Y Zheng

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Dbl family guanine nucleotide exchange factors
    Y Zheng
    Dept of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Trends Biochem Sci 26:724-32. 2001
  2. ncbi Autoinhibition mechanism of proto-Dbl
    F Bi
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Cell Biol 21:1463-74. 2001
  3. ncbi Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    Biochemistry 37:5249-57. 1998
  4. ncbi Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors
    Y Gao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Biol Chem 276:47530-41. 2001
  5. ncbi Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 273:8776-82. 1998
  6. ncbi Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190
    R Li
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 272:32830-5. 1997
  7. ncbi Oligomerization of DH domain is essential for Dbl-induced transformation
    K Zhu
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Cell Biol 21:425-37. 2001
  8. ncbi A built-in arginine finger triggers the self-stimulatory GTPase-activating activity of rho family GTPases
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 274:2609-12. 1999
  9. ncbi Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation
    K Zhu
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 275:25993-6001. 2000
  10. ncbi Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 273:25728-33. 1998

Collaborators

Detail Information

Publications14

  1. ncbi Dbl family guanine nucleotide exchange factors
    Y Zheng
    Dept of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Trends Biochem Sci 26:724-32. 2001
    ..The detailed pictures of their autoregulation, agonist-controlled activation and mechanism of interaction with Rho GTPase substrates, have begun to emerge...
  2. ncbi Autoinhibition mechanism of proto-Dbl
    F Bi
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Cell Biol 21:1463-74. 2001
    ....
  3. ncbi Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and 3BP-1
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    Biochemistry 37:5249-57. 1998
    ....
  4. ncbi Trp(56) of rac1 specifies interaction with a subset of guanine nucleotide exchange factors
    Y Gao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Biol Chem 276:47530-41. 2001
    ....
  5. ncbi Interaction of Rac1 with GTPase-activating proteins and putative effectors. A comparison with Cdc42 and RhoA
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 273:8776-82. 1998
    ....
  6. ncbi Structural determinants required for the interaction between Rho GTPase and the GTPase-activating domain of p190
    R Li
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 272:32830-5. 1997
    ....
  7. ncbi Oligomerization of DH domain is essential for Dbl-induced transformation
    K Zhu
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Mol Cell Biol 21:425-37. 2001
    ....
  8. ncbi A built-in arginine finger triggers the self-stimulatory GTPase-activating activity of rho family GTPases
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 274:2609-12. 1999
    ..cerevisiae CDC42 led to phenotypes consistent with down-regulated CDC42 function. Thus, specific Rho family GTPases may utilize a built-in arginine finger, in addition to RhoGAPs, for negative regulation...
  9. ncbi Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation
    K Zhu
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 275:25993-6001. 2000
    ....
  10. ncbi Negative regulation of Rho family GTPases Cdc42 and Rac2 by homodimer formation
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 273:25728-33. 1998
    ....
  11. ncbi Oligomerization of Rac1 gtpase mediated by the carboxyl-terminal polybasic domain
    B Zhang
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Biol Chem 276:8958-67. 2001
    ....
  12. ncbi Rac1 and extracellularly regulated kinase activation are sufficient for E1A-dependent cooperative transformation of primary epithelial cells, but progression can only be modulated by E1A or Rac1
    R S Fischer
    Department of Microbiology and Immunology, University of Tennessee Health Science Center, Memphis 38163, USA
    Cell Growth Differ 9:209-21. 1998
    ..Thus, hypertransformation is not the result of extracellularly regulated kinase differences but can be effected by perturbations in Rac1 signals, as well as E1A 12S COOH-terminal mutants...
  13. ncbi Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains
    B Zhang
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 272:21999-2007. 1997
    ....
  14. ncbi The faciogenital dysplasia gene product FGD1 functions as a Cdc42Hs-specific guanine-nucleotide exchange factor
    Y Zheng
    Department of Biochemistry, University of Tennessee, Memphis, Tennessee 38163, USA
    J Biol Chem 271:33169-72. 1996
    ..Hence, our results indicate that FGD1, through its DH and PH domains, acts as a Cdc42Hs-specific guanine-nucleotide exchange factor and suggest that the Cdc42Hs GTPase may have a role in mammalian development...