Research Topics
| V P ZharovSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
Research Grants
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Detail Information
Publications
Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapyMaaike Everts
Division of Human Gene Therapy, Department of Medicine, Gene Therapy Center, University of Alabama, Birmingham, Alabama 35294, USA
Nano Lett 6:587-91. 2006..These results indicate the possibility of using adenoviral vectors as carriers for gold nanoparticles...- Photothermal flow cytometry in vitro for detection and imaging of individual moving cellsVladimir P Zharov
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
Cytometry A 71:191-206. 2007..The goal of our investigation was to expand this technique to the detection of flowing cells in vitro... - Photothermal antimicrobial nanotherapy and nanodiagnostics with self-assembling carbon nanotube clustersJin Woo Kim
Department of Biological and Agricultural Engineering, University of Arkansas, Fayetteville, AR 72701, USA
Lasers Surg Med 39:622-34. 2007..In this study, new CNTs' capabilities for photothermal (PT) antimicrobial nanotherapy were explored in vitro using Escherichia coli as a model bacterium... - Nanocluster model of photothermal assay: application for high-sensitive monitoring of nicotine-induced changes in metabolism, apoptosis, and necrosis at a cellular levelVladimir P Zharov
University of Arkansas for Medical Sciences, Philips Classic Laser Laboratories, 4301 West Markham Street, Number 543, Little Rock, Arkansas 72205 7199, USA
J Biomed Opt 10:44011. 2005..Comparison of PT responses of pancreatic tumor cells AR42J with isolated primary pancreatic acinar cells and HepG2 cells shows a universal nature of PT assay... - Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapyVladimir P Zharov
Philips Classic Laser Laboratories, The Arkansas Cancer Research Center, The University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Nanomedicine 1:326-45. 2005.... - In vivo photoacoustic flow cytometry for monitoring of circulating single cancer cells and contrast agentsVladimir P Zharov
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Opt Lett 31:3623-5. 2006..The threshold sensitivity is estimated as one cancer cell in the background of 10(7) normal blood cells... - In vivo photothermal flow cytometry: imaging and detection of individual cells in blood and lymph flowVladimir P Zharov
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Cell Biochem 97:916-32. 2006..g., drug or radiation), in natural biological environments... - Integrated photothermal flow cytometry in vivoVladimir P Zharov
University of Arkansas for Medical Sciences, Philips Classic Laser Laboratories, 4301 West Markham St 543, Little Rock, Arkansas 72205 7199, USA
J Biomed Opt 10:051502. 2005.... 
Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticlesVladimir P Zharov
Philips Classic Laser Laboratories, and Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Biophys J 90:619-27. 2006..1-5 J/cm(2), 100 pulses), and laser-induced bacterial damage observed at different laser fluences and nanoparticle sizes was verified by optical transmission, electron microscopy, and conventional viability testing...- Synergistic enhancement of selective nanophotothermolysis with gold nanoclusters: potential for cancer therapyVladimir P Zharov
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Lasers Surg Med 37:219-26. 2005..We developed a new approach that enhances selective photothermolysis of tumor through laser activation of synergistic phenomena around nanoclusters, which are self-assembled into cancer cells... - Photothermal image flow cytometry in vivoVladimir P Zharov
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Opt Lett 30:628-30. 2005..Potential applications of this optical tool, called PT flow cytometry, are discussed... - Photoacoustic flow cytometry: principle and application for real-time detection of circulating single nanoparticles, pathogens, and contrast dyes in vivoVladimir P Zharov
University of Arkansas for Medical Sciences, Phillips Classic Laser Laboratories, Little Rock, Arkansas 72205, USA
J Biomed Opt 12:051503. 2007.... - Design and application of low-frequency ultrasound and its combination with laser radiation in surgery and therapyV P Zharov
Biomedical Technical Systems Department, Biomedical Engineering Faculty, N E Bauman Moscow State University of Technology, Russia
Crit Rev Biomed Eng 29:502-19. 2001..Some of the above-mentioned technologies were tested experimentally, and the results obtained are considered... - Infrared imaging of subcutaneous veinsVladimir P Zharov
Philips Classic Laser Biomedical Laboratory, University of Arkansas for Medical Sciences, 4301 West Markham Street, Slot 543, Little Rock, AR 72205 7199, USA
Lasers Surg Med 34:56-61. 2004..Here we revisited and explored the capability of near-IR imaging to visualize subcutaneous structures, with a focus on diagnostics of superficial veins... - Far-field photothermal microscopy beyond the diffraction limitVladimir P Zharov
Philips Classic Laser Biomedical Laboratory, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205 7199, USA
Opt Lett 28:1314-6. 2003..Algorithms for obtaining information on the sizes and the shapes of nanotargets are analyzed. Spectral PT lifetime imaging is suggested to provide spatial localization of nanotargets overlapping inside the diffraction volume... - In vivo photoacoustic time-of-flight velocity measurement of single cells and nanoparticlesM Sarimollaoglu
Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Opt Lett 36:4086-8. 2011..1 mm/s to 14 cm/s. Object velocity can be used to identify single cells circulating at different velocities or cell aggregates and to determine a cell's location in a vessel cross-section... - Methods for photoultrasonic treatment of festering wounds in oncological patientsV P Zharov
Biomedical Technical Systems Department, N E Bauman Moscow State University of Technology, Russia
Crit Rev Biomed Eng 29:111-24. 2001..Moreover, this article describes the preliminary experimental results of the aforementioned technology... 
In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cellsEkaterina I Galanzha
Phillips Classic Laser and Nanomedicine Laboratories, Winthrop P Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Nat Nanotechnol 4:855-60. 2009....- Photothermal detection of nicotine-induced apoptotic effects in pancreatic cancer cellsValentin Galitovsky
Philips Classic Laser Biomedical Laboratory, University of Arkansas for Medical Sciences (UAMS, 4301 West Markham St, Slot #543, Little Rock, AR 72205, USA
Life Sci 75:2677-87. 2004..Thus, the PT assay demonstrated the capability for high-sensitivity detection of nicotine's impact, which may be related to a change in cell metabolism, apoptosis, or necrosis, depending on nicotine concentration... - In vivo multispectral, multiparameter, photoacoustic lymph flow cytometry with natural cell focusing, label-free detection and multicolor nanoparticle probesEkaterina I Galanzha
University of Arkansas for Medical Sciences, Philips Classic Laser Laboratories, Winthrop P Rockefeller Cancer Institute, Little Rock, Arkansas 72205, USA
Cytometry A 73:884-94. 2008.... - In vivo Raman flow cytometry for real-time detection of carbon nanotube kinetics in lymph, blood, and tissuesAlexandru S Biris
University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204, USA
J Biomed Opt 14:021006. 2009..Moreover, this technology has the potential for molecular detection and identification of circulating tumor cells, and infections labeled with CNTs... - Nanophotothermolysis of multiple scattered cancer cells with carbon nanotubes guided by time-resolved infrared thermal imagingAlexandru S Biris
University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, Arkansas 72204, USA
J Biomed Opt 14:021007. 2009..The applications are discussed with a focus on the nanophotothermolysis of small tumors, tumor margins, or micrometastases under the guidance of near-IR and microwave radiometry... - In vivo integrated flow image cytometry and lymph/blood vessels dynamic microscopyEkaterina I Galanzha
University of Arkansas for Medical Sciences, Philips Classic Laser Laboratories, Little Rock, Arkansas 72205-7199, USA
J Biomed Opt 10:054018. 2005.... - In vivo fiber-based multicolor photoacoustic detection and photothermal purging of metastasis in sentinel lymph nodes targeted by nanoparticlesEkaterina I Galanzha
Winthrop P Rockefeller Cancer Institute, Phillips Classic Laser and Nanomedicine Laboratories, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Biophotonics 2:528-39. 2009..The earliest detection of DTCs in the lymphatic vessels before the establishment of nodal metastasis may prevent metastasis by well-timed ablation of DTCs... - Nanotechnology-based molecular photoacoustic and photothermal flow cytometry platform for in-vivo detection and killing of circulating cancer stem cellsEkaterina I Galanzha
Department of Biological and Agricultural Engineering and Institute for Nanoscale Materials Science and Engineering, University of Arkansas, Fayetteville, AR, 72701, USA
J Biophotonics 2:725-35. 2009.... - Photothermal and photoacoustic Raman cytometry in vitro and in vivoEvgeny V Shashkov
Phillips Classic Laser and Nanomedicine Laboratories, University of Arkansas for Medical Sciences, 4301 W Markham, Little Rock, AR 72205, USA
Opt Express 18:6929-44. 2010.... - Advances in small animal mesentery models for in vivo flow cytometry, dynamic microscopy, and drug screeningEkaterina I Galanzha
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR 72205 7199, United States
World J Gastroenterol 13:192-218. 2007..Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed... - Ultra-fast photoacoustic flow cytometry with a 0.5 MHz pulse repetition rate nanosecond laserDmitry A Nedosekin
Phillips Classic Laser and Nanomedicine Laboratories, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, AR, 72205, USA
Opt Express 18:8605-20. 2010..5 m/s... - Laser non-contact drug delivery methods: mathematical and experimental substantiationV P Zharov
Biomedical Technical Systems Department, N E Bauman Moscow State University of Technology, Russia
Crit Rev Biomed Eng 29:142-56. 2001..These preparations were injected into gelatinous gel and autopsy skin samples. Possible clinical application is considered for these laser transcutaneous drug delivery methods... - Superhigh-sensitivity photothermal monitoring of individual cell response to antitumor drugVladimir P Zharov
University of Arkansas for Medical Sciences, Philips Classic Laser Laboratories, Little Rock, Arkansas 72205 7199, USA
J Biomed Opt 11:064034. 2006.... - Photothermal confocal spectromicroscopy of multiple cellular chromophores and fluorophoresDmitry A Nedosekin
Phillips Classic Laser and Nanomedicine Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Biophys J 102:672-81. 2012..Confocal PT spectromicroscopy could provide a valuable alternative or supplement to fluorescence microscopy for imaging of nonfluorescent chromophores and certain fluorophores... - Optical monitoring of microlymphatic disturbances during experimental lymphedemaE I Galanzha
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas 72205 7199, USA
Lymphat Res Biol 5:11-27. 2007..Rat mesentery has been widely used to study microvascular functions. The goal of this work is to extend this animal model to monitor blood and lymph microvessel function during lymphedema... - Quantum dots as multimodal photoacoustic and photothermal contrast agentsEvgeny V Shashkov
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Nano Lett 8:3953-8. 2008..Further improvements for this technology are suggested by increasing the conversion of laser energy in PT, PA, and bubble phenomena in hybrid multilayer QDs that have optimized absorption, thermal, and acoustic properties... - Monitoring of nicotine impact in microlymphatics of rat mesentery with time-resolved microscopyE L Galanzha
Philips Classic Laser Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Lymphology 38:181-92. 2005..We conclude that the observed effects are due to the direct action of nicotine on lymphatics. The mechanism by which nicotine induces this response remains to be investigated further... - In vivo high-speed imaging of individual cells in fast blood flowVladimir P Zharov
Philips Classic Laser Biomedical Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199, USA
J Biomed Opt 11:054034. 2006..Potential applications of this technique are discussed with focus on time-resolved monitoring of the cell deformation dynamics in the native biological environment, which may have diagnostic value for the early diagnosis of diseases... - In vivo, noninvasive, label-free detection and eradication of circulating metastatic melanoma cells using two-color photoacoustic flow cytometry with a diode laserEkaterina I Galanzha
Phillips Classic Laser and Nanomedicine Laboratories, Department of Otolaryngology Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Cancer Res 69:7926-34. 2009..These advances make feasible the early diagnosis of melanoma during the initial parallel progression of primary tumor and CTCs, and laser blood purging using noninvasive or hemodialysis-like schematics for the prevention of metastasis... - Combination of viral biology and nanotechnology: new applications in nanomedicineVaibhav Saini
Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294-2180, USA
Nanomedicine 2:200-6. 2006.... - Laser-induced explosion of gold nanoparticles: potential role for nanophotothermolysis of cancerRenat R Letfullin
Department of Physics and Optical Engineering, Rose-Hulman Institute of Technology, Terre Haute, IN 47803-3999, USA
Nanomed 1:473-80. 2006.... - Spectral evaluation of laser-induced cell damage with photothermal microscopyDmitri O Lapotko
Luikov Heat and Mass Transfer Institute, International Research Centre, Minsk, Belarus
Lasers Surg Med 36:22-30. 2005..The correlation between specific change of PT parameters and cell damage permits using PT technique to rapidly estimate the invasive conditions of the laser-cell interactions... - Photothermal time-resolved imaging of living cellsDmitri O Lapotko
Luikov Heat and Mass Transfer Institute, 15 Brovka Street, Minsk, 220072, Belarus
Lasers Surg Med 31:53-63. 2002..The aim of this study was to evaluate a new method of photothermal imaging (PTI) for monitoring short-time nano-scale thermal effects in individual living cells... - Photothermal lens detection of gold nanoparticles: theory and experimentsAnton V Brusnichkin
M V Lomonosov Moscow State University, Chemistry Department, Vorob evy Hills 1 3, GSP 3 Moscow, Russia
Appl Spectrosc 61:1191-201. 2007..Further improvements are discussed, including increasing the sensitivity thresholds up to one nanoparticle in the detected volume...
Research Grants
- In vivo real-time detection of circulating melanoma cellsVladimir P Zharov; Fiscal Year: 2010....
- Photothermal Evaluation of Drug Toxicity at Cell LevelVladimir Zharov; Fiscal Year: 2004..abstract_text> ..
- Multifunctional nanotubes for in vivo detecting/purging circulating cancer cellsVladimir P Zharov; Fiscal Year: 2010....
- Multifunctional nanotubes for in vivo detecting/purging circulating cancer cellsVladimir Zharov; Fiscal Year: 2009....
- In vivo real-time detection of circulating melanoma cellsVladimir Zharov; Fiscal Year: 2009....
- Integrated Photothermal NanoprobesVladimir Zharov; Fiscal Year: 2007..The results of these studies will also make it possible to formulate recommendations on the desired properties of new, clustered nanomaterials for medical applications. ..
- Photothermal Imaging of Live CellsVladimir Zharov; Fiscal Year: 2007..The technical realization of PTI is relatively simple, requiring the combination of conventional optical phase-contrast microscopy and the already routinely used nanosecond laser. ..
- Integrated optical imaging rat of mesenteryVladimir Zharov; Fiscal Year: 2004..The technical realization of this new imaging system is relatively simple, combining transmission microscopy and laser technique already routinely in use. ..