Tuo Fu Zhu

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy
    Tong Wang
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e65071. 2013
  2. ncbi request reprint HIV-1 genotypes in peripheral blood monocytes
    T Zhu
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    J Leukoc Biol 68:338-44. 2000
  3. pmc Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Virol 76:707-16. 2002
  4. ncbi request reprint HIV-1 in peripheral blood monocytes: an underrated viral source
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Box 358070, 960 Republican Street, Seattle, WA 98109 8070, USA
    J Antimicrob Chemother 50:309-11. 2002
  5. pmc Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle 98195, USA
    J Virol 77:6108-16. 2003
  6. ncbi request reprint Persistence of low levels of simian immunodeficiency virus in macaques that were transiently viremic by conventional testing
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Virology 323:208-19. 2004
  7. ncbi request reprint Global human genetics of HIV-1 infection and China
    Tuo Fu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Cell Res 15:833-42. 2005
  8. ncbi request reprint High risk populations and HIV-1 infection in China
    Tuo Fu Zhu
    Department of Laboratory Medicine, Departments of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA
    Cell Res 15:852-7. 2005

Collaborators

Detail Information

Publications8

  1. pmc Successful isolation of infectious and high titer human monocyte-derived HIV-1 from two subjects with discontinued therapy
    Tong Wang
    Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 8:e65071. 2013
    ..However, whether these DNA can produce virions has been an open question for years, due to the inability of isolating high titer and infectious HIV-1 directly from monocytes...
  2. ncbi request reprint HIV-1 genotypes in peripheral blood monocytes
    T Zhu
    Department of Laboratory Medicine, University of Washington, Seattle 98195, USA
    J Leukoc Biol 68:338-44. 2000
    ..Our data provide evidence for HIV-1 evolution in monocytes and their role as a reservoir of HIV-1 in vivo. A better understanding of HIV-1 in monocytes may greatly help the development of new therapeutic strategies for HIV-1 infection...
  3. pmc Evidence for human immunodeficiency virus type 1 replication in vivo in CD14(+) monocytes and its potential role as a source of virus in patients on highly active antiretroviral therapy
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Virol 76:707-16. 2002
    ..In the other four patients, HIV-1 sequences in plasma and the three cell populations were identical. CD14(+) monocytes appear to be one of the potential in vivo sources of HIV-1 in patients receiving HAART...
  4. ncbi request reprint HIV-1 in peripheral blood monocytes: an underrated viral source
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Box 358070, 960 Republican Street, Seattle, WA 98109 8070, USA
    J Antimicrob Chemother 50:309-11. 2002
  5. pmc Persistence of extraordinarily low levels of genetically homogeneous human immunodeficiency virus type 1 in exposed seronegative individuals
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle 98195, USA
    J Virol 77:6108-16. 2003
    ..Understanding the mechanisms that confer diminished replicative capacity of HIV-1 in these hosts is paramount to developing strategies for protection against and control of HIV-1 infection...
  6. ncbi request reprint Persistence of low levels of simian immunodeficiency virus in macaques that were transiently viremic by conventional testing
    Tuofu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    Virology 323:208-19. 2004
    ..LLSI macaques have remained free from SIV-associated illness, and are still alive 10 years after virus inoculation. Understanding the mechanisms underlying this outcome may provide valuable insight into therapy and vaccine development...
  7. ncbi request reprint Global human genetics of HIV-1 infection and China
    Tuo Fu Zhu
    Department of Laboratory Medicine, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    Cell Res 15:833-42. 2005
    ..This review highlights the recent discoveries on global and Chinese genetic polymorphisms and their association with HIV-1 transmission and disease progression...
  8. ncbi request reprint High risk populations and HIV-1 infection in China
    Tuo Fu Zhu
    Department of Laboratory Medicine, Departments of Microbiology, University of Washington School of Medicine, Seattle, WA 98109, USA
    Cell Res 15:852-7. 2005
    ..Sexual transmission, therefore, may serve as a bridge connecting high-risk populations with general populations. There is an urgent need to prevent the spread of HIV from these high-risk populations into the general population of China...

Research Grants18

  1. New Model for NeuroAIDS Utilizing Monocyte-Derived HIV-1
    Tuofu Zhu; Fiscal Year: 2007
    ....
  2. Minimal Levels of HIV-1 in Vaccinated & Exposed Persons
    Tuofu Zhu; Fiscal Year: 2007
    ..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..
  3. Minimal Levels of HIV-1 in Vaccinated & Exposed Persons
    Tuofu Zhu; Fiscal Year: 2006
    ..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..
  4. Role of CD14+ Monocytes in HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2005
    ..Findings from this proposal will provide better understanding of productive infection of HIV-1 in CD 14+ monocytes in vivo, and may also provide great insights to developing new therapeutic strategies to enhance therapy efficacy. ..
  5. Effect of DC-SIGNR Polymorphisms on HIV-1 Infection
    Tuofu Zhu; Fiscal Year: 2003
    ..These studies should assist in the identification of new therapeutic targets and strategies to protect against HIV-1 transmission and control disease progression. ..
  6. Minimal Levels of HIV-1 in Vaccinated & Exposed Persons
    Tuofu Zhu; Fiscal Year: 2003
    ..These studies should assist definition of virologic and immunologic characteristics required to attenuate and/or substantially control HIV-1 infection, a critical goal of AIDS vaccine development. ..