H Zhu

Summary

Affiliation: University of Mississippi Medical Center
Country: USA

Publications

  1. ncbi request reprint Association between I(2) binding sites and monoamine oxidase-B activity in platelets
    H Zhu
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:347-52. 2003
  2. ncbi request reprint Atypical [(3)H]clonidine binding sites in human caudate and platelets on cryostat-cut sections
    H Zhu
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:296-301. 2003
  3. ncbi request reprint Imidazoline receptor antisera-selected cDNA clone and mRNA distribution
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 881:1-7. 1999
  4. ncbi request reprint IRAS splice variants
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:419-26. 2003
  5. ncbi request reprint Plasma agmatine and platelet imidazoline receptors in depression
    A Halaris
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 881:445-51. 1999
  6. ncbi request reprint Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    DNA Cell Biol 19:319-29. 2000
  7. ncbi request reprint Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue
    J E Piletz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:392-9. 2003
  8. ncbi request reprint Agmatine crosses the blood-brain barrier
    J E Piletz
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:64-74. 2003
  9. ncbi request reprint Elevated P-selectin on platelets in depression: response to bupropion
    J E Piletz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Room G128, 2500 North State Street, Jackson, MS 39216 4505, USA
    J Psychiatr Res 34:397-404. 2000
  10. ncbi request reprint Morphine induces synchronous oscillatory discharges in the rat locus coeruleus
    H Zhu
    Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Neurosci 21:RC179. 2001

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Association between I(2) binding sites and monoamine oxidase-B activity in platelets
    H Zhu
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:347-52. 2003
    ..61, P = 0.0016) among 24 human subjects. Nevertheless, the variance in MAO-B activity cannot be completely accounted for in relation to I(2) sites. Therefore, I(2) density and MAO-B activity are only weakly correlated in platelets...
  2. ncbi request reprint Atypical [(3)H]clonidine binding sites in human caudate and platelets on cryostat-cut sections
    H Zhu
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:296-301. 2003
    ..It is suggested that the isotonic buffer conditions inherent to the procedure alter drug affinities to the classical I(1) site...
  3. ncbi request reprint Imidazoline receptor antisera-selected cDNA clone and mRNA distribution
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 881:1-7. 1999
    ..05) between total (6.0 + 9.5 kb) iras mRNA and I1 BMAX values across rat tissues, corrected for housekeeping gene expression. Thus, total iras mRNA appears to be roughly proportional to the density of I1-imidazoline binding sites...
  4. ncbi request reprint IRAS splice variants
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:419-26. 2003
    ..Subtype-selective cDNA expression constructs were therefore generated and used to transfect CHO cells. High-affinity I(1) binding was endowed by IRAS-M and IRAS-L, but not by IRAS-S transfection...
  5. ncbi request reprint Plasma agmatine and platelet imidazoline receptors in depression
    A Halaris
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Ann N Y Acad Sci 881:445-51. 1999
    ..Treatment with the antidepressant bupropion normalized plasma agmatine levels. Correlational evidence is presented that a change in plasma agmatine levels may lead to similar changes in platelet I1 imidazoline receptors...
  6. ncbi request reprint Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization
    J E Piletz
    Department of Psychiatry, University of Mississippi Medical Center, Jackson 39216 4505, USA
    DNA Cell Biol 19:319-29. 2000
    ..Thus, IRAS-1 is the first protein discovered with characteristics of an IR1...
  7. ncbi request reprint Cell signaling by imidazoline-1 receptor candidate, IRAS, and the nischarin homologue
    J E Piletz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:392-9. 2003
    ..These findings suggest that IRAS is a membrane-associated mediator of receptor signaling...
  8. ncbi request reprint Agmatine crosses the blood-brain barrier
    J E Piletz
    University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Ann N Y Acad Sci 1009:64-74. 2003
    ..Therefore, agmatine and its precursor, arginine, cross the blood-brain barrier. CSF agmatine may be newly synthesized from peripherally injected arginine...
  9. ncbi request reprint Elevated P-selectin on platelets in depression: response to bupropion
    J E Piletz
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Room G128, 2500 North State Street, Jackson, MS 39216 4505, USA
    J Psychiatr Res 34:397-404. 2000
    ..The results suggest an elevation in P-selectin on platelet plasma membranes might be a trait marker for depression...
  10. ncbi request reprint Morphine induces synchronous oscillatory discharges in the rat locus coeruleus
    H Zhu
    Department of Pharmacology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Neurosci 21:RC179. 2001
    ..We propose that the morphine-induced long-lasting synchronous oscillatory activity in the LC may be a neuronal signal that could induce synaptic plasticity leading to opioid addiction...
  11. ncbi request reprint Imidazoline receptors associated with noradrenergic terminals in the rostral ventrolateral medulla mediate the hypotensive responses of moxonidine but not clonidine
    C K S Chan
    Neuropharmacology Laboratory, Baker Heart Research Institute, Melbourne, Victoria, Australia
    Neuroscience 132:991-1007. 2005
    ..Furthermore, the noradrenergic innervation may be associated with a 42 kDa imidazoline receptor protein...
  12. ncbi request reprint Cloning and functional identification of a neuronal glutamine transporter
    H Varoqui
    Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 275:4049-54. 2000
    ..GlnT is the first member of the system A family of neutral amino acid transporters with 11 putative membrane-spanning domains and is a potential target to modulate presynaptic glutamatergic function...
  13. ncbi request reprint CD44 interaction with tiam1 promotes Rac1 signaling and hyaluronic acid-mediated breast tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33101, USA
    J Biol Chem 275:1829-38. 2000
    ..Taken together, we believe that the linkage between CD44v3 isoform and the PHn-CC-EX domain of Tiam1 is required for HA stimulated Rac1 signaling and cytoskeleton-mediated tumor cell migration during breast cancer progression...
  14. ncbi request reprint Cloning of novel splice variants of mouse mGluR1
    H Zhu
    Laboratory for Cancer Research, Chemical Biology Department, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Brain Res Mol Brain Res 73:93-103. 1999
    ..Insertion of the E55 exon results in an inframe stop codon. The predicted protein product contains only the extracellular domain of the receptor and may be secreted...
  15. pmc Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Miami, Florida 33136, USA
    J Cell Biol 150:177-91. 2000
    ..These findings suggest that ankyrin-Tiam1 interaction plays a pivotal role in regulating Rac1 signaling and cytoskeleton function required for oncogenic signaling and metastatic breast tumor cell progression...
  16. ncbi request reprint An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease
    S D Yan
    Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Nature 389:689-95. 1997
    ..By interacting with intracellular amyloid-beta, ERAB may therefore contribute to the neuronal dysfunction associated with Alzheimer's disease...
  17. ncbi request reprint CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration
    L Y Bourguignon
    Department of Cell Biology and Anatomy, School of Medicine, University of Miami, Florida 33101, USA
    J Biol Chem 276:7327-36. 2001
    ....
  18. ncbi request reprint Different Mg to Fe ratios in the mixed metal MgFe hydroxy-carbonate compounds and the effect on phosphate binding compared with established phosphate binders
    H Zhu
    Department of Clinical Chemistry, Royal Liverpool University Hospital, 4 th Floor, Duncan Building, Prescot Street, Liverpool L7 8XP, United Kingdom
    J Pharm Sci 91:53-66. 2002
    ..In conclusion, MgFe hydroxy-carbonate compounds are effective phosphate binders and may provide a better alternative to both existing and emerging binders for combating hyperphosphataemia...
  19. ncbi request reprint Decreased levels of apolipoprotein A-I in plasma of schizophrenic patients
    Y J La
    Bio X Center, Shanghai Jiao Tong University, Shanghai, PR China
    J Neural Transm 114:657-63. 2007
    ....
  20. ncbi request reprint Characterization and application of two novel monoclonal antibodies against CD40L: epitope and functional studies on cell membrane CD40L and studies on the origin of soluble serum CD40L
    Y Fan
    Biotechnology Institute, Suzhou University, Suzhou, PR China
    Tissue Antigens 64:257-63. 2004
    ..The results showed that the sCD40L in serum was much lower than that of healthy subjects. These data demonstrate that platelets seem to be a major contributor to sCD40L, though not the only source of sCD40L in serum...
  21. ncbi request reprint A mechanistic basis for the role of cycle arrest in the genetic toxicology of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
    S Creton
    Molecular Toxicology, Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, London SW7 2AZ, UK
    Toxicol Sci 84:335-43. 2005
    ..These cell cycle effects are critical, as they enable cells to effect genome repair, accept mutation, or eliminate excessively damaged cells...
  22. ncbi request reprint Genetic tests of biologic systems in affective disorders
    E Hattori
    Department of Psychiatry, The University of Chicago, Chicago, IL, USA
    Mol Psychiatry 10:719-40. 2005
    ....
  23. ncbi request reprint Differential expression of prostaglandin E receptor subtype EP2 in rat uterus during early pregnancy
    J J Shi
    College of Life Sciences, Northeast Agricultural University, Harbin, China
    Histol Histopathol 20:1021-8. 2005
    ..There was no detectable EP2 expression in both control and decidualized uteri. In conclusion, these data suggest that EP2 expression at implantation site may play an important role during embryo implantation in rats...
  24. ncbi request reprint DLK1: increased expression in gliomas and associated with oncogenic activities
    D Yin
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Oncogene 25:1852-61. 2006
    ..DLK1 antibody blocked cell growth stimulated by DLK1. In summary, these results suggest that DLK1 may play a role in the formation or progression of gliomas...
  25. ncbi request reprint Involvement of hypoxia-inducible factor-1-alpha in multidrug resistance induced by hypoxia in HepG2 cells
    H Zhu
    Institute of Hepato Pancreato Biliary Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China
    J Exp Clin Cancer Res 24:565-74. 2005
    ..Hypoxia-elicited multidrug resistance related protein expression might be a pathway for resistance of HepG2 cells to chemotherapeutics and HIF-1alpha might be involved in this process...
  26. ncbi request reprint Mechanisms of action of the carcinogenic heterocyclic amine PhIP
    N J Gooderham
    Biomolecular Medicine, Imperial College London, Sir Alexander Fleming Building, London SW7 2AZ, UK
    Toxicol Lett 168:269-77. 2007
    ..It is possible that a combination of these DNA damaging and growth promoting properties provide a mechanism for the tumourigenicity of PhIP, and may be key determinants for the tissue specificity of PhIP-induced carcinogenesis...
  27. ncbi request reprint Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth
    L Y Bourguignon
    Enocrine Unit, Department of Medicine, University of California and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Biol Chem 276:48679-92. 2001
    ....
  28. ncbi request reprint Global analysis of protein activities using proteome chips
    H Zhu
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Science 293:2101-5. 2001
    ..Thus, microarrays of an entire eukaryotic proteome can be prepared and screened for diverse biochemical activities. The microarrays can also be used to screen protein-drug interactions and to detect posttranslational modifications...
  29. ncbi request reprint Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death
    L Wang
    Cardiovascular Research Center, Massachusetts General Hospital East Charlestown 02129
    Cell 78:739-50. 1994
    ..These observations suggest that Ich-1 plays an important role in both positive and negative regulation of programmed cell death in vertebrate animals...
  30. ncbi request reprint The Y-box motif mediates redox-dependent transcriptional activation in mouse cells
    J L Duh
    Department of Environmental Health, University of Cincinnati Medical Center, Ohio 45267 0056, USA
    J Biol Chem 270:30499-507. 1995
    ..These results suggest that the Y-box proteins may be an integral component of a eukaryotic redox signaling pathway...
  31. ncbi request reprint Activation of caspase-2 in apoptosis
    H Li
    Cardiovascular Research Center, Massachusetts General Hospital East, Charlestown, Massachusetts 02129 and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 272:21010-7. 1997
    ....
  32. ncbi request reprint Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I
    H Zhu
    Department of Biochemistry and Molecular Biology, Oregon Graduate Institute of Science and Technology, Portland, Oregon 97291 1000, USA
    Arch Biochem Biophys 347:53-61. 1997
    ..This is the first report of the expression of a heart CPT-I in a system devoid of endogenous CPT activity and the functional characterization of a human heart M-CPT-I in the absence of the liver isoform and CPT-II...
  33. ncbi request reprint IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation
    F Mercurio
    Signal Pharmaceuticals, Inc, 5555 Oberlin Drive, San Diego, CA 92121, USA
    Science 278:860-6. 1997
    ..Mutant versions of IKK-2 had pronounced effects on RelA nuclear translocation and NF-kappaB-dependent reporter activity, consistent with a critical role for the IKK kinases in the NF-kappaB signaling pathway...
  34. pmc Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs
    H Zhu
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 94:13985-90. 1997
    ..These RNAs accumulate after infection with virus that has been inactivated by treatment with UV light, indicating that the inducer is present in virions. We conclude that human cytomegalovirus induces interferon-responsive mRNAs...
  35. ncbi request reprint Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    H Li
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 94:491-501. 1998
    ..Coexpression of BclxL inhibits all the apoptotic changes induced by tBID. Our results indicate that BID is a mediator of mitochondrial damage induced by Casp8...
  36. ncbi request reprint Role of ERAB/L-3-hydroxyacyl-coenzyme A dehydrogenase type II activity in Abeta-induced cytotoxicity
    S D Yan
    Departments of Pathology, Physiology and Surgery, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    J Biol Chem 274:2145-56. 1999
    ..We conclude that the generalized alcohol dehydrogenase activity of ERAB/HADH II is central to the cytotoxicity observed in an Abeta-rich environment...
  37. pmc IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex
    F Mercurio
    Signal Pharmaceuticals, Inc, San Diego, California 92121, USA
    Mol Cell Biol 19:1526-38. 1999
    ..IKKAP1 therefore appears to mediate an essential step of the NF-kappaB signal transduction cascade. Heterogeneity of IKK complexes in vivo may provide a mechanism for differential regulation of NF-kappaB activation...
  38. ncbi request reprint A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    H Zhu
    Department of Biochemistry and Cell Biology and Institute for Cell and Developmental Biology, State University of New York, Stony Brook 11794 5215, USA
    Nature 400:687-93. 1999
    ..Smurf1 also enhances cellular responsiveness to the Smad2 (activin/TGF-beta) pathway. Thus, targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals...
  39. ncbi request reprint A novel system A isoform mediating Na+/neutral amino acid cotransport
    D Yao
    Neuroscience Center and the Departments of Opthalmology and Pharmacology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 275:22790-7. 2000
    ....
  40. pmc Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes
    A Marchini
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Virol 75:1870-8. 2001
    ..These experiments provide the first direct demonstration that IE-2 is required for successful HCMV infection and indicate that virus lacking IE-2 arrests early in the replication cycle...
  41. ncbi request reprint Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
    P Kavsak
    Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto M5G 1X5, Canada
    Mol Cell 6:1365-75. 2000
    ..These studies thus define Smad7 as an adaptor in an E3 ubiquitin-ligase complex that targets the TGF beta receptor for degradation...
  42. pmc Analysis of expressed sequence tags from two starvation, time-of-day-specific libraries of Neurospora crassa reveals novel clock-controlled genes
    H Zhu
    Department of Chemistry and Biochemistry, Advanced Center for Genome Technology, University of Oklahoma, Norman, Oklahoma 73019, USA
    Genetics 157:1057-65. 2001
    ..The mRNA levels of all four genes peak in the subjective morning as is the case with previously identified ccgs...
  43. ncbi request reprint The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death
    P Karuman
    Department of Cell Biology, Harvard Medical School, 02115, Boston, MA, USA
    Mol Cell 7:1307-19. 2001
    ..We propose that a deficiency in apoptosis is a key factor in the formation of multiple benign intestinal polyps in PJS patients, and possibly for the subsequent development of malignant tumors in these patients...
  44. ncbi request reprint The lutropin/choriogonadotropin receptor is palmitoylated at intracellular cysteine residues
    H Zhu
    Department of Pharmacology, University of Iowa College of Medicine, Iowa City 52242 1109, USA
    Mol Endocrinol 9:141-50. 1995
    ....