Wenxin Zheng

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
    Yiying Wang
    Department of Obstetrics and Gynecology, Henan Province People s Hospital Zhengzhou, Henan, China
    J Hematol Oncol 6:22. 2013
  2. pmc PAX8: a sensitive and specific marker to identify cancer cells of ovarian origin for patients prior to neoadjuvant chemotherapy
    Yue Wang
    Department of Obstetrics and Gynecology, Henan Province People s Hospital, Zhengzhou, Henan 450003, China
    J Hematol Oncol 6:60. 2013
  3. pmc Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
    Jie Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China 250012
    J Hematol Oncol 5:8. 2012
  4. doi request reprint A proposed model for endometrial serous carcinogenesis
    Wenxin Zheng
    Department of Pathology, University of Arizona, Tucson, 85724, USA
    Am J Surg Pathol 35:e1-e14. 2011
  5. doi request reprint The oncofetal protein IMP3: a novel biomarker for endometrial serous carcinoma
    Wenxin Zheng
    Department of Pathology, University of Arizona Medical College, Tucson, AZ 85724, USA
    Am J Surg Pathol 32:304-15. 2008
  6. ncbi request reprint Occurrence of endometrial glandular dysplasia precedes uterine papillary serous carcinoma
    Wenxin Zheng
    Department of Pathology, College of Medicine University of Arizona, Tucson, Arizona, USA
    Int J Gynecol Pathol 26:38-52. 2007
  7. ncbi request reprint Precursors of endometrial clear cell carcinoma
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Am J Surg Pathol 30:1519-30. 2006
  8. doi request reprint Tubal origin of 'ovarian' low-grade serous carcinoma
    Jie Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Mod Pathol 24:1488-99. 2011
  9. pmc High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    Tao Jiang
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Res 70:5486-96. 2010
  10. ncbi request reprint Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?
    Nicole R Howell
    Department of Pathology, Stony Brook University Hospital, New York, NY, USA
    Int J Gynecol Pathol 26:134-40. 2007

Collaborators

Detail Information

Publications52

  1. pmc Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium
    Yiying Wang
    Department of Obstetrics and Gynecology, Henan Province People s Hospital Zhengzhou, Henan, China
    J Hematol Oncol 6:22. 2013
    ..In this commentary, we summarize the main clinicopathologic features of LS-related EC and propose universal screening for LS in individuals with endometrial cancer...
  2. pmc PAX8: a sensitive and specific marker to identify cancer cells of ovarian origin for patients prior to neoadjuvant chemotherapy
    Yue Wang
    Department of Obstetrics and Gynecology, Henan Province People s Hospital, Zhengzhou, Henan 450003, China
    J Hematol Oncol 6:60. 2013
    ..In the present study, we evaluated if, in addition to the routine morphologic diagnosis, the biomarker PAX8 could be useful in recognition of ovarian epithelial cancer cells prior to the neoadjuvant chemotherapy...
  3. pmc Ovarian serous carcinoma: recent concepts on its origin and carcinogenesis
    Jie Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China 250012
    J Hematol Oncol 5:8. 2012
    ..In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications...
  4. doi request reprint A proposed model for endometrial serous carcinogenesis
    Wenxin Zheng
    Department of Pathology, University of Arizona, Tucson, 85724, USA
    Am J Surg Pathol 35:e1-e14. 2011
    ..The diagnostic criteria, practical applicability, and evidentiary basis for the delineation of this lesion are studied...
  5. doi request reprint The oncofetal protein IMP3: a novel biomarker for endometrial serous carcinoma
    Wenxin Zheng
    Department of Pathology, University of Arizona Medical College, Tucson, AZ 85724, USA
    Am J Surg Pathol 32:304-15. 2008
    ..Although the significance of the latter finding remains unclear, the differential diagnosis between decidual changes and endometrial serous carcinoma is rarely problematic...
  6. ncbi request reprint Occurrence of endometrial glandular dysplasia precedes uterine papillary serous carcinoma
    Wenxin Zheng
    Department of Pathology, College of Medicine University of Arizona, Tucson, Arizona, USA
    Int J Gynecol Pathol 26:38-52. 2007
    ..Further studies are needed to address issues in regard to molecular and cellular mechanisms, reversibility, risk of UPSC development, and clinical management of EmGD...
  7. ncbi request reprint Precursors of endometrial clear cell carcinoma
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine, New Haven, CT, USA
    Am J Surg Pathol 30:1519-30. 2006
    ..Further studies are required to conclusively define the nature of these lesions. However, such studies can only be performed if diagnostic surgical pathologists recognize, highlight, and segregate these lesions for further analysis...
  8. doi request reprint Tubal origin of 'ovarian' low-grade serous carcinoma
    Jie Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, China
    Mod Pathol 24:1488-99. 2011
    ..Genetic and molecular studies are needed to further confirm this finding as tubal origination of ovarian serous cancers will have a significant impact on ovarian cancer prevention and management...
  9. pmc High levels of Nrf2 determine chemoresistance in type II endometrial cancer
    Tao Jiang
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona 85724, USA
    Cancer Res 70:5486-96. 2010
    ..Collectively, we provide a molecular basis for the use of Nrf2 inhibitors to increase the efficacy of chemotherapeutic drugs and to combat chemoresistance, the biggest obstacle in chemotherapy...
  10. ncbi request reprint Carcinomas of ovary and lung with clear cell features: can immunohistochemistry help in differential diagnosis?
    Nicole R Howell
    Department of Pathology, Stony Brook University Hospital, New York, NY, USA
    Int J Gynecol Pathol 26:134-40. 2007
    ..Our results suggest that an immunohistochemical panel consisting of TTF-1, CEA, CA-125, and OCT-4 is helpful in distinguishing most pulmonary and ovarian carcinomas with clear cell features...
  11. pmc Expression of the oncofetal protein IGF2BP3 in endometrial clear cell carcinoma: assessment of frequency and significance
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Hum Pathol 44:1508-15. 2013
    ..These preliminary findings suggest that IMP3 expression may be involved in the pathogenesis of CCC and is worthy of further exploration...
  12. pmc The clinicopathologic significance of p53 and BAF-250a (ARID1A) expression in clear cell carcinoma of the endometrium
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Mod Pathol 26:1101-10. 2013
    ..P53 expression may be a negative prognostic factor in this histotype, and warrants additional studies. Loss of BAF250a expression has no prognostic significance in endometrial clear cell carcinomas...
  13. ncbi request reprint Endometrial glandular dysplasia: a putative precursor lesion of uterine papillary serous carcinoma. Part II: molecular features
    Sharon X Liang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Int J Surg Pathol 12:319-31. 2004
    ..The clinical significance of EmGD needs further studies...
  14. doi request reprint Personal history of breast cancer as a significant risk factor for endometrial serous carcinoma in women aged 55 years old or younger
    Sharon X Liang
    Department of Pathology, Stony Brook University Medical Center, Stony Brook, NY, USA
    Int J Cancer 128:763-70. 2011
    ..Further studies are needed to clarify the relationship between these two cancers in this age group and whether this increased risk is reflective of a genetic predisposition...
  15. ncbi request reprint Molecular genetic evidence supporting the neoplastic nature of the Leydig cell component of ovarian Sertoli-Leydig cell tumors
    Robert E Emerson
    Department of Pathology, Indiana University, Indianapolis, Indiana, USA
    Int J Gynecol Pathol 26:368-74. 2007
    ..Similarly, the heterologous components, when present, appear to share clonal origin with the Sertoli cell components...
  16. doi request reprint Endometrial glandular dysplasia with frequent p53 gene mutation: a genetic evidence supporting its precancer nature for endometrial serous carcinoma
    Lin Jia
    Department of Pathology, Arizona Cancer Center, University of Arizona College of Medicine, Tucson, AZ 85724, USA
    Clin Cancer Res 14:2263-9. 2008
    ..The purpose of this study is to determine if EmGD is genetically linked to ESC and if it can be used for early detection...
  17. ncbi request reprint Microsatellite instability and alteration of the expression of hMLH1 and hMSH2 in ovarian clear cell carcinoma
    Kathy Qi Cai
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Hum Pathol 35:552-9. 2004
    ..A strong correlation exists between alterations in the expression of hMLH1 and hMSH2 and the presence of MSI-H in these tumors. However, immunohistochemical testing alone may miss a small fraction of cases with MSI-H...
  18. ncbi request reprint Variations of mitotic index in normal and dysplastic squamous epithelium of the uterine cervix as a function of endometrial maturation
    Oluwole Fadare
    Department of Pathology, Wilford Hall Medical Center, Lackland AFB, TX, USA
    Mod Pathol 20:1000-8. 2007
    ..The full composite of histopathologic features should form the basis for this determination...
  19. ncbi request reprint Sertoliform endometrioid carcinoma of the endometrium with dual immunophenotypes for epithelial membrane antigen and inhibin alpha: case report and literature review
    Sharon X Liang
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794 7025, USA
    Int J Gynecol Pathol 26:291-7. 2007
    ..Our case is the first documentation of such example and suggests that endometrial carcinoma can undergo true sex cord differentiation...
  20. ncbi request reprint Endometrial glandular dysplasia: a newly defined precursor lesion of uterine papillary serous carcinoma. Part I: morphologic features
    Wenxin Zheng
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Int J Surg Pathol 12:207-23. 2004
    ..Characteristics of p53 and MIB-1 immunostains of EmGD may be of diagnostic usage in surgical pathology practice. Recognition of EmGD may provide an opportunity to improve the management of UPSC...
  21. ncbi request reprint Serous EIC as an early form of uterine papillary serous carcinoma: recent progress in understanding its pathogenesis and current opinions regarding pathologic and clinical management
    Wenxin Zheng
    Department of Pathology, Yale University School of Medicine, 20 York Street, EP 2 608, New Haven, CT 06520 8070, USA
    Gynecol Oncol 96:579-82. 2005
  22. ncbi request reprint Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis
    E Cagnur Ulukus
    Yale University School of Medicine, Department of Pathology, New Haven, CT 06520, USA
    Hum Reprod 20:2958-63. 2005
    ....
  23. doi request reprint HuR expression in the nucleus correlates with high histological grade and poor disease-free survival in ovarian cancer
    Xiaofang Yi
    Arizona Cancer Center, University of Arizona, Tuscon, Arizona 85724 5024, USA
    Aust N Z J Obstet Gynaecol 49:93-8. 2009
    ..Recently, HuR expression, particularly in the cytoplasm, was thought to be associated with the prognosis of several cancers including ovarian cancer...
  24. doi request reprint Serous endometrial intraepithelial carcinoma arising in adenomyosis: a report of 5 cases
    Nisreen Abushahin
    Department of Pathology, University of Arizona College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Int J Gynecol Pathol 30:271-81. 2011
    ..Clinicopathologic data including characterized immunohistochemical stainings and p53 gene sequence analysis are presented and clinical significance is discussed...
  25. doi request reprint Endometrial glandular dysplasia and endometrial intraepithelial neoplasia
    Xiaofang Yi
    Department of Obstetrics and Gynecology and Arizona Cancer Center, University of Arizona College of Medicine, Tucson, Arizona 85724, USA
    Curr Opin Obstet Gynecol 20:20-5. 2008
    ..As endometrial intraepithelial neoplasia has been discussed more extensively in the literature, we focus more on the recent development of endometrial glandular dysplasia in this review...
  26. ncbi request reprint A 44-year-old woman with menometrorrhagia
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA
    Arch Pathol Lab Med 129:e195-8. 2005
  27. ncbi request reprint Initial endometriosis showing direct morphologic evidence of metaplasia in the pathogenesis of ovarian endometriosis
    Wenxin Zheng
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8070, USA
    Int J Gynecol Pathol 24:164-72. 2005
    ..Local production of estrogen, probably in high-levels, may be related to the initial process of endometriosis, although detailed mechanisms remain to be clarified...
  28. pmc Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
    Xiao Jun Wang
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721, USA
    Carcinogenesis 29:1235-43. 2008
    ....
  29. ncbi request reprint Histologic dating of the endometrium: accuracy, reproducibility, and practical value
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8070, USA
    Adv Anat Pathol 12:39-46. 2005
  30. doi request reprint Secretory cell expansion with aging: risk for pelvic serous carcinogenesis
    Jie Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, China Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA
    Gynecol Oncol 131:555-60. 2013
    ..The purpose of our study was to determine if increased number of secretory cells shows difference in age and location and to examine their association with serous neoplasia...
  31. pmc Morphologic and other clinicopathologic features of endometrial clear cell carcinoma: a comprehensive analysis of 50 rigorously classified cases
    Oluwole Fadare
    Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center Nashville, TN, USA Department of Obstetrics and Gynecology, Vanderbilt University Medical Center Nashville, TN, USA
    Am J Cancer Res 3:70-95. 2013
    ....
  32. doi request reprint Detection of PAX8 and p53 is beneficial in recognizing metastatic carcinomas in pelvic washings, especially in cases with suspicious cytology
    Li Xiang
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 W Wenhua Road, Jinan, 250012, P R China
    Gynecol Oncol 127:595-600. 2012
    ..The aim of this study is to evaluate the detection of paired box gene 8 (PAX8) and p53 with immunohistochemistry in pelvic washing cell block sections...
  33. ncbi request reprint Well-differentiated papillary villoglandular adenocarcinoma of the uterine cervix with a focal high-grade component: is there a need for reassessment?
    Oluwole Fadare
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06504, USA
    Virchows Arch 447:883-7. 2005
    ....
  34. ncbi request reprint Mechanisms involved in the evolution of progestin resistance in human endometrial hyperplasia--precursor of endometrial cancer
    Sa Wang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Gynecol Oncol 88:108-17. 2003
    ..The aims of this study are to examine Fas/FasL expression in endometrial hyperplasia of pre- and postprogestin treatment samples and to study the Fas/FasL regulation in vitro with Ishikawa cells after progestin stimulation...
  35. ncbi request reprint Involution of PTEN-null endometrial glands with progestin therapy
    Wenxin Zheng
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Gynecol Oncol 92:1008-13. 2004
    ....
  36. ncbi request reprint Eosinophilic dysplasia of the cervix: a newly recognized variant of cervical squamous intraepithelial neoplasia
    Linglei Ma
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Am J Surg Pathol 28:1474-84. 2004
    ..Since ED possesses histologic features of both dysplasia and metaplasia, we speculate that it may arise from metaplastic cervical squamous epithelium that has subsequently become infected with intermediate- or high-risk HPV...
  37. ncbi request reprint Chromosome 12p abnormalities in dysgerminoma of the ovary: a FISH analysis
    Paolo Cossu-Rocca
    Department of Pathology, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 19:611-5. 2006
    ..FISH analyses for chromosome 12p abnormalities may be a useful diagnostic adjunct for confirming the diagnosis of dysgerminoma and for distinguishing it from nongerm cell malignancies that enter into the differential diagnosis...
  38. ncbi request reprint Microsatellite instability and expression of hMLH1 and hMSH2 proteins in ovarian endometrioid cancer
    Jinsong Liu
    Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mod Pathol 17:75-80. 2004
    ..097). Our results indicate that both microsatellite and loss of heterozygosity at D17S250 are involved in the development of ovarian endometrioid carcinoma...
  39. ncbi request reprint A high-grade uterine leiomyosarcoma with human chorionic gonadotropin production
    Sharon Liang
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, New York 11794, USA
    Int J Gynecol Pathol 25:257-61. 2006
    ..Our case, to the authors' best knowledge, is the first uterine leiomyosarcoma with prominent beta/human chorionic gonadotropin production...
  40. pmc Insights into endometrial serous carcinogenesis and progression
    Oluwole Fadare
    Department of Pathology, Wilford Hall Medical Center, Lackland Air Force Base San Antonio, Texas, USA
    Int J Clin Exp Pathol 2:411-32. 2009
    ..Deciphering the molecular basis for endometrial serous carcinogenesis should uncover potential targets for diagnosis, therapy, and/or disease surveillance...
  41. ncbi request reprint Inhibin expression in ovarian-type stroma in mucinous cystic neoplasms of the pancreas
    Matthew M Yeh
    Department of Pathology, Yale University School of Mediine, New Haven, CT 06520 8023, USA
    Appl Immunohistochem Mol Morphol 12:148-52. 2004
    ..In addition, its limited expression in MCNs of the pancreas may be diagnostically useful in difficult cases...
  42. ncbi request reprint Inhibin immunohistochemical staining: a practical approach for the surgical pathologist in the diagnoses of ovarian sex cord-stromal tumors
    Wenxin Zheng
    Department of Pathology, Yale University School of Medicine, 20 York Street, EP 2 608, New Haven, CT 06520 8070, USA
    Adv Anat Pathol 10:27-38. 2003
    ..In this review, we have listed nine of the most commonly encountered clinical scenarios where alpha-inhibin and other markers could be used in diagnostic surgical pathology of ovarian tumors...
  43. doi request reprint Histopathology of endometrial hyperplasia and endometrial carcinoma. An update by Dr LC Horn et al in Annals of Diagnostic Pathology 2007;11:297-311
    Wenxin Zheng
    Ann Diagn Pathol 12:231-2; author reply 232-3. 2008
  44. ncbi request reprint HER2 protein (p185(HER2)) is only rarely overexpressed in cervical cancer
    Oluwole Fadare
    Int J Gynecol Pathol 23:410-1; author reply 411-2. 2004
  45. ncbi request reprint Membrane proteome analysis of microdissected ovarian tumor tissues using capillary isoelectric focusing/reversed-phase liquid chromatography-tandem MS
    Weijie Wang
    Calibrant Biosystems, 910 Clopper Road, Suite 220N, Gaithersburg, Maryland 20878, USA
    Anal Chem 79:1002-9. 2007
    ....
  46. ncbi request reprint Low-grade endometrial stromal sarcoma: hormonal aspects
    Micheline C Chu
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Gynecol Oncol 90:170-6. 2003
    ..The goal of this work was to determine whether exposure to estrogen following treatment of low-grade endometrial stromal sarcomas affects clinical outcome...
  47. ncbi request reprint Regulation of PTEN (phosphatase and tensin homolog deleted on chromosome 10) expression by estradiol and progesterone in human endometrium
    Ozlem Guzeloglu-Kayisli
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Clin Endocrinol Metab 88:5017-26. 2003
    ..We propose that PTEN might be one of the signaling proteins that estrogen and progesterone are acting to affect endometrial cell proliferation and/or apoptosis...
  48. ncbi request reprint Expression of interleukin-8 receptors in patients with adenomyosis
    Murat Ulukus
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 85:714-20. 2006
    ..To investigate the expression of interleukin-8 (IL-8) receptors CXCR1 and CXCR2 in adenomyosis...
  49. ncbi request reprint Expression of CD117 (c-kit) receptor in dysgerminoma of the ovary: diagnostic and therapeutic implications
    Michael Sever
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Mod Pathol 18:1411-6. 2005
    ..Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options...
  50. ncbi request reprint Expression of interleukin-8 receptors in endometriosis
    Murat Ulukus
    Yale University School of Medicine, Department of Obstetrics and Gynecology, New Haven, CT 06511, USA
    Hum Reprod 20:794-801. 2005
    ....
  51. ncbi request reprint OCT4: a novel biomarker for dysgerminoma of the ovary
    Liang Cheng
    Departments of Pathology and Laboratory Medicine, Indiana University Medical Center, University Hospital 3465, 550 North University Boulevard, Indianapolis, IN 46202, USA
    Am J Surg Pathol 28:1341-6. 2004
    ..OCT4 may aid in the detection of small foci of metastatic dygerminoma in extraovarian sites and may also help distinguish dysgerminoma from other primary and metastatic tumors of the ovary...
  52. ncbi request reprint Cytokeratin and CD30 expression in dysgerminoma
    Paolo Cossu-Rocca
    Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
    Hum Pathol 37:1015-21. 2006
    ..Furthermore, the immunohistochemical staining patterns for cytokeratins, E-cadherin, and CD30 in dysgerminomas need to be considered when assessing differential diagnoses in difficult cases of primary ovarian tumors...