Research Topics
Genomes and Genes
| Xin J ZhouSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthaseXin J Zhou
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
J Pharmacol Exp Ther 300:762-7. 2002..Instead, it is associated with and perhaps partially related to enhanced renal NO inactivation by ROS and diminished NO bioavailability...
Yaa autoimmune phenotypes are conferred by overexpression of TLR7Anna Marie Fairhurst
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Eur J Immunol 38:1971-8. 2008..However, the resolution of TLR7 up-regulation did not eliminate the enhanced humoral autoimmunity observed in B6.SleYaa, suggesting that additional elements in the translocation may contribute to the disease phenotype...- Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritisAnna Marie Fairhurst
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
J Immunol 183:6831-8. 2009..Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ... - Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum amyloid P, and superoxide dismutase as potential markers of lupus nephritisTianfu Wu
Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
J Immunol 184:2183-93. 2010..These findings could have important diagnostic and prognostic ramifications in the management of these renal diatheses... - Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injuryJianlin Chen
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
Kidney Int 79:288-99. 2011..Thus, at least two different cell types express TLR4, each of which contributes to renal injury by temporally different mechanisms during ischemic AKI... 
RANTES deficiency attenuates autoantibody-induced glomerulonephritisChun Xie
Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Mail Code 8884, Y8 212, 5323 Harry Hines Boulevard, Dallas, TX 75390 8884, USA
J Clin Immunol 31:128-35. 2011..These findings indicate that RANTES ablation attenuates immune-mediated nephritis and suggest that this chemokine could be a potential therapeutic target in these diseases...- Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in miceHua Lu
Department of Pathology, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
Am J Physiol Renal Physiol 299:F445-52. 2010..This supposition is supported by increases seen in p65-NF-kappaB, osteopontin, and leukocyte influx in the kidneys of the tempol-treated group... - IRF-1 promotes inflammation early after ischemic acute kidney injuryYanxia Wang
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
J Am Soc Nephrol 20:1544-55. 2009..Taken together, these data suggest that IRF-1 gene activation by reactive oxygen species is an early signal that promotes inflammation after ischemic renal injury... - Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupusTianfu Wu
Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
J Clin Invest 117:2186-96. 2007.... - Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humansKui Liu
Department of Immunology and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
J Clin Invest 119:911-23. 2009..Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus... - Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosusAndrew Wang
University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
Arthritis Rheum 62:3436-46. 2010.... - Strain distribution pattern of immune nephritis--a follow-up studyChun Xie
Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Int Immunol 20:719-28. 2008..Studies aimed at elucidating the genetic factors and molecular pathways responsible for the enhanced renal disease in C58 mice are warranted... - CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupusAndrew Wang
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Immunol 182:4448-58. 2009..These findings underscore the pathogenic role of CXCR4/CXCL12 in lymphoproliferative lupus and lupus nephritis and highlight this axis as a promising therapeutic target in this disease... - Enhanced susceptibility to immune nephritis in DBA/1 mice is contingent upon IL-1 expressionChun Xie
Division of Rheumatology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8884, USA
Clin Immunol 124:49-56. 2007.... - Maladaptive role of IL-6 in ischemic acute renal failureMariusz L Kielar
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Am Soc Nephrol 16:3315-25. 2005..It is concluded that macrophages infiltrate the area of the vascular bundles of the outer medulla, these macrophages produce IL-6, and this IL-6 exacerbates ischemic murine acute renal failure... - PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlprChun Xie
Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Int Immunol 19:509-22. 2007..Hence, hypersignaling via the PI3K/AKT/mTOR axis appears to be an important mechanism underlying autoimmune lymphoproliferative disease, presenting itself as a potential target for therapeutic intervention... - Systemic IFN-alpha drives kidney nephritis in B6.Sle123 miceAnna Marie Fairhurst
Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Eur J Immunol 38:1948-60. 2008..In summary, the predominant impact of systemic IFN-alpha in this murine model is an exacerbation of mechanisms mediating end organ damage... - The aging kidneyXin J Zhou
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Kidney Int 74:710-20. 2008..This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process... - Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cellsYang Liu
Department of Internal Medicine and Center for Immunology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
J Immunol 179:1340-52. 2007..Taken together with a recent report on Sle1(z), these studies suggest that dysregulated receptor-editing of nuclear Ag-reactive B cells may be a major mechanism through which antinuclear Abs arise in lupus... - Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritisTianfu Wu
Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
J Immunol 179:7166-75. 2007..Longitudinal studies are warranted to establish the clinical use of these potential biomarkers... - Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen speciesJunhui Zhen
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Am J Hypertens 21:28-34. 2008..This study explored the effect of increased ROS activity on NOS expression in vitro in human coronary artery endothelial cells (HCAECs) grown in culture and in intact animals... - A retrospective analysis of clinical presentation of lupus nephritisSandeep Singh
Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
Am J Med Sci 342:467-73. 2011..Lupus nephritis (LN) is an ominous complication of systemic lupus erythematosus, and the risk factors for the disease progression are not well characterized... - Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1Qing Qing Wu
Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, TX 75390 8856, USA
Am J Physiol Renal Physiol 300:F1180-92. 2011..Although Nrf2-dependent increases in HO-1 have been described, our data suggest that BARD's effects on tubular and leukocyte HO-1 during ischemic AKI may be Nrf2 independent. We also found that BARD ameliorated cisplatin nephrotoxicity... - CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritisXiaoyan Shi
University of Texas Southwestern Medical School, Dallas, TX 75390 8884, USA
Arthritis Rheum 56:3057-69. 2007..We undertook this study to determine the degree to which generalized B cell hyperactivity can amplify lupus pathogenesis... - A Tlr7 translocation accelerates systemic autoimmunity in murine lupusSrividya Subramanian
Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
Proc Natl Acad Sci U S A 103:9970-5. 2006.... - Renal senescence in 2008: progress and challengesXin J Zhou
Department of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
Int Urol Nephrol 40:823-39. 2008..A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population... - Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha productionYuyang Fu
Division of Rheumatology, and Center for Immunology, University of Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 176:632-9. 2006.... - Renal transplantation in the elderlyRamesh Saxena
Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
Int Urol Nephrol 41:195-210. 2009..Appropriate immunosuppressive agents and dosages should be selected to minimize adverse events while reducing the risk of acute rejections and maximizing patient and renal allograft survival... - Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitroYing Zhang
Div. of Nephrology (Internal Medicine Univ. of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8856, USA
Am J Physiol Renal Physiol 286:F1193-201. 2004..The production of G-CSF by the kidney after ischemia-reperfusion provides a means of communication from the injured kidney to the bone marrow. This supports the known inflammatory response to ischemia... - Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imagingYong Du
Internal Medicine Rheumatology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
PLoS ONE 7:e43941. 2012..The LI-COR IRDye® 800CW RGD optical probe (RGD probe) is a NIR fluorophore, that can target integrin alpha v beta 3 (α(v)β(3)) in tissues... - The role of NK cells in the development of autoantibodiesDorothy Yuan
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
Autoimmunity 44:641-51. 2011..Further experiments provide a possible mechanism for the NK-cell dependence... - Strain distribution pattern of susceptibility to immune-mediated nephritisChun Xie
Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
J Immunol 172:5047-55. 2004..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted... - Acute bile duct ligation ameliorates ischemic renal failureD Rohan Jeyarajah
Department of Surgery, Southwestern Medical School, Dallas, Tex 75390 9156, USA
Nephron Physiol 95:p28-35. 2003..Using a murine model, we now test the hypothesis that these hepatic cytokines help determine the outcome of ischemic acute renal failure... - Endothelial pentraxin 3 contributes to murine ischemic acute kidney injuryJianlin Chen
Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
Kidney Int 82:1195-207. 2012..Thus, endothelial PTX3 plays a pivotal role in the pathogenesis of ischemic acute kidney injury... - Iron overdose: a contributor to adverse outcomes in randomized trials of anemia correction in CKDPeter Van Buren
Departments of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Int Urol Nephrol 44:499-507. 2012..The present review is intended to provide a brief overview of the potential adverse effects of the overzealous use of these agents... - Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapyXin J Zhou
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
Nephrol Dial Transplant 17:992-7. 2002..The present study examined the hypothesis that the improved uraemic platelet function after Epo therapy is, in part, due to correction of the platelet calcium signalling... - Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissuesKamalesh K Sharma
Department of Obstetrics Gynecology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cell Endocrinol 248:79-86. 2006..Our findings suggest that AKR1C3 protects the mineralocorticoid receptor from activation by DOC in mineralocorticoid target cells of the kidney and colon, analogous to cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2... - Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem studyJeremy Deisch
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
Arch Pathol Lab Med 133:1477-82. 2009..From this finding and 3 other IVLBCL cases reported in the literature, we conclude that MLL may play an important role in the lymphomagenesis of IVLBCL at least in a subset of cases... - Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mbSrividya Subramanian
Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
J Immunol 175:1062-72. 2005..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene... - Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus miceZhiyan Liang
Simmons Arthritis Research Center, University of Texas Southwestern Medical School, Dallas 75390, USA
J Exp Med 199:381-98. 2004..To summarize, glomerular-binding anti-dsDNA antibodies appear to be the most pathogenic variety of lupus autoantibodies. The presence of an alternating charge pattern in their HC CDR3 regions appears to be a prominent hallmark of ANAs... - Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strainChun Xie
Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, 75390, USA
Arthritis Rheum 48:1080-92. 2003..The availability of B6-based congenic strains bearing individual NZW-derived lupus susceptibility loci will permit future genetic dissection of end-organ susceptibility in murine lupus... - Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significanceTianfu Wu
University of Texas Southwestern Medical School at Dallas, New York 75390, USA
Arthritis Rheum 56:949-59. 2007..The objective of this study was to determine whether additional mediators may be excreted in the urine during immune-mediated nephritis, using an experimental model with a well-defined disease course...