Yun Ge Zhao

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
    Ai Zheng 28:1168-75. 2009
  2. ncbi An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 176:3032-49. 2010
  3. ncbi H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Glia 56:917-24. 2008
  4. ncbi Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites
    Tiebang Kang
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee 32306 4390, USA
    J Biol Chem 277:25583-91. 2002
  5. ncbi Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Biol Chem 278:15056-64. 2003
  6. ncbi Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA
    Cancer Res 64:590-8. 2004
  7. ncbi Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity
    Tiebang Kang
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee 32306 4390, USA
    J Biol Chem 277:48514-22. 2002
  8. ncbi Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation
    Yunge Zhao
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Physiol Lung Cell Mol Physiol 300:L718-29. 2011
  9. ncbi Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion
    Yunge Zhao
    Department of Pathology, University of Virginia, 415 Lane Road, MR5 Rm3332, Charlottesville, VA 22908, USA
    Biochem Biophys Res Commun 369:1215-20. 2008
  10. ncbi The role of adenosine A2A receptor signaling in bronchiolitis obliterans
    Christine L Lau
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Thorac Surg 88:1071-8. 2009

Collaborators

Detail Information

Publications17

  1. ncbi Expression of matrix metalloproteinase-26 in multiple human cancer tissues and smooth muscle cells
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306, USA
    Ai Zheng 28:1168-75. 2009
    ..This study was to present a comprehensive protein expression profile of MMP-26 in multiple human cancer tissues...
  2. ncbi An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 176:3032-49. 2010
    ..Our data indicate that the U1242 MG xenograft model is valuable for studying GBM extensive invasion and angiogenesis as well as testing anti-invasive and anti-angiogenic therapeutic approaches...
  3. ncbi H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway
    Yunge Zhao
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Glia 56:917-24. 2008
    ..Our results suggest that H-Ras increased uPA expression and activity via the Ras/Raf/MEK signaling pathway leading to enhanced cell invasion and this may contribute to increased invasive growth properties of astrocytomas...
  4. ncbi Intracellular activation of human adamalysin 19/disintegrin and metalloproteinase 19 by furin occurs via one of the two consecutive recognition sites
    Tiebang Kang
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee 32306 4390, USA
    J Biol Chem 277:25583-91. 2002
    ..This report is the first thorough investigation of the intracellular activation of adamalysin 19, demonstrating that furin activated pro-hADAM19 in the secretory pathway via one of the two consecutive furin recognition sites...
  5. ncbi Activation of pro-gelatinase B by endometase/matrilysin-2 promotes invasion of human prostate cancer cells
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida 32306 4390, USA
    J Biol Chem 278:15056-64. 2003
    ..Moreover, MMP-26 and MMP-9 proteins were both expressed in the same human prostate carcinoma tissue samples examined. These results indicate that MMP-26 may be a physiological and pathological activator of pro-MMP-9...
  6. ncbi Endometase/matrilysin-2 in human breast ductal carcinoma in situ and its inhibition by tissue inhibitors of metalloproteinases-2 and -4: a putative role in the initiation of breast cancer invasion
    Yun Ge Zhao
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, Florida, USA
    Cancer Res 64:590-8. 2004
    ..Higher levels of MMP-26 mRNA were also detected in DCIS cells by in situ hybridization...
  7. ncbi Autolytic processing at Glu586-Ser587 within the cysteine-rich domain of human adamalysin 19/disintegrin-metalloproteinase 19 is necessary for its proteolytic activity
    Tiebang Kang
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee 32306 4390, USA
    J Biol Chem 277:48514-22. 2002
    ....
  8. ncbi Depletion of tissue plasminogen activator attenuates lung ischemia-reperfusion injury via inhibition of neutrophil extravasation
    Yunge Zhao
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Am J Physiol Lung Cell Mol Physiol 300:L718-29. 2011
    ..These results suggest that tPA could serve as an important therapeutic target for the prevention and treatment of acute IR injury after lung transplantation...
  9. ncbi Urokinase directly activates matrix metalloproteinases-9: a potential role in glioblastoma invasion
    Yunge Zhao
    Department of Pathology, University of Virginia, 415 Lane Road, MR5 Rm3332, Charlottesville, VA 22908, USA
    Biochem Biophys Res Commun 369:1215-20. 2008
    ..These results suggest that uPA-mediated direct activation of MMP-9 may promote GBM cell invasion...
  10. ncbi The role of adenosine A2A receptor signaling in bronchiolitis obliterans
    Christine L Lau
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Thorac Surg 88:1071-8. 2009
    ....
  11. ncbi Protein kinase C-alpha-mediated regulation of low-density lipoprotein receptor related protein and urokinase increases astrocytoma invasion
    Samson Amos
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA
    Cancer Res 67:10241-51. 2007
    ..Thus, a strategy of combining small molecule inhibitors of PKC-alpha and PI3K could provide a new treatment paradigm for glioblastomas...
  12. ncbi Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line
    Isa M Hussaini
    Department of Pathology, 415 Lane Rd, Box 800904, University of Virginia, Charlottesville, VA 22908, USA
    Am J Pathol 170:356-65. 2007
    ..These results demonstrate that MMP-9 and PKC-alpha or PKC-delta may provide putative therapeutic targets for the control of PA dural invasion...
  13. ncbi Enhanced fibrinolysis protects against lung ischemia-reperfusion injury
    Christine L Lau
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 137:1241-8. 2009
    ..This study investigates the role of the fibrinolytic cascade in lung ischemia-reperfusion injury and investigates the interplay between the fibrinolytic system and the inflammatory response...
  14. ncbi Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor
    Seakwoo Lee
    Department of Chemistry and Biochemistry and Institute of Molecular Biophysics, Florida State University, Tallahassee, FL 32306, USA
    Cell Res 16:750-8. 2006
    ..The present study indicates that MMP-26 and TIMP-4 may play an integral role during the conversion of HGPIN to invasive cancer and may also serve as markers for early prostate cancer diagnosis...
  15. ncbi Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury
    Ashish K Sharma
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 139:474-82. 2010
    ..This study tests the hypothesis that adenosine A(2A) receptor activation attenuates ischemia-reperfusion injury by inhibiting CD4+ T cell activation and subsequent neutrophil infiltration...
  16. ncbi Matrix metalloproteinase-9, a potential biological marker in invasive pituitary adenomas
    Jian Gong
    Department of Neurosurgery, University of Virginia Health System, Charlottesville, VA 22903, USA
    Pituitary 11:37-48. 2008
    ....
  17. ncbi Focal prostate basal cell layer disruptions and leukocyte infiltration are correlated events: A potential mechanism for basal cell layer disruptions and tumor invasion
    Yan Gao Man
    Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology and American Registry of Pathology, 6825 16th Street NW, Washington, DC 20306 6000, USA
    Cancer Detect Prev 29:161-9. 2005
    ..These findings suggest that focal basal cell layer disruptions and leukocyte infiltration are correlated events, representing a potential trigger factor for prostate tumor invasion...