Warren Zigman

Summary

Affiliation: University at Albany
Country: USA

Publications

  1. ncbi Alzheimer's disease in Down syndrome: neurobiology and risk
    Warren B Zigman
    Department of Psychology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Ment Retard Dev Disabil Res Rev 13:237-46. 2007
  2. ncbi Dementia in adults with mental retardation: assessment at a single point in time
    Wayne Silverman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:111-25. 2004
  3. ncbi Shorter telomeres may indicate dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 31:765-71. 2010
  4. ncbi Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
  5. ncbi Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road Staten Island, NY 10314, United States
    Neurosci Lett 440:340-3. 2008
  6. ncbi Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 27:941-5. 2006
  7. ncbi Incidence and temporal patterns of adaptive behavior change in adults with mental retardation
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 107:161-74. 2002
  8. ncbi Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005
  9. ncbi Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
  10. ncbi Maladaptive behaviors related to adaptive decline in aging adults with mental retardation
    Tiina K Urv
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Am J Ment Retard 108:327-39. 2003

Research Grants

  1. GENETICS, MORTALITY AND DEMENTIA IN DOWN SYNDROME
    Warren Zigman; Fiscal Year: 2003

Collaborators

Detail Information

Publications18

  1. ncbi Alzheimer's disease in Down syndrome: neurobiology and risk
    Warren B Zigman
    Department of Psychology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Ment Retard Dev Disabil Res Rev 13:237-46. 2007
    ....
  2. ncbi Dementia in adults with mental retardation: assessment at a single point in time
    Wayne Silverman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:111-25. 2004
    ..Findings suggest that procedures of this type could soon contribute to more accurate and rapid diagnoses of dementia...
  3. ncbi Shorter telomeres may indicate dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 31:765-71. 2010
    ..Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status...
  4. ncbi Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
    ..The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome...
  5. ncbi Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road Staten Island, NY 10314, United States
    Neurosci Lett 440:340-3. 2008
    ....
  6. ncbi Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 27:941-5. 2006
    ..From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status...
  7. ncbi Incidence and temporal patterns of adaptive behavior change in adults with mental retardation
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 107:161-74. 2002
    ....
  8. ncbi Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005
    ..These results suggest that the apolipoprotein E epsilon4 allele has an independent and strong relation to early mortality...
  9. ncbi Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
    ..402, p=.095, 95% CI: .138, 1.173). If the protective effects of statins can be further validated, these findings suggest that their use may delay or prevent AD onset in vulnerable populations...
  10. ncbi Maladaptive behaviors related to adaptive decline in aging adults with mental retardation
    Tiina K Urv
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Am J Ment Retard 108:327-39. 2003
    ....
  11. ncbi Bioavailable estradiol and age at onset of Alzheimer's disease in postmenopausal women with Down syndrome
    Nicole Schupf
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA
    Neurosci Lett 406:298-302. 2006
    ..Our findings support the hypothesis that reductions in estrogen following menopause can contribute to the cascade of pathological processes leading to AD...
  12. ncbi Elevated plasma beta-amyloid peptide Abeta(42) levels, incident dementia, and mortality in Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, PO Box 16, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 64:1007-13. 2007
    ..Individuals with Down syndrome have increased levels of beta-amyloid peptides and an increased risk for AD...
  13. ncbi Association between genetic variants in sortilin-related receptor 1 (SORL1) and Alzheimer's disease in adults with Down syndrome
    Joseph H Lee
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA
    Neurosci Lett 425:105-9. 2007
    ..Thus, further studies are needed to identify functional variants that influence risk for AD in this uniquely vulnerable population...
  14. ncbi Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome
    Nicole Schupf
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, G H Sergievsky Center, New York, NY, USA
    Dement Geriatr Cogn Disord 25:476-82. 2008
    ..Two tightly linked polymorphisms (PvuII and XbaI) in the first intron of estrogen receptor 1 (ESR1), the gene for ER-alpha, have been reported to influence estrogen receptor expression and may influence the risk of AD...
  15. ncbi Mitotic index in Down's syndrome with and without dementia
    Edmund C Jenkins
    Am J Med Genet A 125:315-7. 2004
  16. ncbi Maladaptive behaviors related to dementia status in adults with Down syndrome
    Tiina K Urv
    Eunice Kennedy Shriver Center, University of Massachusetts Medical School, USA
    Am J Ment Retard 113:73-86. 2008
    ..Thus, new concerns regarding these types of behaviors could be particularly useful in clarifying the dementia status of adults with Down syndrome and developing individualized plans for support...
  17. ncbi Incidence and prevalence of dementia in elderly adults with mental retardation without down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Am J Ment Retard 109:126-41. 2004
    ....
  18. ncbi Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21
    Chi Ming Li
    Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons, New York, NY, USA
    BMC Med Genet 7:24. 2006
    ..Down syndrome (DS) is caused by trisomy 21 (+21), but the aberrations in gene expression resulting from this chromosomal aneuploidy are not yet completely understood...

Research Grants5

  1. GENETICS, MORTALITY AND DEMENTIA IN DOWN SYNDROME
    Warren Zigman; Fiscal Year: 2003
    ....