Xin J Zhou

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase
    Xin J Zhou
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Pharmacol Exp Ther 300:762-7. 2002
  2. pmc Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1971-8. 2008
  3. pmc Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Immunol 183:6831-8. 2009
  4. pmc Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum amyloid P, and superoxide dismutase as potential markers of lupus nephritis
    Tianfu Wu
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
    J Immunol 184:2183-93. 2010
  5. doi request reprint Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice
    Hua Lu
    Department of Pathology, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Am J Physiol Renal Physiol 299:F445-52. 2010
  6. doi request reprint RANTES deficiency attenuates autoantibody-induced glomerulonephritis
    Chun Xie
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Mail Code 8884, Y8 212, 5323 Harry Hines Boulevard, Dallas, TX 75390 8884, USA
    J Clin Immunol 31:128-35. 2011
  7. pmc Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury
    Jianlin Chen
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Kidney Int 79:288-99. 2011
  8. pmc IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice
    Toni Gutierrez
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Eur J Immunol 43:382-93. 2013
  9. pmc IRF-1 promotes inflammation early after ischemic acute kidney injury
    Yanxia Wang
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 20:1544-55. 2009
  10. pmc Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus
    Tianfu Wu
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
    J Clin Invest 117:2186-96. 2007

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Nitric oxide synthase expression in hypertension induced by inhibition of glutathione synthase
    Xin J Zhou
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Pharmacol Exp Ther 300:762-7. 2002
    ..Instead, it is associated with and perhaps partially related to enhanced renal NO inactivation by ROS and diminished NO bioavailability...
  2. pmc Yaa autoimmune phenotypes are conferred by overexpression of TLR7
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1971-8. 2008
    ..However, the resolution of TLR7 up-regulation did not eliminate the enhanced humoral autoimmunity observed in B6.SleYaa, suggesting that additional elements in the translocation may contribute to the disease phenotype...
  3. pmc Type I interferons produced by resident renal cells may promote end-organ disease in autoantibody-mediated glomerulonephritis
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    J Immunol 183:6831-8. 2009
    ..Collectively, these studies indicate that an important contribution of IFN-I toward the disease pathology seen in systemic autoimmunity may be exercised at the level of the end-organ...
  4. pmc Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum amyloid P, and superoxide dismutase as potential markers of lupus nephritis
    Tianfu Wu
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
    J Immunol 184:2183-93. 2010
    ..These findings could have important diagnostic and prognostic ramifications in the management of these renal diatheses...
  5. doi request reprint Superoxide dismutase mimetic drug tempol aggravates anti-GBM antibody-induced glomerulonephritis in mice
    Hua Lu
    Department of Pathology, Univ of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Am J Physiol Renal Physiol 299:F445-52. 2010
    ..This supposition is supported by increases seen in p65-NF-kappaB, osteopontin, and leukocyte influx in the kidneys of the tempol-treated group...
  6. doi request reprint RANTES deficiency attenuates autoantibody-induced glomerulonephritis
    Chun Xie
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Mail Code 8884, Y8 212, 5323 Harry Hines Boulevard, Dallas, TX 75390 8884, USA
    J Clin Immunol 31:128-35. 2011
    ..These findings indicate that RANTES ablation attenuates immune-mediated nephritis and suggest that this chemokine could be a potential therapeutic target in these diseases...
  7. pmc Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury
    Jianlin Chen
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Kidney Int 79:288-99. 2011
    ..Thus, at least two different cell types express TLR4, each of which contributes to renal injury by temporally different mechanisms during ischemic AKI...
  8. pmc IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice
    Toni Gutierrez
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Eur J Immunol 43:382-93. 2013
    ..These studies identify a specific role for IL-21 in the class switching of anti-DNA B cells and demonstrate that neither IL-21 nor anti-DNA IgG is required for kidney damage in lyn(-/-) mice...
  9. pmc IRF-1 promotes inflammation early after ischemic acute kidney injury
    Yanxia Wang
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8856, USA
    J Am Soc Nephrol 20:1544-55. 2009
    ..Taken together, these data suggest that IRF-1 gene activation by reactive oxygen species is an early signal that promotes inflammation after ischemic renal injury...
  10. pmc Shared signaling networks active in B cells isolated from genetically distinct mouse models of lupus
    Tianfu Wu
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
    J Clin Invest 117:2186-96. 2007
    ....
  11. pmc Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans
    Kui Liu
    Department of Immunology and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8884, USA
    J Clin Invest 119:911-23. 2009
    ..Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus...
  12. pmc Reactive oxygen species and IRF1 stimulate IFNα production by proximal tubules during ischemic AKI
    Pamela D Winterberg
    Department of Pediatrics, Nephrology Division, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Am J Physiol Renal Physiol 305:F164-72. 2013
    ..Altogether our data support the following autocrine pathway in renal tubular cells: ROS > IRF1 > IFNα > IFNARI > CXCL2...
  13. doi request reprint Strain distribution pattern of immune nephritis--a follow-up study
    Chun Xie
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Int Immunol 20:719-28. 2008
    ..Studies aimed at elucidating the genetic factors and molecular pathways responsible for the enhanced renal disease in C58 mice are warranted...
  14. ncbi request reprint Enhanced susceptibility to immune nephritis in DBA/1 mice is contingent upon IL-1 expression
    Chun Xie
    Division of Rheumatology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Clin Immunol 124:49-56. 2007
    ....
  15. pmc CXCR4/CXCL12 hyperexpression plays a pivotal role in the pathogenesis of lupus
    Andrew Wang
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Immunol 182:4448-58. 2009
    ..These findings underscore the pathogenic role of CXCR4/CXCL12 in lymphoproliferative lupus and lupus nephritis and highlight this axis as a promising therapeutic target in this disease...
  16. doi request reprint Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus
    Andrew Wang
    University of Texas Southwestern Medical Center, Dallas, TX 75390 8884, USA
    Arthritis Rheum 62:3436-46. 2010
    ....
  17. pmc Systemic IFN-alpha drives kidney nephritis in B6.Sle123 mice
    Anna Marie Fairhurst
    Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Eur J Immunol 38:1948-60. 2008
    ..In summary, the predominant impact of systemic IFN-alpha in this murine model is an exacerbation of mechanisms mediating end organ damage...
  18. ncbi request reprint PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr
    Chun Xie
    Division of Rheumatology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Int Immunol 19:509-22. 2007
    ..Hence, hypersignaling via the PI3K/AKT/mTOR axis appears to be an important mechanism underlying autoimmune lymphoproliferative disease, presenting itself as a potential target for therapeutic intervention...
  19. ncbi request reprint Maladaptive role of IL-6 in ischemic acute renal failure
    Mariusz L Kielar
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Soc Nephrol 16:3315-25. 2005
    ..It is concluded that macrophages infiltrate the area of the vascular bundles of the outer medulla, these macrophages produce IL-6, and this IL-6 exacerbates ischemic murine acute renal failure...
  20. doi request reprint The aging kidney
    Xin J Zhou
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Kidney Int 74:710-20. 2008
    ..This review summarizes the structural and functional changes of the aging kidney and highlights the advances made in our understanding of the renal aging process...
  21. pmc A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75235, USA
    Proc Natl Acad Sci U S A 103:9970-5. 2006
    ....
  22. pmc B cell TLR7 expression drives anti-RNA autoantibody production and exacerbates disease in systemic lupus erythematosus-prone mice
    Sun Hee Hwang
    Department of Immunology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    J Immunol 189:5786-96. 2012
    ..Moreover, this enhanced B cell TLR7 expression permits the specific development of Abs to RNA/protein complexes and exacerbates SLE disease...
  23. pmc Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography
    Guiyang Hao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e57418. 2013
    ....
  24. ncbi request reprint Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species
    Junhui Zhen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Hypertens 21:28-34. 2008
    ..This study explored the effect of increased ROS activity on NOS expression in vitro in human coronary artery endothelial cells (HCAECs) grown in culture and in intact animals...
  25. ncbi request reprint Lupus susceptibility genes may breach tolerance to DNA by impairing receptor editing of nuclear antigen-reactive B cells
    Yang Liu
    Department of Internal Medicine and Center for Immunology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    J Immunol 179:1340-52. 2007
    ..Taken together with a recent report on Sle1(z), these studies suggest that dysregulated receptor-editing of nuclear Ag-reactive B cells may be a major mechanism through which antinuclear Abs arise in lupus...
  26. ncbi request reprint Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis
    Tianfu Wu
    Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, TX 75235, USA
    J Immunol 179:7166-75. 2007
    ..Longitudinal studies are warranted to establish the clinical use of these potential biomarkers...
  27. ncbi request reprint Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production
    Yuyang Fu
    Division of Rheumatology, and Center for Immunology, University of Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 176:632-9. 2006
    ....
  28. pmc Serial non-invasive monitoring of renal disease following immune-mediated injury using near-infrared optical imaging
    Yong Du
    Internal Medicine Rheumatology, University of Texas, Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 7:e43941. 2012
    ..The LI-COR IRDye® 800CW RGD optical probe (RGD probe) is a NIR fluorophore, that can target integrin alpha v beta 3 (α(v)β(3)) in tissues...
  29. pmc Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury
    Jianlin Chen
    Department of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Kidney Int 82:1195-207. 2012
    ..Thus, endothelial PTX3 plays a pivotal role in the pathogenesis of ischemic acute kidney injury...
  30. pmc A retrospective analysis of clinical presentation of lupus nephritis
    Sandeep Singh
    Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas 75390 8856, USA
    Am J Med Sci 342:467-73. 2011
    ..Lupus nephritis (LN) is an ominous complication of systemic lupus erythematosus, and the risk factors for the disease progression are not well characterized...
  31. pmc Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1
    Qing Qing Wu
    Department of Internal Medicine, Nephrology Division, UT Southwestern Medical Center, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 300:F1180-92. 2011
    ..Although Nrf2-dependent increases in HO-1 have been described, our data suggest that BARD's effects on tubular and leukocyte HO-1 during ischemic AKI may be Nrf2 independent. We also found that BARD ameliorated cisplatin nephrotoxicity...
  32. ncbi request reprint CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis
    Xiaoyan Shi
    University of Texas Southwestern Medical School, Dallas, TX 75390 8884, USA
    Arthritis Rheum 56:3057-69. 2007
    ..We undertook this study to determine the degree to which generalized B cell hyperactivity can amplify lupus pathogenesis...
  33. doi request reprint Renal senescence in 2008: progress and challenges
    Xin J Zhou
    Department of Pathology, UT Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
    Int Urol Nephrol 40:823-39. 2008
    ..A better understanding of these mechanisms may help to preserve renal function, improve morbidity and mortality, and hopefully reduce healthcare costs for the aging population...
  34. ncbi request reprint Ischemia-reperfusion induces G-CSF gene expression by renal medullary thick ascending limb cells in vivo and in vitro
    Ying Zhang
    Div of Nephrology Internal Medicine Univ of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8856, USA
    Am J Physiol Renal Physiol 286:F1193-201. 2004
    ..The production of G-CSF by the kidney after ischemia-reperfusion provides a means of communication from the injured kidney to the bone marrow. This supports the known inflammatory response to ischemia...
  35. doi request reprint Renal transplantation in the elderly
    Ramesh Saxena
    Division of Nephrology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA
    Int Urol Nephrol 41:195-210. 2009
    ..Appropriate immunosuppressive agents and dosages should be selected to minimize adverse events while reducing the risk of acute rejections and maximizing patient and renal allograft survival...
  36. doi request reprint Reliability of whole slide images as a diagnostic modality for renal allograft biopsies
    Kuang Yu Jen
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    Hum Pathol 44:888-94. 2013
    ..44 [glass] vs 0.42 [WSI]) and acute rejection diagnostic categories (κ = 0.49 [glass] vs 0.51 [WSI]). These data indicate that WSI are as reliable as glass slides for the evaluation of renal allograft biopsies...
  37. doi request reprint The role of NK cells in the development of autoantibodies
    Dorothy Yuan
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Autoimmunity 44:641-51. 2011
    ..Further experiments provide a possible mechanism for the NK-cell dependence...
  38. ncbi request reprint Strain distribution pattern of susceptibility to immune-mediated nephritis
    Chun Xie
    Simmons Arthritis Research Center, Division of Rheumatology, Center for Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 172:5047-55. 2004
    ..Detailed studies to dissect out the immunological and genetic basis of renal disease in these three strains are clearly warranted...
  39. ncbi request reprint Acute bile duct ligation ameliorates ischemic renal failure
    D Rohan Jeyarajah
    Department of Surgery, Southwestern Medical School, Dallas, Tex 75390 9156, USA
    Nephron Physiol 95:p28-35. 2003
    ..Using a murine model, we now test the hypothesis that these hepatic cytokines help determine the outcome of ischemic acute renal failure...
  40. pmc Iron overdose: a contributor to adverse outcomes in randomized trials of anemia correction in CKD
    Peter Van Buren
    Departments of Internal Medicine Nephrology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Int Urol Nephrol 44:499-507. 2012
    ..The present review is intended to provide a brief overview of the potential adverse effects of the overzealous use of these agents...
  41. ncbi request reprint Defective calcium signalling in uraemic platelets and its amelioration with long-term erythropoietin therapy
    Xin J Zhou
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    Nephrol Dial Transplant 17:992-7. 2002
    ..The present study examined the hypothesis that the improved uraemic platelet function after Epo therapy is, in part, due to correction of the platelet calcium signalling...
  42. doi request reprint Segmental tandem triplication of the MLL gene in an intravascular large B-cell lymphoma with multisystem involvement: a comprehensive morphologic, immunophenotypic, cytogenetic, and molecular cytogenetic antemortem study
    Jeremy Deisch
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Arch Pathol Lab Med 133:1477-82. 2009
    ..From this finding and 3 other IVLBCL cases reported in the literature, we conclude that MLL may play an important role in the lymphomagenesis of IVLBCL at least in a subset of cases...
  43. ncbi request reprint Epistatic suppression of systemic lupus erythematosus: fine mapping of Sles1 to less than 1 mb
    Srividya Subramanian
    Center for Immunology and Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Immunol 175:1062-72. 2005
    ..Sle1 Sles1)F(1)s. These findings localize and characterize the suppressive properties of Sles1 and implicate 129 as a useful strain for aiding in the identification of this elusive epistatic modifier gene...
  44. ncbi request reprint Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues
    Kamalesh K Sharma
    Department of Obstetrics Gynecology and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell Endocrinol 248:79-86. 2006
    ..Our findings suggest that AKR1C3 protects the mineralocorticoid receptor from activation by DOC in mineralocorticoid target cells of the kidney and colon, analogous to cortisol inactivation by 11beta-hydroxysteroid dehydrogenase type 2...
  45. pmc Pathogenic profiles and molecular signatures of antinuclear autoantibodies rescued from NZM2410 lupus mice
    Zhiyan Liang
    Simmons Arthritis Research Center, University of Texas Southwestern Medical School, Dallas 75390, USA
    J Exp Med 199:381-98. 2004
    ..To summarize, glomerular-binding anti-dsDNA antibodies appear to be the most pathogenic variety of lupus autoantibodies. The presence of an alternating charge pattern in their HC CDR3 regions appears to be a prominent hallmark of ANAs...
  46. ncbi request reprint Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain
    Chun Xie
    Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Arthritis Rheum 48:1080-92. 2003
    ..Sle1, and B6.Yaa. Based on the observation that aging NZW mice exhibit histologic evidence of GN, we sought to test our hypothesis that NZW mice may be more susceptible to immune-mediated renal damage...
  47. ncbi request reprint Excreted urinary mediators in an animal model of experimental immune nephritis with potential pathogenic significance
    Tianfu Wu
    University of Texas Southwestern Medical School at Dallas, New York 75390, USA
    Arthritis Rheum 56:949-59. 2007
    ..The objective of this study was to determine whether additional mediators may be excreted in the urine during immune-mediated nephritis, using an experimental model with a well-defined disease course...