associated with SHOX deletions
    Andrew R Zinn
    Am J Hum Genet 78:523-5. 2006
  27. ncbi request reprint Maternal X chromosome, visceral adiposity, and lipid profile
    Phillip L Van
    JAMA 295:1373-4. 2006
  28. ncbi request reprint Increased prevalence of ADHD in Turner syndrome with no evidence of imprinting effects
    Heather F Russell
    Division of Human and Molecular Genetics, Department of Pediatrics, The Children s Hospital of Philadelphia, PA, USA
    J Pediatr Psychol 31:945-55. 2006
    ..However, no studies have assessed whether individuals with TS meet strict (DSM-IV) criteria for attention-deficit/hyperactivity disorder (ADHD)...

Research Grants16

  1. Sim1 Function in Feeding Regulation
    Andrew R Zinn; Fiscal Year: 2010
    ..The proposed project will delineate molecular mechanisms within the brain that regulate food intake. ..
  2. Sim1 Function in Feeding Regulation
    Andrew Zinn; Fiscal Year: 2009
    ..The proposed project will delineate molecular mechanisms within the brain that regulate food intake. ..
  3. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2006
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  4. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2004
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  5. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2005
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  6. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2004
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  7. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2003
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  8. Genetics of Turner Syndrome Neurocognitive Phenotype
    Andrew Zinn; Fiscal Year: 2002
    ..The project will combine molecular characterization of subjects with detailed cognitive evaluations to elucidate the role of SHOX or other pseudoautosomal gene deficiencies in the TS neurocognitive phenotype. ..
  9. GENETICS OF TURNER SYNDROME--COGNITIVE/PHYSICAL ASPECTS
    Andrew Zinn; Fiscal Year: 2001
    ..Characterization of these genes would provide insight into the pathophysiology of Turner syndrome as well as processes of normal physical and cognitive development. ..
  10. GENETICS OF TURNER SYNDROME--COGNITIVE/PHYSICAL ASPECTS
    Andrew Zinn; Fiscal Year: 2000
    ..Characterization of these genes would provide insight into the pathophysiology of Turner syndrome as well as processes of normal physical and cognitive development. ..
  11. GENETICS OF TURNER SYNDROME--COGNITIVE/PHYSICAL ASPECTS
    Andrew Zinn; Fiscal Year: 1999
    ..Characterization of these genes would provide insight into the pathophysiology of Turner syndrome as well as processes of normal physical and cognitive development. ..
  12. GENETICS OF TURNER SYNDROME--COGNITIVE/PHYSICAL ASPECTS
    Andrew Zinn; Fiscal Year: 1999
    ..Characterization of these genes would provide insight into the pathophysiology of Turner syndrome as well as processes of normal physical and cognitive development. ..
  13. Sim1 Function in Feeding Regulation
    Andrew R Zinn; Fiscal Year: 2010
    ..The proposed project will delineate molecular mechanisms within the brain that regulate food intake. ..