Xiangdong Zhu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format
    Xiangdong Zhu
    Department of Physics, University of California, CA 95616, USA
    Appl Opt 46:1890-5. 2007
  2. pmc Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays
    James P Landry
    Department of Physics, University of California at Davis, Davis, CA 95616, USA
    Assay Drug Dev Technol 11:326-32. 2013
  3. pmc Fluorescent labeling agents change binding profiles of glycan-binding proteins
    Yiyan Fei
    Department of Physics, University of California at Davis, California 95616, USA
    Mol Biosyst 7:3343-52. 2011
  4. pmc Simultaneous measurement of 10,000 protein-ligand affinity constants using microarray-based kinetic constant assays
    James P Landry
    Department of Physics, University of California at Davis, Davis, CA 95616, USA
    Assay Drug Dev Technol 10:250-9. 2012
  5. pmc Screening small-molecule compound microarrays for protein ligands without fluorescence labeling with a high-throughput scanning microscope
    Yiyan Fei
    University of California at Davis, Department of Physics, Davis, California 95616, USA
    J Biomed Opt 15:016018. 2010

Collaborators

  • Xi Chen
  • Yanhong Li
  • James P Landry
  • Yiyan Fei
  • Guoliang Yu
  • Yaohuang Ke
  • Pierre Lee
  • Hai Yu
  • Yung Shin Sun
  • Harshal A Chokhawala
  • Shengshu Huang
  • Kam Lau
  • Chun Yi Wu
  • Yungshin Sun
  • Xiaobing Wang
  • Kit S Lam
  • Juntao Luo

Detail Information

Publications5

  1. pmc Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format
    Xiangdong Zhu
    Department of Physics, University of California, CA 95616, USA
    Appl Opt 46:1890-5. 2007
    ..x 3 in. (2.54 cm x 7.62 cm) microscope slide...
  2. pmc Discovering small molecule ligands of vascular endothelial growth factor that block VEGF-KDR binding using label-free microarray-based assays
    James P Landry
    Department of Physics, University of California at Davis, Davis, CA 95616, USA
    Assay Drug Dev Technol 11:326-32. 2013
    ..3 to 60 μM. The inhibitory potency of these inhibitors found in the microarray-based assay was confirmed by their inhibition of VEGF-induced VEGFR2 phosphorylation in a cell-based assay...
  3. pmc Fluorescent labeling agents change binding profiles of glycan-binding proteins
    Yiyan Fei
    Department of Physics, University of California at Davis, California 95616, USA
    Mol Biosyst 7:3343-52. 2011
    ..This study highlights the importance of label-free real-time detection of protein-ligand interactions and the potential pitfall in interpreting fluorescence-based assays for characterization of protein-glycan interactions...
  4. pmc Simultaneous measurement of 10,000 protein-ligand affinity constants using microarray-based kinetic constant assays
    James P Landry
    Department of Physics, University of California at Davis, Davis, CA 95616, USA
    Assay Drug Dev Technol 10:250-9. 2012
    ....
  5. pmc Screening small-molecule compound microarrays for protein ligands without fluorescence labeling with a high-throughput scanning microscope
    Yiyan Fei
    University of California at Davis, Department of Physics, Davis, California 95616, USA
    J Biomed Opt 15:016018. 2010
    ....

Research Grants5

  1. High-Speed Label-Free Optical Detection System for Small-Molecule Microarrays
    Xiangdong Zhu; Fiscal Year: 2007
    ..Five 10,000 small molecule encoded bead-aggregate libraries will be prepared and printed on glass slide replicates as microarrays, and these microarrays will be analyzed by the optical detector to be developed in this proposed research. ..
  2. High-Speed Label-Free Optical Detection System for Small-Molecule Microarrays
    Xiangdong Zhu; Fiscal Year: 2009
    ..abstract_text> ..