Affiliation: University of Washington
- Immune surveillance by CD8αα+ skin-resident T cells in human herpes virus infectionJia Zhu
Department of Laboratory Medicine, University of Washington, Seattle, Washington 98195, USA
Nature 497:494-7. 2013..Elicitation of CD8αα(+) T cells may be a critical component for developing effective vaccines against skin and mucosal infections...
- Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodesJoshua T Schiffer
Department of Medicine, Laboratory Medicine, Global Health Medicine, University of Washington, Seattle, WA 98195, USA
Proc Natl Acad Sci U S A 107:18973-8. 2010..The model suggests that the rate of containment of infected cells by the peripheral mucosal immune system is the major driver of duration and severity of HSV-2 reactivation in the immunocompetent host...
- Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisitionJia Zhu
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Nat Med 15:886-92. 2009..The persistence and enrichment of HIV receptor-positive inflammatory cells in the genitalia help explain the inability of anti-HSV-2 therapy to reduce HIV acquisition...
- Evasion of the mucosal innate immune system by herpes simplex virus type 2Tao Peng
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Virol 83:12559-68. 2009..HSV-2's blockade of the innate immune system's production of type I IFN may be a major factor in allowing the virus to break through host mucosal defenses...
- An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infectionTao Peng
Department of Medicine, University of Washington, Seattle, Washington, USA
J Virol 86:10587-96. 2012..Many of these transcripts are known to have half-lives of <48 h, suggesting that cognate antigen is released frequently into the mucosa and that resident CD8(+) T cells act as functional effectors in controlling viral spread...
- Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tractJoshua T Schiffer
Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, United States Department of Medicine, University of Washington, Seattle, United States
elife 2:e00288. 2013..We conclude that HSV-2 infection is characterized by extremely rapid virological growth and containment at multiple contemporaneous sites within genital epithelium. DOI:http://dx.doi.org/10.7554/eLife.00288.001...
- HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivoAude G Chapuis
Program in Immunology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109, USA
Blood 117:5391-402. 2011....
- Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical modelJoshua T Schiffer
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Sci Transl Med 1:7ra16. 2009..Frequent HSV-2 shedding episodes in humans are explained by nearly constant release of small numbers of viruses from neurons that terminate in the genital tract...
- In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaquesAnnelie Tjernlund
Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Retrovirology 7:12. 2010..SIV and HIV predominantly replicate in lymphoid tissue, but the study of virus specific CD8+ T cells in intact lymphoid tissue is difficult, as traditional in situ tetramer staining requires fresh tissue...
- Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivationJia Zhu
Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA
J Exp Med 204:595-603. 2007..These findings indicate that the frequency and clinical course of HSV-2 reactivation in humans is influenced by virus-specific CD8(+) T cells that persist in peripheral mucosa and genital skin after resolution of herpes lesions...
- Independent and cooperative antiviral actions of beta interferon and gamma interferon against herpes simplex virus replication in primary human fibroblastsTao Peng
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
J Virol 82:1934-45. 2008....