Quing Zhu

Summary

Affiliation: University of Connecticut
Country: USA

Publications

  1. pmc Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography
    Yi Yang
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269
    J Biomed Opt 17:90503-1. 2012
  2. pmc A three-parameter logistic model to characterize ovarian tissue using polarization-sensitive optical coherence tomography
    Tianheng Wang
    University of Connecticut, Dept of Electrical and Computer Engineering, Storrs, CT 06269, USA
    Biomed Opt Express 4:772-7. 2013
  3. doi request reprint The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging
    Akram Abuteen
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269, USA
    Phys Chem Chem Phys 15:18502-9. 2013
  4. pmc Breast cancer: assessing response to neoadjuvant chemotherapy by using US-guided near-infrared tomography
    Quing Zhu
    Biomedical Engineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Radiology 266:433-42. 2013
  5. pmc Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers
    Quing Zhu
    University of Connecticut, 371 Fairfield Road, U1157, Storrs, CT 06269, USA
    Neoplasia 7:263-70. 2005
  6. pmc Optical tomography with ultrasound localization: initial clinical results and technical challenges
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Technol Cancer Res Treat 4:235-44. 2005
  7. pmc Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis
    Quing Zhu
    Bioengineering Program, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Radiology 256:367-78. 2010
  8. pmc Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269 1157, USA
    Radiology 237:57-66. 2005
  9. pmc Optimal probing of optical contrast of breast lesions of different size located at different depths by US localization
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, Storrs, CT 06269, USA
    Technol Cancer Res Treat 5:365-80. 2006
  10. pmc Separately reconstructing the structural and functional parameters of a fluorescent inclusion embedded in a turbid medium
    Baohong Yuan
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, 06269, USA
    Opt Express 14:7172-87. 2006

Collaborators

Detail Information

Publications68

  1. pmc Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomography
    Yi Yang
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269
    J Biomed Opt 17:90503-1. 2012
    ....
  2. pmc A three-parameter logistic model to characterize ovarian tissue using polarization-sensitive optical coherence tomography
    Tianheng Wang
    University of Connecticut, Dept of Electrical and Computer Engineering, Storrs, CT 06269, USA
    Biomed Opt Express 4:772-7. 2013
    ..3% specificity were achieved. These results showed that the three-parameter prediction model based on quantitative parameters estimated from PS-OCT images could be a powerful tool to detect and diagnose ovarian cancer...
  3. doi request reprint The evaluation of NIR-absorbing porphyrin derivatives as contrast agents in photoacoustic imaging
    Akram Abuteen
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269, USA
    Phys Chem Chem Phys 15:18502-9. 2013
    ..Some relationships between photophysical parameters of the dyes and the resulting photoacoustic signal strength could be derived. ..
  4. pmc Breast cancer: assessing response to neoadjuvant chemotherapy by using US-guided near-infrared tomography
    Quing Zhu
    Biomedical Engineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Radiology 266:433-42. 2013
    ..To assess initial breast tumor hemoglobin (Hb) content before the initiation of neoadjuvant chemotherapy, monitor the Hb changes at the end of each treatment cycle, and correlate these findings with tumor pathologic response...
  5. pmc Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers
    Quing Zhu
    University of Connecticut, 371 Fairfield Road, U1157, Storrs, CT 06269, USA
    Neoplasia 7:263-70. 2005
    ..By combining ultrasound (US) and near-infrared (NIR) optical imaging, a reliable new technique has emerged for localizing and characterizing tumor angiogenesis within the breast...
  6. pmc Optical tomography with ultrasound localization: initial clinical results and technical challenges
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Technol Cancer Res Treat 4:235-44. 2005
    ....
  7. pmc Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosis
    Quing Zhu
    Bioengineering Program, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Radiology 256:367-78. 2010
    ..To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast...
  8. pmc Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269 1157, USA
    Radiology 237:57-66. 2005
    ..To investigate prospectively the feasibility of using optical tomography with ultrasonographic (US) localization to differentiate malignant from benign breast masses and to compare optical tomography with color Doppler US...
  9. pmc Optimal probing of optical contrast of breast lesions of different size located at different depths by US localization
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, Storrs, CT 06269, USA
    Technol Cancer Res Treat 5:365-80. 2006
    ..A clinical example of a large invasive carcinoma is presented to demonstrate the application of this novel technique...
  10. pmc Separately reconstructing the structural and functional parameters of a fluorescent inclusion embedded in a turbid medium
    Baohong Yuan
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, 06269, USA
    Opt Express 14:7172-87. 2006
    ....
  11. ncbi request reprint Optical imaging as an adjunct to sonograph in differentiating benign from malignant breast lesions
    Q Zhu
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs 06269, USA
    J Biomed Opt 5:229-36. 2000
    ..Maximum deoxyHb and blood concentration changes were greater than 2.9 V on average except one lesion which showed smaller deoxyHb signal (maximum 0.85 V) but the deoxyHb mass and blood concentration mass were highly correlated...
  12. pmc Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localization
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
    Neoplasia 10:1028-40. 2008
    ..NIR/US also may evaluate pathologic response during treatment allowing for tailoring therapies to response...
  13. pmc Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound
    Quing Zhu
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 2157, USA
    Opt Lett 28:337-9. 2003
    ..It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme...
  14. pmc Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT 06269 2157, USA
    Neoplasia 5:379-88. 2003
    ..Furthermore, the small invasive cancers are well localized and have wavelength-dependent appearance in optical absorption maps, whereas the benign lesions appear diffused and relatively wavelength-independent...
  15. ncbi request reprint Simultaneous optical coherence tomography imaging and beta particle detection
    Quing Zhu
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Opt Lett 28:1704-6. 2003
    ..With this prototype device we demonstrate the feasibility of simultaneous optical coherence tomography imaging and detection of beta particles...
  16. pmc Targeting tumor hypoxia with 2-nitroimidazole-indocyanine green dye conjugates
    Yan Xu
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 18:66009. 2013
    ..These findings were supported with fluorescence images of histological sections of tumor samples and an immunohistochemistry technique for identifying tumor hypoxia...
  17. pmc A real-time photoacoustic tomography system for small animals
    John Gamelin
    Department of Electrical Engineering, University of Connecticut, Storrs, CT 06269, USA
    Opt Express 17:10489-98. 2009
    ..The real-time, full 2D tomographic capability of the system paves the way for functional photoacoustic tomographic imaging studies in small animals with sub-second time frame...
  18. pmc Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterization
    Andres Aguirre
    University of Connecticut, Department of Electrical and Computer Engineering, 371 Fairfield Way, Storrs, Connecticut 06269, USA
    J Biomed Opt 14:054014. 2009
    ..The results show excellent coregistration of ultrasound and photoacoustic images. Strong optical absorption from vasculature, especially highly vascularized corpora lutea and low absorption from follicles, is demonstrated...
  19. pmc Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imaging
    Tianheng Wang
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 17:061218. 2012
    ..Simulations were validated using a broadband hydrophone. Quantitative comparisons of photoacoustic images obtained with three corresponding transducers showed that the image quality was not affected by stretching the pulse...
  20. pmc Image reconstruction method for a two-layer tissue structure accounts for chest-wall effects in breast imaging
    Chen Xu
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 13:064029. 2008
    ..Clinical results of breast lesions are also presented to demonstrate the utility of this new imaging algorithm...
  21. pmc Optimal probe design for breast imaging using near-infrared diffused light
    Chen Xu
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 13:044002. 2008
    ..A clinical example is given to demonstrate the utility of this new approach for optimally probing lesions located at different depths...
  22. ncbi request reprint A prototype hybrid intraoperative probe for ovarian cancer detection
    John Gamelin
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, CT 06269, USA
    Opt Express 17:7245-58. 2009
    ....
  23. pmc Photoacoustic imaging enhanced by indocyanine green-conjugated single-wall carbon nanotubes
    Saeid Zanganeh
    University of Connecticut, Departments of Biomedical Engineering and Electrical and Computer Engineering, Storrs, Connecticut 06269
    J Biomed Opt 18:096006. 2013
    ..This feature is highly valuable in guiding surgeons to assess tumor boundaries and dimensions in vivo and to achieve clean tumor margins to improve surgical resection of tumors...
  24. pmc Effect of the chest wall on breast lesion reconstruction
    Yasaman Ardeshirpour
    University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Road U1157, Storrs, Connecticut 06269, USA
    J Biomed Opt 14:044005. 2009
    ..The analysis can also provide guidelines for imaging operators to minimize image artifacts and to produce the best reconstruction results...
  25. pmc Investigation of a diffuse optical measurements-assisted quantitative photoacoustic tomographic method in reflection geometry
    Chen Xu
    University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Road, Unit 2157, Storrs, Connecticut 06269 2157, USA
    J Biomed Opt 17:061213. 2012
    ..The photoacoustic images and fitted absorption coefficients are presented. These results demonstrate the clinical potential of this fitting procedure to quantitatively characterize small lesions in breast imaging...
  26. pmc Dual-mesh optical tomography reconstruction method with a depth correction that uses a priori ultrasound information
    Minming Huang
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Appl Opt 43:1654-62. 2004
    ....
  27. ncbi request reprint Simultaneous reconstruction of absorption and scattering maps with ultrasound localization: feasibility study using transmission geometry
    Minming Huang
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Appl Opt 42:4102-14. 2003
    ..When both the absorption and the scattering coefficients are reconstructed the performance of the frequency-domain systemis much better than that of the dc system...
  28. pmc Estimation of chest-wall-induced diffused wave distortion with the assistance of ultrasound
    Chen Xu
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Appl Opt 44:4255-64. 2005
    ....
  29. ncbi request reprint Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models
    Daqing Piao
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 10:44010. 2005
    ..Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection...
  30. pmc Portable near-infrared diffusive light imager for breast cancer detection
    Nan Guang Chen
    Department of Electrical and Computer Engineering, University of Connecticut, 371 Fairfield Road, Unit 1157, Storrs, CT 06269, USA
    J Biomed Opt 9:504-10. 2004
    ..The entire system is compact in size (<0.051 m(3)) and fast in data acquisition (less than 2 sec for a complete scan). Calibration and the clinical experiment results are presented in the paper...
  31. pmc Light shadowing effect of large breast lesions imaged by optical tomography in reflection geometry
    Chen Xu
    University of Connecticut, Department of Electrical and Computer Engineering, 371 Fairfield Road, Storrs, Connecticut 06269, USA
    J Biomed Opt 15:036003. 2010
    ..Understanding and quantifying the shadowing effect due to optical contrast is important for characterizing larger malignant cancers from benign lesions...
  32. pmc Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography system
    Patrick D Kumavor
    Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Way, Unit 2157, Storrs, Connecticut 06269, USA
    J Biomed Opt 16:046010. 2011
    ..We show in this paper that the relative optical absorption map provided by photoacoustic tomography can potentially guide the diffuse optical tomography to accurately reconstruct target absorption maps...
  33. pmc Imaging tumor oxyhemoglobin and deoxyhemoglobin concentrations with ultrasound-guided diffuse optical tomography
    Nrusingh C Biswal
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269, USA
    Technol Cancer Res Treat 10:417-29. 2011
    ..Clinical examples are given to demonstrate the utility of US-guided optical tomography in mapping heterogeneous deoxyHb and oxyHb distributions in breast cancers...
  34. pmc Analytical solution for light propagation in a two-layer tissue structure with a tilted interface for breast imaging
    Mini Das
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Appl Opt 45:5027-36. 2006
    ..This is expected to improve the accuracy in estimating the optical properties of breast tissue, thus enhancing the accuracy of optical tomography of breast tumors...
  35. ncbi request reprint Co-registered pulse-echo/photoacoustic transvaginal probe for real time imaging of ovarian tissue
    Patrick D Kumavor
    Biomedical Engineering program and Electrical and Computer Engineering Department, University of Connecticut, Storrs CT 06269, USA
    J Biophotonics 6:475-84. 2013
    ..The results suggest that the system along with the probe has great potential for imaging and characterizing of ovarian tissue in vivo...
  36. pmc Artifact reduction method in ultrasound-guided diffuse optical tomography using exogenous contrast agents
    Yasaman Ardeshirpour
    Electrical and Computer Engineering Department, University of Connecticut, Storrs, Connecticut 06269, USA
    J Biomed Opt 16:046015. 2011
    ..Co-registered ultrasound was used to guide the lesion localization. The results have shown that artifacts caused by background mismatch can be reduced significantly by using this new method...
  37. doi request reprint FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imaging
    Umar Alqasemi
    Biomedical Engineering Program, University of Connecticut, Storrs, CT, USA
    IEEE Trans Ultrason Ferroelectr Freq Control 59:1344-53. 2012
    ..A co-registered ultrasound and photoacoustic imaging system consisting of four FPGA modules (64-channels) is constructed, and its performance is demonstrated using phantom targets and in vivo mouse tumor models...
  38. pmc Frequency tracking in optical Doppler tomography using an adaptive notch filter
    Yueli Chen
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 12:014018. 2007
    ..Our simulations and imaging results also demonstrate that this filter has good performance in terms of noise robustness and estimation accuracy compared with existing estimation algorithms...
  39. pmc Imaging tumor hypoxia by near-infrared fluorescence tomography
    Nrusingh C Biswal
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 16:066009. 2011
    ..These findings are supported with fluorescence images of histological sections of tumor samples using a Li-COR scanner and immunohistochemistry technique for tumor hypoxia...
  40. ncbi request reprint Digital signal processor-based real-time optical Doppler tomography system
    Shikui Yan
    Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Road U11257, Storrs, CT 06269 2157, USA
    J Biomed Opt 9:454-63. 2004
    ..Experiments on Intralipid flow demonstrate that a pulsatile flow of several hundred pulses per minute can be faithfully captured in M-scan mode by this DSP system. In vivo imaging of a rat's abdominal blood flow is also presented...
  41. pmc Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissue
    Yi Yang
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 16:090504. 2011
    ..001). These results demonstrated that quantitative measurements of optical scattering coefficient from OCT images could be a potential powerful method for ovarian cancer detection...
  42. pmc Effect of ultrasound transducer face reflectivity on the light fluence inside a turbid medium in photoacoustic imaging
    Behnoosh Tavakoli
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 15:046003. 2010
    ....
  43. ncbi request reprint Doppler angle and flow velocity mapping by combined Doppler shift and Doppler bandwidth measurements in optical Doppler tomography
    Daqing Piao
    Department of Electrical and Computer Engineering, University of Connecticut, Storm, Connecticut 06269 2157, USA
    Opt Lett 28:1120-2. 2003
    ..In vivo study of lip microvascularization demonstrates that this method is capable of providing both flow speed and flow direction information...
  44. pmc Enhanced fluorescence diffuse optical tomography with indocyanine green-encapsulating liposomes targeted to receptors for vascular endothelial growth factor in tumor vasculature
    Saeid Zanganeh
    University of Connecticut, Departments of Bioengineering and Electrical and Computer Engineering, Storrs, Connecticut 06269
    J Biomed Opt 18:126014. 2013
    ..Higher scVEGF-Lip/ICG tumor accumulation was further confirmed by the analysis of fluorescence on cryosections of tumors that were harvested from animals at 400 min after injection with different tracers...
  45. pmc Two-step reconstruction method using global optimization and conjugate gradient for ultrasound-guided diffuse optical tomography
    Behnoosh Tavakoli
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 18:16006. 2013
    ..8 and 3.32 times higher than the benign cases, respectively...
  46. pmc Recognition algorithm for assisting ovarian cancer diagnosis from coregistered ultrasound and photoacoustic images: ex vivo study
    Umar Alqasemi
    University of Connecticut, Biomedical Engineering Program, 371 Fairfield Way, U 2157, Storrs, Connecticut 06269, USA
    J Biomed Opt 17:126003. 2012
    ..92% sensitivity and 95.12% specificity. Furthermore, if we assume that recognizing one image as a cancer is sufficient to consider an ovary as malignant, the SVM classifier achieves 100% sensitivity and 87.88% specificity...
  47. pmc Imaging heterogeneous absorption distribution of advanced breast cancer by optical tomography
    Yan Xu
    University of Connecticut Department of Electrical and Computer Engineering, Storrs, CT 06269, USA
    J Biomed Opt 15:066007. 2010
    ..A clinical example is given to show the complex vasculature distributions seen from an advanced cancer...
  48. ncbi request reprint Quantifying Doppler angle and mapping flow velocity by a combination of Doppler-shift and Doppler-bandwidth measurements in optical Doppler tomography
    Daqing Piao
    Department of Electrical and Computer Engineering, University of Connecticut, 260 Glenbrook Road, U157, Storrs, Connecticut 06269 1157, USA
    Appl Opt 42:5158-66. 2003
    ..As obtained with the method introduced here, the Doppler-angle estimation accuracies of the two sets are 97.6% and 98.2%, respectively, and the estimation accuracies of flow speeds of the two sets are 94.3% and 90.4%, respectively...
  49. ncbi request reprint Characterization of dentin, enamel, and carious lesions by a polarization-sensitive optical coherence tomography system
    Yueli Chen
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 1157, USA
    Appl Opt 44:2041-8. 2005
    ..e., the local textural features and the global structural features. This study indicates that PSOCT has the potential to be a powerful tool for research of dental formation and caries diagnosis...
  50. pmc Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring
    Quing Zhu
    Bioengineering Program, Electrical and Computer Engineering Department, 371 Fairfield Way, University of Connecticut, Storrs, CT 03269, USA
    Surg Oncol Clin N Am 16:307-21. 2007
    ..These functional parameters are valuable for aiding US diagnosis and for assessing chemotherapy response...
  51. pmc Fluorescence imaging of vascular endothelial growth factor in tumors for mice embedded in a turbid medium
    Nrusingh C Biswal
    University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 15:016012. 2010
    ..Fluorescence targets with concentrations as low as sub-25 nM are well reconstructed at depths up to 2 cm in both homogeneous and heterogeneous media with this technique...
  52. pmc Curved array photoacoustic tomographic system for small animal imaging
    John Gamelin
    University of Connecticut, Department of Electrical Engineering, Storrs, Connecticut 06269, USA
    J Biomed Opt 13:024007. 2008
    ..For the first time, according to our knowledge, resolution of sub-200-microm vessels with an overlying turbid medium of greater than 2 cm depth is demonstrated using only intrinsic biological contrast...
  53. pmc Depth-correction algorithm that improves optical quantification of large breast lesions imaged by diffuse optical tomography
    Behnoosh Tavakoli
    Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Road, U1157, Storrs, Connecticut 06269, USA
    J Biomed Opt 16:056002. 2011
    ..In addition, nonhomogenous phantoms are characterized more accurately. Clinical examples show a similar trend as the phantom results and demonstrate the utility of the correction method for improving lesion quantification...
  54. pmc Clustered targets imaged by optical tomography guided by ultrasound
    Yan Xu
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 16:076018. 2011
    ..When two targets, one larger and one smaller, were located closer to each other, the location of the reconstructed absorption mass was shifted toward the larger target and the quantification of the smaller target was limited...
  55. pmc Real-time photoacoustic tomography of cortical hemodynamics in small animals
    Changhui Li
    Washington University in St Louis, Department of Biomedical Engineering Optical Imaging Laboratory, St Louis, Missouri 63130University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269
    J Biomed Opt 15:010509. 2010
    ..Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities...
  56. pmc Optical tomography method that accounts for tilted chest wall in breast imaging
    Yasaman Ardeshirpour
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269 2157, USA
    J Biomed Opt 15:041515. 2010
    ..Fitted two-layer background optical properties obtained from a group of ten patients with chest walls located less than 2 cm deep are more representative of breast tissue and chest-wall optical properties...
  57. pmc Potential role of coregistered photoacoustic and ultrasound imaging in ovarian cancer detection and characterization
    Andres Aguirre
    Biomedical Ultrasonic and Optical Imaging Laboratory, Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT, USA
    Transl Oncol 4:29-37. 2011
    ..0237). For these two groups, we have obtained a sensitivity of 83% and a specificity of 83%. This result suggests that PAI is a promising modality for improving ultrasound diagnosis of ovarian cancer...
  58. pmc Fast, limited-data photoacoustic imaging for multiplexed systems using a frequency-domain estimation technique
    John K Gamelin
    Department of Electrical and Computer Engineering, University of Connecticut, 371 Fairfield Way, Storrs, Connecticut 06269, USA
    Med Phys 38:1503-18. 2011
    ..A new frequency-domain estimation algorithm has been developed that uses a priori information to simultaneously improve imaging quality and time resolution in photoacoustic tomography with incomplete data sets...
  59. pmc Time-gating scheme based on a photodiode for single-photon counting
    Patrick D Kumavor
    University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Way, Unit 2157, Storrs, Connecticut 06269, USA
    Opt Lett 36:2501-3. 2011
    ..The system was also used to successfully resolve a pair of targets with 4 mm separation inside a highly scattering medium by the use of time-gated early-arriving photons...
  60. pmc Emission and absorption properties of indocyanine green in Intralipid solution
    Baohong Yuan
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269 1157, USA
    J Biomed Opt 9:497-503. 2004
    ..Also, in the concentration range of 0 to 2 microM, ICG solution always has a higher absorption coefficient at wavelength 830 nm than that at 660 nm, which is quite different from the ICG in water case...
  61. ncbi request reprint Direct bidirectional angle-insensitive imaging of the flow signal intensity in Doppler optical coherence tomography
    Daqing Piao
    Department of Electrical and Computer Engineering, University of Connecticut, Unit 1157, 371 Fairfield Road, Storrs, Connecticut 06269 1157, USA
    Appl Opt 44:348-57. 2005
    ..Besides the direct directional detection of flow signal intensity, flow speed information can be acquired with postprocessing...
  62. ncbi request reprint Quantitative assessment of flow velocity-estimation algorithms for optical Doppler tomography imaging
    Daqing Piao
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs 06269 2157, USA
    Appl Opt 41:6118-27. 2002
    ..These comparisons demonstrate that the sliding-window filtering technique is superior to the other techniques in terms of velocity estimation accuracy and robustness to noise...
  63. ncbi request reprint Modeling of noninvasive microwave characterization of breast tumors
    Y Huo
    Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT 06269, USA
    IEEE Trans Biomed Eng 51:1089-94. 2004
    ..The technique has potential as a diagnostic tool to characterize breast lesions in conjunction with other imaging modalities such as ultrasound for detection...
  64. ncbi request reprint Quantifying labial blood flow using optical Doppler tomography
    Linda L Otis
    Department of Oral Medicine, The University of Pennsylvania School of Dental Medicine, Philadelphia 19104 6030, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:189-94. 2004
    ..The objective of this study was to determine the feasibility of ODT to image labial blood flow. A prototype ODT imaging system was constructed that characterized and measured labial blood flow in healthy subjects...
  65. ncbi request reprint Minimization of geometric-beam broadening in a grating-based time-domain delay line for optical coherence tomography application
    Zhen Jiang
    School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
    J Opt Soc Am A Opt Image Sci Vis 24:3808-18. 2007
    ..In vitro and in vivo imaging results are presented to demonstrate the improvement. It is also shown that geometric-beam broadening may exist in other optical coherence tomography reference arm configurations...

Research Grants8

  1. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2002
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  2. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2003
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  3. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2004
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  4. Near Infrared Diffused Light Imaging with Ultrasound
    Quing Zhu; Fiscal Year: 2005
    ..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
  5. Near Infrared Diffused Light Imaging with Ultrasound Guidance
    Quing Zhu; Fiscal Year: 2007
    ..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..
  6. Near Infrared Diffused Light Imaging with Ultrasound Guidance
    Quing Zhu; Fiscal Year: 2009
    ..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..
  7. Near Infrared Diffused Light Imaging with Ultrasound Guidance
    Quing Zhu; Fiscal Year: 2010
    ..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..