Ming Zhong

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Retina, retinol, retinal and the natural history of vitamin A as a light sensor
    Ming Zhong
    Department of Physiology, Jules Stein Eye Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Nutrients 4:2069-96. 2012
  2. pmc Differential and isomer-specific modulation of vitamin A transport and the catalytic activities of the RBP receptor by retinoids
    Riki Kawaguchi
    Department of Physiology, Jules Stein Eye Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Membr Biol 246:647-60. 2013
  3. pmc STRA6-catalyzed vitamin A influx, efflux, and exchange
    Riki Kawaguchi
    Department of Physiology, Jules Stein Eye Institute and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Membr Biol 245:731-45. 2012
  4. pmc Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF
    Guo Cheng
    Department of Physiology, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States
    elife 3:e05401. 2014
  5. pmc Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein
    Ming Zhong
    Department of Physiology, Jules Stein Eye Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America
    PLoS ONE 8:e73838. 2013
  6. pmc Receptor-mediated cellular uptake mechanism that couples to intracellular storage
    Riki Kawaguchi
    Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, United States
    ACS Chem Biol 6:1041-51. 2011
  7. doi request reprint A genetic clog in the vitamin A transport machinery
    Ming Zhong
    Howard Hughes Medical Institute, Department of Physiology and Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, U S A
    Cell 161:435-7. 2015

Collaborators

  • Hui Sun
  • Riki Kawaguchi
  • Mariam Ter-Stepanian
  • Guo Cheng
  • Miki Kassai
  • Jun Deng
  • Muayyad Al-Ubaidi
  • David Ong
  • Minghao Jin
  • Quan Yuan
  • Gabriel H Travis
  • Jiamei Yu

Detail Information

Publications7

  1. pmc Retina, retinol, retinal and the natural history of vitamin A as a light sensor
    Ming Zhong
    Department of Physiology, Jules Stein Eye Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Nutrients 4:2069-96. 2012
    ....
  2. pmc Differential and isomer-specific modulation of vitamin A transport and the catalytic activities of the RBP receptor by retinoids
    Riki Kawaguchi
    Department of Physiology, Jules Stein Eye Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Membr Biol 246:647-60. 2013
    ..The effect of retinoids on STRA6 is highly isomer-specific. This study provides unique insights into the RBP receptor's mechanism and reveals that the vitamin A transport machinery can be a target of retinoid-based drugs. ..
  3. pmc STRA6-catalyzed vitamin A influx, efflux, and exchange
    Riki Kawaguchi
    Department of Physiology, Jules Stein Eye Institute and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    J Membr Biol 245:731-45. 2012
    ..STRA6's retinol exchange activity may serve to refresh the intracellular retinoid pool. This exchange is also a previously unknown function of CRBP-I and distinguishes CRBP-I from LRAT...
  4. pmc Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF
    Guo Cheng
    Department of Physiology, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, United States
    elife 3:e05401. 2014
    ..Mutations in the intracellular domain can have profound effects on receptor activities. ..
  5. pmc Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein
    Ming Zhong
    Department of Physiology, Jules Stein Eye Institute, and Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America
    PLoS ONE 8:e73838. 2013
    ..These experiments provide the first evidence for the existence of a transmembrane pore, analogous to the pore of ion channels, for this new type of cell-surface receptor...
  6. pmc Receptor-mediated cellular uptake mechanism that couples to intracellular storage
    Riki Kawaguchi
    Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, United States
    ACS Chem Biol 6:1041-51. 2011
    ..We have also identified a robust small-molecule-based technique to specifically stimulate cellular vitamin A uptake. This technique has implications in treating human diseases...
  7. doi request reprint A genetic clog in the vitamin A transport machinery
    Ming Zhong
    Howard Hughes Medical Institute, Department of Physiology and Jules Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, U S A
    Cell 161:435-7. 2015
    ..Mechanistically, these mutations simultaneously lower RBP's affinity for vitamin A and greatly increase its affinity for its cell-surface receptor, thus dominantly blocking the transmembrane transport of vitamin A...