Haibo Zhou

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc A partial linear model in the outcome-dependent sampling setting to evaluate the effect of prenatal PCB exposure on cognitive function in children
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 67:876-85. 2011
  2. ncbi request reprint A semiparametric empirical likelihood method for data from an outcome-dependent sampling scheme with a continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, 27599, USA
    Biometrics 58:413-21. 2002
  3. ncbi request reprint Random effects logistic regression analysis with auxiliary covariates
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, 27599 7420, USA
    Biometrics 58:352-60. 2002
  4. pmc Outcome-dependent sampling: an efficient sampling and inference procedure for studies with a continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Epidemiology 18:461-8. 2007
  5. ncbi request reprint Statistical models for human fecundability
    Haibo Zhou
    Department of Biostatistics, CB No 7420, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    Stat Methods Med Res 15:181-94. 2006
  6. pmc Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers
    Haibo Zhou
    The Center for Environmental Medicine, Asthma and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Respir Med 103:1358-65. 2009
  7. pmc Semiparametric inference for a 2-stage outcome-auxiliary-dependent sampling design with continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Biostatistics 12:521-34. 2011
  8. doi request reprint Statistical inference for a two-stage outcome-dependent sampling design with a continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 67:194-202. 2011
  9. ncbi request reprint Potential for bias in estimating human fecundability parameters: a comparison of statistical models
    H Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill 27599 7400, USA
    Stat Med 18:411-22. 1999
  10. pmc Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways
    Rebecca C Fry
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Respir Res 13:89. 2012

Collaborators

Detail Information

Publications43

  1. pmc A partial linear model in the outcome-dependent sampling setting to evaluate the effect of prenatal PCB exposure on cognitive function in children
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 67:876-85. 2011
    ..Our model provides further insights into the relation between low-level PCB exposure and children's cognitive function. The results shed new light on a body of inconsistent epidemiologic findings...
  2. ncbi request reprint A semiparametric empirical likelihood method for data from an outcome-dependent sampling scheme with a continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, 27599, USA
    Biometrics 58:413-21. 2002
    ....
  3. ncbi request reprint Random effects logistic regression analysis with auxiliary covariates
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, 27599 7420, USA
    Biometrics 58:352-60. 2002
    ..We analyzed a data set from the Collaborative Perinatal Project using the proposed method and found that the use of DDT increases the risk of preterm births among U.S. children...
  4. pmc Outcome-dependent sampling: an efficient sampling and inference procedure for studies with a continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Epidemiology 18:461-8. 2007
    ..This design, coupled with an appropriate analysis, offers a cost-efficient approach to studying the determinants of a continuous outcome...
  5. ncbi request reprint Statistical models for human fecundability
    Haibo Zhou
    Department of Biostatistics, CB No 7420, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7400, USA
    Stat Methods Med Res 15:181-94. 2006
    ..Aided with improved computing capability, statistical modeling for fertility data has made a remarkable progress in the past decade. The author provides an overview of the historic and current developments for fecundability models...
  6. pmc Influence of C-159T SNP of the CD14 gene promoter on lung function in smokers
    Haibo Zhou
    The Center for Environmental Medicine, Asthma and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Respir Med 103:1358-65. 2009
    ..The effect of CC genotype on severity of COPD is analogous with the effect of this genotype in risk for asthma. CD14 may be a factor in the pathophysiology of COPD, as it is in asthma and smoking-related cardiovascular diseases...
  7. pmc Semiparametric inference for a 2-stage outcome-auxiliary-dependent sampling design with continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Biostatistics 12:521-34. 2011
    ..We illustrate the proposed method by analyzing a data set from an environmental epidemiologic study...
  8. doi request reprint Statistical inference for a two-stage outcome-dependent sampling design with a continuous outcome
    Haibo Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 67:194-202. 2011
    ..The proposed method is illustrated with an environmental health study conducted at National Institutes of Health...
  9. ncbi request reprint Potential for bias in estimating human fecundability parameters: a comparison of statistical models
    H Zhou
    Department of Biostatistics, University of North Carolina at Chapel Hill 27599 7400, USA
    Stat Med 18:411-22. 1999
    ..By contrast, the subject-specific model consistently estimates parameters of interest, if the underlying distribution is properly specified. Data from a fecundability study carried out in North Carolina serves to illustrate these points...
  10. pmc Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways
    Rebecca C Fry
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Respir Res 13:89. 2012
    ..The interplay between immuno-inflammatory function and genomic signaling in those with heightened inflammatory responsiveness to ozone is not well understood...
  11. doi request reprint Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype
    Madeline A Dillon
    Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7310, USA
    Occup Environ Med 68:783-5. 2011
    ..To determine if the GSTM1 null genotype is a risk factor for increased inflammatory response to inhaled endotoxin...
  12. pmc Diesel exhaust exposure and nasal response to attenuated influenza in normal and allergic volunteers
    Terry L Noah
    Department of Pediatrics, University of North Carolina at Chapel Hill, 27599 7310, USA
    Am J Respir Crit Care Med 185:179-85. 2012
    ..Diesel exhaust enhances allergic inflammation, and pollutants are associated with heightened susceptibility to viral respiratory infections. The effects of combined diesel and virus exposure in humans are unknown...
  13. pmc Atopic asthmatic patients have reduced airway inflammatory cell recruitment after inhaled endotoxin challenge compared with healthy volunteers
    Michelle L Hernandez
    Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27516, USA
    J Allergy Clin Immunol 130:869-76.e2. 2012
    ..It is unknown whether this sensitivity is due to dysregulated inflammatory responses after LPS exposure in atopic asthmatic patients...
  14. pmc Mixed effect regression analysis for a cluster-based two-stage outcome-auxiliary-dependent sampling design with a continuous outcome
    Wangli Xu
    Center for Applied Statistics, School of Statistics, Renmin University of China, Beijing 100872, China and Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Biostatistics 13:650-64. 2012
    ..We illustrate the proposed method by analyzing a dataset from the Collaborative Perinatal Project...
  15. pmc Nasal lavage natural killer cell function is suppressed in smokers after live attenuated influenza virus
    Katherine M Horvath
    Curriculum in Toxicology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7127, USA
    Respir Res 12:102. 2011
    ....
  16. ncbi request reprint Maternal serum level of the DDT metabolite DDE in relation to fetal loss in previous pregnancies
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233 MD A3 05, Research Triangle Park, NC, 27709, USA
    Environ Res 97:127-33. 2005
    ..1-1.6). The results were consistent with an adverse effect of DDE on fetal loss, but were inconclusive owing to the possibility that previous pregnancies ending in fetal loss decreased serum DDE levels less than did those carried to term...
  17. pmc Nasal nitric oxide and lifestyle exposure to tobacco smoke
    Haibo Zhou
    Center for Environmental Medicine, Asthma, and Lung Biology, The Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Ann Otol Rhinol Laryngol 120:455-9. 2011
    ....
  18. doi request reprint Nasal PMN response to repeated challenge with endotoxin in healthy volunteers
    Vinod Doreswamy
    Department of Pediatrics, Clinical Fellow, Allergy Immunology, University of North Carolina, Chapel Hill, NC, USA
    Inhal Toxicol 23:142-7. 2011
    ..This was a pilot study to determine if repeated nasal LPS challenge yields attenuation of markers of inflammation (primarily neutrophil response) in the NL fluid of healthy humans...
  19. pmc Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers
    Michelle L Hernandez
    Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Free Radic Biol Med 60:56-62. 2013
    ..These results suggest that γT is a potential therapeutic candidate for prevention or treatment of neutrophilic airway inflammation in diseased populations...
  20. pmc Bronchoscopy-derived correlates of lung injury following inhalational injuries: a prospective observational study
    Samuel W Jones
    Department of Surgery, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS ONE 8:e64250. 2013
    ..In experimental models, factors potentially contributing to ALI risk include inhalation of toxins directly causing cell damage; inflammation; and infection. However, few studies have been done in humans...
  21. pmc Alteration of the nasal responses to influenza virus by tobacco smoke
    Terry L Noah
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Curr Opin Allergy Clin Immunol 12:24-31. 2012
    ..The purpose of this review is to highlight recent data regarding the impact of exposure to tobacco smoke on influenza virus infection. This is timely because of the continuing pattern for influenza to cause epidemics and pandemics...
  22. pmc Gaussian process based bayesian semiparametric quantitative trait Loci interval mapping
    Hanwen Huang
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biometrics 66:222-32. 2010
    ..This analysis is performed in a Bayesian inference framework using Markov chain Monte Carlo. The advantages of our methods are demonstrated via extensive simulations and real data analysis...
  23. pmc The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects
    Neil E Alexis
    Center for Environmental Medicine, Asthma and Lung Biology, UNC School of Medicine, Chapel Hill, NC 27599 7310, USA
    J Allergy Clin Immunol 124:1222-1228.e5. 2009
    ..Ozone is known to cause an immediate decrease in lung function and increased airway inflammation. However, it is not known whether GSTM1 modulates these ozone responses in vivo in human subjects...
  24. pmc Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector
    W K O'Neal
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Mol Med 6:179-95. 2000
    ....
  25. ncbi request reprint Case-cohort analysis of brain cancer and leukemia in electric utility workers using a refined magnetic field job-exposure matrix
    D A Savitz
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
    Am J Ind Med 38:417-25. 2000
    ..The potential association between occupational electric and magnetic field exposure and cancer is well documented in the literature, but there is uncertainty regarding a causal relation...
  26. ncbi request reprint Multiple advantages of alpha-fetoprotein as a marker for in vivo gene transfer
    W K O'Neal
    Department of Molecular and Human Genetics, Southwest Foundation for Biomedical Research, Houston, Texas, 77030, USA
    Mol Ther 2:640-8. 2000
    ..These initial evaluations suggest that AFP is useful as a reporter gene to evaluate gene expression of therapeutic cassettes in multiple tissues, and it should be considered for use in human subjects...
  27. pmc Her4 mediates ligand-dependent antiproliferative and differentiation responses in human breast cancer cells
    C I Sartor
    Department of Radiation Oncology, University of North Carolina, Chapel Hill, North Carolina 27599 7512, USA
    Mol Cell Biol 21:4265-75. 2001
    ..These results suggest that HER4 is both necessary and sufficient to trigger an antiproliferative response in human breast cancer cells...
  28. ncbi request reprint A random effects model for multivariate failure time data from multicenter clinical trials
    J Cai
    Department of Biostatistics, The University of North Carolina at Chapel Hill, 27599 7400, USA
    Biometrics 55:182-9. 1999
    ..The methodology is illustrated with a clinical trial data set from the Studies of Left Ventricular Dysfunction. This shows that the variability of the treatment effect is higher than found by means of simpler models...
  29. pmc Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus
    Terry L Noah
    Department of Pediatrics, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7310, USA
    Environ Health Perspect 119:78-83. 2011
    ..Epidemiologic evidence links tobacco smoke and increased risk for influenza in humans, but the specific host defense pathways involved are unclear...
  30. pmc Increased nasal epithelial ciliary beat frequency associated with lifestyle tobacco smoke exposure
    Haibo Zhou
    Department of Biostatistics, The University of North Carolina at Chapel Hill, 27599 7310, USA
    Inhal Toxicol 21:875-81. 2009
    ..The molecular mechanisms that upregulate CBF may also create a cell molecular milieu capable of provoking the eventual emergence of more overt adverse health effects and the pathogenesis of chronic airway disease...
  31. ncbi request reprint Prenatal exposure to low-level polychlorinated biphenyls in relation to mental and motor development at 8 months
    Julie L Daniels
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Am J Epidemiol 157:485-92. 2003
    ..The reasons for variation in results within this study and across other studies remain unclear...
  32. pmc Phenotypic and physiologic variability in nasal epithelium cultured from smokers and non-smokers exposed to secondhand tobacco smoke
    Johnny L Carson
    Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, CB 7310, 104 Mason Farm Road, Chapel Hill, NC 27599 7310, USA
    In Vitro Cell Dev Biol Anim 46:606-12. 2010
    ..These observations suggest that stable epigenetic factors affecting regulation of ciliary function and phenotype commitment may be operative...
  33. pmc Adjusted exponentially tilted likelihood with applications to brain morphology
    Hongtu Zhu
    Department of Biostatistics and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biometrics 65:919-27. 2009
    ..We demonstrate the application of our new statistical methods to the detection of statistically significant differences in the morphology of the hippocampus between two schizophrenia groups and healthy subjects...
  34. pmc Combination treatment with high-dose vitamin C and alpha-tocopherol does not enhance respiratory-tract lining fluid vitamin C levels in asthmatics
    Michelle Hernandez
    The Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina School of Medicine, 104 Mason Farm Road, Chapel Hill, NC 27599 7310, USA
    Inhal Toxicol 21:173-81. 2009
    ..In conclusion, supplementation with alpha T and high-dose vitamin C does not augment vitamin C levels in the respiratory-tract lining fluid...
  35. doi request reprint Effect of creatinine and specific gravity normalization on urinary biomarker 1,6-hexamethylene diamine
    Linda G T Gaines
    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7431, USA
    J Environ Monit 12:591-9. 2010
    ....
  36. ncbi request reprint Evaluating effects of exposures on embryo viability and uterine receptivity in in vitro fertilization
    H Zhou
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599, USA
    Stat Med 17:1601-12. 1998
    ..We illustrate by applying the method to a recent study of in vitro fertilization carried out in North Carolina. The number of cells at transfer is evidently a marker for embryo viability...
  37. ncbi request reprint A semiparametric empirical likelihood method for biased sampling schemes with auxiliary covariates
    Xiaofei Wang
    Department of Biostatistics and Bioinformatics, Duke University, DUMC 2717, Durham, North Carolina 27710, USA
    Biometrics 62:1149-60. 2006
    ..Simulation studies show that the proposed estimator has nice small sample properties. The proposed method is illustrated with a data example...
  38. ncbi request reprint In utero exposure to background levels of polychlorinated biphenyls and cognitive functioning among school-age children
    Kimberly A Gray
    Division of Extramural Research and Training, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 162:17-26. 2005
    ..22 (95% confidence interval: -0.28, 0.71). In these data, in utero exposure to background levels of PCBs was not associated with lower IQ at age 7 years...
  39. ncbi request reprint In utero exposure to polychlorinated biphenyls and sensorineural hearing loss in 8-year-old children
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, P O Box 12233, MD A3 05, Research Triangle Park, NC 27709, USA
    Neurotoxicol Teratol 26:629-37. 2004
    ..Overall, an adverse effect of early-life, background-level PCB exposure on SNHL was not supported by these data...
  40. ncbi request reprint Maternal serum level of 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene and risk of cryptorchidism, hypospadias, and polythelia among male offspring
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Epidemiol 155:313-22. 2002
    ..9 (95% CI: 0.9, 4.0) for polythelia. For cryptorchidism and polythelia, the results were consistent with a modest-to-moderate association, but in no instance was the estimate very precise. The results were inconclusive...
  41. ncbi request reprint Personal coronary risk profiles modify autonomic nervous system responses to air pollution
    Jiu Chiuan Chen
    Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    J Occup Environ Med 48:1133-42. 2006
    ..We investigated whether PM2.5-mediated autonomic modulation depends on individual coronary risk profiles...
  42. ncbi request reprint Estimating cycle pregnancy probability with incomplete data in contraceptive studies
    Pai Lien Chen
    Division of Biostatistics, Family Health International, Research Triangle Park, North Carolina 27709, USA
    J Biopharm Stat 13:507-17. 2003
    ..Our findings support the U.S. Food and Drug Administration's (FDA) sample size requirements for contraceptive studies. We use data from an effectiveness trial on vaginal contraceptive film (VCF) to illustrate the proposed methods...
  43. ncbi request reprint An unexpected distribution of sodium concentration in serum specimens stored for more than 30 years
    Matthew P Longnecker
    Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Ann Epidemiol 13:178-81. 2003
    ..In two studies using these specimens, we measured sodium concentration to assess desiccation...

Research Grants9

  1. STATISTICAL METHODS FOR OUTCOME-DEPENDENT SAMPLING
    Haibo Zhou; Fiscal Year: 2001
    ..abstract_text> ..
  2. STATISTICAL METHODS FOR OUTCOME-DEPENDENT SAMPLING
    Haibo Zhou; Fiscal Year: 2005
    ..Comparisons with existing methods will be conducted. Related software will be developed. Data sets from ongoing epidemiologic studies of the effects of environmental exposures, and on cancer and other diseases will be analyzed. ..
  3. STATISTICAL METHODS FOR OUTCOME-DEPENDENT SAMPLING
    Haibo Zhou; Fiscal Year: 2009
    ..These designs allow investigators to conduct their study more efficiently for a given budget and hence can help improve the overall efficiency and productivity of the public health research. ..
  4. STATISTICAL METHODS FOR OUTCOME-DEPENDENT SAMPLING
    Haibo Zhou; Fiscal Year: 2010
    ..These include the Cancer Risk in Uranium Miners Study, the Magnetic Fields and Breast Cancer Risk Study, the Collaborative Perinatal Project, the Family Heart Study, and the DDE-antiandrogen Study. ..