Daocheng Zhu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A chimeric human-cat fusion protein blocks cat-induced allergy
    Daocheng Zhu
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095 1680, USA
    Nat Med 11:446-9. 2005
  2. ncbi request reprint Inhibition of interleukin-4-induced class switch recombination by a human immunoglobulin Fc gamma-Fc epsilon chimeric protein
    Takechiyo Yamada
    Hart and Louis Laboratory, Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, California 90095 1680, USA
    J Biol Chem 278:32818-24. 2003
  3. ncbi request reprint B lymphocyte stimulator activates p38 mitogen-activated protein kinase in human Ig class switch recombination
    Takechiyo Yamada
    Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095 1680, USA
    Am J Respir Cell Mol Biol 32:388-94. 2005
  4. ncbi request reprint Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein
    Ke Zhang
    Hart and Louis Lyon Laboratory, Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles School of Medicine, CA 90095 1680, USA
    J Allergy Clin Immunol 114:321-7. 2004
  5. ncbi request reprint Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes
    Konstantinos A Papadakis
    Burns and Allen Research Institute, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90048, USA
    J Immunol 174:4985-90. 2005
  6. pmc Chimeric human fcgamma-allergen fusion proteins in the prevention of allergy
    Ke Zhang
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, UCLA School of Medicine, 52 175 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095 1680, USA
    Immunol Allergy Clin North Am 27:93-103. 2007
  7. ncbi request reprint CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE
    Ke Zhang
    Hart and Louis Laboratory, Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, 90095, USA
    J Allergy Clin Immunol 110:421-8. 2002
  8. ncbi request reprint Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases
    Andrew Saxon
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1680, USA
    Curr Opin Allergy Clin Immunol 4:563-8. 2004
  9. pmc Blockade of peanut allergy with a novel Ara h 2-Fcγ fusion protein in mice
    Yu Liu
    Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Allergy Clin Immunol 131:213-21.e1-5. 2013
  10. pmc A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation
    Daocheng Zhu
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    Nat Med 8:518-21. 2002

Detail Information

Publications14

  1. ncbi request reprint A chimeric human-cat fusion protein blocks cat-induced allergy
    Daocheng Zhu
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, California 90095 1680, USA
    Nat Med 11:446-9. 2005
    ..The Fcgamma-Fel d1 protein alone did not induce mediator release. Chimeric human Fcgamma-allergen fusion proteins may provide a new therapeutic platform for the immune-based therapy of allergic disease...
  2. ncbi request reprint Inhibition of interleukin-4-induced class switch recombination by a human immunoglobulin Fc gamma-Fc epsilon chimeric protein
    Takechiyo Yamada
    Hart and Louis Laboratory, Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, California 90095 1680, USA
    J Biol Chem 278:32818-24. 2003
    ....
  3. ncbi request reprint B lymphocyte stimulator activates p38 mitogen-activated protein kinase in human Ig class switch recombination
    Takechiyo Yamada
    Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, 10833 Le Conte Ave, Los Angeles, CA 90095 1680, USA
    Am J Respir Cell Mol Biol 32:388-94. 2005
    ..These results indicate that BLyS-activated p38 MAPK plays an essential role in BLyS-induced AID-expression and CSR in human B cells...
  4. ncbi request reprint Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein
    Ke Zhang
    Hart and Louis Lyon Laboratory, Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles School of Medicine, CA 90095 1680, USA
    J Allergy Clin Immunol 114:321-7. 2004
    ..We have previously shown that an Fcgamma-Fcepsilon fusion protein, human IgG-IgE Fc fusion protein (GE2), could inhibit FcepsilonRI-mediated mediator releases in vitro and in vivo...
  5. ncbi request reprint Dominant role for TL1A/DR3 pathway in IL-12 plus IL-18-induced IFN-gamma production by peripheral blood and mucosal CCR9+ T lymphocytes
    Konstantinos A Papadakis
    Burns and Allen Research Institute, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90048, USA
    J Immunol 174:4985-90. 2005
    ....
  6. pmc Chimeric human fcgamma-allergen fusion proteins in the prevention of allergy
    Ke Zhang
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, UCLA School of Medicine, 52 175 CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095 1680, USA
    Immunol Allergy Clin North Am 27:93-103. 2007
    ..This article summarizes the therapeutic features and potential of this novel fusion protein for allergic IT...
  7. ncbi request reprint CD40-mediated p38 mitogen-activated protein kinase activation is required for immunoglobulin class switch recombination to IgE
    Ke Zhang
    Hart and Louis Laboratory, Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, 90095, USA
    J Allergy Clin Immunol 110:421-8. 2002
    ..The specific pathways activated by CD40 signaling involving CD40-dependent Ig class switch recombination (CSR) have not been defined...
  8. ncbi request reprint Genetically engineered negative signaling molecules in the immunomodulation of allergic diseases
    Andrew Saxon
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1680, USA
    Curr Opin Allergy Clin Immunol 4:563-8. 2004
    ....
  9. pmc Blockade of peanut allergy with a novel Ara h 2-Fcγ fusion protein in mice
    Yu Liu
    Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Allergy Clin Immunol 131:213-21.e1-5. 2013
    ..Conventional immunotherapy for peanut allergy using crude peanut extracts is not recommended because of the unacceptably high risk of anaphylaxis. Allergen-specific immunotherapy is not currently undertaken for peanut allergy...
  10. pmc A novel human immunoglobulin Fc gamma Fc epsilon bifunctional fusion protein inhibits Fc epsilon RI-mediated degranulation
    Daocheng Zhu
    The Hart and Louise Lyon Laboratory, Division of Clinical Immunology Allergy, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    Nat Med 8:518-21. 2002
    ..This approach, using a Fc gamma Fc epsilon fusion protein to co-aggregate Fc epsilon RI with a receptor containing an immunoreceptor tyrosine-based inhibition motif, has therapeutic potential in IgE- and Fc epsilon RI-mediated diseases...
  11. ncbi request reprint CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase
    Takechiyo Yamada
    Hart and Louis Laboratory, Division of Clinical Immunology, Department of Medicine, UCLA School of Medicine, Los Angeles, California 90095 1680, USA
    J Biol Chem 277:28830-5. 2002
    ..CD45 may be an appropriate target drug for modulating IgE in allergic diseases...
  12. ncbi request reprint Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa
    Konstantinos A Papadakis
    Inflammatory Bowel Disease Center and Burns and Allen Research Institute, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 10:778-88. 2004
    ..Activation-dependent receptor regulation and alteration in receptor-bearing cells, primarily in MLN draining inflamed intestinal tissue, suggest an important role for this T-cell subset in the pathogenesis of human IBD...
  13. ncbi request reprint Co-aggregation of FcgammaRII with FcepsilonRI on human mast cells inhibits antigen-induced secretion and involves SHIP-Grb2-Dok complexes
    Christopher L Kepley
    Department of Internal Medicine, Virginia Commonwealth University Health Systems, Richmond, Virginia 23298, USA
    J Biol Chem 279:35139-49. 2004
    ..Our results demonstrate how human FcepsilonRI-mediated responses can be inhibited by co-aggregation with FcgammaRIIB and implicate Dok, SHIP, and Grb2 as key intermediates in regulating antigen-induced mediator release...
  14. ncbi request reprint FcepsilonRI-FcgammaRII coaggregation inhibits IL-16 production from human Langerhans-like dendritic cells
    Christopher L Kepley
    Department of Internal Medicine, Virginia Commonwealth University, Medical College of Virginia, Richmond, VA, USA
    Clin Immunol 108:89-94. 2003
    ....