Affiliation: University of Illinois at Chicago
Zhao Y, Wang H, Mazzone T. Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res. 2006;312:2454-64 pubmed
..These findings may have significant potential to advance stem-cell-based therapeutics. ..
Zhao Y, Lin B, Dingeldein M, Guo C, Hwang D, Holterman M. New type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes. Transl Res. 2010;155:211-6 pubmed publisher
..These new stem cells will offer a promising avenue for the development of powerful autologous therapeutic products for prevention and reversal of T1D. ..
Zhao Y, Huang Z, Qi M, Lazzarini P, Mazzone T. Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol Lett. 2007;108:78-87 pubmed
..Our findings may advance our understanding of the immunobiology of stem cells and facilitate the therapeutic application of cord blood stem cells. ..
Zhao Y, Lin B, Darflinger R, Zhang Y, Holterman M, Skidgel R. Human cord blood stem cell-modulated regulatory T lymphocytes reverse the autoimmune-caused type 1 diabetes in nonobese diabetic (NOD) mice. PLoS ONE. 2009;4:e4226 pubmed publisher
..These data demonstrate that treatment with mCD4CD62L Tregs can reverse overt diabetes, providing a novel strategy for the treatment of type 1 diabetes as well as other autoimmune diseases. ..
Zhao Y, Guo C, Hwang D, Lin B, Dingeldein M, Mihailescu D, et al
. Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun. 2010;399:629-36 pubmed publisher
..This model can provide a valuable tool for translational research into T1D...
Zhao Y, Jiang Z, Guo C. New hope for type 2 diabetics: targeting insulin resistance through the immune modulation of stem cells. Autoimmun Rev. 2011;11:137-42 pubmed publisher
..This review focuses on recent progress in the use of immune modulation in T2D and discusses the potential for future therapies. New insights are provided on the use of cord blood-derived multipotent stem cells (CB-SC) in T2D...
Zhao Y, Jiang Z, Zhao T, Ye M, Hu C, Yin Z, et al
. Reversal of type 1 diabetes via islet ? cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med. 2012;10:3 pubmed publisher