Xiaofeng Zhou

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA
    Expert Rev Mol Diagn 6:39-50. 2006
  2. ncbi request reprint Salivary transcriptome diagnostics for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 10:8442-50. 2004
  3. ncbi request reprint Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays
    Xiaofeng Zhou
    School of Dentistry, Dental Research Institute, University of California at Los Angeles, CA 90095 1668, USA
    Cancer Genet Cytogenet 159:53-7. 2005
  4. ncbi request reprint Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA
    Cancer Genet Cytogenet 161:86-9. 2005
  5. ncbi request reprint Serum circulating human mRNA profiling and its utility for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, Division of Head and Neck Surgery Otolaryngology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, USA
    J Clin Oncol 24:1754-60. 2006
  6. pmc Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA 90095 1668, USA
    Neoplasia 8:925-32. 2006
  7. ncbi request reprint Current advances in identification of cancer biomarkers in saliva
    Martha Arellano
    School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles CA 90095, USA
    Front Biosci (Schol Ed) 1:296-303. 2009
  8. ncbi request reprint Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry
    Shen Hu
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
    Cancer Genomics Proteomics 4:55-64. 2007
  9. pmc Characterization of salivary RNA by cDNA library analysis
    Noh Jin Park
    UCLA Dental Research Institute, Los Angeles, CA 90095, USA
    Arch Oral Biol 52:30-5. 2007
  10. ncbi request reprint Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA
    Hum Genet 118:504-7. 2005

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Advancement in characterization of genomic alterations for improved diagnosis, treatment and prognostics in cancer
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry and Jonsson Comprehensive Cancer Center, University of California at Los Angeles, Los Angeles, CA, USA
    Expert Rev Mol Diagn 6:39-50. 2006
    ..Potential solutions that may help overcome these challenges are also offered...
  2. ncbi request reprint Salivary transcriptome diagnostics for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, California, USA
    Clin Cancer Res 10:8442-50. 2004
    ..The purpose of this study is to evaluate the diagnostic value of this new approach by using oral squamous cell carcinoma (OSCC) as the proof-of-principle disease...
  3. ncbi request reprint Progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density single nucleotide polymorphism arrays
    Xiaofeng Zhou
    School of Dentistry, Dental Research Institute, University of California at Los Angeles, CA 90095 1668, USA
    Cancer Genet Cytogenet 159:53-7. 2005
    ..This review highlights recent progress on concurrent LOH and CGH analyses utilizing high density SNP arrays and their application in cancer research...
  4. ncbi request reprint Frequent allelic imbalances at 8p and 11q22 in oral and oropharyngeal epithelial dysplastic lesions
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA
    Cancer Genet Cytogenet 161:86-9. 2005
    ..0% of cases, respectively. Our results demonstrate that 8p, 11q22.2 approximately q22.3, and 9p21 are frequent allelic imbalance regions in oral premalignant dysplasia and suggest the presence of tumor suppressor genes in these regions...
  5. ncbi request reprint Serum circulating human mRNA profiling and its utility for oral cancer detection
    Yang Li
    School of Dentistry and Dental Research Institute, Division of Head and Neck Surgery Otolaryngology, David Geffen School of Medicine University of California, Los Angeles, CA 90095, USA
    J Clin Oncol 24:1754-60. 2006
    ..Oral squamous cell carcinoma (OSCC) was selected as the proof-of-concept disease...
  6. pmc Global expression-based classification of lymph node metastasis and extracapsular spread of oral tongue squamous cell carcinoma
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA 90095 1668, USA
    Neoplasia 8:925-32. 2006
    ..Leave-one-out cross-validation showed overall accuracy rates of 85% for both pN and ECS prediction models. Our results demonstrated that the pN and the ECS of OTSCCs can be predicted by gene expression analyses of primary tumors...
  7. ncbi request reprint Current advances in identification of cancer biomarkers in saliva
    Martha Arellano
    School of Dentistry and Dental Research Institute, University of California at Los Angeles, Los Angeles CA 90095, USA
    Front Biosci (Schol Ed) 1:296-303. 2009
    ..With the new molecular profiling technologies such as microarray and proteomics, we are expecting to reveal highly discriminatory genomic and proteomic targets that can best detect the disease status...
  8. ncbi request reprint Discovery of oral fluid biomarkers for human oral cancer by mass spectrometry
    Shen Hu
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA, USA
    Cancer Genomics Proteomics 4:55-64. 2007
    ..Once discovered and validated on a large and independent clinical cohort, oral fluid proteomic biomarkers may be extensively used for future disease diagnosis...
  9. pmc Characterization of salivary RNA by cDNA library analysis
    Noh Jin Park
    UCLA Dental Research Institute, Los Angeles, CA 90095, USA
    Arch Oral Biol 52:30-5. 2007
    ....
  10. ncbi request reprint Allelic imbalance analysis of oral tongue squamous cell carcinoma by high-density single nucleotide polymorphism arrays using whole-genome amplified DNA
    Xiaofeng Zhou
    Dental Research Institute, School of Dentistry, University of California at Los Angeles, Los Angeles, CA, USA
    Hum Genet 118:504-7. 2005
    ..Furthermore, our data suggested a frequent loss at 3p11-p12 for advanced stage OTSCC...
  11. pmc Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells
    Sanjai Sharma
    Division of Hematology Oncology, UCLA West Los Angeles VA Medical Center, 11301 Wilshire Blvd, Bldg 304, Rm E1 115, Los Angeles, CA 90073, USA
    Mol Cancer Ther 10:1751-9. 2011
    ..Our findings reveal that promoter methylation and an upregulated splicing factor (SFRS2) are involved in the E-cadherin missplicing in tumors...
  12. ncbi request reprint Interleukin 6 and interleukin 8 as potential biomarkers for oral cavity and oropharyngeal squamous cell carcinoma
    Maie A R St John
    David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Arch Otolaryngol Head Neck Surg 130:929-35. 2004
    ..These cytokines may contribute to the pathogenesis of this disease, and have been linked with increased tumor growth and metastasis...
  13. ncbi request reprint Detection of DNA copy number abnormality by microarray expression analysis
    Xiaofeng Zhou
    Laboratory of Head and Neck Cancer Research, Dental Research Institute, School of Dentistry, University of California at Los Angeles, 90095 1668, USA
    Hum Genet 114:464-7. 2004
    ..These data show that microarray detection of differential mRNA expression can be used to identify significant DNA CNAs...
  14. ncbi request reprint Concurrent analysis of loss of heterozygosity (LOH) and copy number abnormality (CNA) for oral premalignancy progression using the Affymetrix 10K SNP mapping array
    Xiaofeng Zhou
    School of Dentistry, Dental Research Institute, University of California at Los Angeles, P O Box 951668 Los Angeles, CA 90095 1668, USA
    Hum Genet 115:327-30. 2004
    ..3, 3p14.1-3p13, 11p, 11q14.3-11q22.2, and 11q13.5-11q14.1. These data show that it is feasible to utilize high-density SNP arrays to generate concordant LOH and CNA profiles at high resolution...
  15. ncbi request reprint p12(CDK2-AP1) mediates DNA damage responses induced by cisplatin
    Yong Kim
    School of Dentistry and Dental Research Institute, University of California Los Angeles, Los Angeles, CA 90095, USA
    Oncogene 24:407-18. 2005
    ..These data further suggest p12(CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin...
  16. pmc Transcriptomic dissection of tongue squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA
    BMC Genomics 9:69. 2008
    ..It is significantly more aggressive than other forms of HNOSCC, in terms of local invasion and spread. In this study, we aim to identify specific transcriptomic signatures that associated with OTSCC...
  17. ncbi request reprint Single nucleotide polymorphism mapping array assay
    Xiaofeng Zhou
    Methods Mol Biol 396:295-314. 2007
    ..In this chapter, we will provide a detailed experimental protocol of Affymetrix GeneChip SNP Mapping Array-based whole genome SNP genotyping assay...
  18. ncbi request reprint Dimension reduction and mixed-effects model for microarray meta-analysis of cancer
    Tianwei Yu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Front Biosci 13:2714-20. 2008
    ..A mixed-effects model was applied to identify differentially expressed genes from the merged array data...
  19. ncbi request reprint DNA copy number abnormality of oral squamous cell carcinoma detected with cDNA array-based comparative genomic hybridization
    Xiaofeng Zhou
    Cancer Genet Cytogenet 151:90-2. 2004
  20. pmc Genomic assessments of the frequent loss of heterozygosity region on 8p21.3-p22 in head and neck squamous cell carcinoma
    Hui Ye
    Center for Molecular Biology of Oral Diseases, College of Dentistry, University of Illinois at Chicago, MC860, 801 South Paulina Street, Room 530C, Chicago, IL 60612 7213, USA
    Cancer Genet Cytogenet 176:100-6. 2007
    ..Thus, our results suggest that MTUS1 is one of the candidate tumor suppressor genes for HNSCC residing at 8p21.3 approximately p22. The identification of these candidate genes will facilitate the understanding of tumorigenesis of HNSCC...
  21. pmc A forward-backward fragment assembling algorithm for the identification of genomic amplification and deletion breakpoints using high-density single nucleotide polymorphism (SNP) array
    Tianwei Yu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    BMC Bioinformatics 8:145. 2007
    ..To accurately identify small segments of CNA from SNP array data, segmentation methods that are sensitive to CNA while resistant to noise are required...
  22. pmc Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana
    Zhizhong Chen
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100094, People s Republic of China
    Mol Cell Biol 26:6902-12. 2006
    ..Our results uncover crucial roles for ABO1/ELO2 in modulating ABA and drought responses in Arabidopsis thaliana...
  23. ncbi request reprint Baseline heart rate-corrected QT and eligibility for clinical trials in oncology
    Mary Varterasian
    J Clin Oncol 21:3378-9. 2003