Research Topics
Species | Yong ZhaoSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
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Detail Information
Publications
Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cellsYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL 60612, USA
BMC Med 10:3. 2012....
Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristicsYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, IL 60612, USA
Exp Cell Res 312:2454-64. 2006..These findings may have significant potential to advance stem-cell-based therapeutics...- A unique human blood-derived cell population displays high potential for producing insulinYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
Biochem Biophys Res Commun 360:205-11. 2007..These findings may open up new avenues for autologous blood stem cell-based therapies for diabetes... 
New type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetesYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Transl Res 155:211-6. 2010..These new stem cells will offer a promising avenue for the development of powerful autologous therapeutic products for prevention and reversal of T1D...- Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) miceYong Zhao
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
PLoS ONE 4:e4226. 2009..Regulatory T cells (Tregs) play a pivotal role in maintaining self-tolerance through their inhibitory impact on autoreactive effector T cells. An abnormality of Tregs is associated with initiation of progression of T1D... - Human umbilical cord blood-derived f-macrophages retain pluripotentiality after thrombopoietin expansionYong Zhao
Section of Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
Exp Cell Res 310:311-8. 2005..These findings demonstrate a potential use of CB f-Mphi and may lead to develop new therapeutic strategy for treating dominant disease... - Immune modulation of blood-derived stem cell as a comprehensive tool for treating type 1 diabetesYong Zhao
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Discov Med 8:219-22. 2009..Blood-derived new stem cells have shown promise in both aspects of this treatment... - Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic modelYong Zhao
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Biochem Biophys Res Commun 399:629-36. 2010..This model can provide a valuable tool for translational research into T1D... - Human cord blood stem cells and the journey to a cure for type 1 diabetesYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Autoimmun Rev 10:103-7. 2010.... - New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cellsYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Autoimmun Rev 11:137-42. 2011..This review focuses on recent progress in the use of immune modulation in T2D and discusses the potential for future therapies. New insights are provided on the use of cord blood-derived multipotent stem cells (CB-SC) in T2D... - Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cellYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
Immunol Lett 108:78-87. 2007..Our findings may advance our understanding of the immunobiology of stem cells and facilitate the therapeutic application of cord blood stem cells... - New hope for diabetics: adult blood stem cells can make insulinYong Zhao
Department of Medicine, University of Illinois School of Medicine, Chicago, IL 60612, USA
Discov Med 7:63-7. 2007..Clinical application of these autologous blood-derived insulin-producing cells holds great promise for diabetic treatment... - Stem cell educator therapy and induction of immune balanceYong Zhao
Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Curr Diab Rep 12:517-23. 2012..Our clinical trial reveals that a single treatment with the Stem Cell Educator provides lasting reversal of autoimmunity that allows regeneration of islet β cells and improvement of metabolic control in subjects with long-standing T1D... - Hyperglycemia and advanced glycosylation end products suppress adipocyte apoE expression: implications for adipocyte triglyceride metabolismDoris Joy Espiritu
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Am J Physiol Endocrinol Metab 299:E615-23. 2010..In vivo results using adipose tissue transplantation suggest that reduction of adipocyte apoE, and subsequent reduction of adipocyte triglyceride accumulation, could influence lipid accumulation in nonadipose tissue... - Spermine acts as a negative regulator of macrophage differentiation in human myeloid leukemia cellsIgor M Gavin
Biochip Technology Center, Argonne National Laboratory, Argonne, Illinois, USA
Cancer Res 64:7432-8. 2004..The present studies raise the possibility that agents able to reduce spermine levels in patients' myeloid leukemia cells may enhance the activity of differentiation therapy drugs for this type of leukemia... - The immunity of splenic and peritoneal F4/80(+) resident macrophages in mouse mixed allogeneic chimerasGuangwei Liu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, 100080, China
J Mol Med (Berl) 85:1125-35. 2007..The present study also, for the first time, offered basic information for macrophages maturing in heterogeneous environments... - Dendritic cells induced in the presence of GM-CSF and IL-5Huanfa Yi
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Cytokine 37:35-43. 2007..Together, these data suggest that IL-5 could partially inhibit GM-CSF-induced DC differentiation which could be reversed by IL-4 in vitro... - The influence of cyclosporin A on lymphocyte attenuator expressionChun Zeng
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
J Autoimmun 28:234-44. 2007.... - NK cell tolerance in mixed allogeneic chimerasYong Zhao
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
J Immunol 170:5398-405. 2003..Thus, the present studies demonstrate that NK cells in mixed chimeras are stably tolerant to both donor and host Ags, by mechanisms that are as yet unexplained... - B and T lymphocyte attenuator interacts with CD3zeta and inhibits tyrosine phosphorylation of TCRzeta complex during T-cell activationTing He Wu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Immunol Cell Biol 85:590-5. 2007..These results suggest that BTLA functions to regulate T-cell signaling by controlling the phosphorylated form of TCRzeta accumulation in the lipid raft... - The macrophage heterogeneity: difference between mouse peritoneal exudate and splenic F4/80+ macrophagesGuangwei Liu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
J Cell Physiol 209:341-52. 2006.... - The nonopsonic allogeneic cell phagocytosis of macrophages detected by flow cytometry and two photon fluorescence microscopeGuang-Wei Liu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Transpl Immunol 16:220-6. 2006..Our present data indicated that the FCM and TPM combined method is a practical approach to detect macrophage nonopsonic phagocytosis of allogeneic lymphocytes and to identify the phenotype alteration of macrophages after phagocytosis... - A human peripheral blood monocyte-derived subset acts as pluripotent stem cellsYong Zhao
Biochip Technology Center, Argonne National Laboratory, Argonne, IL 60439, USA
Proc Natl Acad Sci U S A 100:2426-31. 2003..The ability to store, expand, and differentiate these PSC from autologous peripheral blood should make them valuable candidates for transplantation therapy... - Diabetes-induced alteration of F4/80+ macrophages: a study in mice with streptozotocin-induced diabetes for a long termHaixia Ma
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datun Road, Chaoyang, Beijing 100101, China
J Mol Med (Berl) 86:391-400. 2008.... - The inflammatory Th 17 subset in immunity against self and non-self antigensDi Jin
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China
Autoimmunity 41:154-62. 2008.... - BTLA, a new inhibitory B7 family receptor with a TNFR family ligandChun Zeng
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
Cell Mol Immunol 2:427-32. 2005..The exploration of the biological mechanisms and regulation of BTLA will open possibilities on novel therapeutic strategies in immune-related diseases... - Bioimaging nitric oxide in activated macrophages in vitro and hepatic inflammation in vivo based on a copper-naphthoimidazol coordination compoundJie Ouyang
The School of Chemistry and Chemical Engineering, Tianjin University of Technology, 263 Hongqi South Road, Tianjin 300191, China
Nitric Oxide 19:42-9. 2008.... - Transforming growth factor-beta: an important role in CD4+CD25+ regulatory T cells and immune toleranceLianjun Zhang
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China
Autoimmunity 39:269-76. 2006..We will, herein, focus on the crucial role of TGF-beta signaling in Treg cell biology and summarize the current studies regarding TGF-beta in the generation and function of CD4+CD25+Treg cells both in vivo and in vitro... - Immunotoxic effects of perfluorononanoic acid on BALB/c miceXuemei Fang
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100190, China
Toxicol Sci 105:312-21. 2008..Interestingly, at the transcriptional level, the nuclear factor-kappa B signaling pathway appears to be uninvolved in the immunotoxic potential of PFNA... - The differentiation-inducing effect of Nordy on HPV-16 subgenes-immortalized human endocervical cells H8Jing Zhao
Department of Pathology, Chongqing Medical University, Chongqing, PR China
Anticancer Drugs 19:713-9. 2008..Taken together, Nordy could suppress proliferation by inhibiting proliferation-related events and promote cell differentiation in H8 cell. The results suggested that Nordy might be a potential tumor therapeutic agent... - Altered allogeneic immune responses in middle-aged miceYimin Sun
Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, UNMC, Omaha, NE 68198-7690, USA
Cell Mol Immunol 1:440-6. 2004..Further studies on the characteristics of allogeneic immunity in aging individuals may help to determine the appropriated treatment for transplant aging individuals... - Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrowJia Lin Zhang
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA
Transplantation 80:362-9. 2005.... - Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic miceYong Zhao
Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, Omaha, NE 68198 7690, USA
Xenotransplantation 10:232-9. 2003..The cellular infiltrate in xenografts suggests that macrophages may be involved in xenograft rejection. However, the precise role of macrophages in xenograft rejection has not yet been fully addressed... - Prolongation of allogeneic skin graft survival by injection of anti-Ly49A monoclonal antibody YE1/48Tian-Yu Yang
Department of Surgery, University of Nebraska Medical Center, The Lied Transplant Center, 987690 University of Nebraska Medical Center, Omaha, NE 68198-7690, USA
Clin Immunol 106:148-54. 2003..The presence of NK, NKT cells, and some cytotoxic T cells may be essential for YE1/48-mediated immunosuppression in vivo... - Murine CD4 T cells selected in a highly disparate xenogeneic porcine thymus graft do not show rapid decay in the absence of selecting MHC in the peripheryJose-Ignacio Rodriguez-Barbosa
Transplantation Biology Research Center, Bone Marrow Transplantation Section, Surgical Service, Massachusetts General Hospital/Harvard Medical School, Boston, MA 02129, USA
J Immunol 169:6697-710. 2002..Our results support the interpretation that xenogeneic thymic transplantation is a feasible strategy to reconstitute CD4 T cells and render recipients tolerant of a xenogeneic donor... - Transcription factor FOXO3a mediates apoptosis in HIV-1-infected macrophagesMin Cui
Laboratory of Neurotoxicology, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha 68198, USA
J Immunol 180:898-906. 2008..Understanding the PI3K/Akt-1/FOXO3a pathway and its associated death mechanism in macrophages during HIV-1 infection would lead to identification of potential therapeutic avenues for the treatment of HIV-1 infection... - Inhibition of cell growth and induction of G1-phase cell cycle arrest in hepatoma cells by steroid extract from Meretrix meretrixTing-He Wu
Laboratory of Marine Biotechnology, Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, People's Republic of China
Cancer Lett 232:199-205. 2006..In conclusion, MME induces G1 phase cell cycle arrest via both p53-dependent and p53-independent pathways... - MOP3, a component of the molecular clock, regulates the development of B cellsYimin Sun
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
Immunology 119:451-60. 2006..This study also showed a connection between a master regular of circadian rhythm with B-cell development in mice... - Compatibility of porcine and human interleukin 2: implications for xenotransplantationBaojun Zhang
State Key Laboratory of Biomembrane and Membrane Biotechnology, Transplantation Biology Research Division, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Xenotransplantation 13:423-32. 2006..Our data suggested an additional potential advantage for the mixed xenogeneic chimeras... - Thymic epithelial progenitor cells and thymus regeneration: an updateLianjun Zhang
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
Cell Res 17:50-5. 2007..Great progress has been made to characterize the common TEC progenitor cells in recent years. We herein discuss the sole origin paradigm with regard to TEC differentiation as well as these progenitor cells in thymus regeneration... - A novel approach to generate host antitumor T cells: adoptive immunotherapy by T cells maturing in xenogeneic thymusYong Zhao
Transplantation Biology Research Division, The State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences
J Immunother 30:83-8. 2007..This study may offer a novel resource to produce host antitumor T cells for adoptive immunotherapy of tumor patients... - The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in miceYanyan Qu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, 100080, China
Transpl Immunol 17:153-61. 2007..The different effects of rapa on CD4(+)CD25(+)Treg and T effector cells make rapa to be a favorable choice for inducing immune tolerance to self-, allo-, or xeno-antigens... - Changes of CD4+CD25+Foxp3+ regulatory T cells in aged Balb/c miceLiang Zhao
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing, China 100080
J Leukoc Biol 81:1386-94. 2007..The functional defects of CD4(+)CD25(+) Treg cells may shed light on the role of CD4(+)CD25(+) Treg cells in the increased sensitivity to autoimmune diseases of aged populations... - Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2Yong Zhao
Gladstone Institute of Cardiovascular Disease, 1650 Owens Street, San Francisco, CA 94158, USA
Cell 129:303-17. 2007..These findings indicate that subtle alteration of miRNA dosage can have profound consequences in mammals and demonstrate the utility of mammalian loss-of-function models in revealing physiologic miRNA targets... - The two simultaneously occurring processes in one immune response: the positive immune reaction and immune toleranceYong Zhao
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
Med Hypotheses 67:1384-5. 2006..On the other hand, it will impact the immunotherapy for tumors and the development of vaccines... - Allograft inflammatory factor-1 and its immune regulationGuangwei Liu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beisihuan Xi Road 25, Beijing 100080, China
Autoimmunity 40:95-102. 2007..In the present manuscript, the genomic and functional characteristics of AIF-1 family proteins as well as their immune regulatory effects are reviewed... - Beneficial effects of losartan on vascular injury induced by advanced glycosylation end products and their receptors in spontaneous hypertension ratsWei Wei Zhu
Department of Geratology, Shandong Provincial Hospital of Shandong University, No 324 Road, Jinan, Shandong, P R China
Mol Cell Biochem 304:35-43. 2007.... - Regulatory CD4(+)CD25(+) T-cells are controlled by multiple pathways at multiple levelsYanyan Qu
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Int Rev Immunol 26:145-60. 2007.... - Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysmsG Matthew Longo
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 7690, USA
J Clin Invest 110:625-32. 2002..These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA... - Transplant tolerance: is it really free of concerns?Yong Zhao
Trends Immunol 28:376-7. 2007 - The biological role of dectin-1 in immune responseLina Sun
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Datui Road Yi 5, Beijing 100101, China
Int Rev Immunol 26:349-64. 2007..In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. In this paper, we will mainly focus on the characteristics of dectin-1 and its biological role in immune response... - The effects of antibody treatment on regulatory CD4(+)CD25(+) T cellsHuanfa Yi
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China
Transpl Immunol 19:37-44. 2008..In this manuscript, we review the recent progress on the effects of therapeutic antibodies on the development, phenotypic changes and functions of CD4(+)CD25(+) Tregs...