Research Topics
| Quing ZhuSummaryAffiliation: University of Connecticut Country: USA Publications
Research Grants
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Detail Information
Publications
Optical imaging as an adjunct to sonograph in differentiating benign from malignant breast lesionsQ Zhu
University of Connecticut, Department of Electrical and Computer Engineering, Storrs 06269, USA
J Biomed Opt 5:229-36. 2000..Maximum deoxyHb and blood concentration changes were greater than 2.9 V on average except one lesion which showed smaller deoxyHb signal (maximum 0.85 V) but the deoxyHb mass and blood concentration mass were highly correlated...
Optical tomography with ultrasound localization: initial clinical results and technical challengesQuing Zhu
Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
Technol Cancer Res Treat 4:235-44. 2005....- Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstructionQuing Zhu
Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269 1157, USA
Radiology 237:57-66. 2005..To investigate prospectively the feasibility of using optical tomography with ultrasonographic (US) localization to differentiate malignant from benign breast masses and to compare optical tomography with color Doppler US... - Optimal probing of optical contrast of breast lesions of different size located at different depths by US localizationQuing Zhu
Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, Storrs, CT 06269, USA
Technol Cancer Res Treat 5:365-80. 2006..A clinical example of a large invasive carcinoma is presented to demonstrate the application of this novel technique... - Separately reconstructing the structural and functional parameters of a fluorescent inclusion embedded in a turbid mediumBaohong Yuan
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT, 06269, USA
Opt Express 14:7172-87. 2006.... - Noninvasive monitoring of breast cancer during neoadjuvant chemotherapy using optical tomography with ultrasound localizationQuing Zhu
Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
Neoplasia 10:1028-40. 2008..NIR/US also may evaluate pathologic response during treatment allowing for tailoring therapies to response... - Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancersQuing Zhu
University of Connecticut, 371 Fairfield Road, U1157, Storrs, CT 06269, USA
Neoplasia 7:263-70. 2005..By combining ultrasound (US) and near-infrared (NIR) optical imaging, a reliable new technique has emerged for localizing and characterizing tumor angiogenesis within the breast... - Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 casesQuing Zhu
Bioengineering Program, Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT 06269 2157, USA
Neoplasia 5:379-88. 2003..Furthermore, the small invasive cancers are well localized and have wavelength-dependent appearance in optical absorption maps, whereas the benign lesions appear diffused and relatively wavelength-independent... - Simultaneous optical coherence tomography imaging and beta particle detectionQuing Zhu
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
Opt Lett 28:1704-6. 2003..With this prototype device we demonstrate the feasibility of simultaneous optical coherence tomography imaging and detection of beta particles... - Early-stage invasive breast cancers: potential role of optical tomography with US localization in assisting diagnosisQuing Zhu
Bioengineering Program, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269, USA
Radiology 256:367-78. 2010..To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast... - Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasoundQuing Zhu
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269 2157, USA
Opt Lett 28:337-9. 2003..It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme... - A real-time photoacoustic tomography system for small animalsJohn Gamelin
Department of Electrical Engineering, University of Connecticut, Storrs, CT 06269, USA
Opt Express 17:10489-98. 2009..The real-time, full 2D tomographic capability of the system paves the way for functional photoacoustic tomographic imaging studies in small animals with sub-second time frame... - Coregistered three-dimensional ultrasound and photoacoustic imaging system for ovarian tissue characterizationAndres Aguirre
University of Connecticut, Department of Electrical and Computer Engineering, 371 Fairfield Way, Storrs, Connecticut 06269, USA
J Biomed Opt 14:054014. 2009..The results show excellent coregistration of ultrasound and photoacoustic images. Strong optical absorption from vasculature, especially highly vascularized corpora lutea and low absorption from follicles, is demonstrated... - Application of laser pulse stretching scheme for efficiently delivering laser energy in photoacoustic imagingTianheng Wang
University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
J Biomed Opt 17:061218. 2012..Simulations were validated using a broadband hydrophone. Quantitative comparisons of photoacoustic images obtained with three corresponding transducers showed that the image quality was not affected by stretching the pulse... - Optimal probe design for breast imaging using near-infrared diffused lightChen Xu
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 13:044002. 2008..A clinical example is given to demonstrate the utility of this new approach for optimally probing lesions located at different depths... - Image reconstruction method for a two-layer tissue structure accounts for chest-wall effects in breast imagingChen Xu
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 13:064029. 2008..Clinical results of breast lesions are also presented to demonstrate the utility of this new imaging algorithm... - Investigation of a diffuse optical measurements-assisted quantitative photoacoustic tomographic method in reflection geometryChen Xu
University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Road, Unit 2157, Storrs, Connecticut 06269 2157, USA
J Biomed Opt 17:061213. 2012..The photoacoustic images and fitted absorption coefficients are presented. These results demonstrate the clinical potential of this fitting procedure to quantitatively characterize small lesions in breast imaging... - Portable near-infrared diffusive light imager for breast cancer detectionNan Guang Chen
Department of Electrical and Computer Engineering, University of Connecticut, 371 Fairfield Road, Unit 1157, Storrs, CT 06269, USA
J Biomed Opt 9:504-10. 2004..The entire system is compact in size (<0.051 m(3)) and fast in data acquisition (less than 2 sec for a complete scan). Calibration and the clinical experiment results are presented in the paper... - Simultaneous reconstruction of absorption and scattering maps with ultrasound localization: feasibility study using transmission geometryMinming Huang
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
Appl Opt 42:4102-14. 2003..When both the absorption and the scattering coefficients are reconstructed the performance of the frequency-domain systemis much better than that of the dc system... - Estimation of chest-wall-induced diffused wave distortion with the assistance of ultrasoundChen Xu
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
Appl Opt 44:4255-64. 2005.... - Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic modelsDaqing Piao
University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
J Biomed Opt 10:44010. 2005..Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection... - Dual-mesh optical tomography reconstruction method with a depth correction that uses a priori ultrasound informationMinming Huang
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
Appl Opt 43:1654-62. 2004.... - Effect of the chest wall on breast lesion reconstructionYasaman Ardeshirpour
University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Road U1157, Storrs, Connecticut 06269, USA
J Biomed Opt 14:044005. 2009..The analysis can also provide guidelines for imaging operators to minimize image artifacts and to produce the best reconstruction results... - Imaging tumor oxyhemoglobin and deoxyhemoglobin concentrations with ultrasound-guided diffuse optical tomographyNrusingh C Biswal
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269, USA
Technol Cancer Res Treat 10:417-29. 2011..Clinical examples are given to demonstrate the utility of US-guided optical tomography in mapping heterogeneous deoxyHb and oxyHb distributions in breast cancers... - Analytical solution for light propagation in a two-layer tissue structure with a tilted interface for breast imagingMini Das
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
Appl Opt 45:5027-36. 2006..This is expected to improve the accuracy in estimating the optical properties of breast tissue, thus enhancing the accuracy of optical tomography of breast tumors... 
FPGA-based reconfigurable processor for ultrafast interlaced ultrasound and photoacoustic imagingUmar Alqasemi
Biomedical Engineering Program, University of Connecticut, Storrs, CT, USA
IEEE Trans Ultrason Ferroelectr Freq Control 59:1344-53. 2012..A co-registered ultrasound and photoacoustic imaging system consisting of four FPGA modules (64-channels) is constructed, and its performance is demonstrated using phantom targets and in vivo mouse tumor models...- Frequency tracking in optical Doppler tomography using an adaptive notch filterYueli Chen
University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
J Biomed Opt 12:014018. 2007..Our simulations and imaging results also demonstrate that this filter has good performance in terms of noise robustness and estimation accuracy compared with existing estimation algorithms... - A prototype hybrid intraoperative probe for ovarian cancer detectionJohn Gamelin
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, CT 06269, USA
Opt Express 17:7245-58. 2009.... - Digital signal processor-based real-time optical Doppler tomography systemShikui Yan
Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Road U11257, Storrs, CT 06269-2157, USA
J Biomed Opt 9:454-63. 2004..Experiments on Intralipid flow demonstrate that a pulsatile flow of several hundred pulses per minute can be faithfully captured in M-scan mode by this DSP system. In vivo imaging of a rat's abdominal blood flow is also presented... - Target detection and quantification using a hybrid hand-held diffuse optical tomography and photoacoustic tomography systemPatrick D Kumavor
Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Way, Unit 2157, Storrs, Connecticut 06269, USA
J Biomed Opt 16:046010. 2011..We show in this paper that the relative optical absorption map provided by photoacoustic tomography can potentially guide the diffuse optical tomography to accurately reconstruct target absorption maps... - Light shadowing effect of large breast lesions imaged by optical tomography in reflection geometryChen Xu
University of Connecticut, Department of Electrical and Computer Engineering, 371 Fairfield Road, Storrs, Connecticut 06269, USA
J Biomed Opt 15:036003. 2010..Understanding and quantifying the shadowing effect due to optical contrast is important for characterizing larger malignant cancers from benign lesions... - Imaging tumor hypoxia by near-infrared fluorescence tomographyNrusingh C Biswal
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 16:066009. 2011..These findings are supported with fluorescence images of histological sections of tumor samples using a Li-COR scanner and immunohistochemistry technique for tumor hypoxia... - Doppler angle and flow velocity mapping by combined Doppler shift and Doppler bandwidth measurements in optical Doppler tomographyDaqing Piao
Department of Electrical and Computer Engineering, University of Connecticut, Storm, Connecticut 06269 2157, USA
Opt Lett 28:1120-2. 2003..In vivo study of lip microvascularization demonstrates that this method is capable of providing both flow speed and flow direction information... - Breast Cancer: Assessing Response to Neoadjuvant Chemotherapy by Using US-guided Near-Infrared TomographyQuing Zhu
Biomedical Engineering Program, Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Rd, U2157, Storrs, CT 06269 Departments of Pathology and Radiology, Hartford Hospital, Hartford, Conn
Radiology 266:433-42. 2013..Additionally, the tHb changes during early treatment cycles can further predict final pathologic response. © RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.12112415/-/DC1... - Effect of ultrasound transducer face reflectivity on the light fluence inside a turbid medium in photoacoustic imagingBehnoosh Tavakoli
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 15:046003. 2010.... - Artifact reduction method in ultrasound-guided diffuse optical tomography using exogenous contrast agentsYasaman Ardeshirpour
Electrical and Computer Engineering Department, University of Connecticut, Storrs, Connecticut 06269, USA
J Biomed Opt 16:046015. 2011..Co-registered ultrasound was used to guide the lesion localization. The results have shown that artifacts caused by background mismatch can be reduced significantly by using this new method... - Quantifying Doppler angle and mapping flow velocity by a combination of Doppler-shift and Doppler-bandwidth measurements in optical Doppler tomographyDaqing Piao
Department of Electrical and Computer Engineering, University of Connecticut, 260 Glenbrook Road, U157, Storrs, Connecticut 06269-1157, USA
Appl Opt 42:5158-66. 2003..As obtained with the method introduced here, the Doppler-angle estimation accuracies of the two sets are 97.6% and 98.2%, respectively, and the estimation accuracies of flow speeds of the two sets are 94.3% and 90.4%, respectively... - Fluorescence imaging of vascular endothelial growth factor in tumors for mice embedded in a turbid mediumNrusingh C Biswal
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 15:016012. 2010..Fluorescence targets with concentrations as low as sub-25 nM are well reconstructed at depths up to 2 cm in both homogeneous and heterogeneous media with this technique... - Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoringQuing Zhu
Bioengineering Program, Electrical and Computer Engineering Department, 371 Fairfield Way, University of Connecticut, Storrs, CT 03269, USA
Surg Oncol Clin N Am 16:307-21. 2007..These functional parameters are valuable for aiding US diagnosis and for assessing chemotherapy response... - Curved array photoacoustic tomographic system for small animal imagingJohn Gamelin
University of Connecticut, Department of Electrical Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 13:024007. 2008..For the first time, according to our knowledge, resolution of sub-200-microm vessels with an overlying turbid medium of greater than 2 cm depth is demonstrated using only intrinsic biological contrast... - Characterization of dentin, enamel, and carious lesions by a polarization-sensitive optical coherence tomography systemYueli Chen
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269-1157, USA
Appl Opt 44:2041-8. 2005..e., the local textural features and the global structural features. This study indicates that PSOCT has the potential to be a powerful tool for research of dental formation and caries diagnosis... - Optical scattering coefficient estimated by optical coherence tomography correlates with collagen content in ovarian tissueYi Yang
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269, USA
J Biomed Opt 16:090504. 2011..001). These results demonstrated that quantitative measurements of optical scattering coefficient from OCT images could be a potential powerful method for ovarian cancer detection... - Imaging heterogeneous absorption distribution of advanced breast cancer by optical tomographyYan Xu
University of Connecticut Department of Electrical and Computer Engineering, Storrs, CT 06269, USA
J Biomed Opt 15:066007. 2010..A clinical example is given to show the complex vasculature distributions seen from an advanced cancer... - Depth-correction algorithm that improves optical quantification of large breast lesions imaged by diffuse optical tomographyBehnoosh Tavakoli
Electrical and Computer Engineering Department, University of Connecticut, 371 Fairfield Road, U1157, Storrs, Connecticut 06269, USA
J Biomed Opt 16:056002. 2011..In addition, nonhomogenous phantoms are characterized more accurately. Clinical examples show a similar trend as the phantom results and demonstrate the utility of the correction method for improving lesion quantification... - Clustered targets imaged by optical tomography guided by ultrasoundYan Xu
University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
J Biomed Opt 16:076018. 2011..When two targets, one larger and one smaller, were located closer to each other, the location of the reconstructed absorption mass was shifted toward the larger target and the quantification of the smaller target was limited... - Time-gating scheme based on a photodiode for single-photon countingPatrick D Kumavor
University of Connecticut, Electrical and Computer Engineering Department, 371 Fairfield Way, Unit 2157, Storrs, Connecticut 06269, USA
Opt Lett 36:2501-3. 2011..The system was also used to successfully resolve a pair of targets with 4 mm separation inside a highly scattering medium by the use of time-gated early-arriving photons... - Fast, limited-data photoacoustic imaging for multiplexed systems using a frequency-domain estimation techniqueJohn K Gamelin
Department of Electrical and Computer Engineering, University of Connecticut, 371 Fairfield Way, Storrs, Connecticut 06269, USA
Med Phys 38:1503-18. 2011..A new frequency-domain estimation algorithm has been developed that uses a priori information to simultaneously improve imaging quality and time resolution in photoacoustic tomography with incomplete data sets... - Potential role of coregistered photoacoustic and ultrasound imaging in ovarian cancer detection and characterizationAndres Aguirre
Biomedical Ultrasonic and Optical Imaging Laboratory, Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT, USA
Transl Oncol 4:29-37. 2011..0237). For these two groups, we have obtained a sensitivity of 83% and a specificity of 83%. This result suggests that PAI is a promising modality for improving ultrasound diagnosis of ovarian cancer... - Optical tomography method that accounts for tilted chest wall in breast imagingYasaman Ardeshirpour
University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269 2157, USA
J Biomed Opt 15:041515. 2010..Fitted two-layer background optical properties obtained from a group of ten patients with chest walls located less than 2 cm deep are more representative of breast tissue and chest-wall optical properties... - Real-time photoacoustic tomography of cortical hemodynamics in small animalsChanghui Li
Washington University in St Louis, Department of Biomedical Engineering Optical Imaging Laboratory, St Louis, Missouri 63130University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269
J Biomed Opt 15:010509. 2010..Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities... - Quantitative analysis of angle-resolved scattering properties of ovarian tissue using optical coherence tomographyYi Yang
University of Connecticut, Department of Electrical and Computer Engineering, Storrs, Connecticut 06269
J Biomed Opt 17:90503-1. 2012.... - Direct bidirectional angle-insensitive imaging of the flow signal intensity in Doppler optical coherence tomographyDaqing Piao
Department of Electrical and Computer Engineering, University of Connecticut, Unit 1157, 371 Fairfield Road, Storrs, Connecticut 06269 1157, USA
Appl Opt 44:348-57. 2005..Besides the direct directional detection of flow signal intensity, flow speed information can be acquired with postprocessing... - Emission and absorption properties of indocyanine green in Intralipid solutionBaohong Yuan
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, CT 06269-1157, USA
J Biomed Opt 9:497-503. 2004..Also, in the concentration range of 0 to 2 microM, ICG solution always has a higher absorption coefficient at wavelength 830 nm than that at 660 nm, which is quite different from the ICG in water case... - Recognition algorithm for assisting ovarian cancer diagnosis from coregistered ultrasound and photoacoustic images: ex vivo studyUmar Alqasemi
University of Connecticut, Biomedical Engineering Program, 371 Fairfield Way, U 2157, Storrs, Connecticut 06269, USA
J Biomed Opt 17:126003. 2012..92% sensitivity and 95.12% specificity. Furthermore, if we assume that recognizing one image as a cancer is sufficient to consider an ovary as malignant, the SVM classifier achieves 100% sensitivity and 87.88% specificity... - Quantitative assessment of flow velocity-estimation algorithms for optical Doppler tomography imagingDaqing Piao
Department of Electrical and Computer Engineering, University of Connecticut, Storrs 06269 2157, USA
Appl Opt 41:6118-27. 2002..These comparisons demonstrate that the sliding-window filtering technique is superior to the other techniques in terms of velocity estimation accuracy and robustness to noise... - Two-step reconstruction method using global optimization and conjugate gradient for ultrasound-guided diffuse optical tomographyBehnoosh Tavakoli
University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
J Biomed Opt 18:16006. 2013..8 and 3.32 times higher than the benign cases, respectively... - Modeling of noninvasive microwave characterization of breast tumorsY Huo
Electrical and Computer Engineering Department, University of Connecticut, Storrs, CT 06269, USA
IEEE Trans Biomed Eng 51:1089-94. 2004..The technique has potential as a diagnostic tool to characterize breast lesions in conjunction with other imaging modalities such as ultrasound for detection... - Quantifying labial blood flow using optical Doppler tomographyLinda L Otis
Department of Oral Medicine, The University of Pennsylvania School of Dental Medicine, Philadelphia 19104 6030, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:189-94. 2004..The objective of this study was to determine the feasibility of ODT to image labial blood flow. A prototype ODT imaging system was constructed that characterized and measured labial blood flow in healthy subjects... - Minimization of geometric-beam broadening in a grating-based time-domain delay line for optical coherence tomography applicationZhen Jiang
School of Electrical and Computer Engineering, Oklahoma State University, Stillwater, Oklahoma 74078, USA
J Opt Soc Am A Opt Image Sci Vis 24:3808-18. 2007..In vitro and in vivo imaging results are presented to demonstrate the improvement. It is also shown that geometric-beam broadening may exist in other optical coherence tomography reference arm configurations...
Research Grants
- Near Infrared Diffused Light Imaging with UltrasoundQuing Zhu; Fiscal Year: 2005..Completion of this research plan will serve to validate a novel method for detection and diagnosis of breast lesions, resulting in new opportunities for early detection and appropriate treatment of breast carcinoma. ..
- Near Infrared Diffused Light Imaging with Ultrasound GuidanceQuing Zhu; Fiscal Year: 2007..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..
- Near Infrared Diffused Light Imaging with Ultrasound GuidanceQuing Zhu; Fiscal Year: 2009..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..
- Near Infrared Diffused Light Imaging with Ultrasound GuidanceQuing Zhu; Fiscal Year: 2010..Approximately 40 patients who will undergo chemotherapy treatments will be recruited to this pilot study from both institutions. ..