Yutong Zhao

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. pmc Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Signal 21:367-77. 2009
  2. pmc Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Signal 19:2329-38. 2007
  3. pmc Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells
    Yutong Zhao
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:10172-9. 2007
  4. pmc Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
    Yutong Zhao
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Respir Res 10:114. 2009
  5. pmc Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells
    Peter V Usatyuk
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:15339-52. 2009
  6. pmc Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells
    Donghong He
    The Section of Pulmonary and Critical Care, Department of Medicine, Center for Integrative Science Building, 929 East 57th Street, Chicago, IL 60637, USA
    Biochem J 412:153-62. 2008
  7. pmc Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    Irina Gorshkova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:11794-806. 2008
  8. pmc Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs
    Jing Zhao
    Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 301:L547-56. 2011
  9. pmc Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
    Yutong Zhao
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21222, USA
    Biochem J 385:493-502. 2005
  10. pmc Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase
    Evgeny V Berdyshev
    Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e16571. 2011

Collaborators

Detail Information

Publications36

  1. pmc Lysophosphatidic acid signaling in airway epithelium: role in airway inflammation and remodeling
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Signal 21:367-77. 2009
    ..This review summarizes our recent observations of the role of LPA/LPA-Rs in regulation of airway epithelium, especially in relation to the secretion of pro- and anti-inflammatory mediators and regulation of airway barrier function...
  2. pmc Lysophosphatidic acid modulates c-Met redistribution and hepatocyte growth factor/c-Met signaling in human bronchial epithelial cells through PKC delta and E-cadherin
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Signal 19:2329-38. 2007
    ..These results demonstrate that LPA regulates c-Met function through PKC delta and E-cadherin in HBEpCs, suggesting an alternate function of the cross-talk between G-protein-coupled receptors (GPCRs) and RTKs in HBEpCs...
  3. pmc Lysophosphatidic acid induces interleukin-13 (IL-13) receptor alpha2 expression and inhibits IL-13 signaling in primary human bronchial epithelial cells
    Yutong Zhao
    Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 282:10172-9. 2007
    ..Our data suggest a novel mechanism of regulation of IL-13Ralpha2 and IL-13 signaling that may be of physiological relevance to airway inflammation and remodeling...
  4. pmc Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma
    Yutong Zhao
    Department of Medicine, The University of Chicago, Chicago, Illinois, USA
    Respir Res 10:114. 2009
    ..We have demonstrated that LPA induced cytokine and lipid mediator release in human bronchial epithelial cells. Here we provide evidence for the role of LPA and LPA receptors in Th2-dominant airway inflammation...
  5. pmc Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells
    Peter V Usatyuk
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:15339-52. 2009
    ..These results demonstrate a role of PLD in hyperoxia-mediated IQGAP1 activation through Rac1 in tyrosine phosphorylation of Src and cortactin, as well as in p47(phox) translocation and ROS formation in human lung endothelial cells...
  6. pmc Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells
    Donghong He
    The Section of Pulmonary and Critical Care, Department of Medicine, Center for Integrative Science Building, 929 East 57th Street, Chicago, IL 60637, USA
    Biochem J 412:153-62. 2008
    ..Since COX-2 and PGE(2) have been shown to be anti-inflammatory in airway inflammation, the present data suggest a modulating and protective role of LPA in regulating innate immunity and remodelling of the airways...
  7. pmc Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1
    Irina Gorshkova
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 283:11794-806. 2008
    ..Activation of this pathway is necessary to stimulate the migration of lung endothelial cells, a key component of the angiogenic process...
  8. pmc Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs
    Jing Zhao
    Department of Medicine, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Physiol Lung Cell Mol Physiol 301:L547-56. 2011
    ..These results showed that knock down or inhibition of LPA(1) offered significant protection against LPS-induced lung inflammation but not against pulmonary leak as observed in the murine model for lung injury...
  9. pmc Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
    Yutong Zhao
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21222, USA
    Biochem J 385:493-502. 2005
    ..Our results identify LPP-1 as a key regulator of LPA signalling and IL-8 secretion in HBEpCs. Thus LPPs could represent potential targets in regulating leucocyte infiltration and airway inflammation...
  10. pmc Intracellular S1P generation is essential for S1P-induced motility of human lung endothelial cells: role of sphingosine kinase 1 and S1P lyase
    Evgeny V Berdyshev
    Department of Medicine, The University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e16571. 2011
    ..As endothelial cells generate intracellular S1P, here we have investigated the role of sphingosine kinases (SphKs) and S1P lyase (S1PL), that regulate intracellular S1P accumulation, in HPAEC motility...
  11. ncbi request reprint Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells
    Rhett Cummings
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
    J Biol Chem 279:41085-94. 2004
    ..These results demonstrate for the first time that LPA is a potent stimulator of IL-8 production in HBEpCs, which involves PKCdelta/NF-kappaB signaling pathways...
  12. pmc Role of sphingolipids in murine radiation-induced lung injury: protection by sphingosine 1-phosphate analogs
    Biji Mathew
    Institute for Personalized Respiratory Medicine, Section of Pulmonary, Critical Care, and Sleep Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    FASEB J 25:3388-400. 2011
    ..1 and 1 mg/kg i.p., 2×/wk) and to a lesser degree by SEW-2871 (1 mg/kg i.p., 2×/wk), compared with those in controls. These results support the targeting of S1P signaling as a novel therapeutic strategy in RILI...
  13. pmc Autotaxin induces lung epithelial cell migration through lysoPLD activity-dependent and -independent pathways
    Jing Zhao
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 439:45-55. 2011
    ..In addition we also demonstrated association of ATX with the epithelial cell-surface LPA receptor and integrin β4...
  14. pmc Role of acylglycerol kinase in LPA-induced IL-8 secretion and transactivation of epidermal growth factor-receptor in human bronchial epithelial cells
    Satish Kalari
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, Illinois, USA
    Am J Physiol Lung Cell Mol Physiol 296:L328-36. 2009
    ..These results suggest that native AGK regulates LPA-mediated IL-8 secretion involving MAPKs, NF-kappaB, and transactivation of EGF-R. Thus AGK may play an important role in innate immunity and airway remodeling during inflammation...
  15. pmc Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression
    Yutong Zhao
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 45:426-35. 2011
    ..These results identify a novel role for intracellularly generated S1P in protection against ALI and suggest S1PL as a potential therapeutic target...
  16. doi request reprint Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells
    Yutong Zhao
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Am J Respir Cell Mol Biol 40:19-30. 2009
    ..In addition, inhibition of COX-2 partly attenuated PM-induced Prostaglandin E2 and IL-6 release...
  17. pmc Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases
    Yutong Zhao
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:19501-11. 2006
    ....
  18. pmc Lysophosphatidic acid enhances pulmonary epithelial barrier integrity and protects endotoxin-induced epithelial barrier disruption and lung injury
    Donghong He
    Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:24123-32. 2009
    ..These data suggest a protective role of LPA in airway inflammation and remodeling...
  19. pmc Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury
    Viswanathan Natarajan
    Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Am J Respir Cell Mol Biol 49:6-17. 2013
    ....
  20. pmc Lysophosphatidic acid increases soluble ST2 expression in mouse lung and human bronchial epithelial cells
    Jing Zhao
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Cell Signal 24:77-85. 2012
    ..These results unravel a novel sST2 mediated signaling pathway that has physiological relevance to airway inflammation and remodeling...
  21. pmc Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1
    Yutong Zhao
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL 60637, USA
    J Biol Chem 282:14165-77. 2007
    ..This involves the conversion of extracellular S1P to Sph by LPP-1, which facilitates Sph uptake, followed by the intracellular conversion of Sph to S1P by SphK1...
  22. pmc Differential regulation of sphingosine kinases 1 and 2 in lung injury
    Raj Wadgaonkar
    Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
    Am J Physiol Lung Cell Mol Physiol 296:L603-13. 2009
    ..Collectively, our results for the first time demonstrate distinct functional roles of the two SphK isoforms in the regulation of LPS-induced lung injury...
  23. pmc Nrf2 regulates hyperoxia-induced Nox4 expression in human lung endothelium: identification of functional antioxidant response elements on the Nox4 promoter
    Srikanth Pendyala
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Free Radic Biol Med 50:1749-59. 2011
    ..Collectively, these results demonstrate, for the first time, a novel role for Nrf2 in regulating hyperoxia-induced Nox4 transcription via AREs in lung endothelium...
  24. pmc SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation
    Chunbin Zou
    Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 288:6306-16. 2013
    ..These studies authenticate Fbxw15 as a ubiquitin E3 ligase subunit that mediates endotoxin-induced HBO1 depletion in cells, thereby controlling cell replicative capacity...
  25. pmc Extracellular signal-regulated kinase (ERK) regulates cortactin ubiquitination and degradation in lung epithelial cells
    Jing Zhao
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 287:19105-14. 2012
    ..These results provide evidence that LPS modulation of cortactin stability is coordinately regulated by stress kinases and the ubiquitin-proteasomal network...
  26. pmc A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation
    Bill B Chen
    Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Nat Immunol 14:470-9. 2013
    ..These studies identified a pathway of innate immunity that may be useful to detect subjects with altered immune responses during critical illness or provide a basis for therapeutic intervention targeting TRAF protein abundance...
  27. pmc Acyl-CoA:lysophosphatidylcholine acyltransferase I (Lpcat1) catalyzes histone protein O-palmitoylation to regulate mRNA synthesis
    Chunbin Zou
    Department of Medicine, the Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:28019-25. 2011
    ..This epigenetic modification regulates global gene transcriptional activity...
  28. ncbi request reprint De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells
    Evgeny V Berdyshev
    The University of Chicago, Biological Sciences Division, Department of Medicine, 929 E 57th Street, Room W403M, Chicago, IL 60637, USA
    Cell Signal 18:1779-92. 2006
    ....
  29. pmc SCF E3 ligase F-box protein complex SCF(FBXL19) regulates cell migration by mediating Rac1 ubiquitination and degradation
    Jing Zhao
    Department of Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    FASEB J 27:2611-9. 2013
    ..Thus, SCF(FBXL19) targets Rac1 for its disposal, a process regulated by AKT. These findings provide the first evidence of an F-box protein targeting a small G protein for ubiquitination and degradation to modulate cell migration...
  30. ncbi request reprint Involvement of phospholipase D2 in lysophosphatidate-induced transactivation of platelet-derived growth factor receptor-beta in human bronchial epithelial cells
    Lixin Wang
    Department of Medicine, Division of Pulmonary and Critical Care, Johns Hopkins University, Baltimore, Maryland 21224, USA
    J Biol Chem 278:39931-40. 2003
    ..These results show for the first time that transactivation of PDGF-R beta by LPA in HBEpCs is regulated by PLD2...
  31. pmc Simvastatin attenuates radiation-induced murine lung injury and dysregulated lung gene expression
    Biji Mathew
    Section of Pulmonary and Critical Care Medicine, Department of Medicine, University of Chicago, Illinois, USA
    Am J Respir Cell Mol Biol 44:415-22. 2011
    ..These studies identify the involvement of specific genes and gene networks in RILI pathobiology, and confirm that statins represent a novel strategy to limit RILI...
  32. pmc Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling
    Yutong Zhao
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biochim Biophys Acta 1831:86-92. 2013
    ..This article is part of a Special Issue entitled: Advances in Lysophospholipid Research...
  33. pmc LPS impairs phospholipid synthesis by triggering beta-transducin repeat-containing protein (beta-TrCP)-mediated polyubiquitination and degradation of the surfactant enzyme acyl-CoA:lysophosphatidylcholine acyltransferase I (LPCAT1)
    Chunbin Zou
    Department of Medicine, Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 286:2719-27. 2011
    ..LPCAT1 is the first lipogenic substrate for β-TrCP, and the results suggest that modulation of the GSK-3β-SCFβ(TrCP) E3 ligase effector pathway might be a unique strategy to optimize dipalmitoylphosphatidylcholine levels in sepsis...
  34. pmc Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells
    Catherine M Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Biochem J 398:55-62. 2006
    ..These findings demonstrate that trafficking of LPA1 to the nucleus is influenced by cell-matrix interactions and that nuclear LPA1 may be involved in regulating intranuclear protein phosphorylation and signalling...
  35. ncbi request reprint Lysophosphatidic acid enhances interleukin-13 gene expression and promoter activity in T cells
    Joshua Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland 21224, USA
    Am J Physiol Lung Cell Mol Physiol 290:L66-74. 2006
    ..The effects of LPA on IL-13 promoter activation appeared to be distinct from those mediated by GATA-3. LPA can augment IL-13 gene expression in T cells, especially under conditions of submaximal activation...
  36. pmc Transcriptional regulation of lysophosphatidic acid-induced interleukin-8 expression and secretion by p38 MAPK and JNK in human bronchial epithelial cells
    Bahman Saatian
    Division of Pulmonary and Critical Care Medicine and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Biochem J 393:657-68. 2006
    ..These results show an independent role for p38 MAPK and JNK in LPA-induced IL-8 expression and secretion via NF-kappaB and AP-1 transcription respectively in HBEpCs...