Xiaolin Zi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Bioactive suture: a novel immunotherapy for head and neck cancer
    Terry Y Shibuya
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine College of Medicine, Orange, California 92868, USA
    Clin Cancer Res 10:7088-99. 2004
  2. ncbi request reprint Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice
    Xiaolin Zi
    Department of Urology and Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA 92868, USA
    Cancer Res 65:3479-86. 2005
  3. pmc Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice
    Xuesen Li
    Department of Urology, University of California Irvine, Orange, California, United States of America
    PLoS ONE 7:e31213. 2012
  4. pmc Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model
    Zhongbo Liu
    Department of Urology, University of California, Irvine, 101 The City Drive South, Rt 81 Bldg 55 Rm 302, Orange, CA 92868
    Cancer Prev Res (Phila) 6:1365-75. 2013
  5. pmc Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
    Elyssa M Rubin
    Department of Oncology, Children s Hospital of Orange County, Orange, California, USA
    Mol Cancer Ther 9:731-41. 2010
  6. pmc The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
    David S Yee
    Department of Urology and Chao Family Comprehensive Cancer Center, University of California at Irvine Orange, CA 92868, USA
    Mol Cancer 9:162. 2010
  7. pmc Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling
    Yi Guo
    Department of Orthopedic Surgery, Chao Family Comprehensive Cancer Center, University of California, Irvine, CA 92868, USA
    Cancer Res 68:3350-60. 2008
  8. pmc WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
    Yaxiong Tang
    Department of Urology, University of California at Irvine, Irvine, CA 92868, USA
    Mol Cancer Ther 8:458-68. 2009
  9. pmc Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
    Yaxiong Tang
    Department of Urology, University of California, Irvine, Orange, CA 92868, USA
    Int J Cancer 127:1758-68. 2010
  10. pmc Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
    Tao Ji
    Department of Orthopaedic Surgery, UC Irvine Multidisciplinary Sarcoma Center, Chao Family Comprehensive Cancer Center, University of California, Irvine, USA
    Mol Cancer 12:55. 2013

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Bioactive suture: a novel immunotherapy for head and neck cancer
    Terry Y Shibuya
    Department of Otolaryngology Head and Neck Surgery, University of California Irvine College of Medicine, Orange, California 92868, USA
    Clin Cancer Res 10:7088-99. 2004
    ..We have proposed to characterize the mechanism through which bioactive surgical sutures generate a T(H)1 immune response and to define the immune-stimulating half-life of the sutures...
  2. ncbi request reprint Flavokawain A, a novel chalcone from kava extract, induces apoptosis in bladder cancer cells by involvement of Bax protein-dependent and mitochondria-dependent apoptotic pathway and suppresses tumor growth in mice
    Xiaolin Zi
    Department of Urology and Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange, CA 92868, USA
    Cancer Res 65:3479-86. 2005
    ..Finally, the anticarcinogenic effect of flavokawain A was evident in its inhibitory growth of bladder tumor cells in a nude mice model (57% of inhibition) and in soft agar...
  3. pmc Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice
    Xuesen Li
    Department of Urology, University of California Irvine, Orange, California, United States of America
    PLoS ONE 7:e31213. 2012
    ..These results suggest a potential usefulness of a safe kava product or its active components for prevention and treatment of advanced PCa by targeting AR...
  4. pmc Kava chalcone, flavokawain A, inhibits urothelial tumorigenesis in the UPII-SV40T transgenic mouse model
    Zhongbo Liu
    Department of Urology, University of California, Irvine, 101 The City Drive South, Rt 81 Bldg 55 Rm 302, Orange, CA 92868
    Cancer Prev Res (Phila) 6:1365-75. 2013
    ..These results suggest a potential of FKA in preventing the recurrence and progression of non-muscle-invasive UCC...
  5. pmc Wnt inhibitory factor 1 decreases tumorigenesis and metastasis in osteosarcoma
    Elyssa M Rubin
    Department of Oncology, Children s Hospital of Orange County, Orange, California, USA
    Mol Cancer Ther 9:731-41. 2010
    ..Together, these data suggest that WIF-1 exerts potent antiosteosarcoma effect in vivo in mouse models. Therefore, the reexpression of WIF-1 in WIF-1-deficient osteosarcoma represents a potential novel treatment and preventive strategy...
  6. pmc The Wnt inhibitory factor 1 restoration in prostate cancer cells was associated with reduced tumor growth, decreased capacity of cell migration and invasion and a reversal of epithelial to mesenchymal transition
    David S Yee
    Department of Urology and Chao Family Comprehensive Cancer Center, University of California at Irvine Orange, CA 92868, USA
    Mol Cancer 9:162. 2010
    ..We investigated the effect and underlying mechanism of a naturally-occurring Wnt inhibitor, WIF1, on the growth and cellular invasiveness of a bone metastatic PCa cell line, PC3...
  7. pmc Frzb, a secreted Wnt antagonist, decreases growth and invasiveness of fibrosarcoma cells associated with inhibition of Met signaling
    Yi Guo
    Department of Orthopedic Surgery, Chao Family Comprehensive Cancer Center, University of California, Irvine, CA 92868, USA
    Cancer Res 68:3350-60. 2008
    ..These results suggested the usefulness of Frzb in modulating Met signaling as a new treatment strategy for STS...
  8. pmc WIF1, a Wnt pathway inhibitor, regulates SKP2 and c-myc expression leading to G1 arrest and growth inhibition of human invasive urinary bladder cancer cells
    Yaxiong Tang
    Department of Urology, University of California at Irvine, Irvine, CA 92868, USA
    Mol Cancer Ther 8:458-68. 2009
    ..These observations suggest a mechanism for transformation of bladder epithelium on loss of WIF1 function and provide new targets such as SKP2 for intervention in WIF1-deficient bladder cancer...
  9. pmc Flavokawain B, a kava chalcone, induces apoptosis via up-regulation of death-receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growth
    Yaxiong Tang
    Department of Urology, University of California, Irvine, Orange, CA 92868, USA
    Int J Cancer 127:1758-68. 2010
    ..Together, these results suggest robust mechanisms for FKB induction of apoptosis preferentially for HRPC and the potential usefulness of FKB for prevention and treatment of HRPC in an adjuvant setting...
  10. pmc Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
    Tao Ji
    Department of Orthopaedic Surgery, UC Irvine Multidisciplinary Sarcoma Center, Chao Family Comprehensive Cancer Center, University of California, Irvine, USA
    Mol Cancer 12:55. 2013
    ..Its efficacy and low toxicity profile make FKB a promising agent for use as a novel chemotherapeutic agent...
  11. pmc Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model
    Yi Guo
    Department of Orthopaedic Surgery, Musculoskeletal Oncology Laboratory, 101 The City Drive South, Orange, CA 92868, USA
    Clin Orthop Relat Res 466:2039-45. 2008
    ..Therefore, strategies to suppress LRP5-mediated signaling in OS cells may lead to a reduction in local or systemic disease burden...
  12. pmc Flavokawain B, a novel, naturally occurring chalcone, exhibits robust apoptotic effects and induces G2/M arrest of a uterine leiomyosarcoma cell line
    Ramez N Eskander
    Departments of Obstetrics and Gynecology, University of California Irvine, Orange, CA, USA
    J Obstet Gynaecol Res 38:1086-94. 2012
    ..To examine the effects of flavokawain B (FKB), a novel kava chalcone, on the growth of uterine leiomyosarcoma (LMS) cells and investigated its utility in the treatment of uterine LMS...
  13. ncbi request reprint Blocking Wnt/LRP5 signaling by a soluble receptor modulates the epithelial to mesenchymal transition and suppresses met and metalloproteinases in osteosarcoma Saos-2 cells
    Yi Guo
    Department of Orthopaedic Surgery, University of California, Irvine, 101 The City Drive South, Orange, California 92868, USA
    J Orthop Res 25:964-71. 2007
    ..SLRP5 transfection decreased both Met expression and hepatocyte growth factor (HGF)-induced cell motility. Taken together, these results support a role for Wnt/LRP5 signaling in invasiveness of a subset of OS cells...
  14. doi request reprint The Wnt signaling pathway: implications for therapy in osteosarcoma
    Peter McQueen
    Department of Orthopaedic Surgery, University of California at Irvine, Orange, CA 92868, USA
    Expert Rev Anticancer Ther 11:1223-32. 2011
    ..Research involving the Wnt signaling pathway and cancer stem cells holds promise for novel treatment options in the future...
  15. pmc Flavokawain B, a kava chalcone, induces apoptosis in synovial sarcoma cell lines
    Toshinori Sakai
    Department of Orthopaedic Surgery, University of California Irvine, 101 The City Drive South, Orange, California 92868, USA
    J Orthop Res 30:1045-50. 2012
    ..FKB may be a new chemotherapeutic strategy for patients with SS and deserves further investigation as a potential agent in the treatment of this malignancy...
  16. pmc Effects of the kava chalcone flavokawain A differ in bladder cancer cells with wild-type versus mutant p53
    Yaxiong Tang
    1Department of Urology, University of California, Irvine, Orange, California 92868, USA
    Cancer Prev Res (Phila) 1:439-51. 2008
    ..This selectivity of flavokawain A for inducing a G(2)-M arrest in p53-defective cells deserves further investigation as a new mechanism for the prevention and treatment of bladder cancer...
  17. ncbi request reprint Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness
    Xiaolin Zi
    Department of Urology, University of California, Irvine, Orange, California 92868, USA
    Cancer Res 65:9762-70. 2005
    ..Together, these data suggest that Frzb/sFRP3 and DN-LRP5 exhibit antitumor activity through the reversal of epithelial-to-mesenchymal transition and inhibition of MMP activities in a subset of prostate cancer...
  18. pmc Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancer
    Thanh H Dellinger
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of California at Irvine Medical Center, Chao Family Comprehensive Cancer Center, Orange, CA 92868, USA
    Gynecol Oncol 126:259-67. 2012
    ..Emerging evidence implicates the Wnt antagonist Dickkopf-3 (Dkk3) as a tumor suppressor and potential biomarker in solid tumors. We investigated whether Dkk3 plays an important role in the carcinogenesis of endometrial cancer (EC)...
  19. pmc Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy
    Zhongbo Liu
    Department of Urology, University of California, Irvine, Orange, California 92868, USA
    Mol Carcinog 51:257-67. 2012
    ..Therefore, the R. rosea extract and salidroside deserve further study as novel agents for chemoprevention of bladder carcinogenesis...
  20. pmc Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention
    Xuejiao Tian
    Department of Urology, University of California, Irvine, Orange CA 92868, USA
    Curr Cancer Drug Targets 13:558-79. 2013
    ....
  21. pmc Lycopene enhances docetaxel's effect in castration-resistant prostate cancer associated with insulin-like growth factor I receptor levels
    Yaxiong Tang
    Department of Urology, University of California, Irvine, Orange, CA, USA
    Neoplasia 13:108-19. 2011
    ..CRPC patients with IGF-IR-overexpressing tumors may be most likely to benefit from this combination...
  22. pmc The effect of gartanin, a naturally occurring xanthone in mangosteen juice, on the mTOR pathway, autophagy, apoptosis, and the growth of human urinary bladder cancer cell lines
    Zhongbo Liu
    Department of Urology, University of California, Irvine, Orange, California 92868, USA
    Nutr Cancer 65:68-77. 2013
    ..Together, these results suggested that gartanin is a multiple targeting agent that is suitable for further study into its chemopreventive properties for human urinary bladder cancer...
  23. pmc Potential molecular targeting of splice variants for cancer treatment
    Christopher A Blair
    Department of Urology, University of California, Irvine, Orange, CA 92868, USA
    Indian J Exp Biol 49:836-9. 2011
    ....
  24. pmc Dkk-3, a secreted wnt antagonist, suppresses tumorigenic potential and pulmonary metastasis in osteosarcoma
    Carol H Lin
    Department of Oncology, CHOC Children s Hospital, 455 South Main Street, Orange, CA 92868, USA Department of Orthopaedic Surgery, University of California, Irvine, 101 The City Drive South, Orange, CA 92868, USA
    Sarcoma 2013:147541. 2013
    ..Together, these data suggest that Dkk-3 has a negative impact on the progression of osteosarcoma. Reexpressing Dkk-3 in Dkk-3-deficient OS tumors may prove to be of benefit as a preventive or therapeutic strategy...
  25. ncbi request reprint Overexpression of ErbB2 receptor inhibits IGF-I-induced Shc-MAPK signaling pathway in breast cancer cells
    Yuhong Lu
    Division of Experimental Medicine, Department of Medicine and Department of Oncology, McGill University, Montreal, Que, Canada
    Biochem Biophys Res Commun 313:709-15. 2004
    ..They are consistent with the view that the IGF-IR mediated attenuation of trastuzumab-induced growth inhibition we recently described is dependent on IGF-I-induced PI3K signaling rather than IGF-I-induced MAPK signaling...

Research Grants7

  1. Kava extract, Flavokawains and Bladder Cancer Prevention
    Xiaolin Zi; Fiscal Year: 2004
    ....
  2. Lycopene & Docetaxel in Prostate Cancer: An IGF-I Receptor Targeting Approach
    Xiaolin Zi; Fiscal Year: 2007
    ....
  3. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2009
    ....
  4. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2010
    ....
  5. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2011
    ..Together, these studies will provide a firm answer to the promise of flavokawin A as a chemoprventative and/or chemotherapeutic agent. ..
  6. Chemoprevention of urinary bladder carcinogenesis by flavokawain A
    Xiaolin Zi; Fiscal Year: 2010
    ....