Research Topics
Genomes and Genes | Yong Hui ZhengSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Newly identified host factors modulate HIV replicationYong-Hui Zheng
Department of Medicine, Rosalind Russell Arthritis Research Center, University of California, San Francisco, San Francisco, CA 94143, USA
Immunol Lett 97:225-34. 2005
Intracellular immunity to HIV-1: newly defined retroviral battles inside infected cellsYong Hui Zheng
Department of Medicine, Rosalind Russell Arthritis Research Center, University of California, San Francisco, CA 94143 0703, USA
Retrovirology 2:25. 2005..These processes also offer a tantalizing glimpse at basic cellular mechanisms that might restrict the movement of mobile genetic elements and protect the genome...
Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machineryMatthias Geyer
Department of Medicine, University of California, San Francisco, California 94143 0703, USA
J Biol Chem 277:28521-9. 2002..Finally, blocking the expression of V1H decreased the enhancement of virion infectivity by Nef. Thus, V1H can function as an adaptor for interactions between Nef and AP-2...
Human p32 protein relieves a post-transcriptional block to HIV replication in murine cellsYong Hui Zheng
Department of Medicine, Rosalind Russell Medical Research Center, Mt Zion Research Building Room N231, 2340 Sutter Street, University of California, San Francisco, CA 94115, USA
Nat Cell Biol 5:611-8. 2003..A single substitution in hp32 of Gly 35 to Asp 35, which is found in mp32, abrogates this activity. Thus, hp32 overcomes an important post-transcriptional block to HIV replication in murine cells...
Nef increases the synthesis of and transports cholesterol to lipid rafts and HIV-1 progeny virionsYong Hui Zheng
Department of Medicine, Rosalind Russell Medical Research Center, University of California, San Francisco, CA 94143 0703, USA
Proc Natl Acad Sci U S A 100:8460-5. 2003..Thus, Nef also transports newly synthesized cholesterol to the site of viral budding. As such, it provides essential building blocks for the formation of viruses that replicate optimally in the host...
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replicationYong Hui Zheng
Departments of Medicine, Microbiology, and Immunology, University of California, San Francisco, 3rd and Parnassus Ave, San Francisco, CA 94143 0703, USA
J Virol 78:6073-6. 2004..Thus, APOBEC family members might have evolved as a general defense mechanism of the body against retroviruses, retrotransposons, and other mobile genetic elements...
